DE69619267T2 - Verfahren zur herstellung von 3-amino-1,2,4-benzotriazindioxide - Google Patents

Verfahren zur herstellung von 3-amino-1,2,4-benzotriazindioxide

Info

Publication number
DE69619267T2
DE69619267T2 DE69619267T DE69619267T DE69619267T2 DE 69619267 T2 DE69619267 T2 DE 69619267T2 DE 69619267 T DE69619267 T DE 69619267T DE 69619267 T DE69619267 T DE 69619267T DE 69619267 T2 DE69619267 T2 DE 69619267T2
Authority
DE
Germany
Prior art keywords
amino
benzofurazan
oxide
benzotriazindioxides
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69619267T
Other languages
English (en)
Other versions
DE69619267D1 (de
Inventor
E Philion
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Publication of DE69619267D1 publication Critical patent/DE69619267D1/de
Application granted granted Critical
Publication of DE69619267T2 publication Critical patent/DE69619267T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69619267T 1995-12-04 1996-11-21 Verfahren zur herstellung von 3-amino-1,2,4-benzotriazindioxide Expired - Fee Related DE69619267T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/566,979 US5672702A (en) 1995-12-04 1995-12-04 Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide
PCT/US1996/018761 WO1997020828A1 (en) 1995-12-04 1996-11-21 Process for preparing 3-amino-1,2,4-benzotriazine dioxide

Publications (2)

Publication Number Publication Date
DE69619267D1 DE69619267D1 (de) 2002-03-21
DE69619267T2 true DE69619267T2 (de) 2003-12-24

Family

ID=24265255

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69619267T Expired - Fee Related DE69619267T2 (de) 1995-12-04 1996-11-21 Verfahren zur herstellung von 3-amino-1,2,4-benzotriazindioxide

Country Status (19)

Country Link
US (1) US5672702A (de)
EP (1) EP0865435B1 (de)
JP (1) JP2000501705A (de)
KR (1) KR100502041B1 (de)
CN (1) CN1068595C (de)
AT (1) ATE213234T1 (de)
AU (1) AU721627B2 (de)
BR (1) BR9611864A (de)
CZ (1) CZ292732B6 (de)
DE (1) DE69619267T2 (de)
DK (1) DK0865435T3 (de)
ES (1) ES2172696T3 (de)
HK (1) HK1017358A1 (de)
MX (1) MX9804421A (de)
NO (1) NO311216B1 (de)
NZ (1) NZ323602A (de)
PT (1) PT865435E (de)
RU (1) RU2178413C2 (de)
WO (1) WO1997020828A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003042192A1 (en) * 2001-11-13 2003-05-22 Sanofi-Synthelabo Preparation of 3-amino-1,2,4-benzotriazine dioxide
WO2007041546A2 (en) * 2005-10-03 2007-04-12 Genetix Pharmaceuticals, Inc. Method for selectively depleting hypoxic cells
CN101683319B (zh) * 2008-09-24 2012-09-05 杭州民生药业有限公司 一种替拉扎明非肠道给药含水制剂及其制备方法
JP2015500295A (ja) * 2011-12-07 2015-01-05 エスアールアイ インターナショナルＳＲＩ Ｉｎｔｅｒｎａｔｉｏｎａｌ ヒト結核菌を標的とする医薬としてのベンゾトリアジンオキサイド類
US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3980779A (en) * 1972-02-01 1976-09-14 Bayer Aktiengesellschaft 3-Amino-1,2,4-benzotriazine-1,4-di-N-oxide compositions and method of using same
BE794742A (fr) * 1972-02-01 1973-07-30 Bayer Ag Nouveaux di-n-oxydes (1,4) de benzo-1,2,4-triazine, leur procede de preparation et leur application comme medicaments et additifs de nutrition
US3957779A (en) * 1972-11-15 1976-05-18 Bayer Aktiengesellschaft Benzo-1,2,4-triazines
DE2255947A1 (de) * 1972-11-15 1974-05-22 Bayer Ag Substituierte 3-amino-benzo-1,2,4triazin-di-n-oxide (1,4), verfahren zu ihrer herstellung sowie ihre verwendung als antimikrobielle mittel
DE2255946A1 (de) * 1972-11-15 1974-05-22 Bayer Ag Verfahren zur herstellung von neuen eckige klammer auf 3-benzo-1,2,4-triazinyldioxid (1,4) eckige klammer zu -harnstoffen, sowie ihre verwendung als arzneimittel und futterzusatzmittel
US3991189A (en) * 1972-11-15 1976-11-09 Bayer Aktiengesellschaft Microbiocidal methods and compositions using substituted 1,2,4-triazine-1,4-di-N-oxide derivatives
DE3790581T1 (de) * 1986-09-25 1988-08-25
US5175287A (en) * 1986-09-25 1992-12-29 S R I International Process for preparing 1,2,4-benzotriazine oxides
JP3034541B2 (ja) * 1989-09-18 2000-04-17 エスアールアイ インターナショナル 放射線増感剤および選択的細胞毒性物質としての１，２，４―ベンゾトリアジンオキシド
US5484612A (en) * 1993-09-22 1996-01-16 The Board Of Trustees Of The Leland Stanford Junior University Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin

Also Published As

Publication number Publication date
CN1207736A (zh) 1999-02-10
CZ172398A3 (cs) 1998-09-16
KR19990071913A (ko) 1999-09-27
RU2178413C2 (ru) 2002-01-20
NZ323602A (en) 1999-10-28
NO982315L (no) 1998-05-20
US5672702A (en) 1997-09-30
JP2000501705A (ja) 2000-02-15
EP0865435A4 (de) 1998-12-23
WO1997020828A1 (en) 1997-06-12
PT865435E (pt) 2002-07-31
AU1058897A (en) 1997-06-27
ATE213234T1 (de) 2002-02-15
DE69619267D1 (de) 2002-03-21
NO982315D0 (no) 1998-05-20
BR9611864A (pt) 1999-05-18
EP0865435B1 (de) 2002-02-13
AU721627B2 (en) 2000-07-13
DK0865435T3 (da) 2002-05-27
HK1017358A1 (en) 1999-11-19
NO311216B1 (no) 2001-10-29
KR100502041B1 (ko) 2005-09-26
CN1068595C (zh) 2001-07-18
ES2172696T3 (es) 2002-10-01
CZ292732B6 (cs) 2003-12-17
MX9804421A (es) 1998-09-30
EP0865435A1 (de) 1998-09-23

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR

8327 Change in the person/name/address of the patent owner

Owner name: SRI INTERNATIONAL, MENLO PARK, CALIF., US

8339 Ceased/non-payment of the annual fee