DE69710486T2 - Mikroventil zum füllen des behälters eines transdermalen medikamentenverabreichungssystems - Google Patents
Mikroventil zum füllen des behälters eines transdermalen medikamentenverabreichungssystemsInfo
- Publication number
- DE69710486T2 DE69710486T2 DE69710486T DE69710486T DE69710486T2 DE 69710486 T2 DE69710486 T2 DE 69710486T2 DE 69710486 T DE69710486 T DE 69710486T DE 69710486 T DE69710486 T DE 69710486T DE 69710486 T2 DE69710486 T2 DE 69710486T2
- Authority
- DE
- Germany
- Prior art keywords
- layer
- substrate
- charge
- resistor
- valve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000758 substrate Substances 0.000 claims abstract description 41
- 239000000446 fuel Substances 0.000 claims abstract description 18
- 238000002485 combustion reaction Methods 0.000 claims abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 47
- 229910052581 Si3N4 Inorganic materials 0.000 claims description 23
- 238000004519 manufacturing process Methods 0.000 claims description 18
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 claims description 18
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 16
- 229910052710 silicon Inorganic materials 0.000 claims description 16
- 239000010703 silicon Substances 0.000 claims description 16
- 239000000377 silicon dioxide Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- 235000012239 silicon dioxide Nutrition 0.000 claims description 15
- 239000012530 fluid Substances 0.000 claims description 14
- 229920001220 nitrocellulos Polymers 0.000 claims description 14
- 239000000020 Nitrocellulose Substances 0.000 claims description 12
- 239000007789 gas Substances 0.000 claims description 12
- 230000004888 barrier function Effects 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 9
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 8
- 239000013543 active substance Substances 0.000 claims description 7
- 239000000567 combustion gas Substances 0.000 claims description 6
- 229910021420 polycrystalline silicon Inorganic materials 0.000 claims description 6
- 239000003380 propellant Substances 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 5
- 239000004065 semiconductor Substances 0.000 claims description 5
- 229910021529 ammonia Inorganic materials 0.000 claims description 4
- 238000007740 vapor deposition Methods 0.000 claims description 4
- 229910004205 SiNX Inorganic materials 0.000 claims description 3
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 3
- 238000010292 electrical insulation Methods 0.000 claims description 3
- 230000001960 triggered effect Effects 0.000 claims description 3
- MROCJMGDEKINLD-UHFFFAOYSA-N dichlorosilane Chemical compound Cl[SiH2]Cl MROCJMGDEKINLD-UHFFFAOYSA-N 0.000 claims description 2
- 238000013467 fragmentation Methods 0.000 claims description 2
- 238000006062 fragmentation reaction Methods 0.000 claims description 2
- 229910052990 silicon hydride Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims 1
- 229920005591 polysilicon Polymers 0.000 claims 1
- 239000002737 fuel gas Substances 0.000 abstract 1
- 239000010410 layer Substances 0.000 description 67
- 229910052814 silicon oxide Inorganic materials 0.000 description 15
- 239000012528 membrane Substances 0.000 description 11
- 239000010408 film Substances 0.000 description 8
- 230000036571 hydration Effects 0.000 description 7
- 238000006703 hydration reaction Methods 0.000 description 7
- 239000000017 hydrogel Substances 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 238000001647 drug administration Methods 0.000 description 2
- 125000003055 glycidyl group Chemical group C(C1CO1)* 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- WGTYBPLFGIVFAS-UHFFFAOYSA-M tetramethylammonium hydroxide Chemical compound [OH-].C[N+](C)(C)C WGTYBPLFGIVFAS-UHFFFAOYSA-M 0.000 description 2
- 229910003818 SiH2Cl2 Inorganic materials 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 239000003989 dielectric material Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000000572 ellipsometry Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 238000001465 metallisation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000010301 surface-oxidation reaction Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
- F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
- F15C5/00—Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/003—Valves for single use only
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0065—Operating means specially adapted for microvalves using chemical activation
- F16K99/0067—Operating means specially adapted for microvalves using chemical activation actuated by a pyrotechnical charge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/0074—Fabrication methods specifically adapted for microvalves using photolithography, e.g. etching
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/008—Multi-layer fabrications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0082—Microvalves adapted for a particular use
- F16K2099/0086—Medical applications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/1624—Destructible or deformable element controlled
- Y10T137/1632—Destructible element
- Y10T137/1647—Explosive actuation
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Fluid Mechanics (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Theoretical Computer Science (AREA)
- Dermatology (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Computer Hardware Design (AREA)
- Vascular Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Portable Nailing Machines And Staplers (AREA)
- Closures For Containers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9614230A FR2756032B1 (fr) | 1996-11-21 | 1996-11-21 | Vanne miniature et son procede de fabrication, dispositif de remplissage de reservoir comprenant une telle vanne |
| FR9706613A FR2764034B3 (fr) | 1997-05-29 | 1997-05-29 | Vanne miniature et son procede de fabrication |
| PCT/FR1997/002101 WO1998022719A1 (fr) | 1996-11-21 | 1997-11-20 | Vanne miniature pour le remplissage du reservoir d'un appareil d'administration transdermique de medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69710486D1 DE69710486D1 (de) | 2002-03-21 |
| DE69710486T2 true DE69710486T2 (de) | 2002-10-31 |
Family
ID=26233113
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69710486T Expired - Lifetime DE69710486T2 (de) | 1996-11-21 | 1997-11-20 | Mikroventil zum füllen des behälters eines transdermalen medikamentenverabreichungssystems |
| DE0939862T Pending DE939862T1 (de) | 1996-11-21 | 1997-11-20 | Mikroventil zum füllen des behälters eines transdermalen medikamentenverabreichungssystems |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE0939862T Pending DE939862T1 (de) | 1996-11-21 | 1997-11-20 | Mikroventil zum füllen des behälters eines transdermalen medikamentenverabreichungssystems |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6247485B1 (enExample) |
| EP (1) | EP0939862B1 (enExample) |
| JP (1) | JP4114087B2 (enExample) |
| KR (1) | KR100453439B1 (enExample) |
| AT (1) | ATE213309T1 (enExample) |
| AU (1) | AU725913B2 (enExample) |
| BR (1) | BR9713381A (enExample) |
| CA (1) | CA2272326C (enExample) |
| CZ (1) | CZ294564B6 (enExample) |
| DE (2) | DE69710486T2 (enExample) |
| ES (1) | ES2138575T3 (enExample) |
| HU (1) | HU222607B1 (enExample) |
| IL (1) | IL130043A0 (enExample) |
| NO (1) | NO322934B1 (enExample) |
| NZ (1) | NZ336015A (enExample) |
| PL (1) | PL185319B1 (enExample) |
| SK (1) | SK284825B6 (enExample) |
| WO (1) | WO1998022719A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9155871B2 (en) | 2010-11-19 | 2015-10-13 | C. Miethke Gmbh & Co Kg | Electrically operable, in one possible embodiment programmable hydrocephalus valve |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6527716B1 (en) | 1997-12-30 | 2003-03-04 | Altea Technologies, Inc. | Microporation of tissue for delivery of bioactive agents |
| US6131385A (en) * | 1997-08-18 | 2000-10-17 | Trw Inc. | Integrated pulsed propulsion system for microsatellite |
| FR2774684B1 (fr) * | 1998-02-10 | 2000-03-03 | Poudres & Explosifs Ste Nale | Nouveaux materiaux pyrotechniques non detonables pour microsystemes |
| DK1124607T3 (da) * | 1998-07-14 | 2009-01-26 | Altea Therapeutics Corp | Kontrolleret fjernelse af biologisk membran ved hjælp af pyroteknisk ladning til transmembran transport |
| US6349740B1 (en) * | 1999-04-08 | 2002-02-26 | Abbott Laboratories | Monolithic high performance miniature flow control unit |
| US20030078499A1 (en) * | 1999-08-12 | 2003-04-24 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
| ATE290364T1 (de) * | 1999-08-18 | 2005-03-15 | Microchips Inc | Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien |
| US6378292B1 (en) | 2000-11-10 | 2002-04-30 | Honeywell International Inc. | MEMS microthruster array |
| FR2828245B1 (fr) * | 2001-04-27 | 2005-11-11 | Poudres & Explosifs Ste Nale | Microactionneurs pyrotechniques pour microsystemes |
| FR2827377B1 (fr) * | 2001-07-13 | 2003-12-05 | Poudres & Explosifs Ste Nale | Dispositif d'allumage pour microcharges pyrotechniques |
| AU2003225735A1 (en) * | 2002-03-11 | 2003-09-29 | Altea Therapeutics Corporation | Transdermal drug delivery patch system, method of making same and method of using same |
| US8116860B2 (en) | 2002-03-11 | 2012-02-14 | Altea Therapeutics Corporation | Transdermal porator and patch system and method for using same |
| FR2836907B1 (fr) | 2002-03-11 | 2005-03-18 | Commissariat Energie Atomique | Microvanne a actionnement pyrotechnique |
| US9918665B2 (en) | 2002-03-11 | 2018-03-20 | Nitto Denko Corporation | Transdermal porator and patch system and method for using same |
| US6953455B2 (en) * | 2002-07-30 | 2005-10-11 | Hospira, Inc. | Medicine delivery system |
| FR2846318B1 (fr) * | 2002-10-24 | 2005-01-07 | Commissariat Energie Atomique | Microstructure electromecanique integree comportant des moyens de reglage de la pression dans une cavite scellee et procede de reglage de la pression |
| US6800070B2 (en) * | 2002-11-07 | 2004-10-05 | George Mazidji | Lockable tranquilizer bracelet |
| FR2847246B1 (fr) * | 2002-11-19 | 2005-07-08 | Poudres & Explosifs Ste Nale | Microactionneur pyrotechnique double effet pour microsysteme et microsysteme utilisant un tel microactionneur |
| FR2856046B1 (fr) | 2003-06-16 | 2005-07-29 | Biomerieux Sa | Microvanne fluidique a ouverture par commande electrique |
| FR2857427B1 (fr) | 2003-07-10 | 2005-08-26 | Biomerieux Sa | Vanne a commande electrique comprenant une membrane microporeuse |
| US7470266B2 (en) * | 2003-09-16 | 2008-12-30 | I-Flow Corporation | Fluid medication delivery device |
| US8016811B2 (en) * | 2003-10-24 | 2011-09-13 | Altea Therapeutics Corporation | Method for transdermal delivery of permeant substances |
| FR2865508B1 (fr) * | 2004-01-27 | 2006-03-03 | Snpe Materiaux Energetiques | Microsysteme pyrotechnique et procede de fabrication d'un microsysteme. |
| AU2005284908B2 (en) | 2004-09-13 | 2011-12-08 | Morningside Venture Investments Limited | Biosynchronous transdermal drug delivery |
| US7827983B2 (en) * | 2004-12-20 | 2010-11-09 | Hewlett-Packard Development Company, L.P. | Method for making a pharmaceutically active ingredient abuse-prevention device |
| FR2883860B1 (fr) * | 2005-03-29 | 2007-06-08 | Commissariat Energie Atomique | Procede de fabrication de micro-canaux enterres et micro-dispositif comprenant de tels micro-canaux. |
| US20070075079A1 (en) * | 2005-10-05 | 2007-04-05 | Harlan Stokes | Flavored container lid |
| CN103523738B (zh) * | 2012-07-06 | 2016-07-06 | 无锡华润上华半导体有限公司 | 微机电系统薄片及其制备方法 |
| WO2016123406A1 (en) | 2015-01-28 | 2016-08-04 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| ES1157758Y (es) * | 2016-04-27 | 2016-08-22 | Descansare Sleep Lab S L | Dispositivo de control de flujo de aire |
| US20180100601A1 (en) * | 2016-10-08 | 2018-04-12 | Zepto Life Technology, LLC | Electrolytic membrane valve |
| US20180135770A1 (en) * | 2016-11-11 | 2018-05-17 | Honeywell International Inc. | Apparatus and methods for thermally activated micro-valve |
| EP3548134A1 (en) * | 2016-12-05 | 2019-10-09 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| CA3049529A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| KR102075594B1 (ko) * | 2017-11-13 | 2020-02-11 | 재단법인대구경북과학기술원 | 약물 전달 장치 및 이의 제조방법 |
| CA3101966A1 (en) | 2018-05-29 | 2019-12-05 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| US12397141B2 (en) | 2018-11-16 | 2025-08-26 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3184097A (en) * | 1962-01-19 | 1965-05-18 | Earl E Kilmer | Valve with exploding diaphragm |
| US4622031A (en) | 1983-08-18 | 1986-11-11 | Drug Delivery Systems Inc. | Indicator for electrophoretic transcutaneous drug delivery device |
| US5135479A (en) * | 1983-08-18 | 1992-08-04 | Drug Delivery Systems, Inc. | Programmable control and mounting system for transdermal drug applicator |
| US5186001A (en) | 1991-11-08 | 1993-02-16 | University Of Southern California | Transient energy release microdevices and methods |
| US5310404A (en) * | 1992-06-01 | 1994-05-10 | Alza Corporation | Iontophoretic delivery device and method of hydrating same |
| US5366454A (en) * | 1993-03-17 | 1994-11-22 | La Corporation De L'ecole Polytechnique | Implantable medication dispensing device |
-
1997
- 1997-11-20 EP EP19970947111 patent/EP0939862B1/fr not_active Expired - Lifetime
- 1997-11-20 CA CA 2272326 patent/CA2272326C/en not_active Expired - Lifetime
- 1997-11-20 NZ NZ33601597A patent/NZ336015A/xx not_active IP Right Cessation
- 1997-11-20 SK SK639-99A patent/SK284825B6/sk not_active IP Right Cessation
- 1997-11-20 JP JP52329398A patent/JP4114087B2/ja not_active Expired - Lifetime
- 1997-11-20 HU HU0001065A patent/HU222607B1/hu active IP Right Grant
- 1997-11-20 PL PL97333628A patent/PL185319B1/pl unknown
- 1997-11-20 BR BR9713381A patent/BR9713381A/pt not_active IP Right Cessation
- 1997-11-20 AU AU52277/98A patent/AU725913B2/en not_active Expired
- 1997-11-20 DE DE69710486T patent/DE69710486T2/de not_active Expired - Lifetime
- 1997-11-20 AT AT97947111T patent/ATE213309T1/de not_active IP Right Cessation
- 1997-11-20 US US09/285,000 patent/US6247485B1/en not_active Expired - Lifetime
- 1997-11-20 IL IL13004397A patent/IL130043A0/xx not_active IP Right Cessation
- 1997-11-20 DE DE0939862T patent/DE939862T1/de active Pending
- 1997-11-20 CZ CZ19991766A patent/CZ294564B6/cs not_active IP Right Cessation
- 1997-11-20 KR KR10-1999-7004475A patent/KR100453439B1/ko not_active Expired - Lifetime
- 1997-11-20 ES ES97947111T patent/ES2138575T3/es not_active Expired - Lifetime
- 1997-11-20 WO PCT/FR1997/002101 patent/WO1998022719A1/fr not_active Ceased
-
1999
- 1999-05-21 NO NO19992481A patent/NO322934B1/no not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9155871B2 (en) | 2010-11-19 | 2015-10-13 | C. Miethke Gmbh & Co Kg | Electrically operable, in one possible embodiment programmable hydrocephalus valve |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69710486D1 (de) | 2002-03-21 |
| ATE213309T1 (de) | 2002-02-15 |
| KR20000069060A (ko) | 2000-11-25 |
| HUP0001065A3 (en) | 2001-02-28 |
| PL185319B1 (pl) | 2003-04-30 |
| NO322934B1 (no) | 2006-12-18 |
| HU222607B1 (hu) | 2003-08-28 |
| DE939862T1 (de) | 2000-04-06 |
| ES2138575T1 (es) | 2000-01-16 |
| EP0939862B1 (fr) | 2002-02-13 |
| SK63999A3 (en) | 2000-05-16 |
| US6247485B1 (en) | 2001-06-19 |
| CA2272326C (en) | 2005-03-29 |
| CZ176699A3 (cs) | 2000-02-16 |
| KR100453439B1 (ko) | 2004-10-15 |
| NO992481D0 (no) | 1999-05-21 |
| NZ336015A (en) | 2000-11-24 |
| ES2138575T3 (es) | 2002-10-01 |
| JP4114087B2 (ja) | 2008-07-09 |
| AU725913B2 (en) | 2000-10-26 |
| CA2272326A1 (en) | 1998-05-28 |
| WO1998022719A1 (fr) | 1998-05-28 |
| AU5227798A (en) | 1998-06-10 |
| NO992481L (no) | 1999-05-21 |
| SK284825B6 (sk) | 2005-12-01 |
| IL130043A0 (en) | 2000-02-29 |
| CZ294564B6 (cs) | 2005-02-16 |
| JP2001505491A (ja) | 2001-04-24 |
| HUP0001065A2 (hu) | 2000-08-28 |
| BR9713381A (pt) | 2000-03-21 |
| EP0939862A1 (fr) | 1999-09-08 |
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Owner name: CROSSJECT, PARIS, FR |