DE69306969T2 - Therapeutisches anti-hiv oligonukleotid und arzneimittel - Google Patents
Therapeutisches anti-hiv oligonukleotid und arzneimittelInfo
- Publication number
- DE69306969T2 DE69306969T2 DE69306969T DE69306969T DE69306969T2 DE 69306969 T2 DE69306969 T2 DE 69306969T2 DE 69306969 T DE69306969 T DE 69306969T DE 69306969 T DE69306969 T DE 69306969T DE 69306969 T2 DE69306969 T2 DE 69306969T2
- Authority
- DE
- Germany
- Prior art keywords
- hiv
- oligonucleotides
- medicinal product
- therapeutic anti
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 4
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 230000036436 anti-hiv Effects 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 3
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 101710163270 Nuclease Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000029087 digestion Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000004713 phosphodiesters Chemical class 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95813592A | 1992-10-05 | 1992-10-05 | |
| PCT/US1993/009392 WO1994008004A1 (en) | 1992-10-05 | 1993-10-04 | Therapeutic anti-hiv oligonucleotide and pharmaceutical |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69306969D1 DE69306969D1 (de) | 1997-02-06 |
| DE69306969T2 true DE69306969T2 (de) | 1997-05-07 |
Family
ID=25500631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69306969T Expired - Fee Related DE69306969T2 (de) | 1992-10-05 | 1993-10-04 | Therapeutisches anti-hiv oligonukleotid und arzneimittel |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5684147A (de) |
| EP (1) | EP0664833B1 (de) |
| JP (1) | JPH08504570A (de) |
| KR (1) | KR950704482A (de) |
| AT (1) | ATE146819T1 (de) |
| AU (1) | AU678415B2 (de) |
| BR (1) | BR9307191A (de) |
| CA (1) | CA2146364A1 (de) |
| CZ (1) | CZ85495A3 (de) |
| DE (1) | DE69306969T2 (de) |
| DK (1) | DK0664833T3 (de) |
| ES (1) | ES2096343T3 (de) |
| FI (1) | FI951600A (de) |
| GR (1) | GR3022315T3 (de) |
| HU (1) | HUT72400A (de) |
| NO (1) | NO951307L (de) |
| NZ (1) | NZ257434A (de) |
| PL (1) | PL308261A1 (de) |
| WO (1) | WO1994008004A1 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030026782A1 (en) | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5733781A (en) * | 1994-07-19 | 1998-03-31 | Gen-Probe Incorporated | Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus |
| US6776986B1 (en) | 1996-06-06 | 2004-08-17 | Novartis Ag | Inhibition of HIV-1 replication by antisense RNA expression |
| EP1584681A3 (de) * | 1997-07-10 | 2005-11-09 | GeneSense Technologies Inc. | Antisense oligonukleotid-sequenzen als inhibitoren für mikroorganismen |
| US6610539B1 (en) * | 1997-07-10 | 2003-08-26 | Genesense Technologies, Inc. | Antisense oligonucleotide sequences as inhibitors of microorganisms |
| EP1007657B1 (de) | 1997-08-19 | 2006-02-08 | Idera Pharmaceuticals, Inc. | Hiv-spezifische oligonukleotide und verfahren zu deren verwendung |
| EP1733735B1 (de) | 1998-05-22 | 2017-03-22 | Ottawa Hospital Research Institute | Verfahren und Produkte zur Induktion von mukosaler Immunität |
| EP1129064B1 (de) | 1998-11-12 | 2008-01-09 | Invitrogen Corporation | Transportreagentien |
| US6977245B2 (en) * | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| US6623920B1 (en) * | 1999-07-09 | 2003-09-23 | Gen-Probe Incorporated | Detection of HIV-1 by nucleic acid amplification |
| US7271148B2 (en) * | 1999-12-23 | 2007-09-18 | The Board Of Regents Of The University Of Texas System | Inhibition of cellular proteases |
| DE60131430T2 (de) * | 2000-01-14 | 2008-10-16 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Oligodeoxynukleotide und ihre verwendung zur induktion einer immunreaktion |
| US6582920B2 (en) | 2000-09-01 | 2003-06-24 | Gen-Probe Incorporated | Amplification of HIV-1 RT sequences for detection of sequences associated with drug-resistance mutations |
| JP2002125687A (ja) * | 2000-10-30 | 2002-05-08 | Tosoh Corp | Ｈｉｖ−１検出のためのオリゴヌクレオチドおよび検出法 |
| US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
| AU2002361468A1 (en) | 2001-08-14 | 2003-03-18 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human S | Method for rapid generation of mature dendritic cells |
| JP4383534B2 (ja) | 2001-08-17 | 2009-12-16 | コーリー ファーマシューティカル ゲーエムベーハー | 改善した活性を有する組み合わせモチーフ免疫刺激オリゴヌクレオチド |
| US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
| US7615227B2 (en) | 2001-12-20 | 2009-11-10 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce angiogenesis |
| US8263091B2 (en) | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
| ATE544466T1 (de) | 2002-10-29 | 2012-02-15 | Coley Pharm Group Inc | Verwendung von cpg oligonukleotide zur behandlung von hepatitis c virus infektion |
| AU2003300919A1 (en) | 2002-12-11 | 2004-06-30 | Coley Pharmaceutical Gmbh | 5' cpg nucleic acids and methods of use |
| EP1627563A1 (de) | 2004-08-10 | 2006-02-22 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Verfahren und Mittel zur Herstellung einer stabilisierten Zelle |
| EP1647595A1 (de) * | 2004-10-15 | 2006-04-19 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Nukleinsäuren gegen Viren, insbesondere gegen HIV |
| US8399423B2 (en) * | 2005-10-12 | 2013-03-19 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| EP1954811B1 (de) | 2005-11-17 | 2011-06-08 | TET Systems GmbH & Co. KG | Induzierbare expressionssysteme |
| USRE49583E1 (en) | 2005-11-17 | 2023-07-18 | Tet Systems Gmbh & Co. Kg | Inducible expression systems |
| HUE037580T2 (hu) | 2005-12-09 | 2018-09-28 | Academisch Medisch Centrum Bij De Univ Van Amsterdam | Eszközök és eljárások ellenanyag-termelõ sejtek stabilitásának befolyásolására |
| US9005974B2 (en) | 2005-12-09 | 2015-04-14 | Academish Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
| AU2010271583B2 (en) | 2009-07-15 | 2015-02-12 | Kling Biotherapeutics B.V. | Means and methods for producing high affinity antibodies |
| WO2011119920A2 (en) | 2010-03-25 | 2011-09-29 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| ES2626671T3 (es) | 2010-12-02 | 2017-07-25 | Aimm Therapeutics B.V. | Medios y métodos para producir anticuerpos de alta afinidad |
| RS57397B8 (sr) | 2011-06-10 | 2020-01-31 | Univ Oregon Health & Science | Cmv glikoproteini i rekombinantni vektori |
| US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| EP2679596B1 (de) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 Env-proteinvariante |
| US9932364B2 (en) | 2013-08-26 | 2018-04-03 | The Royal Institution For The Advancement Of Learning/Mcgill University | Antisense-based small RNA agents targeting the Gag open reading frame of HIV-1 RNA |
| US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| WO2015115892A1 (en) | 2014-01-31 | 2015-08-06 | Aimm Therapeutics B.V. | Means and methods for producing stable antibodies |
| WO2016011203A1 (en) | 2014-07-15 | 2016-01-21 | Life Technologies Corporation | Compositions with lipid aggregates and methods for efficient delivery of molecules to cells |
| US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE208813T1 (de) * | 1988-02-16 | 2001-11-15 | Greatbatch Gen Aid Ltd | Modifizierte zellen mit resistenz gegen retroviralinfektionen |
| JPH04501052A (ja) * | 1988-02-26 | 1992-02-27 | ザ・ウスター・フアウンデーシヨン・フオー・バイオメデイカル・リサーチ | 外来性オリゴヌクレオチドによるｈｔｌｖ―３の抑制 |
-
1993
- 1993-10-04 CA CA002146364A patent/CA2146364A1/en not_active Abandoned
- 1993-10-04 CZ CZ95854A patent/CZ85495A3/cs unknown
- 1993-10-04 EP EP93924289A patent/EP0664833B1/de not_active Expired - Lifetime
- 1993-10-04 PL PL93308261A patent/PL308261A1/xx unknown
- 1993-10-04 BR BR9307191A patent/BR9307191A/pt not_active Application Discontinuation
- 1993-10-04 JP JP6509354A patent/JPH08504570A/ja active Pending
- 1993-10-04 DE DE69306969T patent/DE69306969T2/de not_active Expired - Fee Related
- 1993-10-04 KR KR1019950701317A patent/KR950704482A/ko not_active Application Discontinuation
- 1993-10-04 AT AT93924289T patent/ATE146819T1/de not_active IP Right Cessation
- 1993-10-04 NZ NZ257434A patent/NZ257434A/en unknown
- 1993-10-04 DK DK93924289.7T patent/DK0664833T3/da active
- 1993-10-04 HU HU9500995A patent/HUT72400A/hu unknown
- 1993-10-04 AU AU54028/94A patent/AU678415B2/en not_active Ceased
- 1993-10-04 ES ES93924289T patent/ES2096343T3/es not_active Expired - Lifetime
- 1993-10-04 WO PCT/US1993/009392 patent/WO1994008004A1/en not_active Application Discontinuation
-
1994
- 1994-10-07 US US08/319,823 patent/US5684147A/en not_active Expired - Lifetime
-
1995
- 1995-04-04 NO NO951307A patent/NO951307L/no unknown
- 1995-04-04 FI FI951600A patent/FI951600A/fi not_active Application Discontinuation
-
1997
- 1997-01-17 GR GR960403507T patent/GR3022315T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU678415B2 (en) | 1997-05-29 |
| NO951307D0 (no) | 1995-04-04 |
| AU5402894A (en) | 1994-04-26 |
| HUT72400A (en) | 1996-04-29 |
| DK0664833T3 (da) | 1997-04-14 |
| BR9307191A (pt) | 1999-03-30 |
| ES2096343T3 (es) | 1997-03-01 |
| EP0664833A1 (de) | 1995-08-02 |
| JPH08504570A (ja) | 1996-05-21 |
| ATE146819T1 (de) | 1997-01-15 |
| NO951307L (no) | 1995-06-01 |
| GR3022315T3 (en) | 1997-04-30 |
| NZ257434A (en) | 1997-01-29 |
| EP0664833B1 (de) | 1996-12-27 |
| FI951600A0 (fi) | 1995-04-04 |
| DE69306969D1 (de) | 1997-02-06 |
| WO1994008004A1 (en) | 1994-04-14 |
| HU9500995D0 (en) | 1995-06-28 |
| CA2146364A1 (en) | 1994-04-14 |
| KR950704482A (ko) | 1995-11-20 |
| CZ85495A3 (en) | 1996-03-13 |
| FI951600A (fi) | 1995-05-10 |
| US5684147A (en) | 1997-11-04 |
| PL308261A1 (en) | 1995-07-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE146819T1 (de) | Therapeutisches anti-hiv oligonukleotid und arzneimittel | |
| CA2165821A1 (en) | Antisense oligonucleotides and therapeutic use thereof in human immunodeficiency virus infection | |
| AU8771398A (en) | Novel hiv-specific synthetic oligonucleotides and methods of their use | |
| WO1994024144A3 (en) | Enhanced triple-helix and double-helix formation with oligomers containing modified purines | |
| ATE181960T1 (de) | Gegensinnige hemmer des humanen immunmangel virus (hiv) | |
| HU9403788D0 (en) | Self-stabilized oligonucleotides as therapeutic agents | |
| DE69330372T2 (de) | ZUSAMMENSETZUNGEN UND VERFAHREN FüR DIE BEHANDLUNG VON MIT HEPATITIS C VIREN ASSOZIIERTEN KRANKHEITEN | |
| HUP0103465A2 (hu) | A VEGF expressziójának gátlására szolgáló rövid oligonukleotidok | |
| ATE138384T1 (de) | Olionukleotidalkylphosphonate und - phosphonothioate | |
| BR0316363A (pt) | Nucleosìdeos 2'-ramificado e mutação de flaviviridae | |
| PL319512A1 (en) | Viral material and nucleotidic fragments associated with sclerosis multiplex or diagnostic, prophylactic and therapeutic purposes | |
| KR960704034A (ko) | 단백질 생산, 세포 증식 및(또는) 전염병 병원균의 증식에 대한 올리고뉴클레오티드 저해의 향상법(Enhancement of Oligonucleotide Inhibition of Protein Production, Cell Proliferation, and/or Multiplication of Infectious Disease Pathogens) | |
| AP1674A (en) | The genome of the HIV-1 inter-subtype (C/B') and use thereof. | |
| ES2112062T3 (es) | Oligonucleotidos con actividad anti-citomegalovirus. | |
| EP0733640A4 (de) | Doppelsträngiges oligonukleotid und karzinostatisches mittel das dieses als aktiven inhaltsstoff enthält | |
| KR960000914A (ko) | 이소프레닐 단백질 트랜스퍼라아제의 발현을 억제하는 올리고뉴클레오티드 | |
| MX9703188A (es) | Acidos nucleicos de aminoacido. | |
| TH23381A (th) | โอลิโกนิวคลีโอไทด์สำหรับยับยั้งการแสดงลักษณะของไอโซพรีนิลโปรตีนทรานสเฟอเรส | |
| Egan et al. | Abasic Oligodeoxyribonucleoside Phosphorothioates as Inhibitors of the Human Immunodeficiency Virus-1 (HIV-1) Phosphorothioate Inhibition of HIV-1 Reverse Transcriptase and Interactions with Syrian Hampster Fibroblast (V79) Cells | |
| ATE480560T1 (de) | Zusammensetzung zur behandlung von periodontalen erkrankungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |