DE69637642D1 - Und kombinierte zusammensetzungen und deren verwendung - Google Patents

Und kombinierte zusammensetzungen und deren verwendung

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Publication number
DE69637642D1
DE69637642D1 DE69637642T DE69637642T DE69637642D1 DE 69637642 D1 DE69637642 D1 DE 69637642D1 DE 69637642 T DE69637642 T DE 69637642T DE 69637642 T DE69637642 T DE 69637642T DE 69637642 D1 DE69637642 D1 DE 69637642D1
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Germany
Prior art keywords
compositions
recombinant viruses
products therefrom
antibodies generated
combined compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69637642T
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German (de)
English (en)
Inventor
Enzo Paoletti
Joanne Maki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Connaught Technology Corp
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Connaught Technology Corp
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Publication of DE69637642D1 publication Critical patent/DE69637642D1/de
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767449B1 (en) 1981-12-24 2010-08-03 Health Research Incorporated Methods using modified vaccinia virus
US5505941A (en) * 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
US7374768B1 (en) 1990-09-25 2008-05-20 Xenova Research Limited Viral vaccines
US6309647B1 (en) * 1999-07-15 2001-10-30 Aventis Pasteur Poxvirus—canine dispemper virus (CDV) or measles virus recombinants and compositions and methods employing the recombinants
EP0561034B1 (en) * 1991-08-26 1999-06-09 IMMUNO Aktiengesellschaft Direct molecular cloning of a modified chordopox virus genome
WO1995030018A2 (en) * 1994-04-29 1995-11-09 Immuno Aktiengesellschaft Recombinant poxviruses with foreign polynucleotides in essential regions
FR2750865B1 (fr) * 1996-06-27 1998-12-04 Rhone Merieux Vaccin vivant recombinant a base d'herpesvirus canin, notamment contre la maladie de carre, la rage ou le virus parainfluenza de type 2
US7294338B2 (en) * 1996-07-19 2007-11-13 Merial Polynucleotide vaccine formula against canine pathologies, in particular respiratory and digestive pathologies
US6368603B1 (en) * 1997-03-05 2002-04-09 Merial Limited Lyme combination compositions and uses
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
FR2775601B1 (fr) * 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
US6497883B1 (en) 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
ATE391726T1 (de) 1999-10-22 2008-04-15 Sanofi Pasteur Ltd Modifiziertes gp100 und dessen verwendung
WO2001045735A2 (en) * 1999-12-21 2001-06-28 Merial Compositions and vaccines containing antigen(s) of cryptosporidium parvum and of another enteric pathogen
US20030027246A1 (en) * 2000-03-31 2003-02-06 Artur Pedyczak Immunogenic peptides derived from prostate-specific membrane antigen (PSMA) and uses thereof
PT1282702E (pt) 2000-05-10 2007-02-28 Ludwig Inst Cancer Res Polipéptidos imunogénicos codificados por minigenes mage e suas utilizações
US7097842B2 (en) * 2000-11-23 2006-08-29 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
JP4421188B2 (ja) * 2000-11-23 2010-02-24 バヴァリアン・ノルディック・アクティーゼルスカブ 変性ワクシニアアンカラウイルス変異体
US7628980B2 (en) * 2000-11-23 2009-12-08 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
FR2823222B1 (fr) 2001-04-06 2004-02-06 Merial Sas Vaccin contre le virus de la fievre du nil
US20030228327A1 (en) * 2001-11-05 2003-12-11 Lasher Alfred W. DNA-based plasmid formulations and vaccines and prophylactics containing the same
US20070269456A1 (en) * 2001-11-05 2007-11-22 Lasher Alfred W DNA-based plasmid formulations and vaccines and prophylactics containing the same
JP4801880B2 (ja) * 2002-04-19 2011-10-26 バヴァリアン・ノルディック・アクティーゼルスカブ 新生仔予防接種用変異ワクシニアウイルスアンカラ
EP1499635B8 (en) 2002-05-02 2014-04-16 David Lovejoy Teneurin c-terminal associated peptides (tcap) and uses thereof
ATE393212T2 (de) * 2002-09-05 2008-05-15 Bavarian Nordic As Verfahren zur amplifikation von einem poxvirus in serumfreien verhältnissen
EP1572985A4 (en) * 2002-12-13 2008-03-19 Aventis Pasteur Inc ALVAC PRODUCTION ON AVIAN STEM CELLS
US8663622B2 (en) * 2002-12-16 2014-03-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Recombinant vaccine viruses expressing IL-15 and methods using the same
US7468273B2 (en) 2003-05-01 2008-12-23 Meial Limited Canine GHRH gene, polypeptides and methods of use
US20060240039A1 (en) * 2003-06-13 2006-10-26 Isis Innovation Limited Vaccines
JP5576010B2 (ja) 2003-08-04 2014-08-20 ザ・ホスピタル・フォー・シック・チルドレン ラフォラ病遺伝子
EP1689858B1 (en) 2003-11-13 2013-05-15 University Of Georgia Research Foundation, Inc. Methods of characterizing infectious bursal disease virus
WO2005118672A1 (en) * 2004-06-02 2005-12-15 The Governors Of The University Of Alberta Polymer based nano-carriers for the solubilization and delivery of hydrophobic drugs
US7998733B2 (en) 2004-10-05 2011-08-16 Merial Limited Chimeric vectors
DK1881845T3 (da) * 2005-04-25 2010-06-07 Merial Ltd Nipah-virusvacciner
US20080241184A1 (en) 2005-08-25 2008-10-02 Jules Maarten Minke Canine influenza vaccines
US7771995B2 (en) 2005-11-14 2010-08-10 Merial Limited Plasmid encoding human BMP-7
EP3536704B1 (en) 2005-11-14 2021-08-25 Boehringer Ingelheim Animal Health USA Inc. Gene therapy for renal failure
US7455844B2 (en) 2006-03-29 2008-11-25 Merial Limited Vaccine against streptococci
US7682619B2 (en) 2006-04-06 2010-03-23 Cornell Research Foundation, Inc. Canine influenza virus
US7862821B2 (en) 2006-06-01 2011-01-04 Merial Limited Recombinant vaccine against bluetongue virus
WO2008064451A1 (en) * 2006-11-30 2008-06-05 University Of British Columbia Poxviridae treatment comprising tap-1 and/or tap-2 as a molecular adjuvant
WO2008136790A1 (en) 2007-05-02 2008-11-13 Merial Limited Dna plasmids having improved expression and stability
US8603808B2 (en) 2008-05-08 2013-12-10 Merial Limited Leishmania vaccine using sand fly salivary immunogen
CA2765298A1 (en) 2008-06-27 2009-12-30 University Of Guelph Probiotic bacterial molecules and their use in methods to treat/prevent infection by harmful bacteria and to provide nutritional health
BR122019001455B1 (pt) 2008-10-24 2021-01-19 Merial, Inc. vacina contra o vírus da doença equina africana
CA2829916C (en) 2011-03-21 2019-08-20 Vaxin Inc. Intranasal administration of an adenovirus vector to induce a protective immune response to an inhalation pathogen
US9216213B2 (en) 2011-04-20 2015-12-22 Merial, Inc. Adjuvanted rabies vaccine with improved viscosity profile
ES2674439T3 (es) 2011-06-01 2018-06-29 Merial, Inc. Administración sin aguja de vacunas contra el VSRRP
AU2012284558B2 (en) 2011-07-20 2017-06-29 Centre National De La Recherche Scientifique Recombinant feline leukemia virus vaccine containing optimized feline leukemia virus envelope gene
CN103841963B (zh) 2011-08-12 2018-04-24 梅里亚股份有限公司 用于生物产品特别是疫苗的真空辅助保存
EP2586461A1 (en) 2011-10-27 2013-05-01 Christopher L. Parks Viral particles derived from an enveloped virus
AU2013221502C1 (en) 2012-02-14 2018-03-01 Boehringer Ingelheim Animal Health USA Inc. Recombinant poxviral vectors expressing both rabies and OX40 proteins, and vaccines made therefrom
NZ700470A (en) 2012-03-20 2016-04-29 Merial Inc Recombinant equine herpesvirus-1 vaccine containing mutated glycoprotein c and uses thereof
CN105026422B (zh) 2012-03-27 2019-09-27 西安大略大学 Sh2结构域变体
US9347065B2 (en) 2012-03-29 2016-05-24 International Aids Vaccine Initiative Methods to improve vector expression and genetic stability
EP2968435B1 (en) 2013-03-12 2019-01-30 Tel HaShomer Medical Research Infrastructure and Services Ltd. Synthetic peptides for the treatment of autoimmune diseases
WO2016073410A1 (en) 2014-11-03 2016-05-12 Merial, Inc. Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus
EP3042666A1 (en) 2015-01-06 2016-07-13 Rheinisch-Westfälische Technische Hochschule Aachen ITIH5 fragments for the treatment of cancer
ES2903443T3 (es) 2015-04-28 2022-04-01 Avivagen Inc Carotenoides oxidados y componentes de los mismos para prevenir la enteritis necrótica
TW202203966A (zh) * 2020-03-31 2022-02-01 澳大利亞商賽門蒂斯公司 用於防範ｃｏｖｉｄ－１９之以減毒的痘病毒載體為底質之疫苗
CN116656730B (zh) * 2023-05-25 2024-03-19 军事科学院军事医学研究院军事兽医研究所 一种表达狂犬病病毒g、m蛋白的重组金丝雀痘病毒及其构建方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100242671B1 (ko) * 1991-03-07 2000-03-02 고돈 에릭 유전학적으로 처리한 백신 균주
US5349741A (en) * 1992-06-24 1994-09-27 L.H. Carbide Corporation Method of making an interlocked core spaced for anneal penetration

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US5843456A (en) 1998-12-01
ATE404220T1 (de) 2008-08-15
EP0835133A1 (en) 1998-04-15
PT835133E (pt) 2008-11-19
AU6314996A (en) 1996-12-30
AU711472B2 (en) 1999-10-14
JP4140862B2 (ja) 2008-08-27
DK0835133T3 (da) 2008-12-01
JP2000500115A (ja) 2000-01-11
WO1996040241A1 (en) 1996-12-19
EP0835133A4 (en) 2003-01-02
CA2223416A1 (en) 1996-12-19
ES2314980T3 (es) 2009-03-16

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