DE69627091D1 - N-(2-substituierte-3-(2-aminoethyl)-1H-indol-5-yl)-amide als 5-HT1F Agonisten - Google Patents
N-(2-substituierte-3-(2-aminoethyl)-1H-indol-5-yl)-amide als 5-HT1F AgonistenInfo
- Publication number
- DE69627091D1 DE69627091D1 DE69627091T DE69627091T DE69627091D1 DE 69627091 D1 DE69627091 D1 DE 69627091D1 DE 69627091 T DE69627091 T DE 69627091T DE 69627091 T DE69627091 T DE 69627091T DE 69627091 D1 DE69627091 D1 DE 69627091D1
- Authority
- DE
- Germany
- Prior art keywords
- indol
- aminoethyl
- amides
- substituted
- ht1f agonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US521395P | 1995-10-10 | 1995-10-10 | |
US1585196P | 1996-05-22 | 1996-05-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69627091D1 true DE69627091D1 (de) | 2003-05-08 |
DE69627091T2 DE69627091T2 (de) | 2003-12-18 |
Family
ID=26674078
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69627091T Expired - Fee Related DE69627091T2 (de) | 1995-10-10 | 1996-10-09 | N-(2-substituierte-3-(2-aminoethyl)-1H-indol-5-yl)-amide als 5-HT1F Agonisten |
Country Status (9)
Country | Link |
---|---|
US (3) | US5942536A (de) |
EP (1) | EP0768301B1 (de) |
JP (1) | JPH11513666A (de) |
AT (1) | ATE236122T1 (de) |
AU (1) | AU7261196A (de) |
CA (1) | CA2234166A1 (de) |
DE (1) | DE69627091T2 (de) |
ES (1) | ES2194960T3 (de) |
WO (1) | WO1997013512A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5942536A (en) * | 1995-10-10 | 1999-08-24 | Eli Lilly And Company | N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists |
US5962473A (en) * | 1996-08-16 | 1999-10-05 | Eli Lilly And Company | Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F |
WO1998015545A1 (en) * | 1996-10-08 | 1998-04-16 | Eli Lilly And Company | New serotonin 5-ht1f agonists |
ES2212814T3 (es) * | 1996-10-31 | 2004-08-01 | Harbor Branch Oceanographic Institution, Inc. | Uso de compuestos y composiciones antiinflamatorias neurogenicas. |
WO1998047868A1 (en) * | 1997-04-18 | 1998-10-29 | Smithkline Beecham Plc | Heterocycle-containing urea derivatives as 5ht1a, 5ht1b and 5ht1d receptor antagonists |
US6128537A (en) * | 1997-05-01 | 2000-10-03 | Medtronic, Inc | Techniques for treating anxiety by brain stimulation and drug infusion |
US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
US5905084A (en) * | 1997-11-14 | 1999-05-18 | Eli Lilly And Company | 5-HTIF -agonists effective in treating migraine |
US6403808B1 (en) * | 1999-12-10 | 2002-06-11 | Virginia Commonwealth University | Selective 5-HT6 receptor ligands |
US6777428B1 (en) | 1999-02-10 | 2004-08-17 | Eli Lilly And Company | 5-HT1f agonist |
FR2792313A1 (fr) * | 1999-04-13 | 2000-10-20 | Synthelabo | Derives de 2-aminoethyl-indole, leur preparation et leur application en therapeutique |
IL130169A (en) * | 1999-05-27 | 2006-08-20 | Neurim Pharma 1991 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
DE19963178A1 (de) * | 1999-12-27 | 2001-07-05 | Gruenenthal Gmbh | Substituierte Indol-Mannichbasen |
BR0206595A (pt) * | 2001-01-30 | 2004-07-13 | Lilly Co Eli | Composto, composição farmacêutica, e uso de um composto |
CA2357114C (en) * | 2001-03-22 | 2010-06-29 | Pooger Properties Ltd. | Use of melatonin in the manufacture of a medicament for treating attention deficit hyperactive disorder |
JP4264689B2 (ja) * | 2001-06-05 | 2009-05-20 | ダイキン工業株式会社 | 酸の分離方法 |
AU2002346403A1 (en) * | 2001-11-16 | 2003-06-10 | University And Community College System Of Nevada On Behalf Of The University Of Nevada, Reno | Method for selective conjugation of analytes to enzymes without unwanted enzyme-enzyme cross-linking |
TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
US20050124620A1 (en) * | 2002-04-09 | 2005-06-09 | Martyn Frederickson | Pharmaceutical compounds |
JP2006505571A (ja) * | 2002-10-15 | 2006-02-16 | リゲル ファーマシューテイカルズ、インコーポレイテッド | 置換されたインドール及びhcv阻害剤としてのその使用 |
WO2004041781A1 (en) * | 2002-11-07 | 2004-05-21 | Suven Life Sciences Limited | Preparation of 3-aminoalkyl-substituted indole derivatives from phenylhydrazines and aminoketones |
DE10254596A1 (de) * | 2002-11-22 | 2004-06-03 | Merck Patent Gmbh | Indolderivate |
ES2388547T3 (es) * | 2003-04-18 | 2012-10-16 | Eli Lilly And Company | Compuestos de (piperidiniloxi)fenilo, (piperidiniloxi)piridinilo, (piperidinilsulfanil)fenilo y (piperidinilsulfanil)piridinilo como agonistas de 5-HT 1F |
UA82711C2 (en) | 2003-09-12 | 2008-05-12 | Эли Лилли Энд Компани | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists |
ES2291978T3 (es) | 2003-12-17 | 2008-03-01 | Eli Lilly And Company | Compuestos de (4-aminociclohexen-1-il)fenilo y (4-aminociclohexen-1-il)piridinilo sustituidos como agonistas de 5-ht1f. |
US7403118B2 (en) * | 2005-11-29 | 2008-07-22 | Checkpoint Systems, Inc. | Security device with perimeter alarm |
EP1953153A1 (de) * | 2007-01-31 | 2008-08-06 | Laboratorios del Dr. Esteve S.A. | Heterocyclyl-substituierte Sulfonamide für die Behandlung von Wahrnehmungsstörungen bzw. Ernährungserkrankungen |
US8697876B2 (en) | 2010-04-02 | 2014-04-15 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists |
ES2570452B1 (es) * | 2014-10-15 | 2017-04-19 | Fundación Para La Investigación Biomédida Del Hospital Universitario De La Princesa | Compuestos derivados de acrilato de 3-Alquilamino-1H-Indolilo y su uso en el tratamiento de enfermedades neurodegenerativas |
TWI776175B (zh) | 2019-07-09 | 2022-09-01 | 美商美國禮來大藥廠 | 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體,以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3472870A (en) * | 1966-08-29 | 1969-10-14 | Mead Johnson & Co | Sulfonamidotryptamines |
US3591603A (en) * | 1968-05-13 | 1971-07-06 | Little Inc A | 3(3-indole) - lower-alkylamines |
US3915990A (en) * | 1973-03-13 | 1975-10-28 | Nelson Res & Dev | Tryptamines |
US3903084A (en) * | 1974-02-11 | 1975-09-02 | Upjohn Co | Carboximidoyl urea derivatives |
ZA815541B (en) * | 1980-08-12 | 1983-03-30 | Glaxo Group Ltd | Heterocyclic compounds |
ZW19381A1 (en) * | 1980-08-12 | 1983-03-09 | Glaxo Group Ltd | Heterocyclic compounds |
US4803218A (en) * | 1982-09-29 | 1989-02-07 | Mcneilab, Inc. | 3-aminoalkyl-1H-indole-5-urea and amide derivatives |
US4544663A (en) * | 1984-05-07 | 1985-10-01 | Sandoz, Inc. | Indolamine derivatives as anti-fertility agents |
US5030640A (en) * | 1989-01-05 | 1991-07-09 | Merck & Co., Inc. | Novel β-adrenergic agonists and pharmaceutical compositions thereof |
IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
CA2064815C (en) * | 1990-06-07 | 1999-11-16 | Alan Duncan Robertson | Therapeutic heterocyclic compounds |
DE4026614A1 (de) * | 1990-08-23 | 1992-02-27 | Bayer Ag | Phosphonopyrrolidin- und piperidin-haltige pseudopeptide vom statintyp, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel gegen retroviren |
US5192770A (en) * | 1990-12-07 | 1993-03-09 | Syntex (U.S.A.) Inc. | Serotonergic alpha-oxoacetamides |
SK278998B6 (sk) * | 1991-02-01 | 1998-05-06 | Merck Sharp & Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu, spôsob i |
TW263508B (de) * | 1991-02-12 | 1995-11-21 | Pfizer | |
FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
HUT69705A (en) * | 1991-11-25 | 1995-09-28 | Pfizer | Indole derivatives |
IL106445A (en) * | 1992-07-30 | 1998-01-04 | Merck Sharp & Dohme | History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them |
TW251284B (de) * | 1992-11-02 | 1995-07-11 | Pfizer | |
GB9226532D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
DE4321366A1 (de) * | 1993-06-26 | 1995-01-05 | Merck Patent Gmbh | Piperidine und Piperazine |
GB9402680D0 (en) * | 1994-02-11 | 1994-04-06 | Zeneca Ltd | Pyrrolidine derivatives |
US5439918A (en) * | 1994-03-14 | 1995-08-08 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5962815A (en) * | 1995-01-18 | 1999-10-05 | Prolinx Labs Corporation | Antifuse interconnect between two conducting layers of a printed circuit board |
US5942536A (en) * | 1995-10-10 | 1999-08-24 | Eli Lilly And Company | N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists |
WO1998015545A1 (en) * | 1996-10-08 | 1998-04-16 | Eli Lilly And Company | New serotonin 5-ht1f agonists |
-
1996
- 1996-10-08 US US09/043,360 patent/US5942536A/en not_active Expired - Fee Related
- 1996-10-08 AU AU72611/96A patent/AU7261196A/en not_active Abandoned
- 1996-10-08 JP JP9515134A patent/JPH11513666A/ja not_active Ceased
- 1996-10-08 WO PCT/US1996/016122 patent/WO1997013512A1/en active Application Filing
- 1996-10-08 CA CA002234166A patent/CA2234166A1/en not_active Abandoned
- 1996-10-09 EP EP96307334A patent/EP0768301B1/de not_active Expired - Lifetime
- 1996-10-09 ES ES96307334T patent/ES2194960T3/es not_active Expired - Lifetime
- 1996-10-09 DE DE69627091T patent/DE69627091T2/de not_active Expired - Fee Related
- 1996-10-09 AT AT96307334T patent/ATE236122T1/de not_active IP Right Cessation
-
1999
- 1999-05-21 US US09/316,871 patent/US5998630A/en not_active Expired - Fee Related
- 1999-10-12 US US09/416,043 patent/US6126932A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2234166A1 (en) | 1997-04-17 |
US5942536A (en) | 1999-08-24 |
ATE236122T1 (de) | 2003-04-15 |
DE69627091T2 (de) | 2003-12-18 |
WO1997013512A1 (en) | 1997-04-17 |
EP0768301B1 (de) | 2003-04-02 |
ES2194960T3 (es) | 2003-12-01 |
AU7261196A (en) | 1997-04-30 |
JPH11513666A (ja) | 1999-11-24 |
US6126932A (en) | 2000-10-03 |
US5998630A (en) | 1999-12-07 |
EP0768301A1 (de) | 1997-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |