DE69620136T2 - Antibakterielle präparate für die ohren ohne irritierende, sensibilisierende und ototoxische wirkungen - Google Patents

Antibakterielle präparate für die ohren ohne irritierende, sensibilisierende und ototoxische wirkungen

Info

Publication number
DE69620136T2
DE69620136T2 DE69620136T DE69620136T DE69620136T2 DE 69620136 T2 DE69620136 T2 DE 69620136T2 DE 69620136 T DE69620136 T DE 69620136T DE 69620136 T DE69620136 T DE 69620136T DE 69620136 T2 DE69620136 T2 DE 69620136T2
Authority
DE
Germany
Prior art keywords
amount effective
sensitizing
irritating
ears
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69620136T
Other languages
English (en)
Other versions
DE69620136D1 (de
Inventor
Shivaji Purwar
David Goldman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of DE69620136D1 publication Critical patent/DE69620136D1/de
Application granted granted Critical
Publication of DE69620136T2 publication Critical patent/DE69620136T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Endoscopes (AREA)
DE69620136T 1995-06-06 1996-06-05 Antibakterielle präparate für die ohren ohne irritierende, sensibilisierende und ototoxische wirkungen Expired - Lifetime DE69620136T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46504895A 1995-06-06 1995-06-06
PCT/US1996/008864 WO1996039146A1 (en) 1995-06-06 1996-06-05 Non-irritation, non-sensitizing, non-ototoxic otic antibacterial compositions

Publications (2)

Publication Number Publication Date
DE69620136D1 DE69620136D1 (de) 2002-05-02
DE69620136T2 true DE69620136T2 (de) 2002-08-01

Family

ID=23846298

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69620136T Expired - Lifetime DE69620136T2 (de) 1995-06-06 1996-06-05 Antibakterielle präparate für die ohren ohne irritierende, sensibilisierende und ototoxische wirkungen

Country Status (17)

Country Link
US (1) US5965549A (de)
EP (1) EP0782448B1 (de)
CN (1) CN1137685C (de)
AT (1) ATE214931T1 (de)
AU (1) AU708540B2 (de)
CA (1) CA2199294C (de)
DE (1) DE69620136T2 (de)
DK (1) DK0782448T3 (de)
ES (1) ES2173287T3 (de)
HK (1) HK1002552A1 (de)
IL (1) IL120317A (de)
MX (1) MX9701731A (de)
NZ (1) NZ309624A (de)
PT (1) PT782448E (de)
TW (1) TW464499B (de)
WO (1) WO1996039146A1 (de)
ZA (1) ZA964653B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716830B2 (en) 1998-09-30 2004-04-06 Alcon, Inc. Ophthalmic antibiotic compositions containing moxifloxacin
US6509327B1 (en) 1998-09-30 2003-01-21 Alcon Manufacturing, Ltd. Compositions and methods for treating otic, ophthalmic and nasal infections
AR020661A1 (es) * 1998-09-30 2002-05-22 Alcon Lab Inc Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
US6395746B1 (en) * 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
EP1117406A1 (de) * 1998-09-30 2001-07-25 Alcon Laboratories, Inc. Antibiotische zusammensetzungen zur behandlung der auge, der nase und den ohren
US6500360B2 (en) * 1999-06-18 2002-12-31 Bernard Bendiner Sorbic acid and/or its derivatives, such as potassium sorbate, as a preventative for rust, corrosion and scale on metal surfaces
US6156294A (en) 1999-11-28 2000-12-05 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
US7064132B2 (en) * 1999-11-28 2006-06-20 Scientific Development And Research, Inc. Composition and method for treatment of otitis external
ES2160090B1 (es) * 2000-03-16 2002-07-01 Vita Invest Sa Composiciones acuosas de ciprofloxacino, contenidas en envases monodosis y su utilizacion.
AU2001276928A1 (en) 2000-07-26 2002-02-05 Alcon Universal Ltd. Improved process for manufacturing compositions containing ciprofloxacin and hydrocortisone
EP1331945A2 (de) 2000-09-25 2003-08-06 Bayer Healthcare, LLC Ohren-mikrobische kombinationen zur behandlung von tieren mit zerbrochenen trommelfellen
BR0212898A (pt) 2001-09-21 2004-10-13 Alcon Inc Método de tratamento de infecções do ouvido médio
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
US20040101506A1 (en) * 2002-11-25 2004-05-27 Fust Charles A. Composition for the prevention and treatment of inflammation of the ear
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
JP2006520779A (ja) * 2003-03-20 2006-09-14 ファルマシア コーポレイション 抗炎症薬の分散性処方物
US20050004098A1 (en) * 2003-03-20 2005-01-06 Britten Nancy Jean Dispersible formulation of an anti-inflammatory agent
US20050009931A1 (en) * 2003-03-20 2005-01-13 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20040214753A1 (en) * 2003-03-20 2004-10-28 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
WO2005009472A2 (en) * 2003-07-31 2005-02-03 Pharmacia & Upjohn Company Llc Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
CN1829510A (zh) * 2003-07-31 2006-09-06 法马西亚和厄普乔恩公司 抗炎剂的可分散性制剂
US8940321B2 (en) 2003-12-12 2015-01-27 Otic Pharma Ltd. Compositions for treatment of ear disorders and methods of use thereof
US8030362B2 (en) * 2003-12-12 2011-10-04 Otic Pharma Ltd. Compositions for treatment of ear disorders and methods of use thereof
US20060019987A1 (en) * 2004-07-23 2006-01-26 Fust Charles A Methods and compositions for inhibiting, destroying, and/or inactivating viruses
PL1962805T3 (pl) 2005-12-08 2017-01-31 Insmed Incorporated Kompozycje środków przeciwzapalnych oparte na lipidach do leczenia infekcji płucnych
WO2008137717A1 (en) 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
UA111147C2 (uk) * 2009-11-11 2016-04-11 Байєр Б.В. Способи та композиції для лікування або профілактики зовнішнього отиту
ES2391721T3 (es) 2010-03-01 2012-11-29 Laboratorios Salvat, S.A. Disoluciones acuosas transparentes de acetónido de fluocinolona para el tratamiento de la infamación de oído
HU227743B1 (en) * 2011-07-22 2012-02-28 Debreceni Egyetem Eardrop composition and process for producing this
MX2014006803A (es) * 2011-12-09 2014-07-09 Lupin Ltd Composiciones farmaceuticas topicas de agentes antimicrobianos y agentes antiinflamatorios.
CA2891487A1 (en) 2012-11-29 2014-06-05 Insmed Incorporated Stabilized vancomycin formulations
PL3142643T3 (pl) 2014-05-15 2019-12-31 Insmed Incorporated Sposoby leczenia zakażeń płuc prątkami niegruźliczymi
US9393243B1 (en) 2015-07-14 2016-07-19 Nilesh Parikh Topical Ciprofloxacin compositions
WO2019191627A1 (en) 2018-03-30 2019-10-03 Insmed Incorporated Methods for continuous manufacture of liposomal drug products

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4025620A (en) * 1975-10-22 1977-05-24 Leo Pharmaceutical Products Ltd., A/S Treatment of canine otitis and composition therefor
US4670444B1 (en) * 1980-09-03 1999-02-09 Bayer Ag and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds
ATE34720T1 (de) * 1983-03-31 1988-06-15 Payne Packaging Ltd Streifen.
DE3537761A1 (de) * 1985-10-24 1987-04-30 Bayer Ag Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure
DE3704907A1 (de) * 1987-02-17 1988-08-25 Bayer Ag Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden
DE3902079A1 (de) * 1988-04-15 1989-10-26 Bayer Ag I.m. injektionsformen von gyrase-inhibitoren
US5061729A (en) * 1988-06-08 1991-10-29 Biogal Gyogyszergyar Pharmaceutical composition and process for preparing the same
US5271939A (en) * 1988-10-03 1993-12-21 Alcon Laboratories, Inc. Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation
US5260073A (en) * 1990-05-21 1993-11-09 Norwich Eaton Pharmaceuticals, Inc. Use of phenylpropanolamine as a mucus secretogogue in the upper airways
WO1994010976A1 (en) * 1992-11-16 1994-05-26 Ciba Vision Ag, Hettlingen Polyvinyl alcohol/borate ophthalmic drug delivery system
US5422116A (en) * 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
ES2088742B1 (es) * 1994-06-29 1997-03-16 Salvat Lab Sa Composicion antibiotica de aplicacion otica.

Also Published As

Publication number Publication date
US5965549A (en) 1999-10-12
DK0782448T3 (da) 2002-07-08
EP0782448B1 (de) 2002-03-27
NZ309624A (en) 1999-04-29
DE69620136D1 (de) 2002-05-02
IL120317A (en) 2000-08-13
EP0782448A4 (de) 1998-05-20
CA2199294A1 (en) 1996-12-12
TW464499B (en) 2001-11-21
CN1137685C (zh) 2004-02-11
CA2199294C (en) 2000-09-19
AU5984096A (en) 1996-12-24
CN1160999A (zh) 1997-10-01
AU708540B2 (en) 1999-08-05
WO1996039146A1 (en) 1996-12-12
ATE214931T1 (de) 2002-04-15
IL120317A0 (en) 1998-06-15
EP0782448A1 (de) 1997-07-09
ZA964653B (en) 1996-12-12
HK1002552A1 (en) 1998-09-04
PT782448E (pt) 2002-07-31
ES2173287T3 (es) 2002-10-16
MX9701731A (es) 1997-10-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BAYER HEALTHCARE AG, 51373 LEVERKUSEN, DE

8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT, 1335, DE