ES2190541T3 - Procedimiento para la utilizacion de oligonucleotidos con dinucleosidos cpg modificados. - Google Patents

Procedimiento para la utilizacion de oligonucleotidos con dinucleosidos cpg modificados.

Info

Publication number
ES2190541T3
ES2190541T3 ES97941505T ES97941505T ES2190541T3 ES 2190541 T3 ES2190541 T3 ES 2190541T3 ES 97941505 T ES97941505 T ES 97941505T ES 97941505 T ES97941505 T ES 97941505T ES 2190541 T3 ES2190541 T3 ES 2190541T3
Authority
ES
Spain
Prior art keywords
oligonucleotides
gene expression
cpg
dinucleosids
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97941505T
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English (en)
Inventor
Sudhir Agrawal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aceragen Inc
Original Assignee
Hybridon Inc
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Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Application granted granted Critical
Publication of ES2190541T3 publication Critical patent/ES2190541T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/311—Phosphotriesters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine

Abstract

LA INVENCION SE REFIERE A OLIGONUCLEOTIDOS MODIFICADOS QUE SON UTILES PARA ESTUDIOS DE EXPRESION GENETICA Y PARA APROXIMACIONES TERAPEUTICAS POR ANTISENTIDO. LA INVENCION SUMINISTRA OLIGONUCLEOTIDOS MODIFICADOS QUE INHIBEN LA EXPRESION GENETICA Y QUE PRODUCEN MENORES EFECTOS COLATERALES QUE LOS OLIGONUCLEOTIDOS DE FOSFOROTIOATO CONVENCIONALES. EN PARTICULAR, LA INVENCION SUMINISTRA OLIGONUCLEOTIDOS MODIFICADOS QUE CONTIENEN CPG QUE CUANDO SE ADMINISTRAN A UN MAMIFERO REDUCEN LA ESPLENOMEGALIA Y EL EMPOBRECIMIENTO PLAQUETARIO CON RELACION A LOS OLIGONUCLEOTIDOS DE FOSFOROTIOATO CONVENCIONALES QUE CONTIENEN CPG. LA INVENCION SUMINISTRA ADEMAS PROCEDIMIENTOS PARA UTILIZAR LOS OLIGONUCLEOTIDOS PARA MODULAR LA EXPRESION GENETICA IN VIVO, INCLUYENDO EL USO PARA EL TRATAMIENTO TERAPEUTICO DE LAS ENFERMEDADES PROVOCADAS POR LA EXPRESION GENETICA ABERRANTE.
ES97941505T 1996-09-10 1997-09-10 Procedimiento para la utilizacion de oligonucleotidos con dinucleosidos cpg modificados. Expired - Lifetime ES2190541T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/711,568 US5856462A (en) 1996-09-10 1996-09-10 Oligonucleotides having modified CpG dinucleosides

Publications (1)

Publication Number Publication Date
ES2190541T3 true ES2190541T3 (es) 2003-08-01

Family

ID=24858610

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97941505T Expired - Lifetime ES2190541T3 (es) 1996-09-10 1997-09-10 Procedimiento para la utilizacion de oligonucleotidos con dinucleosidos cpg modificados.

Country Status (11)

Country Link
US (1) US5856462A (es)
EP (1) EP0928335B1 (es)
JP (1) JP5265067B2 (es)
AT (1) ATE236248T1 (es)
AU (1) AU4339997A (es)
CA (1) CA2265917C (es)
DE (1) DE69720481T2 (es)
DK (1) DK0928335T3 (es)
ES (1) ES2190541T3 (es)
PT (1) PT928335E (es)
WO (1) WO1998011211A2 (es)

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PT928335E (pt) 2003-07-31
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ATE236248T1 (de) 2003-04-15
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