DE69630688T2 - Elektrochemilumineszente enzymbiosensoren - Google Patents

Elektrochemilumineszente enzymbiosensoren Download PDF

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Publication number
DE69630688T2
DE69630688T2 DE69630688T DE69630688T DE69630688T2 DE 69630688 T2 DE69630688 T2 DE 69630688T2 DE 69630688 T DE69630688 T DE 69630688T DE 69630688 T DE69630688 T DE 69630688T DE 69630688 T2 DE69630688 T2 DE 69630688T2
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DE
Germany
Prior art keywords
oxidoreductase
conjugate
enzyme
nad
nadh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69630688T
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German (de)
English (en)
Other versions
DE69630688D1 (de
Inventor
T. Mark MARTIN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioveris Corp
Original Assignee
IGEN International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IGEN International Inc filed Critical IGEN International Inc
Publication of DE69630688D1 publication Critical patent/DE69630688D1/de
Application granted granted Critical
Publication of DE69630688T2 publication Critical patent/DE69630688T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
DE69630688T 1995-06-06 1996-06-06 Elektrochemilumineszente enzymbiosensoren Expired - Fee Related DE69630688T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US467712 1995-06-06
US08/467,712 US6852502B1 (en) 1995-06-06 1995-06-06 Electrochemiluminescent enzyme biosensors
PCT/US1996/009869 WO1996039534A1 (en) 1995-06-06 1996-06-06 Electrochemiluminescent enzyme biosensors

Publications (2)

Publication Number Publication Date
DE69630688D1 DE69630688D1 (de) 2003-12-18
DE69630688T2 true DE69630688T2 (de) 2004-09-23

Family

ID=23856828

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69630688T Expired - Fee Related DE69630688T2 (de) 1995-06-06 1996-06-06 Elektrochemilumineszente enzymbiosensoren

Country Status (8)

Country Link
US (1) US6852502B1 (https=)
EP (1) EP0837949B1 (https=)
JP (1) JP3618759B2 (https=)
AT (1) ATE254186T1 (https=)
AU (1) AU698465B2 (https=)
CA (1) CA2223017A1 (https=)
DE (1) DE69630688T2 (https=)
WO (1) WO1996039534A1 (https=)

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US8008037B2 (en) 2008-03-27 2011-08-30 Roche Diagnostics Operations, Inc. Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline
PT2271938E (pt) 2008-04-11 2014-05-09 Univ Texas Método e aparelho de amplificação de quimiluminescênci electrogerada por nanopartículas
AU2009244904B2 (en) 2008-05-08 2014-04-17 Board Of Regents Of The University Of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
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JP6979941B2 (ja) 2015-08-20 2021-12-15 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Ｐｅｇ化分析物特異的結合剤を用いた粒子に基づくイムノアッセイ
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JP7068323B2 (ja) 2017-02-02 2022-05-16 エフ．ホフマン－ラ ロシュ アーゲー 少なくとも２種のペグ化された分析物特異的結合剤を使用する免疫アッセイ
EP3781600A1 (en) 2018-04-18 2021-02-24 F. Hoffmann-La Roche AG Novel anti-thymidine kinase antibodies
JP7577647B2 (ja) 2018-08-31 2024-11-05 エフ． ホフマン－ラ ロシュ アーゲー Ｄｌｂｃｌについての予後指標におけるチミジンキナーゼ（ｔｋ－１）
CN110938667A (zh) * 2018-09-21 2020-03-31 中国科学院天津工业生物技术研究所 一种酶电极、生物传感器及其制备方法和用途
EP4004551A1 (en) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG Substance p as blood biomarker for the non-invasive diagnosis of endometriosis
WO2021013785A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a9 as blood biomarker for the non-invasive diagnosis of endometriosis
EP4004555A1 (en) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a6 as blood biomarker for the non-invasive diagnosis of endometriosis
WO2021013783A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a12 as blood biomarker for the non-invasive diagnosis of endometriosis
EP4004553A1 (en) 2019-07-22 2022-06-01 F. Hoffmann-La Roche AG S100a8 as blood biomarker for the non-invasive diagnosis of endometriosis
KR20220100883A (ko) 2019-11-15 2022-07-18 에프. 호프만-라 로슈 아게 환자 샘플의 질량분석법 측정을 위한 베타-락탐 항생제의 유도체화
JP7851928B2 (ja) 2020-11-02 2026-04-27 エフ． ホフマン－ラ ロシュ アーゲー ＳＡＲＳ－ＣｏＶ－２ヌクレオカプシド抗体
WO2022207628A1 (en) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf as blood biomarker for the non-invasive diagnosis of endometriosis
WO2022207685A1 (en) 2021-04-01 2022-10-06 F. Hoffmann-La Roche Ag Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis
CN117337394A (zh) 2021-05-17 2024-01-02 豪夫迈·罗氏有限公司 sFRP4作为血液生物标志物用于子宫腺肌病的非侵入性诊断
WO2023072904A1 (en) 2021-10-26 2023-05-04 F. Hoffmann-La Roche Ag Monoclonal antibodies specific for sars-cov-2 rbd
KR20230060229A (ko) * 2021-10-27 2023-05-04 한국전기연구원 광열 모듈레이션 레이저 스펙클 영상을 이용한 포도당 농도 측정 시스템, 방법, 및 상기 방법을 실행시키기 위한 컴퓨터 판독 가능한 프로그램을 기록한 기록 매체
WO2023131594A1 (en) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm)
JP2025520600A (ja) 2022-06-23 2025-07-03 エフ． ホフマン－ラ ロシュ アーゲー 子宮内膜症を診断するためおよび子宮内膜症の病期を分類するための方法
EP4558830A1 (en) 2022-07-22 2025-05-28 F. Hoffmann-La Roche AG Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
JP2025524027A (ja) 2022-07-22 2025-07-25 エフ． ホフマン－ラ ロシュ アーゲー 多嚢胞性卵巣症候群の診断のための（血液）バイオマーカーとしてのメテオリン様タンパク質（ｍｅｔｒｎｌ）
EP4558826A1 (en) 2022-07-22 2025-05-28 F. Hoffmann-La Roche AG Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
CN120693408A (zh) 2022-12-05 2025-09-23 直接传感有限公司 非乳酸羟基酸的酶促检测
CN121532654A (zh) 2023-07-20 2026-02-13 豪夫迈·罗氏有限公司 针对抗体组合物的筛选方法
CN121752901A (zh) 2023-07-28 2026-03-27 豪夫迈·罗氏有限公司 作为子宫内膜异位症的生物标志物的血清EphA1

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Also Published As

Publication number Publication date
ATE254186T1 (de) 2003-11-15
US6852502B1 (en) 2005-02-08
EP0837949A1 (en) 1998-04-29
DE69630688D1 (de) 2003-12-18
AU6382296A (en) 1996-12-24
CA2223017A1 (en) 1996-12-12
EP0837949A4 (en) 2000-05-17
AU698465B2 (en) 1998-10-29
JP3618759B2 (ja) 2005-02-09
JPH11507536A (ja) 1999-07-06
EP0837949B1 (en) 2003-11-12
WO1996039534A1 (en) 1996-12-12

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: BIOVERIS CORP.(N.D.GES.D.STAATES DELAWARE), GAITHE

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee