DE69609108T2 - Verbesserte Immunoessayreagenzien zum Nachweis von Kannabinoiden - Google Patents

Verbesserte Immunoessayreagenzien zum Nachweis von Kannabinoiden

Info

Publication number
DE69609108T2
DE69609108T2 DE69609108T DE69609108T DE69609108T2 DE 69609108 T2 DE69609108 T2 DE 69609108T2 DE 69609108 T DE69609108 T DE 69609108T DE 69609108 T DE69609108 T DE 69609108T DE 69609108 T2 DE69609108 T2 DE 69609108T2
Authority
DE
Germany
Prior art keywords
linear
lower alkyl
detection
branched lower
cannabinoids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69609108T
Other languages
English (en)
Other versions
DE69609108D1 (de
Inventor
Raymond Albert Hui
Steven Mark Rosen
Salvatore Joseph Salmone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69609108D1 publication Critical patent/DE69609108D1/de
Publication of DE69609108T2 publication Critical patent/DE69609108T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948—Sedatives, e.g. cannabinoids, barbiturates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69609108T 1995-04-05 1996-03-26 Verbesserte Immunoessayreagenzien zum Nachweis von Kannabinoiden Expired - Lifetime DE69609108T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/417,331 US5817766A (en) 1995-04-05 1995-04-05 Reagents for a cannabinoid immunoassay

Publications (2)

Publication Number Publication Date
DE69609108D1 DE69609108D1 (de) 2000-08-10
DE69609108T2 true DE69609108T2 (de) 2001-03-22

Family

ID=23653524

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69609108T Expired - Lifetime DE69609108T2 (de) 1995-04-05 1996-03-26 Verbesserte Immunoessayreagenzien zum Nachweis von Kannabinoiden

Country Status (7)

Country Link
US (1) US5817766A (de)
EP (1) EP0736529B1 (de)
JP (2) JP4229990B2 (de)
AT (1) ATE194339T1 (de)
CA (1) CA2172663C (de)
DE (1) DE69609108T2 (de)
ES (1) ES2148617T3 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2770828B2 (ja) * 1997-03-21 1998-07-02 松下電器産業株式会社 文書出力装置
EP1110602B1 (de) * 1999-04-28 2009-04-15 Toray Industries, Inc. Stoffe zur enternung von cannabinoiden und säulen mit diesen stoffen zur entfernung von cannabinoiden
US6686209B2 (en) 2001-03-12 2004-02-03 Lifepoint, Inc. Reagents for detecting cannabinoids
JP4459629B2 (ja) * 2002-04-12 2010-04-28 メルク エンド カムパニー インコーポレーテッド 二環式アミド
US8288544B2 (en) 2003-07-01 2012-10-16 Roche Diagnostics Operations, Inc. Electrochemical affinity biosensor system and methods
US20060051824A1 (en) * 2004-09-03 2006-03-09 Haoyun An Tetrahydrocannabinoid antigens and method of use
US7465586B2 (en) * 2004-11-03 2008-12-16 Labone, Inc. Oral detection test for cannabinoid use
WO2007008037A1 (en) * 2005-07-12 2007-01-18 Jeil Pharmaceutical Co., Ltd. Novel chromen-2-one based hydroxamic acid derivatives having anti-inflammatory activity, the preparation thereof and a composition containing the same for treating inflammatory disease
KR100794515B1 (ko) 2005-07-12 2008-01-16 제일약품주식회사 항염증 활성을 갖는 크로멘-2-온 모핵 히드록사민 산유도체, 이의 제조방법 및 이를 포함하는 염증 질환의치료를 위한 조성물
GB201102544D0 (en) * 2011-02-14 2011-03-30 Randox Lab Ltd Assay
US9434687B2 (en) 2011-02-14 2016-09-06 Randox Laboratories Limited Detection of synthetic cannabinoids
US9441033B2 (en) * 2011-02-14 2016-09-13 Randox Laboratories Limited Detection of synthetic cannabinoids
US9435817B2 (en) 2011-02-14 2016-09-06 Randox Laboratories Limited Detection of synthetic cannabinoids
US10408786B2 (en) 2012-06-14 2019-09-10 ChemiSensor, LLP Distributable chemical sampling and sensing system
EP2698385A1 (de) * 2012-08-14 2014-02-19 Randox Laboratories Ltd. Nachweis von synthetischen Cannabionoiden
EP2698383B1 (de) * 2012-08-14 2020-11-25 Randox Laboratories Ltd. Nachweis von synthetischen Cannabionoiden
EP2698384A1 (de) * 2012-08-14 2014-02-19 Randox Laboratories Ltd. Nachweis von synthetischen Cannabionoiden
US9817007B2 (en) * 2014-03-05 2017-11-14 John Scott Perez Method and apparatus for real-time detection of human cannabinoid intoxication
US10308712B2 (en) 2014-03-27 2019-06-04 Bird Rock Bio, Inc. Antibodies that bind human cannabinoid 1 (CB1) receptor
EP3356833A4 (de) 2015-09-30 2019-04-10 Bird Rock Bio, Inc. Antikörper zur bindung des humanen cannabinoidrezeptors 1 (cb1)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2354492A (en) * 1941-11-26 1944-07-25 Adams Roger Marihuana active compound
US4329281A (en) * 1978-06-05 1982-05-11 Hoffmann-La Roche Inc. Hapten compositions
US4438207A (en) * 1979-09-26 1984-03-20 Hoffmann-La Roche Inc. Radioimmunoassay for cannabinoids
US5223441A (en) * 1986-10-09 1993-06-29 Syntex (U.S.A.) Inc. Receptors for immune complexes
US4833073A (en) * 1987-01-27 1989-05-23 Hoffmann-La Roche Inc. Immunoassay for tetrahydrocannabinol metabolites
US5264373A (en) * 1987-02-17 1993-11-23 Abbott Laboratories Fluorescence polarization immunoassay for tetrahydrocannabinoids
DE3855490T2 (de) * 1987-02-17 1997-03-27 Abbott Lab Fluoreszenz-Polarisationsimmunotest für Tetrahydrocannabinoide
US5144030A (en) * 1987-02-17 1992-09-01 Abbott Laboratories Fluorescene polarization immunoassay for tetrahydrocannabinoids
JPS63257177A (ja) * 1987-04-13 1988-10-25 Hitachi Ltd 超高圧水銀灯
JPS63257178A (ja) * 1987-04-13 1988-10-25 Nec Home Electronics Ltd コンパクト型蛍光ランプ
JPH01273582A (ja) * 1988-04-26 1989-11-01 Matsushita Electric Ind Co Ltd モノクローナル抗体産生細胞ライン及びモノクローナル抗体及び免疫原
JP2600850B2 (ja) * 1988-10-04 1997-04-16 松下電器産業株式会社 テトラヒドロカンナビノール誘導体
US5237057A (en) * 1992-04-06 1993-08-17 Biosite Diagnostics, Inc. Tetrahydrocannabinol derivatives and protein and polypeptide tetrahydrocannabinol derivative conjugates and labels
US5315015A (en) * 1992-11-10 1994-05-24 Hoffmann-La Roche Inc. Compounds having improved fluorescence in fluorescence polarization immunoassays and immunoassays utilizing same

Also Published As

Publication number Publication date
EP0736529B1 (de) 2000-07-05
JPH08283258A (ja) 1996-10-29
EP0736529A1 (de) 1996-10-09
US5817766A (en) 1998-10-06
ATE194339T1 (de) 2000-07-15
JP2009051839A (ja) 2009-03-12
DE69609108D1 (de) 2000-08-10
JP4229990B2 (ja) 2009-02-25
CA2172663A1 (en) 1996-10-06
CA2172663C (en) 2008-12-02
ES2148617T3 (es) 2000-10-16

Similar Documents

Publication Publication Date Title
DE69609108T2 (de) Verbesserte Immunoessayreagenzien zum Nachweis von Kannabinoiden
NO171274C (no) Tetrahydrocannabinolderivater samt anvendelse derav ved immunoassay for paavisning av cannabinol-metabolitter
DE69121844T2 (de) Immunotest für Cyclosporin
ATE127923T1 (de) Elektrochemilumineszenz-testverfahren.
DE19981132D2 (de) Funktionelle Vitamin-D-Derivate und Verfahren zur Bestimmung von 25-Hydroxy- und 1alpha,25-Dihydroxy-Vitamin-D
FI891012A (fi) Menetelmä ja väline immuunikokeissa esiintyvien häiriötekijöiden kompensoimiseksi
KR870700637A (ko) 사이클로스포린에 대한 단일클론성 항체
EP0375422A3 (de) Zusammensetzung und Methoden zur Bestimmung der Anwesenheit von Amphetaminen in einer Probe, die in Verdacht steht, Amphetamine und/oder Metamphetamine zu enthalten
DE69610716D1 (de) Topiramate-immunoassay, sowie analoge und antikörper
ATE199373T1 (de) Aminoalkylmaleimide und davon abgeleitete hapten- und antigenderivate sowie konjugate mit peptiden oder proteinen
ES2153361T3 (es) Reactivos y procedimientos de cuantificacion de la totalidad de las doxepinas en fluidos biologicos.
ATE257155T1 (de) Reagenzien für einen lysergsäurediethylamid- immuntest
KR930703290A (ko) 코티닌 면역검정용 합텐, 트레이서, 면역원 및 항체
CA2083313A1 (en) Colorimetric methods and reagents for the assay of calcium in a test sample
KR910020436A (ko) 바비튜레이트 검정법, 트레이서, 면역원, 항체 및 키트
ES2151491T3 (es) Reactivos y procedimientos de cuantificacion de la imipramina o de la desipramina en fluidos biologicos.
DE59310190D1 (de) Immunchemisches Verfahren zum Nachweis eines Analyten
ATE110470T1 (de) Immuntestverfahren von chondrocalcin.
WO1997024621A3 (en) Reagents for measuring lead levels via the quantification of porphobilinogen
KR830002745A (ko) 피페라진 유도체의 제법
KR890002348A (ko) 반응성 디스아조염료 화합물