DE69626650D1 - Verwendung von aminoadamantan-verbindungen als immunregulatoren - Google Patents

Verwendung von aminoadamantan-verbindungen als immunregulatoren

Info

Publication number
DE69626650D1
DE69626650D1 DE69626650T DE69626650T DE69626650D1 DE 69626650 D1 DE69626650 D1 DE 69626650D1 DE 69626650 T DE69626650 T DE 69626650T DE 69626650 T DE69626650 T DE 69626650T DE 69626650 D1 DE69626650 D1 DE 69626650D1
Authority
DE
Germany
Prior art keywords
compounds
aminoadamantan
immune regulators
aminoadamantane
neutrophils
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69626650T
Other languages
English (en)
Other versions
DE69626650T2 (de
Inventor
F Elstner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merz Pharma GmbH and Co KGaA
Original Assignee
Merz Pharma GmbH and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma GmbH and Co KGaA filed Critical Merz Pharma GmbH and Co KGaA
Publication of DE69626650D1 publication Critical patent/DE69626650D1/de
Application granted granted Critical
Publication of DE69626650T2 publication Critical patent/DE69626650T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
DE69626650T 1995-08-25 1996-08-21 Verwendung von aminoadamantan-verbindungen als immunregulatoren Expired - Fee Related DE69626650T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19531342A DE19531342B4 (de) 1995-08-25 1995-08-25 Verwendung von Aminoadamantan-Verbindungen als Immunregulatoren
PCT/EP1996/003678 WO1997007791A1 (en) 1995-08-25 1996-08-21 Use of aminoadamantane compounds as immunoregulators

Publications (2)

Publication Number Publication Date
DE69626650D1 true DE69626650D1 (de) 2003-04-17
DE69626650T2 DE69626650T2 (de) 2003-12-18

Family

ID=7770407

Family Applications (3)

Application Number Title Priority Date Filing Date
DE19531342A Expired - Fee Related DE19531342B4 (de) 1995-08-25 1995-08-25 Verwendung von Aminoadamantan-Verbindungen als Immunregulatoren
DE69626650T Expired - Fee Related DE69626650T2 (de) 1995-08-25 1996-08-21 Verwendung von aminoadamantan-verbindungen als immunregulatoren
DE2003199029 Pending DE10399029I1 (de) 1995-08-25 1996-08-21 Verwendung von Aminoadamantan-Verbindungen als Immunregulatoren.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19531342A Expired - Fee Related DE19531342B4 (de) 1995-08-25 1995-08-25 Verwendung von Aminoadamantan-Verbindungen als Immunregulatoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2003199029 Pending DE10399029I1 (de) 1995-08-25 1996-08-21 Verwendung von Aminoadamantan-Verbindungen als Immunregulatoren.

Country Status (21)

Country Link
US (2) US6172116B1 (de)
EP (2) EP1293201A3 (de)
JP (1) JPH11512093A (de)
KR (1) KR100392986B1 (de)
CN (1) CN1282452C (de)
AT (1) ATE234083T1 (de)
AU (1) AU718219B2 (de)
CA (1) CA2230159C (de)
CZ (1) CZ299356B6 (de)
DE (3) DE19531342B4 (de)
DK (1) DK0845984T3 (de)
EE (1) EE04261B1 (de)
ES (1) ES2193259T3 (de)
GE (1) GEP19991779B (de)
IL (1) IL123394A (de)
MX (1) MX217078B (de)
NO (1) NO319153B1 (de)
RU (1) RU2219916C2 (de)
UA (1) UA57711C2 (de)
WO (1) WO1997007791A1 (de)
ZA (1) ZA967137B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100482233C (zh) * 1999-04-28 2009-04-29 贝卢斯健康(国际）有限公司 用于治疗淀粉样变性的组合物和方法
US6444702B1 (en) 2000-02-22 2002-09-03 Neuromolecular, Inc. Aminoadamantane derivatives as therapeutic agents
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US7414076B2 (en) * 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
EA200600428A1 (ru) * 2004-06-24 2007-04-27 Акционерное Общество "Олайнфарм" Иммуностимулирующее и интерфероногенное средство
AU2005326962A1 (en) 2004-12-22 2006-08-17 Bellus Health (International) Limited Methods and compositions for treating amyloid-related diseases
WO2009019534A2 (en) 2006-10-12 2009-02-12 Bellus Health (International) Limited Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
TWI511958B (zh) * 2010-08-09 2015-12-11 Shionogi & Co 胺基金剛烷胺基甲酸酯衍生物之製造方法
EP3474831A1 (de) 2016-06-23 2019-05-01 Corium International, Inc. Haftende matrix mit hydrophilen und hydrophoben bereichen und einem therapeutischen wirkstoff
WO2018022814A1 (en) 2016-07-27 2018-02-01 Corium International, Inc. Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
MX2019001104A (es) 2016-07-27 2019-10-02 Corium Int Inc Sistemas de suministro transdermico de memantina.
KR20230109782A (ko) 2016-07-27 2023-07-20 코리움, 엘엘씨 아민 약물의 나트륨 바이카보네이트 제자리 전환 구동된경피성 전달
US11173132B2 (en) 2017-12-20 2021-11-16 Corium, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450761A (en) * 1967-03-30 1969-06-17 Sun Oil Co 1-aminoethyldimethyladamantane
DE4014672A1 (de) * 1990-05-08 1991-11-14 Werner E G Prof Dr Mueller Verwendung von adamantan-derivaten zur zytoprotektion von nicht-infizierten und virus-infizierten lymphozyten als auch anderen zelltypen

Also Published As

Publication number Publication date
EP1293201A2 (de) 2003-03-19
ZA967137B (en) 1997-03-12
EE04261B1 (et) 2004-04-15
US6255348B1 (en) 2001-07-03
NO319153B1 (no) 2005-06-27
AU718219B2 (en) 2000-04-13
KR100392986B1 (ko) 2003-11-17
US6172116B1 (en) 2001-01-09
EE9800057A (et) 1998-08-17
CZ299356B6 (cs) 2008-07-02
ES2193259T3 (es) 2003-11-01
DK0845984T3 (da) 2003-06-23
CN1198669A (zh) 1998-11-11
IL123394A (en) 2004-07-25
JPH11512093A (ja) 1999-10-19
CZ52498A3 (cs) 1999-04-14
IL123394A0 (en) 1998-09-24
MX9801496A (es) 1998-05-31
NO980793D0 (no) 1998-02-25
EP0845984A1 (de) 1998-06-10
RU2219916C2 (ru) 2003-12-27
GEP19991779B (en) 1999-10-05
CA2230159A1 (en) 1997-03-06
DE19531342B4 (de) 2007-11-29
MX217078B (es) 2003-10-22
UA57711C2 (uk) 2003-07-15
DE19531342A1 (de) 1997-02-27
DE69626650T2 (de) 2003-12-18
NO980793L (no) 1998-02-25
EP0845984B1 (de) 2003-03-12
AU6926396A (en) 1997-03-19
ATE234083T1 (de) 2003-03-15
CA2230159C (en) 2008-02-26
EP1293201A3 (de) 2003-05-21
WO1997007791A1 (en) 1997-03-06
KR19990044096A (ko) 1999-06-25
CN1282452C (zh) 2006-11-01
DE10399029I1 (de) 2004-01-08

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Legal Events

Date Code Title Description
V448 Application of spc

Free format text: PRODUCT NAME: MEMANTIN; REGISTRATION NO/DATE: EU/1/02/219/001 - EU/1/02/219/006; 20020515

Spc suppl protection certif: 103 99 029

Filing date: 20030730

V454 Spc application withdrawn or to be regarded as withdrawn

Free format text: PRODUCT NAME: MEMANTIN; REGISTRATION NO/DATE: EU/1/02/219/001 - EU/1/02/219/006; 20020515

Spc suppl protection certif: 103 99 029

Filing date: 20030730

8364 No opposition during term of opposition
V492 Spc regarded as annulled caused by lapse of basic patent

Free format text: PRODUCT NAME: MEMANTIN; REGISTRATION NO/DATE: EU/1/02/219/001 - EU/1/02/219/006; 20020515

Spc suppl protection certif: 103 99 029

Filing date: 20030730

8339 Ceased/non-payment of the annual fee