DE69705516T2 - D-mannit und seine herstellung - Google Patents

D-mannit und seine herstellung

Info

Publication number
DE69705516T2
DE69705516T2 DE69705516T DE69705516T DE69705516T2 DE 69705516 T2 DE69705516 T2 DE 69705516T2 DE 69705516 T DE69705516 T DE 69705516T DE 69705516 T DE69705516 T DE 69705516T DE 69705516 T2 DE69705516 T2 DE 69705516T2
Authority
DE
Germany
Prior art keywords
mannite
production
mannitol
excipient
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69705516T
Other languages
English (en)
Other versions
DE69705516D1 (de
DE69705516T3 (de
Inventor
Tomohiro Yoshinari
Fritz Schueckler
Norbert Poellinger
Shinji Maegata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Bayer AG
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14109240&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69705516(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG, Takeda Chemical Industries Ltd filed Critical Bayer AG
Publication of DE69705516D1 publication Critical patent/DE69705516D1/de
Application granted granted Critical
Publication of DE69705516T2 publication Critical patent/DE69705516T2/de
Publication of DE69705516T3 publication Critical patent/DE69705516T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/26—Hexahydroxylic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Steroid Compounds (AREA)
DE69705516T 1996-04-16 1997-04-14 D-mannit und seine herstellung Expired - Lifetime DE69705516T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9440196 1996-04-16
JP9440196 1996-04-16
PCT/JP1997/001286 WO1997038960A1 (en) 1996-04-16 1997-04-14 D-mannitol and its preparation

Publications (3)

Publication Number Publication Date
DE69705516D1 DE69705516D1 (de) 2001-08-09
DE69705516T2 true DE69705516T2 (de) 2002-04-25
DE69705516T3 DE69705516T3 (de) 2004-09-30

Family

ID=14109240

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69705516T Expired - Lifetime DE69705516T3 (de) 1996-04-16 1997-04-14 D-mannit und seine herstellung

Country Status (27)

Country Link
US (1) US6503918B2 (de)
EP (1) EP0902777B2 (de)
KR (1) KR20000005486A (de)
CN (1) CN1221398A (de)
AT (1) ATE202768T1 (de)
AU (1) AU718658B2 (de)
BG (1) BG63460B1 (de)
BR (1) BR9708672A (de)
CA (1) CA2251092A1 (de)
CU (1) CU22776A3 (de)
CZ (1) CZ333698A3 (de)
DE (1) DE69705516T3 (de)
DK (1) DK0902777T4 (de)
EA (1) EA000968B1 (de)
ES (1) ES2158540T5 (de)
GR (1) GR3036760T3 (de)
HU (1) HUP9902165A3 (de)
ID (1) ID16566A (de)
IL (1) IL126580A (de)
NO (2) NO311349B1 (de)
NZ (1) NZ332313A (de)
PL (1) PL329614A1 (de)
PT (1) PT902777E (de)
SK (1) SK282768B6 (de)
TR (1) TR199802079T2 (de)
TW (1) TW515787B (de)
WO (1) WO1997038960A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10008506A1 (de) * 2000-02-24 2001-09-13 Bayer Ag Verfahren zur Herstellung von pharmazeutischen Darreichungsformen
FR2807034B1 (fr) † 2000-03-29 2002-06-14 Roquette Freres Mannitol pulverulent et son procede de fabrication
JPWO2002024167A1 (ja) * 2000-09-19 2004-01-29 第一製薬株式会社 医薬組成物
US6855333B1 (en) 2000-10-03 2005-02-15 Mutual Pharmaceutical Co., Inc. Stabilization of solid thyroid drug formulations
US6979462B1 (en) 2000-10-03 2005-12-27 Mutual Pharmaceutical Co., Inc. Stabilization of solid drug formulations
DE10161402A1 (de) * 2001-12-13 2003-06-18 Merck Patent Gmbh Verfahren zur Herstellung von direkt tablettierbarem beta-Mannit
US7462232B2 (en) * 2002-05-14 2008-12-09 Fmc Corporation Microcrystalline cellulose compositions
US8163797B2 (en) * 2003-12-31 2012-04-24 Actavis Elizabeth Llc Method of treating with stable pravastatin formulation
US7879382B2 (en) * 2005-09-30 2011-02-01 Fmc Corporation Stabilizers and compositions and products comprising same
US8486450B2 (en) 2005-12-28 2013-07-16 Takeda Pharmaceutical Company Limited Method of producing solid preparation disintegrating in the oral cavity
BRPI0708108B1 (pt) 2006-02-20 2021-12-14 Chugai Seiyaku Kabushiki Kaisha Composição farmacêutica compreendendo fosfato de oseltamivir
US8932629B2 (en) * 2006-10-27 2015-01-13 Fmc Corporation Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations
RU2478375C2 (ru) 2007-03-13 2013-04-10 ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД. Распадающаяся во рту таблетка
CA2687813C (en) * 2007-05-22 2015-07-07 Ssci, Inc. Preparation of mannitol modification iii
DE102007052070A1 (de) 2007-10-30 2009-05-07 Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg Candesartancilexetil
EP2651397A2 (de) 2010-12-17 2013-10-23 Merck Patent GmbH Verfahren zur herstellung von direkt tablettierbarem -mannit
WO2013052118A1 (en) 2011-10-05 2013-04-11 Fmc Corporation Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses
JP6188030B2 (ja) 2011-10-05 2017-08-30 エフ エム シー コーポレーションＦｍｃ Ｃｏｒｐｏｒａｔｉｏｎ 微結晶セルロースおよびカルボキシメチルセルロースの安定化剤組成物、該組成物の製造方法並びに食品製品
PL2787837T3 (pl) 2011-12-09 2017-09-29 Fmc Corporation Współścierana kompozycja stabilizatora
CN106535661B (zh) * 2014-07-21 2020-08-04 罗盖特公司 用于通过直接压缩进行压片的糖组合物
IT201900002857A1 (it) 2019-02-27 2020-08-27 Ntc S R L Procedimento di riempimento di contenitori con una polvere
CN113116843A (zh) * 2021-05-11 2021-07-16 福建海西新药创制有限公司 一种含有缬沙坦的药物组合物及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145146A (en) 1961-10-31 1964-08-18 Warner Lambert Pharmaceutical Modified mannitol for pharmaceutical tablets
DE3245170A1 (de) 1982-12-07 1984-06-07 Merck Patent Gmbh, 6100 Darmstadt Verbesserter sorbit, verfahren zur herstellung und verwendung
FR2571046B1 (fr) 1984-10-03 1987-10-16 Roquette Freres Procede de preparation de mannitol granulaire directement compressible
FR2571045B1 (fr) 1984-10-03 1987-12-11 Roquette Freres Mannitol granulaire directement compressible et son procede de fabrication
JPH0653658B2 (ja) 1984-12-17 1994-07-20 中外製薬株式会社 安定な錠剤の製造法
NO177005C (no) 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
DE69022861T2 (de) 1989-01-24 1996-04-04 Spi Polyols Inc Kryoschützende kristalline Sorbitolkügelchen.
DK0390435T3 (da) 1989-03-29 1994-03-21 Takeda Chemical Industries Ltd Blanding indeholdende en forbindelse fra vitamin B gruppen, og fremstilling deraf
US5177080A (en) 1990-12-14 1993-01-05 Bayer Aktiengesellschaft Substituted pyridyl-dihydroxy-heptenoic acid and its salts
HU9203780D0 (en) * 1991-12-12 1993-03-29 Sandoz Ag Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
FR2710637B1 (fr) 1993-09-28 1995-12-08 Roquette Freres Mannitol pulvérulent de friabilité modérée et son procédé de préparation.
AUPM411494A0 (en) 1994-02-25 1994-03-24 Central Sydney Area Health Service Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum
US6235947B1 (en) * 1997-04-14 2001-05-22 Takeda Chemical Industries, Ltd. D-mannitol and its preparation

Also Published As

Publication number Publication date
HUP9902165A3 (en) 2001-01-29
EA199800888A1 (ru) 1999-04-29
PL329614A1 (en) 1999-03-29
IL126580A0 (en) 1999-08-17
PT902777E (pt) 2001-11-30
CZ333698A3 (cs) 1999-01-13
ATE202768T1 (de) 2001-07-15
TW515787B (en) 2003-01-01
NO984803L (no) 1998-12-16
KR20000005486A (ko) 2000-01-25
TR199802079T2 (xx) 1999-02-22
CU22776A3 (es) 2002-07-24
US20020107420A1 (en) 2002-08-08
EP0902777B1 (de) 2001-07-04
BR9708672A (pt) 1999-08-03
ES2158540T3 (es) 2001-09-01
DK0902777T4 (da) 2004-10-11
EP0902777A1 (de) 1999-03-24
HUP9902165A2 (hu) 1999-11-29
BG102818A (en) 1999-05-31
WO1997038960A1 (en) 1997-10-23
NO984803D0 (no) 1998-10-15
CN1221398A (zh) 1999-06-30
BG63460B1 (bg) 2002-02-28
AU718658B2 (en) 2000-04-20
AU2522297A (en) 1997-11-07
CA2251092A1 (en) 1997-10-23
DK0902777T3 (da) 2001-09-24
ES2158540T5 (es) 2004-11-16
SK143298A3 (en) 1999-04-13
NZ332313A (en) 2000-02-28
NO20012249D0 (no) 2001-05-07
NO20012249L (no) 1998-12-16
EP0902777B2 (de) 2004-06-16
DE69705516D1 (de) 2001-08-09
DE69705516T3 (de) 2004-09-30
EA000968B1 (ru) 2000-08-28
US6503918B2 (en) 2003-01-07
IL126580A (en) 2001-08-08
ID16566A (id) 1997-10-16
GR3036760T3 (en) 2001-12-31
SK282768B6 (sk) 2002-12-03
NO311349B1 (no) 2001-11-19

Similar Documents

Publication Publication Date Title
DE69705516D1 (de) D-mannit und seine herstellung
DE69312448D1 (de) Regelung des Bohrlochringraumdruckes
ITMI920162A1 (it) Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
DK0938308T3 (da) Antiparasitiske midler
DE69709003D1 (de) Herstellung von Bisphenol-A
BG94868A (bg) Мутант на бактерията сlоsтrifiuм нisтоlyтiсuм, метод за получаването му и използуването му за производство на свободна от клострипаин колагеназа
DE69804513D1 (de) Herstellung von zeolith-l
ITMI931346A0 (it) Procedimento di impianto per l'attivazione di materiale carbonioso
DE59405004D1 (de) Herstellung von 2-H-Heptafluorpropan
DE69502001T2 (de) Herstellung von uranoxid
ITRM940221A0 (it) Procedimento per il trattamento superficiale di cilindri di apertura per la filatura ad estremita' aperta.
DE69820078D1 (de) Druckfosgenierung von alkoholen zur herstellung von chloroformiaten
ITMI922551A0 (it) Procedimento per la produzione di carbone attivo
DE69502395T2 (de) Herstellung von triarylboran
DE69623986T2 (de) Herstellung von Allomelanin
DE69702961T2 (de) Herstellung von 1,1-difluorethan
DE69705849T2 (de) Herstellung von 3,5-lutidin
DE69619812T2 (de) Kontinuierliche herstellung von 1,1-difluorethan
IT1247618B (it) Procedimento per la fabbricazione di rivestimenti decorativi per i mobili d'arredamento
DE69704268T2 (de) Herstellung von alpha-fluorketonen
IT8948044A0 (it) Procedimento per la produzione di diaframmi per altoparlanti di materiali totalmente carbonacei
ITVI940186A0 (it) Procedimento per l'esecuzione di diaframmi per l'impermeabilizzazione del sottosuolo e prodotto impermeabilizzante costituente il diaframma
KR950028313U (ko) 키 보드의 높이조절장치
ITMI930708A0 (it) Procedimento per la realizzazione di un cilindro abrasivo nonche' cilindro abrasivo ottenuto con il procedimento
UA28053C2 (uk) Спосіб одержання горілки "витязь"

Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA CHEMICAL INDUSTRIES, LTD., OSAKA, JP

8366 Restricted maintained after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP