DE69603101T2 - Verfahren zur Synthese der alpha-substiuierten Akrylsäuren und N-(mercaptoacyl)aminsäuren - Google Patents

Verfahren zur Synthese der alpha-substiuierten Akrylsäuren und N-(mercaptoacyl)aminsäuren

Info

Publication number
DE69603101T2
DE69603101T2 DE69603101T DE69603101T DE69603101T2 DE 69603101 T2 DE69603101 T2 DE 69603101T2 DE 69603101 T DE69603101 T DE 69603101T DE 69603101 T DE69603101 T DE 69603101T DE 69603101 T2 DE69603101 T2 DE 69603101T2
Authority
DE
Germany
Prior art keywords
substd
formula
alpha
malonate
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69603101T
Other languages
English (en)
Other versions
DE69603101D1 (de
Inventor
Pierre Duhamel
Lucette Duhamel
Denis Danvy
Thierry Monteil
Jeanne-Marie Lecomte
Jean-Charles Schwartz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioprojet SC
Original Assignee
Bioprojet SC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprojet SC filed Critical Bioprojet SC
Application granted granted Critical
Publication of DE69603101D1 publication Critical patent/DE69603101D1/de
Publication of DE69603101T2 publication Critical patent/DE69603101T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/18—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by addition of thiols to unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/56—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
DE69603101T 1995-03-03 1996-03-01 Verfahren zur Synthese der alpha-substiuierten Akrylsäuren und N-(mercaptoacyl)aminsäuren Expired - Lifetime DE69603101T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9502494A FR2731219B1 (fr) 1995-03-03 1995-03-03 Procede de synthese d'acides acryliques alpha-substitues et leur application

Publications (2)

Publication Number Publication Date
DE69603101D1 DE69603101D1 (de) 1999-08-12
DE69603101T2 true DE69603101T2 (de) 1999-12-09

Family

ID=9476709

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69603101T Expired - Lifetime DE69603101T2 (de) 1995-03-03 1996-03-01 Verfahren zur Synthese der alpha-substiuierten Akrylsäuren und N-(mercaptoacyl)aminsäuren

Country Status (10)

Country Link
US (2) US5786494A (de)
EP (1) EP0729936B1 (de)
JP (1) JP3845806B2 (de)
AT (1) ATE181910T1 (de)
CA (1) CA2170822C (de)
DE (1) DE69603101T2 (de)
DK (1) DK0729936T3 (de)
ES (1) ES2136946T3 (de)
FR (1) FR2731219B1 (de)
GR (1) GR3030854T3 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2816309B1 (fr) * 2000-11-09 2002-12-27 Bioprojet Soc Civ Procede de synthese de derives n-(mercaptoacyl)-amino-acides a partir d'acides acryliques alpha-substitues
US7227034B2 (en) * 2004-11-22 2007-06-05 Xerox Corporation Process for arylamine production
CN100439356C (zh) * 2005-09-16 2008-12-03 上海医药工业研究院 2-羟甲基-3-取代苯基丙酸化合物、其制备方法和用途
CN100448865C (zh) * 2005-09-16 2009-01-07 上海医药工业研究院 用于法西多曲合成的中间体及其合成用途
US8192449B2 (en) * 2005-10-25 2012-06-05 Brainlab Ag Non-penetrating fixing device
DE602005012836D1 (de) 2005-10-25 2009-04-02 Brainlab Ag Nichteindringende Befestigungsvorrichtung
CN101768095A (zh) * 2008-12-26 2010-07-07 山东齐都药业有限公司 一种消旋卡多曲的制备方法
CN102317256B (zh) * 2010-03-22 2013-12-11 北京世纪迈劲生物科技有限公司 制备消旋卡多曲的方法
CN102391146B (zh) * 2011-08-01 2014-01-08 山东铂源药业有限公司 一种消旋卡多曲中间体2-（苄基丙烯酰胺）乙酸苄酯的制备方法
CN103755611A (zh) * 2014-01-16 2014-04-30 陕西汉江药业集团股份有限公司 一种消旋卡多曲的制备方法
CN104744252B (zh) * 2015-02-02 2016-09-14 天津理工大学 一种仿生含水多相催化体系催化芳香醛与丙二酸二酯间缩合反应的方法
CN107129450B (zh) * 2017-06-05 2019-05-03 山东裕欣药业有限公司 一种消旋卡多曲晶体化合物及其制备方法
CN107602406B (zh) * 2017-08-29 2019-08-20 陕西汉江药业集团股份有限公司 消旋卡多曲中作为外标物的两种杂质的制备方法及含量控制方法
CN110283109B (zh) * 2019-07-10 2021-01-08 陕西汉江药业集团股份有限公司 一种工业化制备消旋卡多曲的方法
CN115583903A (zh) * 2022-09-13 2023-01-10 湖北广辰药业有限公司 一种快速制备消旋卡多曲的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE94132C (de) *
CH480288A (de) * 1967-03-07 1969-10-31 Lonza Ag Verfahren zur Herstellung von Butylidenmalonsäureester
DE2853732A1 (de) * 1978-12-13 1980-07-03 Technochemie Gmbh Verfahren zur herstellung von di-n- propylessigsaeure
FR2652087B1 (fr) * 1989-09-15 1993-10-15 Bioprojet Ste Civile Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques.
FR2682952B1 (fr) * 1991-10-25 1993-12-03 Institut Nal Sante Recherc Medic Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
GR3030854T3 (en) 1999-11-30
CA2170822C (en) 2010-05-18
CA2170822A1 (en) 1996-09-04
FR2731219A1 (fr) 1996-09-06
US5786494A (en) 1998-07-28
ATE181910T1 (de) 1999-07-15
JP3845806B2 (ja) 2006-11-15
US5945548A (en) 1999-08-31
JPH08325194A (ja) 1996-12-10
EP0729936A1 (de) 1996-09-04
DE69603101D1 (de) 1999-08-12
EP0729936B1 (de) 1999-07-07
FR2731219B1 (fr) 1997-04-25
DK0729936T3 (da) 1999-11-22
ES2136946T3 (es) 1999-12-01

Similar Documents

Publication Publication Date Title
DE69603101D1 (de) Verfahren zur Synthese der alpha-substiuierten Akrylsäuren und N-(mercaptoacyl)aminsäuren
Yadav et al. Montmorillonite KSF clay catalyzed one-pot synthesis of α-aminonitriles
ATE425165T1 (de) Verfahren zur zubereitung von inhibitoren des nukleosid-metabolismus
DE69328962D1 (de) Verfahren zur herstellng von cyano-methoxyiminomethylderivaten
DE60328964D1 (de) Neue optisch aktive verbindungen, verfahren zur kinetischen optischen trennung von carbonsäurederivaten und katalysatoren dafür
DE60202203D1 (de) Neues verfahren zur herstellung von oxabispidinen
ATE359272T1 (de) Verfahren zur herstellung von 3-hydroxy-n-1,6-
DE58900982D1 (de) Verfahren zur herstellung von alpha, beta -ungesaettigten ketonen.
DE59302956D1 (de) Verfahren zur Herstellung von E-Oximethern von Phenylglyoxylsäureestern
ATE384067T1 (de) Verfahren zur herstellung von 3-cephemderivaten
ATE251135T1 (de) Verfahren zur herstellung von 1-substituierten pyrrol-3-carbonsäure-derivaten
ATE259785T1 (de) Verfahren zur herstellung von 2-alkylthio- substituierten benzoesäurederivaten
ATE248808T1 (de) Verfahren zur herstellung von aminocyanacetamid
DE59700707D1 (de) Verfahren zur Racemisierung optisch aktiver Amine
DE69004977D1 (de) Verfahren zur Herstellung von 8-Hydroxyoktansäure.
ATE231844T1 (de) Verfahren zur herstellung von pyrazin-2-aminen
DE69913517D1 (de) Verfahren zur herstellung einer kristallsuspensionhenonen
ATE342251T1 (de) Verfahren zur herstellung der 2-(dimethylamino)-1-(dimethylaminomethyl)ethyle (methyl)acrylat
DE60028998D1 (de) Verfahren zur herstellung einer benzylamin-verbindung
MY105302A (en) Process for dehydrating corticosteroid intermediates.
ATE248796T1 (de) Verfahren zur herstellung von alpha- halogenketonen
ATE177737T1 (de) Verfahren zur herstellung von 5-arylhydantoin
DE60008699D1 (de) Verfahren zur herstellung von optisch aktiven pyrroloazepinderivaten
DE50009160D1 (de) Verfahren zur herstellung von optisch aktiven 3,3,3- trifluormethyl- 2- alkylpropionsäurederivaten
DE3775721D1 (de) Verfahren zur herstellung von veretherten 3-hydroxyvaleriansaeureestern.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition