DE69703841T2 - Elektrochemischer festphasensynthese von polymere - Google Patents

Elektrochemischer festphasensynthese von polymere

Info

Publication number
DE69703841T2
DE69703841T2 DE69703841T DE69703841T DE69703841T2 DE 69703841 T2 DE69703841 T2 DE 69703841T2 DE 69703841 T DE69703841 T DE 69703841T DE 69703841 T DE69703841 T DE 69703841T DE 69703841 T2 DE69703841 T2 DE 69703841T2
Authority
DE
Germany
Prior art keywords
solid phase
phase synthesis
polymers
electrochemical solid
electrochemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69703841T
Other languages
English (en)
Other versions
DE69703841D1 (de
Inventor
D Montgomery
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Combimatrix Corp
Original Assignee
Combimatrix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combimatrix Corp filed Critical Combimatrix Corp
Publication of DE69703841D1 publication Critical patent/DE69703841D1/de
Application granted granted Critical
Publication of DE69703841T2 publication Critical patent/DE69703841T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00713—Electrochemical synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
DE69703841T 1996-07-05 1997-07-03 Elektrochemischer festphasensynthese von polymere Expired - Lifetime DE69703841T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2100296P 1996-07-05 1996-07-05
PCT/US1997/011463 WO1998001221A1 (en) 1996-07-05 1997-07-03 Electrochemical solid phase synthesis of polymers

Publications (2)

Publication Number Publication Date
DE69703841D1 DE69703841D1 (de) 2001-02-08
DE69703841T2 true DE69703841T2 (de) 2001-08-09

Family

ID=21801778

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69703841T Expired - Lifetime DE69703841T2 (de) 1996-07-05 1997-07-03 Elektrochemischer festphasensynthese von polymere

Country Status (14)

Country Link
US (1) US6444111B1 (de)
EP (1) EP0910467B1 (de)
JP (2) JP4303319B2 (de)
AT (1) ATE198427T1 (de)
AU (1) AU734511B2 (de)
CA (1) CA2259523C (de)
DE (1) DE69703841T2 (de)
DK (1) DK0910467T3 (de)
ES (1) ES2156000T3 (de)
HK (1) HK1020540A1 (de)
IL (1) IL127898A0 (de)
TW (1) TW593334B (de)
WO (1) WO1998001221A1 (de)
ZA (1) ZA975891B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10156329A1 (de) * 2001-07-17 2003-02-06 Frieder Breitling Verfahren und Anordnung zum Anbringen von in Transportmittel immobilisierten Substanzen sowie Monomerpartikel

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US6306348B1 (en) * 1993-11-01 2001-10-23 Nanogen, Inc. Inorganic permeation layer for micro-electric device
US7314708B1 (en) 1998-08-04 2008-01-01 Nanogen, Inc. Method and apparatus for electronic synthesis of molecular structures
US7172864B1 (en) 1993-11-01 2007-02-06 Nanogen Methods for electronically-controlled enzymatic reactions
US20040086917A1 (en) * 1995-09-27 2004-05-06 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US20030050438A1 (en) * 1998-01-05 2003-03-13 Montgomery Donald D. Electrochemical solid phase synthesis
US6093302A (en) * 1998-01-05 2000-07-25 Combimatrix Corporation Electrochemical solid phase synthesis
WO1999067019A1 (en) * 1998-06-24 1999-12-29 Therasense, Inc. Combinatorial electrochemical syntheses
FR2789401B1 (fr) * 1999-02-08 2003-04-04 Cis Bio Int Procede de fabrication de matrices de ligands adresses sur un support
WO2000051721A2 (en) * 1999-03-01 2000-09-08 Combimatrix Corporation Combinatorial chelator array
ES2243247T3 (es) * 1999-03-11 2005-12-01 Combimatrix Corporation Matrices de autoensamblaje.
WO2000053625A2 (en) * 1999-03-11 2000-09-14 Combimatrix Corporation Microarrays of peptide affinity probes for analyzing gene products and methods for analyzing gene products
FR2796571B1 (fr) * 1999-07-19 2001-09-14 Bio Merieux Dispositif d'analyse avec une biopuce
WO2001016376A1 (en) * 1999-09-02 2001-03-08 Corning Incorporated Porous substrates for dna arrays
WO2001023082A2 (en) * 1999-09-30 2001-04-05 Nanogen, Inc. Biomolecular attachment sites on microelectronic arrays
ATE408141T1 (de) * 1999-10-20 2008-09-15 Shigeori Takenaka Gen-detektionschip, sensor und nachweisverfahren
US6303082B1 (en) * 1999-12-15 2001-10-16 Nanogen, Inc. Permeation layer attachment chemistry and method
US20010044112A1 (en) * 2000-03-24 2001-11-22 Lyles Mark B. High throughput screening array containing porous material
US8568766B2 (en) 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
US10539561B1 (en) 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
US6960298B2 (en) 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
FR2834383B1 (fr) * 2001-12-27 2004-02-13 Commissariat Energie Atomique Procede de depot selectif de matiere sur des electrodes de biocapteurs ou de puces realises a partir d'un meme substrat
US7563600B2 (en) 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
JP2005538735A (ja) * 2002-09-17 2005-12-22 パーキネルマー ラス インコーポレイテッド 核酸反応のリアルタイム検出法
DK1599173T3 (en) * 2002-11-13 2017-06-06 Uab Res Found SYNTHETIC SINGLE DOMAIN POLYPEPTIDES SIMILARING APOLIPOPROTEIN E AND PROCEDURES FOR THEIR USE
US7217396B2 (en) * 2003-05-05 2007-05-15 The Board Of Trustees Of The University Of Illinois Microfabricated micro fluid channels
US20040228962A1 (en) * 2003-05-16 2004-11-18 Chang Liu Scanning probe microscopy probe and method for scanning probe contact printing
FR2855269B1 (fr) * 2003-05-21 2007-06-08 Commissariat Energie Atomique Dispositif et procedes d'accrochage/decrochage d'une cible ou d'un objet present dans un echantillon
US7416911B2 (en) * 2003-06-24 2008-08-26 California Institute Of Technology Electrochemical method for attaching molecular and biomolecular structures to semiconductor microstructures and nanostructures
US7723099B2 (en) * 2003-09-10 2010-05-25 Abbott Point Of Care Inc. Immunoassay device with immuno-reference electrode
WO2005089110A2 (en) * 2004-02-27 2005-09-29 President And Fellows Of Harvard College Polynucleotide synthesis
JP2005285980A (ja) * 2004-03-29 2005-10-13 Sanyo Electric Co Ltd 半導体装置および半導体装置の製造方法
US20050239112A1 (en) * 2004-04-01 2005-10-27 Migenix, Inc. Methods and processes for attaching compounds to matrices
CA2513340A1 (en) * 2004-08-25 2006-02-25 F. Hoffmann-La Roche Ag Reusable substrate for dna microarray production
JP4742544B2 (ja) * 2004-09-08 2011-08-10 凸版印刷株式会社 遺伝子チェック装置及び方法
US7718579B2 (en) * 2004-09-13 2010-05-18 Combimatrix Corporation Electrochemical deblocking using a hydrazine derivative
US7314542B2 (en) * 2004-09-23 2008-01-01 Nanogen, Inc. Methods and materials for optimization of electronic transportation and hybridization reactions
US20060102471A1 (en) * 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer
US20060105355A1 (en) * 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer having a linker moiety
US20060166285A1 (en) * 2005-01-26 2006-07-27 Jainamma Krotz Charged permeation layers for use on active electronic matrix devices
US20060189166A1 (en) * 2005-02-22 2006-08-24 Combimatrix Corporation Process for performing an isolated Pd(II)-mediated oxidation reaction
US20070034513A1 (en) 2005-03-25 2007-02-15 Combimatrix Corporation Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
US20060240443A1 (en) * 2005-04-20 2006-10-26 Combimatrix Corporation Microarray-based single nucleotide polymorphism, sequencing, and gene expression assay method
US8053774B2 (en) 2005-06-06 2011-11-08 Intel Corporation Method and apparatus to fabricate polymer arrays on patterned wafers using electrochemical synthesis
US8940143B2 (en) * 2007-06-29 2015-01-27 Intel Corporation Gel-based bio chip for electrochemical synthesis and electrical detection of polymers
JP4639982B2 (ja) * 2005-06-17 2011-02-23 凸版印刷株式会社 マイクロ反応チップ
US20070037169A1 (en) * 2005-08-09 2007-02-15 Combimatrix Corporation Selective Dehybridization using Electrochemically-Generated Reagent on an Electrode Microarray
US20070065877A1 (en) 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
US20070231794A1 (en) 2005-09-21 2007-10-04 Combimatrix Corporation Process to detect binding events on an electrode microarray using enzymes
US7281419B2 (en) * 2005-09-21 2007-10-16 The Board Of Trustees Of The University Of Illinois Multifunctional probe array system
US8855955B2 (en) * 2005-09-29 2014-10-07 Custom Array, Inc. Process and apparatus for measuring binding events on a microarray of electrodes
US7544574B2 (en) * 2005-10-11 2009-06-09 Intermolecular, Inc. Methods for discretized processing of regions of a substrate
US20070092871A1 (en) * 2005-10-20 2007-04-26 Combimatrix Corporation Microarray for pathogen identification
US20070122842A1 (en) * 2005-11-30 2007-05-31 Rajasekaran John J Massively parallel synthesis of proteinaceous biomolecules
JP4774980B2 (ja) * 2005-12-21 2011-09-21 凸版印刷株式会社 Ｄｎａチップ装置
US20070154946A1 (en) * 2005-12-29 2007-07-05 Rajasekaran John J Massively parallel synthesis of biopolymeric arrays
US20070207487A1 (en) * 2006-01-25 2007-09-06 Emig Christopher J Photoelectrochemical synthesis of high density combinatorial polymer arrays
JP2009528037A (ja) * 2006-03-01 2009-08-06 エフ．ホフマン−ラ ロシュ アーゲー 核酸増幅用基材
US20070231805A1 (en) * 2006-03-31 2007-10-04 Baynes Brian M Nucleic acid assembly optimization using clamped mismatch binding proteins
US7687103B2 (en) * 2006-08-31 2010-03-30 Gamida For Life B.V. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
WO2008027558A2 (en) 2006-08-31 2008-03-06 Codon Devices, Inc. Iterative nucleic acid assembly using activation of vector-encoded traits
US20080108149A1 (en) * 2006-10-23 2008-05-08 Narayan Sundararajan Solid-phase mediated synthesis of molecular microarrays
US7892719B2 (en) * 2006-11-03 2011-02-22 Intel Corporation Photonic crystal EUV photoresists
US7622295B2 (en) * 2006-12-19 2009-11-24 Edelmira Cabezas Molecular microarrays and helical peptides
US8999724B2 (en) 2006-12-28 2015-04-07 Intel Corporation Method and apparatus for match quality analysis of analyte binding
US7923237B2 (en) * 2006-12-28 2011-04-12 Intel Corporation Method and apparatus for combined electrochemical synthesis and detection of analytes
US8614086B2 (en) * 2006-12-28 2013-12-24 Intel Corporation Quality control methods for the manufacture of polymer arrays
US20090176664A1 (en) * 2007-06-01 2009-07-09 Keting Chu High density peptide arrays containing kinase or phosphatase substrates
AU2008296478B9 (en) 2007-08-28 2015-03-19 The Uab Research Foundation Synthetic apolipoprotein E mimicking polypeptides and methods of use
EP2195340A4 (de) 2007-08-28 2011-05-11 Uab Research Foundation Synthetische apolipoprotein e-imitierende polypeptide und verwendungsverfahren
EP2227322B1 (de) * 2007-12-13 2012-02-22 Sven Oscarsson Partielle derivatisierung von partikeln
EP2307130A1 (de) 2008-06-27 2011-04-13 STMicroelectronics (Research & Development) Limited Pixelvorrichtung für die biologische analyse, cmos-biosensor und entsprechende herstellungsverfahren
FR2933198B1 (fr) * 2008-06-27 2010-08-27 Univ Aix Marseill Iii Paul Cezanne Procede de fabrication d'un biocapteur sur substrat semi-conducteur
FR2933197A1 (fr) * 2008-06-27 2010-01-01 Univ Paul Cezanne Universite D Dispositif d'analyse biologique de type pixel,biocapteur cmos et procedes de fabrication correspondants
US8697605B2 (en) 2008-06-30 2014-04-15 Intel Corporation Polymer co-location in surface-attached biopolymers and arrays of biopolymers
WO2011056872A2 (en) 2009-11-03 2011-05-12 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
US9216414B2 (en) 2009-11-25 2015-12-22 Gen9, Inc. Microfluidic devices and methods for gene synthesis
WO2011085075A2 (en) 2010-01-07 2011-07-14 Gen9, Inc. Assembly of high fidelity polynucleotides
WO2011090793A2 (en) 2010-01-20 2011-07-28 Customarray, Inc. Multiplex microarray of serially deposited biomolecules on a microarray
WO2012064975A1 (en) 2010-11-12 2012-05-18 Gen9, Inc. Protein arrays and methods of using and making the same
LT3360963T (lt) 2010-11-12 2020-02-25 Gen9, Inc. Nukleorūgščių sintezės būdai ir įrenginiai
CA2820956C (en) 2010-12-10 2016-05-03 University Of Central Florida Research Foundation, Inc. Methods and compositions comprising il-7 receptor ligands
US20130059296A1 (en) 2011-08-26 2013-03-07 Gen9, Inc. Compositions and Methods For High Fidelity Assembly of Nucleic Acids
WO2013049227A2 (en) * 2011-09-26 2013-04-04 Geneart Ag High efficiency, small volume nucleic acid synthesis
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
US10081807B2 (en) 2012-04-24 2018-09-25 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
LT2864531T (lt) 2012-06-25 2019-03-12 Gen9, Inc. Nukleorūgšties konstravimo ir aukšto produktyvumo sekvenavimo būdai
US10563240B2 (en) 2013-03-14 2020-02-18 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
US9404922B2 (en) 2013-07-15 2016-08-02 The Rockefeller University Recombinant phages and proteins
WO2015153486A1 (en) 2014-03-31 2015-10-08 Multerra Bio, Inc. Low-cost packaging for fluidic and device co-integration
US10653747B2 (en) 2014-07-31 2020-05-19 Uab Research Foundation ApoE mimetic peptides and higher potency to clear plasma cholesterol
CN115927293A (zh) 2014-12-09 2023-04-07 生命技术公司 高效小体积核酸合成
CN106799196A (zh) * 2015-11-26 2017-06-06 上海美迪维康生物科技有限公司 Dna原位合成半导体芯片及其控制方法
TW201735286A (zh) 2016-02-11 2017-10-01 天工方案公司 使用可回收載體基板之裝置封裝
US20170243739A1 (en) * 2016-02-24 2017-08-24 Skyworks Solutions, Inc. 3d micromold and pattern transfer
US10453763B2 (en) 2016-08-10 2019-10-22 Skyworks Solutions, Inc. Packaging structures with improved adhesion and strength
CN106248758B (zh) * 2016-09-30 2019-04-16 南京理工大学 一种dna探针与电极表面相互作用的分析方法
US10532356B2 (en) * 2017-11-09 2020-01-14 International Business Machines Corporation pH control for analyte detection
JP2020002095A (ja) * 2018-06-29 2020-01-09 国立大学法人東京工業大学 電気化学的手法による修飾タンパク質の製造方法
AU2019311199A1 (en) 2018-07-23 2021-01-28 Dna Script Massively parallel enzymatic synthesis of nucleic acid strands
EP3894593A2 (de) 2018-12-13 2021-10-20 DNA Script Direkte oligonukleotidsynthese auf zellen und biomolekülen
US11584956B2 (en) 2018-12-21 2023-02-21 Microsoft Technology Licensing, Llc Selectively controllable cleavable linkers
CN109735528A (zh) * 2019-02-27 2019-05-10 天津大学 用于染料降解的整体型生物反应器的制备方法
EP3976752A4 (de) 2019-05-31 2023-03-01 Illumina, Inc. Durchflusszelle mit selektiver abscheidung oder aktivierung von nukleotiden
US11773422B2 (en) 2019-08-16 2023-10-03 Microsoft Technology Licensing, Llc Regulation of polymerase using cofactor oxidation states
US11795450B2 (en) 2019-09-06 2023-10-24 Microsoft Technology Licensing, Llc Array-based enzymatic oligonucleotide synthesis
CA3151411A1 (en) 2019-09-23 2021-04-01 Adrian Horgan Increasing long-sequence yields in template-free enzymatic synthesis of polynucleotides
US11896945B2 (en) * 2019-10-09 2024-02-13 Microsoft Technology Licensing, Llc High surface area coatings for solid-phase synthesis
US11592420B2 (en) 2020-07-17 2023-02-28 Robert Bosch Gmbh Closed-loop PH control with differential sensor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4280885A (en) * 1979-11-09 1981-07-28 Savery James W Method of and apparatus for active electro-chemical water and similar environmental contaminant elimination in semi-conductor and other electronic and electrical devices and the like
US5510481A (en) * 1990-11-26 1996-04-23 The Regents, University Of California Self-assembled molecular films incorporating a ligand
US5364851A (en) * 1991-06-14 1994-11-15 International Synthecon, Llc Conformationally restricted biologically active peptides, methods for their production and uses thereof
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
CA2064683A1 (en) * 1992-03-26 1993-09-27 Krishna Mohan Rao Kallury Formation of thermostable enzymes with extra-ordinary heat tolerance by immobilization on phospholipid matrices
US5667667A (en) * 1992-04-24 1997-09-16 Isis Innovation Limited Electrochemical treatment of surfaces
FR2703359B1 (fr) * 1993-03-31 1995-06-23 Cis Bio Int Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation .
US5756362A (en) * 1993-10-12 1998-05-26 Cornell Research Foundation, Inc. Liposome-enhanced immunoaggregation assay and test device
US5952172A (en) * 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5824470A (en) * 1995-05-30 1998-10-20 California Institute Of Technology Method of preparing probes for sensing and manipulating microscopic environments and structures
US5798035A (en) * 1996-10-03 1998-08-25 Pharmacopeia, Inc. High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10156329A1 (de) * 2001-07-17 2003-02-06 Frieder Breitling Verfahren und Anordnung zum Anbringen von in Transportmittel immobilisierten Substanzen sowie Monomerpartikel

Also Published As

Publication number Publication date
ZA975891B (en) 1998-07-23
ES2156000T3 (es) 2001-06-01
TW593334B (en) 2004-06-21
AU734511B2 (en) 2001-06-14
JP4303319B2 (ja) 2009-07-29
JP2000514802A (ja) 2000-11-07
JP4740020B2 (ja) 2011-08-03
HK1020540A1 (en) 2000-05-12
DE69703841D1 (de) 2001-02-08
CA2259523A1 (en) 1998-01-15
DK0910467T3 (da) 2001-05-21
AU3588497A (en) 1998-02-02
WO1998001221A1 (en) 1998-01-15
ATE198427T1 (de) 2001-01-15
JP2006291359A (ja) 2006-10-26
EP0910467B1 (de) 2001-01-03
IL127898A0 (en) 1999-11-30
CA2259523C (en) 2010-01-12
US6444111B1 (en) 2002-09-03
EP0910467A1 (de) 1999-04-28

Similar Documents

Publication Publication Date Title
DE69703841T2 (de) Elektrochemischer festphasensynthese von polymere
Reisfeld et al. Disk electrophoresis of basic proteins and peptides on polyacrylamide gels.
CA2192262C (en) Method for purification and transfer to separation/detection systems of dna sequencing samples and plates used therefor
DZ1721A1 (fr) Appareil électro-chimique pour l'émission de puissance utilisent une électrode à air.
DE69623494D1 (de) Elektrochemische erkennung von nukleinsäurehybridation
RU2003118328A (ru) Электрохимический элемент
CA2240661A1 (en) Method and apparatus for reducing reactant crossover in an electrochemical fuel cell
ES2075955T3 (es) Reactivo mediador redox y biosensor.
WO2001042508A3 (en) Methods and compositions relating to electrical detection of nucleic acid reactions
HK1066062A1 (en) Electrochemical cell
CA2199657A1 (en) Biosensor and method for quantitating biochemical substrate using the same
AU2951397A (en) A method and a reactor for electrochemical conversion of a material e.g. soot particles being insoluble in a fluid
WO1990009591A3 (en) Methods and apparatus using galvanic immunoelectrodes
Jelan et al. Chemically reversible electroreduction of guanine in a polynucleotide chain
EP0387026A3 (de) Biosensor-Vorrichtung
Caglio et al. On the efficiency of methylene blue versus persulfate catalysis of polyacrylamide gels, as investigated by capillary zone electrophoresis
SU1038871A1 (ru) Способ вольтамперометрического определени 3,4-бензпирена
WO1997020068A3 (en) Method for generating multiple double stranded nucleic acids
EP0300662A3 (de) Ionenselektive Elektroden
RU99122679A (ru) Способ выделения органических кислот из водных растворов
JPS56137899A (en) Determining method of glucose concentration
IT1182220B (it) Metodo di dosaggio di enzimi
RU93053791A (ru) Железоселективный электрод

Legal Events

Date Code Title Description
8364 No opposition during term of opposition