DE69525254T2 - Substituierte oxim-derivate verwendbar als pde iv hemmer - Google Patents

Substituierte oxim-derivate verwendbar als pde iv hemmer

Info

Publication number
DE69525254T2
DE69525254T2 DE69525254T DE69525254T DE69525254T2 DE 69525254 T2 DE69525254 T2 DE 69525254T2 DE 69525254 T DE69525254 T DE 69525254T DE 69525254 T DE69525254 T DE 69525254T DE 69525254 T2 DE69525254 T2 DE 69525254T2
Authority
DE
Germany
Prior art keywords
pde
inhibitors
derivatives used
oxime derivatives
substituted oxime
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69525254T
Other languages
English (en)
Other versions
DE69525254D1 (de
Inventor
Clifford Head
John Warrelow
Peter Alexander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Celltech Ltd
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Application granted granted Critical
Publication of DE69525254D1 publication Critical patent/DE69525254D1/de
Publication of DE69525254T2 publication Critical patent/DE69525254T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69525254T 1994-06-23 1995-06-23 Substituierte oxim-derivate verwendbar als pde iv hemmer Expired - Fee Related DE69525254T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9412672A GB9412672D0 (en) 1994-06-23 1994-06-23 Chemical compounds
PCT/GB1995/001474 WO1996000215A1 (en) 1994-06-23 1995-06-23 Substituted oxime derivatives useful as pde iv inhibitors

Publications (2)

Publication Number Publication Date
DE69525254D1 DE69525254D1 (de) 2002-03-14
DE69525254T2 true DE69525254T2 (de) 2002-12-19

Family

ID=10757248

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69525254T Expired - Fee Related DE69525254T2 (de) 1994-06-23 1995-06-23 Substituierte oxim-derivate verwendbar als pde iv hemmer

Country Status (7)

Country Link
US (1) US5693659A (de)
EP (1) EP0766673B1 (de)
AU (1) AU2747395A (de)
DE (1) DE69525254T2 (de)
ES (1) ES2168110T3 (de)
GB (1) GB9412672D0 (de)
WO (1) WO1996000215A1 (de)

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Also Published As

Publication number Publication date
EP0766673A1 (de) 1997-04-09
EP0766673B1 (de) 2002-01-30
WO1996000215A1 (en) 1996-01-04
AU2747395A (en) 1996-01-19
US5693659A (en) 1997-12-02
GB9412672D0 (en) 1994-08-10
DE69525254D1 (de) 2002-03-14
ES2168110T3 (es) 2002-06-01

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Owner name: CELLTECH R&D LTD., SLOUGH, BERKSHIRE, GB

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