DE69620876T2 - Bestimmung von steroiden durch kompetitiven immunoassay - Google Patents

Bestimmung von steroiden durch kompetitiven immunoassay

Info

Publication number
DE69620876T2
DE69620876T2 DE69620876T DE69620876T DE69620876T2 DE 69620876 T2 DE69620876 T2 DE 69620876T2 DE 69620876 T DE69620876 T DE 69620876T DE 69620876 T DE69620876 T DE 69620876T DE 69620876 T2 DE69620876 T2 DE 69620876T2
Authority
DE
Germany
Prior art keywords
steroid
solid phase
kit
conjugate
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69620876T
Other languages
English (en)
Other versions
DE69620876D1 (de
Inventor
T Williams
R Groskopf
N Baker
A Agdeppa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of DE69620876D1 publication Critical patent/DE69620876D1/de
Application granted granted Critical
Publication of DE69620876T2 publication Critical patent/DE69620876T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/806—Fertility tests
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/906—Fertility tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69620876T 1995-03-03 1996-02-26 Bestimmung von steroiden durch kompetitiven immunoassay Expired - Fee Related DE69620876T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/398,226 US5663054A (en) 1995-03-03 1995-03-03 Determination of steroids by competitive immunoassay
PCT/US1996/002495 WO1996027800A1 (en) 1995-03-03 1996-02-26 Determination of steroids by competitive immunoassay

Publications (2)

Publication Number Publication Date
DE69620876D1 DE69620876D1 (de) 2002-05-29
DE69620876T2 true DE69620876T2 (de) 2002-12-12

Family

ID=23574524

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69620876T Expired - Fee Related DE69620876T2 (de) 1995-03-03 1996-02-26 Bestimmung von steroiden durch kompetitiven immunoassay

Country Status (8)

Country Link
US (3) US5663054A (de)
EP (1) EP0813684B1 (de)
JP (1) JP3640970B2 (de)
AT (1) ATE216780T1 (de)
CA (1) CA2214085A1 (de)
DE (1) DE69620876T2 (de)
ES (1) ES2176445T3 (de)
WO (1) WO1996027800A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854009A (en) * 1995-09-19 1998-12-29 Immuna Care Corporation Method of detecting estrogen-sensitive pathologies
US5977319A (en) * 1996-10-21 1999-11-02 Cambridge Antibody Technology Limited Specific binding members for estradiol; materials and methods
US6300082B1 (en) * 1998-03-20 2001-10-09 Ia, Inc. Method and apparatus for measurement of the effect of test compounds on signal transduction at the level of biological receptors
CA2283597C (en) 1998-10-02 2008-02-05 Ortho-Clinical Diagnostics, Inc. Reduced cortisol conjugates
US6174665B1 (en) 1999-09-10 2001-01-16 Biex, Inc. Hormone replacement therapy monitoring
JP2005503530A (ja) * 1999-09-10 2005-02-03 バイエックス，インコーポレイティド ホルモン補充療法のモニタリング
US7410807B2 (en) * 2000-07-24 2008-08-12 D Aurora Vito J Pregnancy and sex identification test based on saliva or other bodily fluids
US20030124618A1 (en) * 2001-12-04 2003-07-03 Lattec I/S Device for analysing analyte compounds and use hereof
JP3637392B2 (ja) * 2002-04-08 2005-04-13 独立行政法人産業技術総合研究所 燃料電池
EP1539183A4 (de) 2002-08-28 2007-04-25 Hollis Eden Pharmaceuticals Therapeutische behandlungsmethoden
US20060068501A1 (en) * 2004-09-30 2006-03-30 Nj International Llc Apparatus and methods for steroid hormone testing
EP1982183B9 (de) * 2006-01-19 2012-12-12 Lattec I/S Trockenteststreifenvorrichtung und verfahren zur bestimmung eines analyten in einer probe
PL1982182T3 (pl) * 2006-01-19 2012-09-28 Lattec I/S Nowa konstrukcja przyrządu w postaci suchego paska oraz sposób oznaczania analitu w próbce przy użyciu przyrządu w postaci suchego paska
WO2008106149A1 (en) * 2007-02-28 2008-09-04 Children's Medical Center Corporation Methods for predicting the onset of menarche
JP5701666B2 (ja) * 2011-04-14 2015-04-15 株式会社Ｌｓｉメディエンス 高親和性抗ハプテンポリクローナル抗体の作製法
WO2013025532A2 (en) * 2011-08-12 2013-02-21 Siemens Healthcare Diagnostics Inc. Detection of sex steroids
JP6221466B2 (ja) * 2013-07-29 2017-11-01 東ソー株式会社 ハプテンの測定方法
GB201317458D0 (en) * 2013-10-02 2013-11-13 Spd Swiss Prec Diagnostics Gmbh Improved pregnancy test device and method
EP3172570A4 (de) 2014-07-25 2017-12-27 Becton, Dickinson and Company Analytteststreifenassays und teststreifen und kits zur verwendung beim üben davon
WO2016156981A1 (en) 2015-04-02 2016-10-06 Swiss Precision Diagnostics Gmbh Improved pregnancy test device & method
MA49256A (fr) 2017-06-05 2021-05-26 ObsEva SA Schémas posologiques comprenant un antagoniste de l'hormone de libération des gonadotrophines pour le traitement de l'endométriose

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282325A (en) * 1971-05-14 1981-08-04 Syva Company Enzyme bound corticosteroids
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
JPS60260592A (ja) * 1984-06-08 1985-12-23 Teikoku Hormone Mfg Co Ltd ステロイド測定用抗原
EP0200960A1 (de) * 1985-05-08 1986-11-12 Abbott Laboratories Fluoreszenzpolarisationsimmunoassay auf Gesamtöstriol
US4962192A (en) * 1986-07-17 1990-10-09 Board Of Governors Of Wayne State University Chemiluminescent 1,2-dioxetane compounds
US4857652A (en) * 1986-07-17 1989-08-15 Board Of Governors Of Wayne State University Chemiluminescent 1,2-dioxetane compounds
WO1988000695A1 (en) * 1986-07-24 1988-01-28 Quest Systems, Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
US4990443A (en) * 1988-01-25 1991-02-05 Boehringer Mannheim Gmbh Hapten-protein conjugates and methods of use in immunoassays
FR2627588A1 (fr) * 1988-02-24 1989-08-25 Ire Medgenix Sa Procede de dosage immunologique d'une substance de structure haptenique
JPH02213766A (ja) * 1989-02-15 1990-08-24 Mochida Pharmaceut Co Ltd 免疫測定用試薬および免疫測定器具
GB8926407D0 (en) * 1989-11-22 1990-01-10 Gen Electric Plc Polymers
US5342760A (en) * 1992-06-10 1994-08-30 Abbott Laboratories Determination of estradiol by competitive immunoassay
US5395938A (en) * 1992-08-21 1995-03-07 Nichols Institute Diagnostics Biotinylated chemiluminescent labels and their conjugates, assays and assay kits
US5491071A (en) * 1993-08-03 1996-02-13 Abbott Laboratories Reagents and methods for the detection and quantification of testosterone in fluid samples

Also Published As

Publication number Publication date
ATE216780T1 (de) 2002-05-15
US5932431A (en) 1999-08-03
US6201141B1 (en) 2001-03-13
WO1996027800A1 (en) 1996-09-12
JPH11501397A (ja) 1999-02-02
DE69620876D1 (de) 2002-05-29
EP0813684A1 (de) 1997-12-29
CA2214085A1 (en) 1996-09-12
EP0813684B1 (de) 2002-04-24
US5663054A (en) 1997-09-02
ES2176445T3 (es) 2002-12-01
JP3640970B2 (ja) 2005-04-20

Similar Documents

Publication Publication Date Title
DE69620876D1 (de) Bestimmung von steroiden durch kompetitiven immunoassay
Dressendörfer et al. Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement
Leclercq et al. Abbott monoclonal enzyme immunoassay measurement of estrogen receptors in human breast cancer: a European multicenter study
CA2217818A1 (en) Chemiluminescent immunoassay for antibody detection
GB2029011A (en) The use of a synthetic bifunctional ligand for the immunometric determination of the concentration ratio of two solutes
ATE221997T1 (de) Immunoassays zum nachweis von antiphospholipid- antikörpern
Elder et al. An enzyme-linked immunosorbent assay (ELISA) for plasma testosterone
Al-Dujaili Development and validation of a simple and direct ELISA method for the determination of conjugated (glucuronide) and non-conjugated testosterone excretion in urine
KR960029789A (ko) 생체내 물질의 면역학적 분석용 키트 및 면역학적 분석 방법
Ito et al. Simultaneous determination of alpha-fetoprotein, human chorionic gonadotropin and estriol in serum of pregnant women by time-resolved fluoroimmunoassay
Oda et al. Determination of bufalin-like immunoreactivity in serum of humans and rats by time-resolved fluoroimmunoassay for using a monoclonal antibody
Kayoko et al. Enzyme immunoassay of serum testosterone
McConway et al. Development and evaluation of a simple, direct, solid-phase radioimmunoassay of serum cortisol from readily available reagents
Mares et al. Synthesis of a novel biotin-estradiol conjugate and its use for the development of a direct, broad range enzyme immunoassay for plasma estradiol
JP2669703B2 (ja) 測定法、用途及び構成部品
Yoshiharu et al. Fluorescence quenching immunoassay of serum cortisol
Ren et al. Development of a high‐throughput, indirect antibody immobilization format chemiluminescence enzyme immunoassay (CLEIA) for the determination of progesterone in human serum
KR880701380A (ko) 고상 분석 방법
El Jabri Enzyme immunoassay for plasma estradiol using a monoclonal antibody
DE69725118D1 (en) Reagentien für tests für mycophenolsäure
HUP0100948A2 (hu) Antitest kompeticiós teszt (AKT) P-glikoprotein és egyéb sejtfelszíni receptorok, pumpák és fehérjék konformáció-változásainak kvalitatív, illetve konformáció-függő kvantitatív kimutatására és annak alkalmazásai
Van Weemen et al. Enzyme-immunoassay of steroids: Possibilities and pitfalls
Harwood et al. Development of enzyme immunoassay for endogenous ouabain-like compound in human plasma
Osterman et al. Enzyme immunoassay of estrogen-like substances in plasma, with polyethylene glycol as precipitant.
Hisahiko et al. A non-chromatographic radioimmunoassay for serum dehydroepiandrosterone using a mixture of antisera

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee