DE69435277D1 - Klonierung und rekombinante Herstellung von Phospholipase aus Vespidae und immunologische Therapien darauf basierend - Google Patents

Klonierung und rekombinante Herstellung von Phospholipase aus Vespidae und immunologische Therapien darauf basierend

Info

Publication number
DE69435277D1
DE69435277D1 DE69435277T DE69435277T DE69435277D1 DE 69435277 D1 DE69435277 D1 DE 69435277D1 DE 69435277 T DE69435277 T DE 69435277T DE 69435277 T DE69435277 T DE 69435277T DE 69435277 D1 DE69435277 D1 DE 69435277D1
Authority
DE
Germany
Prior art keywords
phospholipase
nucleic acids
recombinant
vespidae
cloning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69435277T
Other languages
English (en)
Inventor
Te Piao King
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Application granted granted Critical
Publication of DE69435277D1 publication Critical patent/DE69435277D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE69435277T 1993-03-11 1994-03-10 Klonierung und rekombinante Herstellung von Phospholipase aus Vespidae und immunologische Therapien darauf basierend Expired - Lifetime DE69435277D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3140093A 1993-03-11 1993-03-11
US08/180,209 US5593877A (en) 1993-03-11 1994-01-11 Nucleic acid and recombinant production of vespid venom hyaluronidase

Publications (1)

Publication Number Publication Date
DE69435277D1 true DE69435277D1 (de) 2010-04-08

Family

ID=21859247

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69435277T Expired - Lifetime DE69435277D1 (de) 1993-03-11 1994-03-10 Klonierung und rekombinante Herstellung von Phospholipase aus Vespidae und immunologische Therapien darauf basierend
DE69434890T Expired - Lifetime DE69434890T2 (de) 1993-03-11 1994-03-10 Klonierung und rekombinante herstellung von vespidengift-hyaluronidase und darauf beruhende immunologische therapien

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69434890T Expired - Lifetime DE69434890T2 (de) 1993-03-11 1994-03-10 Klonierung und rekombinante herstellung von vespidengift-hyaluronidase und darauf beruhende immunologische therapien

Country Status (10)

Country Link
US (4) US5593877A (de)
EP (2) EP1650304B1 (de)
JP (2) JP3816515B2 (de)
AT (2) ATE347601T1 (de)
AU (1) AU693785B2 (de)
CA (2) CA2157864C (de)
DE (2) DE69435277D1 (de)
DK (2) DK1650304T3 (de)
ES (1) ES2278379T3 (de)
WO (1) WO1994020623A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3637087B2 (ja) * 1994-11-28 2005-04-06 和男 鈴木 新規な白血球活性化因子
US5789194A (en) * 1995-05-23 1998-08-04 Heska Corporation Parasitic helminth venom allergen antigen 5-like genes and proteins
US6610292B2 (en) * 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US5866120A (en) 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US5804201A (en) * 1996-03-11 1998-09-08 The Rockefeller University Immunomodulatory peptides of vespid antigen 5
GB9724531D0 (en) * 1997-11-19 1998-01-21 Smithkline Biolog Novel compounds
KR20010041806A (ko) 1998-03-09 2001-05-25 에드워드 에이취. 댄스 효소 각막교정술에 사용되는 각막 경화제의 용도
US6835550B1 (en) * 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6936249B1 (en) * 1998-04-15 2005-08-30 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6838269B1 (en) * 1998-04-15 2005-01-04 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
US6372471B1 (en) 1998-10-01 2002-04-16 The Rockefeller University Cloning and recombinant production of vespid venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon
US6773695B2 (en) 2000-10-05 2004-08-10 Mannkind Corporation Modulation of allergic response
ATE448793T1 (de) 2001-03-02 2009-12-15 Univ Rockefeller Rekombinante hybrid-allergenkonstrukte mit verringerter allergenität unter beibehaltung der immunogenität des natürlichen allergens
MXPA03011987A (es) 2003-12-19 2005-06-23 Osio Sancho Alberto Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal.
DK1786908T3 (da) * 2004-08-18 2010-06-07 Bayer Cropscience Ag Planter med forøget plastidisk aktivitet af stivelsesphosphorylerende R3-enzym
WO2008149364A2 (en) * 2007-06-07 2008-12-11 Sarah Brenner Methods for diagnosing hypersensitivity reactions
DE102007031417A1 (de) * 2007-07-04 2009-01-08 Friedrich-Schiller-Universität Jena Hyaluronatlyase mit erhöhter Wirksamkeit, insbesondere für die Herstellung von pharmazeutischen Formulierungen und Medizinprodukten, sowie deren Verwendung
EP2243791A1 (de) 2009-03-03 2010-10-27 PLS-Design GmbH Klonierung und rekombinante Produktion von Wespengiftprotease und zugehörige Verwendungsverfahren
WO2012029142A1 (ja) * 2010-09-01 2012-03-08 三菱電機株式会社 レーザ加工装置および基板位置検出方法
IN2015KN00596A (de) 2012-08-10 2015-07-17 Osio Corp D B A Yolia Health
TWI788307B (zh) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
WO2018094167A1 (en) 2016-11-17 2018-05-24 Iovance Biotherapeutics, Inc. Remnant tumor infiltrating lymphocytes and methods of preparing and using the same
CN108950015B (zh) * 2018-08-06 2021-11-23 中国计量大学 鉴别福寿螺杂交型的多重pcr检测试剂盒及其检测方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469677A (en) * 1980-02-19 1984-09-04 Michael J Gabriel Polypeptide active immunosuppressant fraction
US4822608A (en) * 1987-09-14 1989-04-18 Vespa Laboratories, Inc. Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof
CA2067182A1 (en) 1990-08-13 1992-02-14 Rudolf Valenta Birch pollen allergen p14 for diagnosis and therapy of allergic diseases
WO1992022655A1 (en) * 1991-06-10 1992-12-23 Lucky Limited Hepatitis c diagnostics and vaccines
GB9204583D0 (en) * 1992-03-03 1992-04-15 Unilever Plc Recombinant plant enzyme
CA2150378C (en) * 1992-11-30 2007-10-30 Joel Moss Mammalian muscle nad:arginine adp-ribosyltransferase
US5532142A (en) * 1993-02-12 1996-07-02 Board Of Regents, The University Of Texas System Method of isolation and purification of fusion polypeptides

Also Published As

Publication number Publication date
JP3816515B2 (ja) 2006-08-30
ATE347601T1 (de) 2006-12-15
AU693785B2 (en) 1998-07-09
US5612209A (en) 1997-03-18
DK0688362T3 (da) 2007-04-10
DK1650304T3 (da) 2010-06-14
DE69434890D1 (de) 2007-01-18
EP1650304A3 (de) 2006-07-12
EP1650304A2 (de) 2006-04-26
US6287559B1 (en) 2001-09-11
DE69434890T2 (de) 2007-10-18
ATE458817T1 (de) 2010-03-15
US5593877A (en) 1997-01-14
CA2157864A1 (en) 1994-09-15
ES2278379T3 (es) 2007-08-01
WO1994020623A1 (en) 1994-09-15
US6270763B1 (en) 2001-08-07
JPH08508399A (ja) 1996-09-10
EP0688362B1 (de) 2006-12-06
CA2157864C (en) 2009-05-12
CA2654420A1 (en) 1994-09-15
EP0688362A1 (de) 1995-12-27
EP1650304B1 (de) 2010-02-24
AU6404194A (en) 1994-09-26
JP2006000119A (ja) 2006-01-05

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