DE69505780D1 - 3-Phenylisochinolin-1(2H)-one-Derivate als Liganden der mit GABAA Rezeptoren verbundenen Benzodiazepine Rezeptoren - Google Patents
3-Phenylisochinolin-1(2H)-one-Derivate als Liganden der mit GABAA Rezeptoren verbundenen Benzodiazepine RezeptorenInfo
- Publication number
- DE69505780D1 DE69505780D1 DE69505780T DE69505780T DE69505780D1 DE 69505780 D1 DE69505780 D1 DE 69505780D1 DE 69505780 T DE69505780 T DE 69505780T DE 69505780 T DE69505780 T DE 69505780T DE 69505780 D1 DE69505780 D1 DE 69505780D1
- Authority
- DE
- Germany
- Prior art keywords
- receptors
- phenylisoquinolin
- ligands
- derivatives
- benzodiazepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9415837A FR2728900B1 (fr) | 1994-12-29 | 1994-12-29 | Derives de 3-phenylisoquinolein-1(2h)-one, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69505780D1 true DE69505780D1 (de) | 1998-12-10 |
Family
ID=9470390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69505780T Expired - Lifetime DE69505780D1 (de) | 1994-12-29 | 1995-12-18 | 3-Phenylisochinolin-1(2H)-one-Derivate als Liganden der mit GABAA Rezeptoren verbundenen Benzodiazepine Rezeptoren |
Country Status (22)
Country | Link |
---|---|
US (1) | US5665733A (de) |
EP (1) | EP0719764B1 (de) |
JP (1) | JPH08239365A (de) |
KR (1) | KR960022472A (de) |
CN (1) | CN1131150A (de) |
AR (1) | AR002016A1 (de) |
AT (1) | ATE172966T1 (de) |
AU (1) | AU698595B2 (de) |
BR (1) | BR9506106A (de) |
CA (1) | CA2166234A1 (de) |
CO (1) | CO4700298A1 (de) |
CZ (1) | CZ348995A3 (de) |
DE (1) | DE69505780D1 (de) |
FI (1) | FI956298A (de) |
FR (1) | FR2728900B1 (de) |
HU (1) | HU215394B (de) |
IL (1) | IL116590A0 (de) |
NO (1) | NO955326L (de) |
NZ (1) | NZ280765A (de) |
PL (1) | PL312079A1 (de) |
SK (1) | SK165795A3 (de) |
ZA (1) | ZA9511046B (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2750427B1 (fr) * | 1996-06-28 | 1998-08-07 | Synthelabo | Derives de 1-oxo-1, 2-dihydroisoquinoleine-4-propanamide, leur preparation et leur application en therapeutique |
FR2772758B1 (fr) * | 1997-12-22 | 2000-02-04 | Synthelabo | Derives de 1-oxo-1,2-dihydroisoquinoleine-4-propanamide, leur preparation et leur application en therapeutique |
DE60335911D1 (de) * | 2002-12-20 | 2011-03-10 | Daiichi Sankyo Co Ltd | Isochinolinonderivate und deren verwendung als medikamente |
GB0420722D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
MX2009001478A (es) * | 2006-08-10 | 2009-03-31 | Ferrer Int | Compuestos de 1h-quinolin-4-ona, procedimientos, usos y composiciones. |
EP1886996A1 (de) * | 2006-08-10 | 2008-02-13 | Ferrer Internacional, S.A. | 1H-Chinolin-4-on Verbindungen mit Affinität für den GABA Rezeptor, Prozesse, Verwendungen und Zusammensetzungen |
US8741917B2 (en) | 2009-01-15 | 2014-06-03 | Rutgers, The State University Of New Jersey | Benzo [C] phenanthridines as antimicrobial agents |
US20120059026A1 (en) * | 2009-04-30 | 2012-03-08 | University Of Medicine And Dentistry Of New Jersey | Antimicrobial agents |
FR2956816B1 (fr) * | 2010-03-01 | 2012-05-18 | Univ Joseph Fourier | Utilisation de quinolones pour la preparation de medicaments, nouvelles quinolones et leur procede de synthese |
WO2011156626A1 (en) | 2010-06-09 | 2011-12-15 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
US9102617B2 (en) | 2010-06-25 | 2015-08-11 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
US9822108B2 (en) | 2012-01-13 | 2017-11-21 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
US9475783B2 (en) | 2012-03-21 | 2016-10-25 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
US9458150B2 (en) | 2013-11-08 | 2016-10-04 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
JP2019507801A (ja) | 2016-02-25 | 2019-03-22 | タクシス ファーマシューティカルズ, インコーポレイテッド | 合成プロセス及び中間体 |
CA3058183A1 (en) | 2017-03-30 | 2018-10-04 | Taxis Pharmaceuticals, Inc. | Synthetic processes and synthetic intermediates |
TW202202495A (zh) * | 2020-03-26 | 2022-01-16 | 匈牙利商羅特格登公司 | 作為gamma-胺基丁酸A受體次單元alpha 5受體調節劑之㖠啶及吡啶并〔3,4-c〕嗒𠯤衍生物 |
US20240043418A1 (en) * | 2020-03-26 | 2024-02-08 | Richter Gedeon Nyrt. | 1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa a5 receptor modulators |
-
1994
- 1994-12-29 FR FR9415837A patent/FR2728900B1/fr not_active Expired - Fee Related
-
1995
- 1995-12-18 EP EP95402842A patent/EP0719764B1/de not_active Expired - Lifetime
- 1995-12-18 DE DE69505780T patent/DE69505780D1/de not_active Expired - Lifetime
- 1995-12-18 AT AT95402842T patent/ATE172966T1/de not_active IP Right Cessation
- 1995-12-21 NZ NZ280765A patent/NZ280765A/en unknown
- 1995-12-27 AR ARP950100767A patent/AR002016A1/es unknown
- 1995-12-27 JP JP7340607A patent/JPH08239365A/ja active Pending
- 1995-12-28 ZA ZA9511046A patent/ZA9511046B/xx unknown
- 1995-12-28 KR KR1019950061341A patent/KR960022472A/ko not_active Application Discontinuation
- 1995-12-28 CA CA002166234A patent/CA2166234A1/en not_active Abandoned
- 1995-12-28 CZ CZ953489A patent/CZ348995A3/cs unknown
- 1995-12-28 SK SK1657-95A patent/SK165795A3/sk unknown
- 1995-12-28 CN CN95120638A patent/CN1131150A/zh active Pending
- 1995-12-28 FI FI956298A patent/FI956298A/fi not_active Application Discontinuation
- 1995-12-28 US US08/579,677 patent/US5665733A/en not_active Expired - Fee Related
- 1995-12-28 IL IL11659095A patent/IL116590A0/xx unknown
- 1995-12-28 NO NO955326A patent/NO955326L/no unknown
- 1995-12-28 AU AU40712/95A patent/AU698595B2/en not_active Ceased
- 1995-12-28 PL PL95312079A patent/PL312079A1/xx unknown
- 1995-12-28 BR BR9506106A patent/BR9506106A/pt not_active Application Discontinuation
- 1995-12-28 HU HU9503848A patent/HU215394B/hu not_active IP Right Cessation
- 1995-12-28 CO CO95062144A patent/CO4700298A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CZ348995A3 (en) | 1996-07-17 |
SK165795A3 (en) | 1996-07-03 |
IL116590A0 (en) | 1996-03-31 |
HU215394B (hu) | 1998-12-28 |
BR9506106A (pt) | 1997-12-23 |
AU4071295A (en) | 1996-07-04 |
AR002016A1 (es) | 1998-01-07 |
EP0719764A1 (de) | 1996-07-03 |
HU9503848D0 (en) | 1996-02-28 |
ZA9511046B (en) | 1996-07-11 |
EP0719764B1 (de) | 1998-11-04 |
KR960022472A (ko) | 1996-07-18 |
JPH08239365A (ja) | 1996-09-17 |
NZ280765A (en) | 1996-08-27 |
FR2728900B1 (fr) | 1997-01-31 |
NO955326D0 (no) | 1995-12-28 |
US5665733A (en) | 1997-09-09 |
FI956298A0 (fi) | 1995-12-28 |
FR2728900A1 (fr) | 1996-07-05 |
FI956298A (fi) | 1996-06-30 |
AU698595B2 (en) | 1998-11-05 |
PL312079A1 (en) | 1996-07-08 |
NO955326L (no) | 1996-07-01 |
HUT74187A (en) | 1996-11-28 |
CN1131150A (zh) | 1996-09-18 |
ATE172966T1 (de) | 1998-11-15 |
CA2166234A1 (en) | 1996-06-30 |
CO4700298A1 (es) | 1998-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |