DE69632244D1 - Diagnostisches markierungsmittel - Google Patents
Diagnostisches markierungsmittelInfo
- Publication number
- DE69632244D1 DE69632244D1 DE69632244T DE69632244T DE69632244D1 DE 69632244 D1 DE69632244 D1 DE 69632244D1 DE 69632244 T DE69632244 T DE 69632244T DE 69632244 T DE69632244 T DE 69632244T DE 69632244 D1 DE69632244 D1 DE 69632244D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- diagnostic marker
- alkyl group
- atom
- detection system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003550 marker Substances 0.000 title abstract 3
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 2
- 238000012327 Endoscopic diagnosis Methods 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
- A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
- G01N2474/20—Immunohistochemistry assay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/801—Drug, bio-affecting and body treating compositions involving antibody or fragment thereof produced by recombinant dna technology
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/802—Antibody or antigen-binding fragment thereof that binds gram-positive bacteria
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Holo Graphy (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1228395 | 1995-01-30 | ||
JP1228395 | 1995-01-30 | ||
JP22361395 | 1995-08-31 | ||
JP22361395 | 1995-08-31 | ||
PCT/JP1996/000169 WO1996023525A1 (fr) | 1995-01-30 | 1996-01-30 | Marqueur de diagnostic |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69632244D1 true DE69632244D1 (de) | 2004-05-27 |
DE69632244T2 DE69632244T2 (de) | 2005-04-14 |
Family
ID=26347861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69632244T Expired - Fee Related DE69632244T2 (de) | 1995-01-30 | 1996-01-30 | Diagnostisches Markierungsmittel |
Country Status (10)
Country | Link |
---|---|
US (1) | US5968479A (de) |
EP (1) | EP0800831B9 (de) |
KR (1) | KR100397020B1 (de) |
CN (1) | CN1093768C (de) |
AT (1) | ATE264694T1 (de) |
AU (1) | AU4497096A (de) |
CA (1) | CA2211470A1 (de) |
DE (1) | DE69632244T2 (de) |
NO (1) | NO308895B1 (de) |
WO (1) | WO1996023525A1 (de) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020028474A1 (en) * | 1996-09-19 | 2002-03-07 | Daiichi Pure Chemical Co., Ltd. | Composition for immunohistochemical staining |
US7179222B2 (en) | 1996-11-20 | 2007-02-20 | Olympus Corporation | Fluorescent endoscope system enabling simultaneous achievement of normal light observation based on reflected light and fluorescence observation based on light with wavelengths in infrared spectrum |
US6293911B1 (en) | 1996-11-20 | 2001-09-25 | Olympus Optical Co., Ltd. | Fluorescent endoscope system enabling simultaneous normal light observation and fluorescence observation in infrared spectrum |
US6027709A (en) * | 1997-01-10 | 2000-02-22 | Li-Cor Inc. | Fluorescent cyanine dyes |
DE19717904A1 (de) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
US6110630A (en) * | 1998-06-18 | 2000-08-29 | Beckman Coulter, Inc. | Efficient activated cyanine dyes |
US8557298B2 (en) | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
JP2000095758A (ja) | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
US7547721B1 (en) | 1998-09-18 | 2009-06-16 | Bayer Schering Pharma Ag | Near infrared fluorescent contrast agent and fluorescence imaging |
AU2097500A (en) * | 1999-12-15 | 2001-06-25 | Fuji Photo Film Co., Ltd. | Near infrared fluorescent contrast agent and fluorescence imaging |
US6190641B1 (en) * | 2000-01-18 | 2001-02-20 | Mallinckrodt Inc. | Indocyanine dyes |
US20030223935A1 (en) * | 2001-03-05 | 2003-12-04 | Gray Brian D. | Fluorescent membrane intercalating probes and methods for their use |
WO2001066153A1 (en) * | 2000-03-03 | 2001-09-13 | Phanos Technologies, Inc. | Fluorescent membrane intercalating probes and methods for their use |
ATE315066T1 (de) * | 2000-09-19 | 2006-02-15 | Li Cor Inc | Cyaninfarbstoffe |
US6673334B1 (en) * | 2000-10-16 | 2004-01-06 | Mallinkcrodt, Inc. | Light sensitive compounds for instant determination of organ function |
US6669926B1 (en) * | 2000-10-16 | 2003-12-30 | Mallinckrodt, Inc. | Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients |
US6936827B1 (en) | 2001-02-21 | 2005-08-30 | The United States Of America As Represented By The Department Of The Interior | Detecting device for fluorescent-labeled material |
AU2002252459A1 (en) * | 2001-03-22 | 2002-10-08 | Minerva Biotechnologies Corporation | Customized therapeutics and in situ diagnostics |
US6761878B2 (en) * | 2001-10-17 | 2004-07-13 | Mallinckrodt, Inc. | Pathological tissue detection and treatment employing targeted benzoindole optical agents |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
US20040082863A1 (en) * | 2002-03-15 | 2004-04-29 | Mcgreevy James | Device and method for the photodynamic diagnosis of tumor tissue |
US6972022B1 (en) | 2002-03-27 | 2005-12-06 | Michael Griffin | Skin-marking device |
GB0208989D0 (en) * | 2002-04-19 | 2002-05-29 | Amersham Biosciences Uk Ltd | Methods for measuring enzyme activity |
SE0300631D0 (sv) * | 2003-03-10 | 2003-03-10 | Staffan Gunnarsson | Transponder med solcell |
EP1496050A1 (de) * | 2003-07-08 | 2005-01-12 | Roche Diagnostics GmbH | Chemilumineszente Verbindungen und deren Verwendung |
NO20035683D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av prostatakreft |
NO20035681D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av lungekreft |
NO20035682D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av ösofagkreft og Barretts ösofag |
US7705150B2 (en) * | 2004-02-04 | 2010-04-27 | Biosearch Technologies, Inc. | Cyanine dyes |
FR2889700B1 (fr) * | 2005-08-11 | 2012-11-23 | Synthinnove Lab | Marqueurs, leur procede de fabrication et leurs applications |
ITSV20060002A1 (it) * | 2006-01-19 | 2007-07-20 | Ferrania Technologies Spa | Colorante fluorescente di tipo cianinico |
WO2007088051A2 (en) | 2006-01-31 | 2007-08-09 | Bayer Schering Pharma Aktiengesellschaft | Modulation of mdl-1 activity for treatment of inflammatory disease |
EP1987846B1 (de) * | 2006-02-23 | 2016-07-13 | Adeka Corporation | Diagnostischer marker |
JP2008043396A (ja) * | 2006-08-11 | 2008-02-28 | Olympus Corp | 内視鏡システム |
EP2069054A1 (de) * | 2006-08-30 | 2009-06-17 | GE Healthcare Bio-Sciences Corp. | System und verfahren zur charakterisierung von membranen und membranfiltriervorrichtungen |
JP2008148791A (ja) * | 2006-12-14 | 2008-07-03 | Olympus Corp | 内視鏡システム |
EP2005970A1 (de) | 2007-06-22 | 2008-12-24 | Berlin Science Partners GmbH i.V. | Bildgebende Diagnostik durch Kombination von Kontrastmitteln |
GB0718957D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Optical imaging agents |
US9097667B2 (en) * | 2007-12-14 | 2015-08-04 | Biotium, Inc. | Fluorescent compounds |
EP2100621A1 (de) | 2008-03-10 | 2009-09-16 | mivenion GmbH | Polyether-Polyol-Dendron-Konjugate mit Effektormolekülen für biologisches Targeting |
JP5497006B2 (ja) | 2008-04-14 | 2014-05-21 | ザ ジェネラル ホスピタル コーポレイション | 膵管腺癌の検出および治療のためのプレクチン−1標的化剤 |
JP5500875B2 (ja) * | 2009-01-30 | 2014-05-21 | キヤノン株式会社 | 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤 |
US20110021908A1 (en) * | 2009-05-27 | 2011-01-27 | Lumicell Diagnostics, Inc. | Methods and systems for spatially identifying abnormal cells |
US9155471B2 (en) | 2009-05-27 | 2015-10-13 | Lumicell, Inc'. | Methods and systems for spatially identifying abnormal cells |
WO2011003996A1 (en) | 2009-07-09 | 2011-01-13 | F. Hoffmann-La Roche Ag | In vivo tumor vasculature imaging |
CA2768330A1 (en) | 2009-07-28 | 2011-02-03 | F. Hoffmann-La Roche Ag | Non-invasive in vivo optical imaging method |
US8658434B2 (en) * | 2009-10-28 | 2014-02-25 | Biotium, Inc. | Fluorescent pyrene compounds |
US8877171B2 (en) | 2010-02-03 | 2014-11-04 | Mivenion Gmbh | Polyanionic multivalent macromolecules for intracellular targeting of proliferation and protein synthesis |
RU2012148816A (ru) | 2010-05-07 | 2014-06-20 | Ф. Хоффманн-Ля Рош Аг | Метод диагностики для определения клеток ex vivo |
US20120171694A1 (en) * | 2010-07-30 | 2012-07-05 | Vermillion, Inc. | Predictive markers and biomarker panels for ovarian cancer |
US9012242B2 (en) | 2010-09-20 | 2015-04-21 | Caliper Life Sciences | Multivalent fluorescent probes |
FR2967675B1 (fr) * | 2010-11-24 | 2015-02-27 | Pf Medicament | Derives fluorescents de cyanines polyamines en tant que sonde de diagnostic |
US9314304B2 (en) | 2010-12-08 | 2016-04-19 | Lumicell, Inc. | Methods and system for image guided cell ablation with microscopic resolution |
JP6100704B2 (ja) | 2011-03-07 | 2017-03-22 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 治療用抗体についてのインビボ試験の手段および方法 |
EP2683413A1 (de) | 2011-03-07 | 2014-01-15 | F.Hoffmann-La Roche Ag | In-vivo-auswahl therapeutisch aktiver antikörper |
EP2689024B1 (de) | 2011-03-25 | 2016-01-13 | Almac Sciences (Scotland) Limited | Enzymtests |
EP2863957B1 (de) | 2012-07-20 | 2018-11-28 | Canon Kabushiki Kaisha | Verbindung und die verbindung enthaltendes kontrastmittel für fotoakustische bildgebung |
US9517278B2 (en) | 2012-07-20 | 2016-12-13 | Canon Kabushiki Kaisha | Compound and photoacoustic imaging contrast medium containing the compound |
WO2014013729A1 (en) | 2012-07-20 | 2014-01-23 | Canon Kabushiki Kaisha | Contrast agent for photoacoustic imaging |
CZ304948B6 (cs) * | 2013-01-02 | 2015-02-04 | Vysoká škola chemicko-technologická v Praze | Využití polymethiniových solí jako senzorů pro nádorové markery |
CA2906056A1 (en) | 2013-03-14 | 2014-09-25 | Lumicell, Inc. | Medical imaging device and methods of use |
US10017551B2 (en) | 2013-03-15 | 2018-07-10 | The Regents Of The University Of California | Peptides having reduced toxicity that stimulate cholesterol efflux |
US11559580B1 (en) * | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
BR112016005802A2 (pt) * | 2013-09-17 | 2017-09-12 | Blaze Bioscience Inc | conjugados de clorotoxina e métodos de seu uso |
CA2961095C (en) * | 2014-09-17 | 2021-02-09 | Rigshospitalet | Upar targeting peptide for use in perioperative optical imaging of invasive cancer |
CN108264475A (zh) * | 2016-12-30 | 2018-07-10 | 中国科学院深圳先进技术研究院 | 吲哚菁绿衍生物及制备方法 |
WO2018132361A1 (en) | 2017-01-10 | 2018-07-19 | Sun Chemical Corporation | In-line coating weight and radiant energy exposure measurement |
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US5627027A (en) * | 1986-04-18 | 1997-05-06 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
US4762701A (en) * | 1986-10-31 | 1988-08-09 | Smithkline Beckman Corporation | In vivo cellular tracking |
DE3828360A1 (de) * | 1988-08-20 | 1990-02-22 | Stanowsky Alexander Dr | Farbstoff-markierter antitumor-antikoerper und verfahren zu seiner herstellung |
ATE206124T1 (de) * | 1990-05-15 | 2001-10-15 | Diatron Corp | Nachweisbar markierte markerverbindung mit einem fluorophor-rest , eine fluorescenz-probe mit der markerverbindung und verwendungen derselben. |
GB9014307D0 (en) * | 1990-06-27 | 1990-08-15 | Scient Generics Ltd | Method of treatment and compositions therefor |
JP3354975B2 (ja) * | 1992-10-06 | 2002-12-09 | イビデン株式会社 | 蛍光標識試薬および蛍光免疫測定法 |
JP3176163B2 (ja) * | 1993-01-28 | 2001-06-11 | イビデン株式会社 | 蛍光標識試薬および蛍光免疫測定法 |
AU7135494A (en) * | 1993-07-17 | 1995-02-13 | Aprogenex, Inc. | Analogues of reporter groups as backgroung reducers in hybridization assays |
JPH0783925A (ja) * | 1993-09-17 | 1995-03-31 | Ibiden Co Ltd | 蛍光標識試薬および蛍光免疫測定法 |
JP3368011B2 (ja) * | 1993-10-04 | 2003-01-20 | キヤノン株式会社 | 核酸検出法 |
-
1996
- 1996-01-30 CA CA002211470A patent/CA2211470A1/en not_active Abandoned
- 1996-01-30 US US08/875,398 patent/US5968479A/en not_active Expired - Fee Related
- 1996-01-30 AU AU44970/96A patent/AU4497096A/en not_active Abandoned
- 1996-01-30 KR KR1019970705159A patent/KR100397020B1/ko not_active IP Right Cessation
- 1996-01-30 DE DE69632244T patent/DE69632244T2/de not_active Expired - Fee Related
- 1996-01-30 CN CN96192854A patent/CN1093768C/zh not_active Expired - Fee Related
- 1996-01-30 EP EP96901142A patent/EP0800831B9/de not_active Expired - Lifetime
- 1996-01-30 WO PCT/JP1996/000169 patent/WO1996023525A1/ja active IP Right Grant
- 1996-01-30 AT AT96901142T patent/ATE264694T1/de not_active IP Right Cessation
-
1997
- 1997-07-29 NO NO973484A patent/NO308895B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO973484D0 (no) | 1997-07-29 |
NO973484L (no) | 1997-09-30 |
WO1996023525A1 (fr) | 1996-08-08 |
CN1093768C (zh) | 2002-11-06 |
EP0800831A4 (de) | 2000-04-26 |
AU4497096A (en) | 1996-08-21 |
EP0800831A1 (de) | 1997-10-15 |
ATE264694T1 (de) | 2004-05-15 |
NO308895B1 (no) | 2000-11-13 |
US5968479A (en) | 1999-10-19 |
CA2211470A1 (en) | 1996-08-08 |
EP0800831B9 (de) | 2004-11-10 |
KR100397020B1 (ko) | 2004-04-29 |
DE69632244T2 (de) | 2005-04-14 |
EP0800831B1 (de) | 2004-04-21 |
CN1180316A (zh) | 1998-04-29 |
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