DE69630688T2 - Elektrochemilumineszente enzymbiosensoren - Google Patents

Elektrochemilumineszente enzymbiosensoren Download PDF

Info

Publication number
DE69630688T2
DE69630688T2 DE69630688T DE69630688T DE69630688T2 DE 69630688 T2 DE69630688 T2 DE 69630688T2 DE 69630688 T DE69630688 T DE 69630688T DE 69630688 T DE69630688 T DE 69630688T DE 69630688 T2 DE69630688 T2 DE 69630688T2
Authority
DE
Germany
Prior art keywords
oxidoreductase
conjugate
enzyme
nad
nadh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69630688T
Other languages
German (de)
English (en)
Other versions
DE69630688D1 (de
Inventor
T. Mark MARTIN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioveris Corp
Original Assignee
IGEN International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IGEN International Inc filed Critical IGEN International Inc
Publication of DE69630688D1 publication Critical patent/DE69630688D1/de
Application granted granted Critical
Publication of DE69630688T2 publication Critical patent/DE69630688T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
DE69630688T 1995-06-06 1996-06-06 Elektrochemilumineszente enzymbiosensoren Expired - Fee Related DE69630688T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US467712 1995-06-06
US08/467,712 US6852502B1 (en) 1995-06-06 1995-06-06 Electrochemiluminescent enzyme biosensors
PCT/US1996/009869 WO1996039534A1 (en) 1995-06-06 1996-06-06 Electrochemiluminescent enzyme biosensors

Publications (2)

Publication Number Publication Date
DE69630688D1 DE69630688D1 (de) 2003-12-18
DE69630688T2 true DE69630688T2 (de) 2004-09-23

Family

ID=23856828

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69630688T Expired - Fee Related DE69630688T2 (de) 1995-06-06 1996-06-06 Elektrochemilumineszente enzymbiosensoren

Country Status (8)

Country Link
US (1) US6852502B1 (https=)
EP (1) EP0837949B1 (https=)
JP (1) JP3618759B2 (https=)
AT (1) ATE254186T1 (https=)
AU (1) AU698465B2 (https=)
CA (1) CA2223017A1 (https=)
DE (1) DE69630688T2 (https=)
WO (1) WO1996039534A1 (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010003647A1 (en) * 1995-06-07 2001-06-14 Ji Sun Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same
EP0821726B1 (en) * 1995-03-10 2014-05-07 Meso Scale Technologies, LLC. Multi-array, multi-specific electrochemiluminescence testing
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US7400256B2 (en) 2000-11-03 2008-07-15 Cargill, Incorporated Chill cooler storage and selection system
US6724309B2 (en) * 2000-11-03 2004-04-20 Excel Corporation Method and apparatus for tracking carcasses
US7766730B2 (en) 2000-11-03 2010-08-03 Cargill, Incorporated Carcass tracking
DE60322708D1 (de) * 2002-06-17 2008-09-18 Arkray Inc Glucosesensor unter verwendung von glucosedehydrogenase
ES2675044T3 (es) * 2005-06-03 2018-07-06 Board Of Regents Of The University Of Texas System Electroquímica y quimioluminiscencia electrogenerada con un único electrodo faradaico
CA2625638C (en) 2005-11-08 2014-03-11 Surmodics, Inc. Ultra-thin photo-polymer coatings and uses thereof
CA2682147C (en) 2007-03-30 2017-08-08 Ambrx, Inc. Modified fgf-21 polypeptides and their uses
US8008037B2 (en) 2008-03-27 2011-08-30 Roche Diagnostics Operations, Inc. Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline
HRP20140460T1 (hr) 2008-04-11 2014-06-20 Board Of Regents Of The University Of Texas System Postupak i uređaj za pojačanje elektrogenerirane kemiluminescencije nanočestica
KR101603356B1 (ko) 2008-05-08 2016-03-14 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 전기발생 화학발광에 사용되는 발광 나노구조 물질
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
SMT202100388T1 (it) 2014-10-24 2021-09-14 Bristol Myers Squibb Co Polipeptidi fgf-21 modificati e loro usi
ES2734807T3 (es) 2015-08-20 2019-12-12 Hoffmann La Roche Inmunoensayo basado en partículas que usa un agente de unión específica a un analito pegilado
KR102437995B1 (ko) 2016-03-07 2022-08-29 에프. 호프만-라 로슈 아게 항-p53 항체의 검출
WO2018141768A1 (en) 2017-02-02 2018-08-09 Roche Diagnostics Gmbh Immunoassay using at least two pegylated analyte-specific binding agents
EP3781600A1 (en) 2018-04-18 2021-02-24 F. Hoffmann-La Roche AG Novel anti-thymidine kinase antibodies
ES2983797T3 (es) 2018-08-31 2024-10-24 Hoffmann La Roche Timidina cinasa (TK-1) en índices pronóstico para LDLBG
CN110938667A (zh) * 2018-09-21 2020-03-31 中国科学院天津工业生物技术研究所 一种酶电极、生物传感器及其制备方法和用途
WO2021013786A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a6 as blood biomarker for the non-invasive diagnosis of endometriosis
WO2021013783A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a12 as blood biomarker for the non-invasive diagnosis of endometriosis
WO2021013784A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a8 as blood biomarker for the non-invasive diagnosis of endometriosis
WO2021013785A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a9 as blood biomarker for the non-invasive diagnosis of endometriosis
JP7315780B2 (ja) 2019-07-22 2023-07-26 エフ． ホフマン－ラ ロシュ アーゲー 子宮内膜症の非侵襲的診断のための血液バイオマーカーとしてのサブスタンスｐ
WO2021094409A1 (en) 2019-11-15 2021-05-20 F. Hoffmann-La Roche Ag Derivatization of beta-lactam antibiotics for massspec measurements in patient samples
US20230406909A1 (en) 2020-11-02 2023-12-21 Roche Diagnostics Operations, Inc. Sars-cov-2 nucleocapsid antibodies
WO2022207628A1 (en) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf as blood biomarker for the non-invasive diagnosis of endometriosis
WO2022207685A1 (en) 2021-04-01 2022-10-06 F. Hoffmann-La Roche Ag Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis
WO2022243210A1 (en) 2021-05-17 2022-11-24 F. Hoffmann-La Roche Ag sFRP4 AS BLOOD BIOMARKER FOR THE NON-INVASIVE DIAGNOSIS OF ADENOMYOSIS
CN118434762A (zh) 2021-10-26 2024-08-02 豪夫迈·罗氏有限公司 对SARS-CoV-2 RBD具有特异性的单克隆抗体
KR20230060229A (ko) * 2021-10-27 2023-05-04 한국전기연구원 광열 모듈레이션 레이저 스펙클 영상을 이용한 포도당 농도 측정 시스템, 방법, 및 상기 방법을 실행시키기 위한 컴퓨터 판독 가능한 프로그램을 기록한 기록 매체
WO2023131594A1 (en) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm)
EP4544305A1 (en) 2022-06-23 2025-04-30 F. Hoffmann-La Roche AG Method for diagnosing endometriosis and for classifying the stage of endometriosis
EP4558825A1 (en) 2022-07-22 2025-05-28 F. Hoffmann-La Roche AG Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome
JP2025523884A (ja) 2022-07-22 2025-07-25 エフ． ホフマン－ラ ロシュ アーゲー 多嚢胞性卵巣症候群の診断のための（血液）バイオマーカーとしての線維芽細胞増殖因子結合タンパク質１（ｆｇｆｂｐ１）
JP2025524025A (ja) 2022-07-22 2025-07-25 エフ． ホフマン－ラ ロシュ アーゲー 多嚢胞性卵巣症候群の診断のための（血液）バイオマーカーとしてのロイコトリエンａ４ヒドロラーゼ（ｌｔａ４ｈ）
EP4630571A1 (en) 2022-12-05 2025-10-15 DirectSens GmbH Enzymatic detection of non-lactate hydroxy acids
WO2025017135A1 (en) 2023-07-20 2025-01-23 F. Hoffmann-La Roche Ag Screening methods for antibody compositions
WO2025026908A1 (en) 2023-07-28 2025-02-06 Roche Diagnostics Gmbh Serum epha1 as biomarker for endometriosis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221605A (en) 1984-10-31 1993-06-22 Igen, Inc. Luminescent metal chelate labels and means for detection
US5310687A (en) 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5147806A (en) 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
US5250415A (en) 1987-04-08 1993-10-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Process for the preparation of glucose dehydrogenase from Bacillus megaterium
US5061455A (en) 1987-04-30 1991-10-29 United Technologies Corporation Apparatus for removing carbon dioxide from air
US5093268A (en) 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
US5340722A (en) 1988-08-24 1994-08-23 Avl Medical Instruments Ag Method for the determination of the concentration of an enzyme substrate and a sensor for carrying out the method
US5068088A (en) 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5235808A (en) 1990-02-12 1993-08-17 General Electric Company Exhaust nozzle including idle thrust spoiling
US5324835A (en) 1990-03-30 1994-06-28 Biosensor Laboratories Co., Ltd. Pyridazinoquinoxalinones for use as chemiluminescent agents
US5229202A (en) 1990-05-22 1993-07-20 Mitsubishi Kasei Corporation Carbon fiber and carbon fiber-reinforced resin composition using it
US5264092A (en) 1991-10-02 1993-11-23 Moltech Corporation Redox polymer modified electrode for the electrochemical regeneration of coenzyme
JP2541081B2 (ja) 1992-08-28 1996-10-09 日本電気株式会社 バイオセンサ及びバイオセンサの製造・使用方法
US5527710A (en) * 1994-12-02 1996-06-18 Igen, Inc. Rate measurements of biomolecular reactions using electrochemiluminescence
EP0821726B1 (en) * 1995-03-10 2014-05-07 Meso Scale Technologies, LLC. Multi-array, multi-specific electrochemiluminescence testing

Also Published As

Publication number Publication date
AU6382296A (en) 1996-12-24
EP0837949A1 (en) 1998-04-29
DE69630688D1 (de) 2003-12-18
EP0837949B1 (en) 2003-11-12
JPH11507536A (ja) 1999-07-06
ATE254186T1 (de) 2003-11-15
AU698465B2 (en) 1998-10-29
US6852502B1 (en) 2005-02-08
WO1996039534A1 (en) 1996-12-12
EP0837949A4 (en) 2000-05-17
CA2223017A1 (en) 1996-12-12
JP3618759B2 (ja) 2005-02-09

Similar Documents

Publication Publication Date Title
DE69630688T2 (de) Elektrochemilumineszente enzymbiosensoren
Situmorang et al. Immobilisation of enzyme throughout a polytyramine matrix: a versatile procedure for fabricating biosensors
Rubinstein et al. Electrogenerated chemiluminescent determination of oxalate
DE69637001T2 (de) Elektrochemilumineszenz-enzymimmunoassay
CH635438A5 (en) Test process operating using a specific bond for the investigation of a liquid medium on a ligand and reagent for carrying out the process
EP1239049A2 (de) Wasserstofperoxid Bestimmung mittels Oxidasen und Lanthanoid-Liganden-Komplexen
DE69123852T2 (de) Testtechnik
Piano et al. Amperometric lactate biosensor for flow injection analysis based on a screen-printed carbon electrode containing Meldola's Blue-Reinecke salt, coated with lactate dehydrogenase and NAD+
AT390803B (de) Verfahren zur bestimmung der konzentration eines enzymsubstrates und sensor zur durchfuehrung des verfahrens
Holzapfel-Pschorn et al. Sensitive methods for the determination of microbial activities in water samples using fluorigenic substrates
DE3885048T2 (de) Testzusammensetzung, Vorrichtung und Verfahren zur visuellen Bestimmung von Wasserstoffperoxyd.
Yao et al. Electrochemical dehydrogenase-based homogeneous assays in whole blood
DE2722391A1 (de) Verfahren zur bestimmung eines chemischen stoffes durch ermittlung freigesetzter elektromagnetischer strahlung
Gajovic et al. Comparison of two enzyme sequences for a novel l‐malate biosensor
JPH11344460A (ja) 液体および培地の評価法
DE3850346T2 (de) Verfahren zur Selbstdurchführung von Enzymkinetik.
Tabata et al. A chemiluminometric method for NADPH and NADH using a two‐enzyme bioreactor and its application to the determination of magnesium in serum
Gilmartin et al. Development of one-shot biosensors for the measurement of uric acid and cholesterol
DE60022961T2 (de) Verfahren zur quantitativen Bestimmung von Mannose und Reagenz hierzu
DE4344646A1 (de) Vorrichtung für einen kompetitiven Immuno-Assay zur Bestimmung von Haptenen
EP1445603A1 (de) Fluorimetrische Bestimmung von Analyten durch Amin-N-Oxide als Redoxindikatoren
DE69518995T2 (de) Ein Verfahren zum Nachweis von Biomolekülen mit Hilfe eines enzymatischen Amplifizierungssystems
Sim Bioelectrochemical detection of three alcohols based on a conducting organic salt electrode
Guilbault Biosensors
DE19602078A1 (de) Vorrichtung für amperometrische kompetitive homogene Enzymimmunotests

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: BIOVERIS CORP.(N.D.GES.D.STAATES DELAWARE), GAITHE

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee