DE69715216D1 - Gastroprotektive flavon-/flavanon-verbindungen mit therapeutischem effekt auf entzündliche darmerkrankungen - Google Patents

Gastroprotektive flavon-/flavanon-verbindungen mit therapeutischem effekt auf entzündliche darmerkrankungen

Info

Publication number
DE69715216D1
DE69715216D1 DE69715216T DE69715216T DE69715216D1 DE 69715216 D1 DE69715216 D1 DE 69715216D1 DE 69715216 T DE69715216 T DE 69715216T DE 69715216 T DE69715216 T DE 69715216T DE 69715216 D1 DE69715216 D1 DE 69715216D1
Authority
DE
Germany
Prior art keywords
flavanon
flavon
gastroprotective
inflammable
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69715216T
Other languages
English (en)
Other versions
DE69715216T2 (de
Inventor
Moohi Yoo
Won Son
Yon Kim
Bae Kim
Hoe Kim
Deuk Lee
Jho Lim
In Lim
Ok Ahn
Gi Baik
Sung Kim
Young Oh
Kwon Ryu
Sung Yang
Chan Shin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dong A Pharmaceutical Co Ltd
Original Assignee
Dong A Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong A Pharmaceutical Co Ltd filed Critical Dong A Pharmaceutical Co Ltd
Publication of DE69715216D1 publication Critical patent/DE69715216D1/de
Application granted granted Critical
Publication of DE69715216T2 publication Critical patent/DE69715216T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
DE69715216T 1996-07-25 1997-07-25 Gastroprotektive flavon-/flavanon-verbindungen mit therapeutischem effekt auf entzündliche darmerkrankungen Expired - Lifetime DE69715216T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019960030494A KR100447918B1 (ko) 1996-07-25 1996-07-25 대장을포함한위장관보호작용을갖는플라본및플라바논화합물
PCT/KR1997/000144 WO1998004541A1 (en) 1996-07-25 1997-07-25 Gastroprotective flavone/flavanone compounds with therapeutic effect on inflammatory bowel disease

Publications (2)

Publication Number Publication Date
DE69715216D1 true DE69715216D1 (de) 2002-10-10
DE69715216T2 DE69715216T2 (de) 2003-05-08

Family

ID=19467593

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69715216T Expired - Lifetime DE69715216T2 (de) 1996-07-25 1997-07-25 Gastroprotektive flavon-/flavanon-verbindungen mit therapeutischem effekt auf entzündliche darmerkrankungen

Country Status (8)

Country Link
US (1) US6025387A (de)
EP (1) EP0915864B1 (de)
JP (1) JP3377214B2 (de)
KR (1) KR100447918B1 (de)
CA (1) CA2261267C (de)
DE (1) DE69715216T2 (de)
DK (1) DK0915864T3 (de)
WO (1) WO1998004541A1 (de)

Families Citing this family (39)

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DE19902773A1 (de) * 1999-01-25 2000-07-27 Sertuerner Arzneimittel Gmbh Anticholestatische Wirksamkeit von Luteolin
JP2001181190A (ja) * 1999-12-22 2001-07-03 Takeda Chem Ind Ltd 医薬組成物
US7638554B2 (en) * 2002-04-18 2009-12-29 Sri International Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
US20030229136A1 (en) * 2002-04-18 2003-12-11 Nurulain Zaveri Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents
DE60317661T2 (de) * 2002-05-17 2008-10-30 Merckle Gmbh Annelierte pyrrol-verbindungen als protonenpumpenhemmer zur behandlung von geschwüren
JP2006516562A (ja) * 2003-01-24 2006-07-06 ステート オブ イスラエル、ミニストリー オブ アグリカルチャー 抗酸化活性を増強するための相乗的な組成物及び方法
US20040176471A1 (en) * 2003-03-07 2004-09-09 Kaohsiung Medical University Novel chalcone derivatives and pharmaceutical compositions comprising the same
KR20050024121A (ko) * 2003-09-04 2005-03-10 동아제약주식회사 7-카르복시메틸옥시-3',4',5-트리메톡시 플라본.일수화물, 이의 제조방법 및 용도
EP2277595A3 (de) 2004-06-24 2011-09-28 Novartis Vaccines and Diagnostics, Inc. Verbindungen zur Immunopotenzierung
JP2007297283A (ja) * 2004-07-28 2007-11-15 Santen Pharmaceut Co Ltd 新規桂皮酸関連化合物
KR20080091436A (ko) 2006-01-09 2008-10-13 카운실 오브 사이언티픽 엔드 인더스트리얼 리서치 위장관 독성, 관련 증상 및 궤양 치료용 천연물질
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
TW200808739A (en) 2006-04-06 2008-02-16 Novartis Vaccines & Diagnostic Quinazolines for PDK1 inhibition
KR100930467B1 (ko) * 2007-06-07 2009-12-08 동아제약주식회사 점액분비를 촉진시키는 3',4',5-트리메톡시 플라본 유도체화합물, 그의 제조방법 및 약학적 용도
US20080319051A1 (en) * 2007-06-22 2008-12-25 Bionovo, Inc. Liquiritigenin and derivatives as selective estrogen receptor beta agonists
US20090042818A1 (en) * 2007-06-22 2009-02-12 Bionovo, Inc. Liquiritigenin and Derivatives as Selective Estrogen Receptor Beta Agonists
KR101381999B1 (ko) * 2007-07-06 2014-04-14 동아에스티 주식회사 위염 치료제의 효력을 극대화시키기 위한 가용화 위체류시스템 매트릭스 제제
KR101391494B1 (ko) 2007-11-26 2014-05-07 동아에스티 주식회사 위염 치료제의 효력을 극대화시키기 위한 나노서스펜젼
CA2710122A1 (en) 2007-12-20 2009-07-02 Novartis Ag Thiazole derivatives used as pi 3 kinase inhibitors
WO2009110008A1 (en) * 2008-03-05 2009-09-11 Council Of Scientific & Industrial Research Anti-ulcer activity of flavone analogs
EP2112145A1 (de) * 2008-04-24 2009-10-28 AxoGlia Therapeutics S.A. Chromenonderivate zur Behandlung von neurodegenerativen Krankheiten
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
JP5712580B2 (ja) * 2010-11-30 2015-05-07 株式会社ツムラ ５，７‐ジヒドロキシ‐６‐メトキシフラボン類の製造方法
PL2670753T3 (pl) 2011-01-31 2017-05-31 Novartis Ag Nowe pochodne heterocykliczne
MX340452B (es) 2011-10-28 2016-07-08 Novartis Ag Novedosos derivados de purina y su uso en el tratamiento de enfermedades.
WO2013173283A1 (en) 2012-05-16 2013-11-21 Novartis Ag Dosage regimen for a pi-3 kinase inhibitor
CA2930359C (en) 2013-12-06 2022-03-01 Novartis Ag Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor
US10376488B2 (en) * 2014-09-05 2019-08-13 ONENESS BIOTECH CO., Ltd Use of flavonoids in manufacturing compositions for wound healing
WO2017077445A1 (en) 2015-11-02 2017-05-11 Novartis Ag Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
CN111374971A (zh) * 2020-04-26 2020-07-07 南开大学 香叶木素在制备用于治疗炎症性肠病的药物中的应用
CN111454240B (zh) * 2020-04-30 2023-05-16 上海爱启医药技术有限公司 制备二硒醚化合物的方法
CN115197190A (zh) * 2021-04-09 2022-10-18 中国海洋大学 一种新型植物黄酮衍生物及其制备方法和应用
CN115197191A (zh) * 2021-04-09 2022-10-18 中国海洋大学 一种新型中药黄酮衍生物及其制备方法和应用
KR102356603B1 (ko) 2021-08-05 2022-02-08 지엘팜텍주식회사 안구건조증 치료를 위한 레코플라본 함유 점안 조성물
KR102583151B1 (ko) 2021-08-05 2023-09-26 지엘팜텍주식회사 안구건조증 치료를 위한 레코플라본 함유 점안 조성물 및 이의 제조방법
WO2023014117A1 (ko) 2021-08-05 2023-02-09 지엘팜텍주식회사 안구건조증 치료를 위한 레코플라본 함유 점안 조성물 및 이의 제조방법

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JPS6025923A (ja) * 1983-07-22 1985-02-08 Otsuka Pharmaceut Co Ltd ５−リポキシゲナ−ゼ阻害剤
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KR890700117A (ko) * 1986-12-12 1989-03-02 쓰무라 아끼라 유효성분으로서 칼콘 유도체를 함유하는 항 궤양제 및 신규의 칼콘 유도체
US5278174A (en) * 1990-06-04 1994-01-11 Scios Nova, Inc. Sigma binding site agents
IT1245371B (it) * 1991-03-28 1994-09-20 Geymonat Spa Derivati di flavoni, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
US5399584A (en) * 1992-05-05 1995-03-21 The Procter & Gamble Company Use of flavone derivatives for gastroprotection
JPH0725761A (ja) * 1993-07-09 1995-01-27 Kureha Chem Ind Co Ltd 軟骨保護剤

Also Published As

Publication number Publication date
DK0915864T3 (da) 2002-12-30
US6025387A (en) 2000-02-15
WO1998004541A1 (en) 1998-02-05
JPH11514015A (ja) 1999-11-30
DE69715216T2 (de) 2003-05-08
JP3377214B2 (ja) 2003-02-17
EP0915864B1 (de) 2002-09-04
KR100447918B1 (ko) 2005-09-28
CA2261267C (en) 2003-10-07
CA2261267A1 (en) 1998-02-05
EP0915864A1 (de) 1999-05-19

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