JPH08508399A - ホスホリパーゼ及びヒアルロニダーゼのようなスズメバチ毒酵素のクローニング及び組換え体の生産並びにそれに基づく免疫学的治療 - Google Patents
ホスホリパーゼ及びヒアルロニダーゼのようなスズメバチ毒酵素のクローニング及び組換え体の生産並びにそれに基づく免疫学的治療Info
- Publication number
- JPH08508399A JPH08508399A JP6520320A JP52032094A JPH08508399A JP H08508399 A JPH08508399 A JP H08508399A JP 6520320 A JP6520320 A JP 6520320A JP 52032094 A JP52032094 A JP 52032094A JP H08508399 A JPH08508399 A JP H08508399A
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- sequence
- seq
- venom
- wasp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.スズメバチ毒酵素をコードする核酸又はその免疫調節断片、誘導体又は類縁 体。 2.該スズメバチ毒酵素がホスホリパーゼである請求項1記載の核酸。 3.該スズメバチ毒酵素がドリコベスプラ(Dolichovespula)属のスズメバチ由 来である請求項2記載の核酸。 4.該スズメバチ毒酵素が、マクラータ(maculata)種由来のホスホリパーゼで あり、配列番号17に示されたアミノ酸配列を有する請求項3記載の核酸。 5.該スズメバチ毒酵素がベスプラ(Vespula)属由来である請求項2記載の核 酸。 6.該スズメバチ毒酵素が、ブルガリス(vulgaris)種由来のホスホリパーゼで あり、配列番号27に示されたアミノ酸配列を有する請求項5記載の核酸。 7.配列番号16に示されたヌクレオチド配列を有する請求項4記載の核酸。 8.配列番号16に示されたヌクレオチド配列を有する核酸に対してハイブリッ ド形成可能な核酸。 9.配列番号26に示されたヌクレオチド配列を有する請求項6記載の核酸。 10.配列番号26に示されたヌクレオチド配列を有する核酸に対してハイブリッ ド形成可能な核酸。 11.該スズメバチ毒酵素がヒアルロニダーゼである請求項1記載の核酸。 12.該スズメバチ毒酵素がドリコベスプラマクラータ種由来であり、配列番号5 5に示されたアミノ酸配列を有する請求項11記載の核酸。 13.配列番号54に示されたヌクレオチド配列を有する請求項12記載の核酸。 14.配列番号54に示されたヌクレオチド配列を有する核酸に対してハイブリッ ド形成可能な核酸。 15.該スズメバチ毒酵素のT細胞エピトープの免疫調節部分をコードする請求項 1記載の核酸。 16.請求項15記載の核酸によってコードされたポリペプチド。 17.該スズメバチ毒酵素のB細胞エピトープの抗原部分をコードする請求項1記 載の核酸。 18.請求項17記載の核酸によってコードされたポリペプチド。 19.該スズメバチ毒酵素のT細胞エピトープの免疫調節部分をコードする請求項 2記載の核酸。 20.請求項19記載の核酸によってコードされたポリペプチド。 21.該スズメバチ毒ホスホリパーゼのB細胞エピトープの抗原部分をコードする 請求項2記載の核酸。 22.請求項21記載の核酸によってコードされたポリペプチド。 23.該スズメバチ毒ヒアルロニダーゼのT細胞エピトープの免疫調節部分をコー ドする請求項11記載の核酸。 24.請求項23記載の核酸によってコードされたポリペプチド。 25.該スズメバチ毒ヒアルロニダーゼのB細胞エピトープの少なくとも抗原部分 をコードする請求項11記載の核酸。 26.請求項25記載の核酸によってコードされたポリペプチド。 27.操作上プロモーターを伴った請求項1、2又は11記載の核酸配列を含む発現 ベクター。 28.スズメバチ毒酵素又はその免疫調節断片、誘導体又は類縁体の生産方法であ って、 (a)請求項27記載の発現ベクターで形質転換した細胞を培養し、該細胞によ って該スズメバチ毒酵素を発現させる工程;及び (b)そのように発現した該スズメバチ毒酵素をその培養液から回収する工程 :を含む方法。 29.請求項16、18、20、22、24又は26記載のポリペプチド及び薬学的に許容しう る担体を含むスズメバチ毒アレルゲン特異的アレルギー症状の治療に有効な医薬 組成物。 30.請求項29記載の医薬組成物の治療上有効な量を投与することを含むスズメバ チ毒アレルゲン特異的アレルギー症状の治療方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3140093A | 1993-03-11 | 1993-03-11 | |
US08/031,400 | 1993-03-11 | ||
US08/180,209 US5593877A (en) | 1993-03-11 | 1994-01-11 | Nucleic acid and recombinant production of vespid venom hyaluronidase |
US08/180,209 | 1994-01-11 | ||
PCT/US1994/002629 WO1994020623A1 (en) | 1993-03-11 | 1994-03-10 | Cloning and recombinant production of vespid venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005238009A Division JP2006000119A (ja) | 1993-03-11 | 2005-08-18 | ホスホリパーゼ及びヒアルロニダーゼのようなスズメバチ毒酵素のクローニング及び組換え体の生産並びにそれに基づく免疫学的治療 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08508399A true JPH08508399A (ja) | 1996-09-10 |
JP3816515B2 JP3816515B2 (ja) | 2006-08-30 |
Family
ID=21859247
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52032094A Expired - Fee Related JP3816515B2 (ja) | 1993-03-11 | 1994-03-10 | ホスホリパーゼ及びヒアルロニダーゼのようなスズメバチ毒酵素のクローニング及び組換え体の生産並びにそれに基づく免疫学的治療 |
JP2005238009A Pending JP2006000119A (ja) | 1993-03-11 | 2005-08-18 | ホスホリパーゼ及びヒアルロニダーゼのようなスズメバチ毒酵素のクローニング及び組換え体の生産並びにそれに基づく免疫学的治療 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005238009A Pending JP2006000119A (ja) | 1993-03-11 | 2005-08-18 | ホスホリパーゼ及びヒアルロニダーゼのようなスズメバチ毒酵素のクローニング及び組換え体の生産並びにそれに基づく免疫学的治療 |
Country Status (10)
Country | Link |
---|---|
US (4) | US5593877A (ja) |
EP (2) | EP0688362B1 (ja) |
JP (2) | JP3816515B2 (ja) |
AT (2) | ATE347601T1 (ja) |
AU (1) | AU693785B2 (ja) |
CA (2) | CA2157864C (ja) |
DE (2) | DE69435277D1 (ja) |
DK (2) | DK0688362T3 (ja) |
ES (1) | ES2278379T3 (ja) |
WO (1) | WO1994020623A1 (ja) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3637087B2 (ja) * | 1994-11-28 | 2005-04-06 | 和男 鈴木 | 新規な白血球活性化因子 |
US5789194A (en) * | 1995-05-23 | 1998-08-04 | Heska Corporation | Parasitic helminth venom allergen antigen 5-like genes and proteins |
US6610292B2 (en) * | 1995-11-22 | 2003-08-26 | Ista Pharmaceuticals, Inc. | Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders |
US5866120A (en) | 1995-11-22 | 1999-02-02 | Advanced Corneal Systems, Inc. | Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase |
US5804201A (en) * | 1996-03-11 | 1998-09-08 | The Rockefeller University | Immunomodulatory peptides of vespid antigen 5 |
GB9724531D0 (en) * | 1997-11-19 | 1998-01-21 | Smithkline Biolog | Novel compounds |
JP2002506013A (ja) | 1998-03-09 | 2002-02-26 | イスタ ファーマシューティカルズ インコーポレイテッド | 酵素角膜矯正術における角膜硬化剤の使用 |
US6838269B1 (en) * | 1998-04-15 | 2005-01-04 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
US6936249B1 (en) * | 1998-04-15 | 2005-08-30 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
US6835550B1 (en) * | 1998-04-15 | 2004-12-28 | Genencor International, Inc. | Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins |
US6372471B1 (en) | 1998-10-01 | 2002-04-16 | The Rockefeller University | Cloning and recombinant production of vespid venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon |
US6773695B2 (en) | 2000-10-05 | 2004-08-10 | Mannkind Corporation | Modulation of allergic response |
DK1499349T3 (da) | 2001-03-02 | 2010-04-06 | Univ Rockefeller | Rekombinante hybrid-allergenkonstrukter med reduceret allergenitet, der bibeholder det naterulige allergens immunogenitet |
MXPA03011987A (es) | 2003-12-19 | 2005-06-23 | Osio Sancho Alberto | Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal. |
WO2006018319A1 (en) * | 2004-08-18 | 2006-02-23 | Bayer Cropscience Gmbh | Plants with increased plastidic activity of r3 starch-phosphorylating enzyme |
WO2008149364A2 (en) * | 2007-06-07 | 2008-12-11 | Sarah Brenner | Methods for diagnosing hypersensitivity reactions |
DE102007031417A1 (de) * | 2007-07-04 | 2009-01-08 | Friedrich-Schiller-Universität Jena | Hyaluronatlyase mit erhöhter Wirksamkeit, insbesondere für die Herstellung von pharmazeutischen Formulierungen und Medizinprodukten, sowie deren Verwendung |
EP2243791A1 (en) | 2009-03-03 | 2010-10-27 | PLS-Design GmbH | Cloning and recombinant production of Vespula venom protease and methods of use thereof |
KR101435352B1 (ko) * | 2010-09-01 | 2014-08-28 | 미쓰비시덴키 가부시키가이샤 | 레이저 가공장치 및 기판위치 검출방법 |
IN2015KN00596A (ja) | 2012-08-10 | 2015-07-17 | Osio Corp D B A Yolia Health | |
TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
TWI826360B (zh) | 2016-11-17 | 2023-12-21 | 美商艾歐凡斯生物治療公司 | 殘餘腫瘤浸潤性淋巴細胞及製備和使用彼之方法 |
CN108950015B (zh) * | 2018-08-06 | 2021-11-23 | 中国计量大学 | 鉴别福寿螺杂交型的多重pcr检测试剂盒及其检测方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4469677A (en) * | 1980-02-19 | 1984-09-04 | Michael J Gabriel | Polypeptide active immunosuppressant fraction |
US4822608A (en) * | 1987-09-14 | 1989-04-18 | Vespa Laboratories, Inc. | Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof |
EP0495064B1 (en) | 1990-08-13 | 2001-07-11 | "BIOMAY" Produktions- und Handelsgesellschaft m.b.H. | Birch pollen allergen p14 for diagnosis and therapy of allergic diseases |
GB2272443B (en) * | 1991-06-10 | 1995-10-25 | Lucky Ltd | Nucleotide and amino acid sequences of Korean hepatitis C virus |
GB9204583D0 (en) * | 1992-03-03 | 1992-04-15 | Unilever Plc | Recombinant plant enzyme |
JP3352691B2 (ja) * | 1992-11-30 | 2002-12-03 | アメリカ合衆国 | 哺乳動物の筋肉のnad:アルギニンadp−リボシルトランスフェラーゼ |
US5532142A (en) * | 1993-02-12 | 1996-07-02 | Board Of Regents, The University Of Texas System | Method of isolation and purification of fusion polypeptides |
-
1994
- 1994-01-11 US US08/180,209 patent/US5593877A/en not_active Expired - Lifetime
- 1994-03-10 DE DE69435277T patent/DE69435277D1/de not_active Expired - Lifetime
- 1994-03-10 AU AU64041/94A patent/AU693785B2/en not_active Ceased
- 1994-03-10 EP EP94911550A patent/EP0688362B1/en not_active Expired - Lifetime
- 1994-03-10 AT AT94911550T patent/ATE347601T1/de not_active IP Right Cessation
- 1994-03-10 AT AT05017821T patent/ATE458817T1/de not_active IP Right Cessation
- 1994-03-10 DK DK94911550T patent/DK0688362T3/da active
- 1994-03-10 WO PCT/US1994/002629 patent/WO1994020623A1/en active IP Right Grant
- 1994-03-10 CA CA002157864A patent/CA2157864C/en not_active Expired - Fee Related
- 1994-03-10 DE DE69434890T patent/DE69434890T2/de not_active Expired - Lifetime
- 1994-03-10 DK DK05017821.9T patent/DK1650304T3/da active
- 1994-03-10 EP EP05017821A patent/EP1650304B1/en not_active Expired - Lifetime
- 1994-03-10 JP JP52032094A patent/JP3816515B2/ja not_active Expired - Fee Related
- 1994-03-10 CA CA002654420A patent/CA2654420A1/en not_active Abandoned
- 1994-03-10 ES ES94911550T patent/ES2278379T3/es not_active Expired - Lifetime
-
1995
- 1995-02-08 US US08/385,745 patent/US5612209A/en not_active Expired - Lifetime
- 1995-06-07 US US08/485,388 patent/US6270763B1/en not_active Expired - Fee Related
- 1995-06-07 US US08/474,853 patent/US6287559B1/en not_active Expired - Fee Related
-
2005
- 2005-08-18 JP JP2005238009A patent/JP2006000119A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US5593877A (en) | 1997-01-14 |
DE69435277D1 (de) | 2010-04-08 |
ES2278379T3 (es) | 2007-08-01 |
CA2157864C (en) | 2009-05-12 |
US6270763B1 (en) | 2001-08-07 |
ATE458817T1 (de) | 2010-03-15 |
ATE347601T1 (de) | 2006-12-15 |
US5612209A (en) | 1997-03-18 |
EP1650304A3 (en) | 2006-07-12 |
CA2654420A1 (en) | 1994-09-15 |
AU693785B2 (en) | 1998-07-09 |
WO1994020623A1 (en) | 1994-09-15 |
JP3816515B2 (ja) | 2006-08-30 |
EP0688362B1 (en) | 2006-12-06 |
US6287559B1 (en) | 2001-09-11 |
DE69434890T2 (de) | 2007-10-18 |
EP1650304B1 (en) | 2010-02-24 |
DE69434890D1 (de) | 2007-01-18 |
CA2157864A1 (en) | 1994-09-15 |
EP0688362A1 (en) | 1995-12-27 |
DK1650304T3 (da) | 2010-06-14 |
AU6404194A (en) | 1994-09-26 |
EP1650304A2 (en) | 2006-04-26 |
DK0688362T3 (da) | 2007-04-10 |
JP2006000119A (ja) | 2006-01-05 |
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