DE69532032D1 - Pharmazeutische formulierung, die ein beta-lactamase hemmendes penem in kombination mit einem beta-laktam-antibiotikum enthalten und ihre verwendung zur behandlung von bakteriellen infektionen - Google Patents

Pharmazeutische formulierung, die ein beta-lactamase hemmendes penem in kombination mit einem beta-laktam-antibiotikum enthalten und ihre verwendung zur behandlung von bakteriellen infektionen

Info

Publication number
DE69532032D1
DE69532032D1 DE69532032T DE69532032T DE69532032D1 DE 69532032 D1 DE69532032 D1 DE 69532032D1 DE 69532032 T DE69532032 T DE 69532032T DE 69532032 T DE69532032 T DE 69532032T DE 69532032 D1 DE69532032 D1 DE 69532032D1
Authority
DE
Germany
Prior art keywords
beta
penem
combination
lactam antibiotic
pharmaceutical formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69532032T
Other languages
English (en)
Other versions
DE69532032T2 (de
Inventor
K Coleman
J E Neale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9408164A external-priority patent/GB9408164D0/en
Priority claimed from GB9408161A external-priority patent/GB9408161D0/en
Priority claimed from GB9408162A external-priority patent/GB9408162D0/en
Priority claimed from GB9408163A external-priority patent/GB9408163D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE69532032D1 publication Critical patent/DE69532032D1/de
Application granted granted Critical
Publication of DE69532032T2 publication Critical patent/DE69532032T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69532032T 1994-04-25 1995-04-22 Pharmazeutische formulierung, die ein beta-lactamase hemmendes penem in kombination mit einem beta-laktam-antibiotikum enthalten und ihre verwendung zur behandlung von bakteriellen infektionen Expired - Fee Related DE69532032T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB9408163 1994-04-25
GB9408164A GB9408164D0 (en) 1994-04-25 1994-04-25 Pharmaceutical formulations
GB9408161 1994-04-25
GB9408161A GB9408161D0 (en) 1994-04-25 1994-04-25 Pharmaceutical formulations
GB9408162A GB9408162D0 (en) 1994-04-25 1994-04-25 Pharmaceutical formulations
GB9408163A GB9408163D0 (en) 1994-04-25 1994-04-25 Pharmaceutical formulations
GB9408162 1994-04-25
GB9408164 1994-04-25
PCT/EP1995/001546 WO1995028935A1 (en) 1994-04-25 1995-04-22 Pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections

Publications (2)

Publication Number Publication Date
DE69532032D1 true DE69532032D1 (de) 2003-12-04
DE69532032T2 DE69532032T2 (de) 2004-07-22

Family

ID=27451150

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69532032T Expired - Fee Related DE69532032T2 (de) 1994-04-25 1995-04-22 Pharmazeutische formulierung, die ein beta-lactamase hemmendes penem in kombination mit einem beta-laktam-antibiotikum enthalten und ihre verwendung zur behandlung von bakteriellen infektionen

Country Status (17)

Country Link
US (3) US5911985A (de)
EP (1) EP0758240B1 (de)
JP (2) JP3865770B2 (de)
KR (1) KR100363604B1 (de)
CN (1) CN1094353C (de)
AT (1) ATE252906T1 (de)
AU (1) AU690685B2 (de)
BR (1) BR9507521A (de)
CZ (1) CZ286898B6 (de)
DE (1) DE69532032T2 (de)
ES (1) ES2206502T3 (de)
HU (1) HUT76340A (de)
MX (1) MX9605149A (de)
NO (1) NO964500L (de)
NZ (1) NZ285085A (de)
PL (1) PL179415B1 (de)
WO (1) WO1995028935A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6472383B1 (en) 1994-04-25 2002-10-29 Smithkline Beecham P.L.C. Pharmaceutical formulations
EP1199077A1 (de) * 2000-10-19 2002-04-24 Amura Limited Stabilisierte Oxapenem-3-carbonsäure enthaltende Arzneimittel durch Gefriergetrocknen mit pharmazeutischen Trägern
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
TW200716104A (en) * 2005-06-01 2007-05-01 Wyeth Corp Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
TW200716102A (en) * 2005-06-01 2007-05-01 Wyeth Corp Bicyclic 6-alkylidene-penems as class-D β -lactamases inhibitors
US20070027130A1 (en) * 2005-07-27 2007-02-01 Wyeth Tricyclic 6-alkylidene-penem beta-lactamase inhibitors and beta-lactam antibiotic combination: a broad spectrum antibiotic
TW200727897A (en) * 2005-07-27 2007-08-01 Wyeth Corp Bicyclic 6-alkylidene-penem β-lactamase inhibitors and β-lactam antibiotic combination: a broad spectrum antibiotic
GT200600380A (es) * 2005-08-24 2007-03-29 Proceso para la preparacion de inhibidores de beta-lactamasa

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
EP0018203B1 (de) * 1979-04-21 1983-03-02 Beecham Group Plc Clavulansäure-Derivate, ihre Herstellung und Verwendung in Arzneimitteln
DE3176517D1 (en) * 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
EP0120613A1 (de) * 1983-03-02 1984-10-03 Beecham Group Plc Penem-Derivate und Vorstufenverbindungen
GB8518416D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB8518422D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
GB8518421D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
BR8603523A (pt) * 1985-07-27 1987-03-04 Sumitomo Metal Ind Processo e aparelho para gaseificar um material carbonaceo solido em um banho de metal em fusao
GB9222700D0 (en) * 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds

Also Published As

Publication number Publication date
AU2407395A (en) 1995-11-16
BR9507521A (pt) 1997-09-16
KR970702723A (ko) 1997-06-10
KR100363604B1 (ko) 2003-04-11
PL179415B1 (pl) 2000-09-29
NO964500L (no) 1996-11-26
WO1995028935A1 (en) 1995-11-02
JP2005298525A (ja) 2005-10-27
PL317045A1 (en) 1997-03-03
NO964500D0 (no) 1996-10-23
CN1149254A (zh) 1997-05-07
HU9602928D0 (en) 1996-12-30
CN1094353C (zh) 2002-11-20
CZ315696A3 (en) 1997-06-11
MX9605149A (es) 1997-12-31
US5939066A (en) 1999-08-17
ATE252906T1 (de) 2003-11-15
JPH09512260A (ja) 1997-12-09
AU690685B2 (en) 1998-04-30
ES2206502T3 (es) 2004-05-16
EP0758240A1 (de) 1997-02-19
HUT76340A (en) 1997-08-28
DE69532032T2 (de) 2004-07-22
US5911985A (en) 1999-06-15
CZ286898B6 (en) 2000-07-12
EP0758240B1 (de) 2003-10-29
JP3865770B2 (ja) 2007-01-10
NZ285085A (en) 1998-04-27
US5776455A (en) 1998-07-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee