DE69636813T2 - Heparine-proteine kovalente Konjugate, die eine Alpha-Carbonyl-Amin enthalten und Verfahren für deren Produktion - Google Patents
Heparine-proteine kovalente Konjugate, die eine Alpha-Carbonyl-Amin enthalten und Verfahren für deren Produktion Download PDFInfo
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- DE69636813T2 DE69636813T2 DE69636813T DE69636813T DE69636813T2 DE 69636813 T2 DE69636813 T2 DE 69636813T2 DE 69636813 T DE69636813 T DE 69636813T DE 69636813 T DE69636813 T DE 69636813T DE 69636813 T2 DE69636813 T2 DE 69636813T2
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- Prior art keywords
- heparin
- ath
- glycosaminoglycan
- protein
- conjugate
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Classifications
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- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
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Landscapes
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- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- Diabetes (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Prostheses (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US564976 | 1995-11-30 | ||
| US08/564,976 US6562781B1 (en) | 1995-11-30 | 1995-11-30 | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
| PCT/CA1996/000799 WO1997019701A2 (en) | 1995-11-30 | 1996-11-29 | Glycosaminoglycan-antithrombin iii/heparin cofactor ii conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69636813D1 DE69636813D1 (de) | 2007-02-15 |
| DE69636813T2 true DE69636813T2 (de) | 2007-10-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69636813T Expired - Lifetime DE69636813T2 (de) | 1995-11-30 | 1996-11-29 | Heparine-proteine kovalente Konjugate, die eine Alpha-Carbonyl-Amin enthalten und Verfahren für deren Produktion |
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| Country | Link |
|---|---|
| US (2) | US6562781B1 (enExample) |
| EP (1) | EP0863768B1 (enExample) |
| JP (1) | JP4166275B2 (enExample) |
| AT (1) | ATE350066T1 (enExample) |
| AU (1) | AU7688396A (enExample) |
| CA (1) | CA2237159C (enExample) |
| DE (1) | DE69636813T2 (enExample) |
| WO (1) | WO1997019701A2 (enExample) |
Families Citing this family (37)
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| AU2003233428B2 (en) * | 2002-04-01 | 2008-07-31 | The University Of Texas Medical Branch | Treatment of lung disorder |
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| KR20070092754A (ko) * | 2004-12-27 | 2007-09-13 | 백스터 인터내셔널 인코포레이티드 | 중합체 - 폰 빌레브란트 인자 - 접합체 |
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| US9925209B2 (en) | 2008-03-19 | 2018-03-27 | The Board Of Regents Of The University Of Oklahoma | Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same |
| US9687559B2 (en) | 2008-03-19 | 2017-06-27 | The Board Of Regents Of The University Of Oklahoma | Heparosan polymers and methods of making and using same for the enhancement of therapeutics |
| EP2341941A4 (en) * | 2008-09-09 | 2014-12-10 | Univ Oklahoma | HEPAROSANPOLYMERS AND METHOD FOR THE PRODUCTION THEREOF AND THEIR USE THEREOF FOR THE REINFORCEMENT OF THERAPEUTICS |
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-
1995
- 1995-11-30 US US08/564,976 patent/US6562781B1/en not_active Expired - Fee Related
-
1996
- 1996-11-29 AT AT96939779T patent/ATE350066T1/de not_active IP Right Cessation
- 1996-11-29 AU AU76883/96A patent/AU7688396A/en not_active Abandoned
- 1996-11-29 JP JP52003397A patent/JP4166275B2/ja not_active Expired - Fee Related
- 1996-11-29 DE DE69636813T patent/DE69636813T2/de not_active Expired - Lifetime
- 1996-11-29 EP EP96939779A patent/EP0863768B1/en not_active Expired - Lifetime
- 1996-11-29 WO PCT/CA1996/000799 patent/WO1997019701A2/en not_active Ceased
- 1996-11-29 CA CA2237159A patent/CA2237159C/en not_active Expired - Lifetime
-
2002
- 2002-10-11 US US10/268,965 patent/US20030100487A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6562781B1 (en) | 2003-05-13 |
| AU7688396A (en) | 1997-06-19 |
| ATE350066T1 (de) | 2007-01-15 |
| JP2000501082A (ja) | 2000-02-02 |
| EP0863768A2 (en) | 1998-09-16 |
| EP0863768B1 (en) | 2007-01-03 |
| US20030100487A1 (en) | 2003-05-29 |
| WO1997019701A3 (en) | 1997-08-28 |
| DE69636813D1 (de) | 2007-02-15 |
| WO1997019701A2 (en) | 1997-06-05 |
| CA2237159A1 (en) | 1997-06-05 |
| JP4166275B2 (ja) | 2008-10-15 |
| CA2237159C (en) | 2010-11-16 |
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