DE69434807D1 - Methode und system zur erhöhten produktion von kommerziell wichtigen exoproteinen in gram-positiven bakterien - Google Patents

Methode und system zur erhöhten produktion von kommerziell wichtigen exoproteinen in gram-positiven bakterien

Info

Publication number
DE69434807D1
DE69434807D1 DE69434807T DE69434807T DE69434807D1 DE 69434807 D1 DE69434807 D1 DE 69434807D1 DE 69434807 T DE69434807 T DE 69434807T DE 69434807 T DE69434807 T DE 69434807T DE 69434807 D1 DE69434807 D1 DE 69434807D1
Authority
DE
Germany
Prior art keywords
exoproteins
gram
pct
positive bacteria
increasing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434807T
Other languages
English (en)
Other versions
DE69434807T2 (de
Inventor
Vesa Kontinen
Matti Sarvas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes AS
Original Assignee
Novozymes AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes AS filed Critical Novozymes AS
Application granted granted Critical
Publication of DE69434807D1 publication Critical patent/DE69434807D1/de
Publication of DE69434807T2 publication Critical patent/DE69434807T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69434807T 1993-02-26 1994-02-25 Methode und system zur erhöhten produktion von kommerziell wichtigen exoproteinen in gram-positiven bakterien Expired - Lifetime DE69434807T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2415493A 1993-02-26 1993-02-26
US24154 1993-02-26
PCT/FI1994/000072 WO1994019471A1 (en) 1993-02-26 1994-02-25 Method and system for enhanced production of commercially important exoproteins in gram-positive bacteria

Publications (2)

Publication Number Publication Date
DE69434807D1 true DE69434807D1 (de) 2006-09-14
DE69434807T2 DE69434807T2 (de) 2007-03-29

Family

ID=21819138

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69434807T Expired - Lifetime DE69434807T2 (de) 1993-02-26 1994-02-25 Methode und system zur erhöhten produktion von kommerziell wichtigen exoproteinen in gram-positiven bakterien

Country Status (9)

Country Link
US (1) US5780261A (de)
EP (1) EP0686195B1 (de)
JP (2) JPH08507207A (de)
CN (1) CN1080307C (de)
AT (1) ATE335083T1 (de)
AU (1) AU6142694A (de)
DE (1) DE69434807T2 (de)
DK (1) DK0686195T3 (de)
WO (1) WO1994019471A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630328B2 (en) 1909-07-15 2003-10-07 Genencor International, Inc. Increasing production of proteins in gram-positive microorganisms
US7118757B1 (en) * 1988-12-19 2006-10-10 Wyeth Holdings Corporation Meningococcal class 1 outer-membrane protein vaccine
KR0169913B1 (ko) * 1996-03-14 1999-01-15 김은영 신균주 바실러스속 ds11과 이로부터 생산되는 신규 파이타아제
US5945278A (en) * 1996-07-08 1999-08-31 The Finnish National Public Health Institute Method and system for enhanced production of commercially important exoproteins in gram-positive bacteria
US5919999A (en) * 1996-11-14 1999-07-06 Queen's University At Kingston Enhanced transport with a plastid membrane transport protein
US20030157642A1 (en) 1997-07-15 2003-08-21 Caldwell Robert M. Increasing production of proteins in gram-positive microorganisms
ATE252641T1 (de) * 1997-07-15 2003-11-15 Genencor Int Erhöhung der proteinproduktion in gram-positiven mikroorganismen
US6506579B1 (en) 1997-07-15 2003-01-14 Genencor International, Inc. Increasing production of proteins in gram-positive microorganisms using SecG
DK1003873T3 (da) * 1997-07-16 2005-08-01 Genencor Int Öget produktion af proteiner i grampositive mikroorganismer
EP1035863B1 (de) * 1997-12-05 2006-03-15 Virginia Tech Intellectual Properties, Inc. Ein impfstoff mit einem überexprimierenden homologen antigen sowie verfahren zu dessen herstellung
EP1038959A1 (de) 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Faktor VIII ohne B-Domän, der ein oder mehrere Insertionsstücke von verkürztem Intron I des Faktors IX enthält
US20050000666A1 (en) * 2003-05-06 2005-01-06 Novozymes A/S Use of hemicellulase composition in mechanical pulp production
EP1694846B1 (de) 2003-12-10 2014-10-01 Novozymes A/S Zelle mit verbesserter, vom protein mrga oder einem homolog vermittelter sekretion
EP2422811A2 (de) 2004-10-27 2012-02-29 MedImmune, LLC Modulation von Antikörperspezifität mittels Anpassung der Affinität zu verwandten Antigenen
JP5226958B2 (ja) * 2007-02-22 2013-07-03 花王株式会社 組換え微生物
CN103443278B (zh) 2011-03-23 2017-07-04 诺维信公司 生产分泌型多肽的方法
WO2012127002A1 (en) 2011-03-23 2012-09-27 Novozymes A/S Sweet-tasting polypeptide from gram-positive bacteria
EP2546272A1 (de) 2011-07-15 2013-01-16 Ticona GmbH Verfahren zur Herstellung von Oxymethylenpolymeren
CN104845923B (zh) * 2014-02-14 2018-03-23 中国科学院微生物研究所 生产l‑组氨酸的方法及其专用重组菌
US11667922B2 (en) 2018-03-26 2023-06-06 Novozymes A/S Fungal chaperone proteins
CN113366113A (zh) 2019-01-30 2021-09-07 诺维信公司 同源折叠酶共表达
CN113785056A (zh) * 2019-03-08 2021-12-10 诺维信公司 改善蛋白酶表达的手段和方法
EP4433588A1 (de) 2021-11-16 2024-09-25 Danisco US Inc. Zusammensetzungen und verfahren zur verbesserten proteinproduktion in bacillus-zellen
WO2024146919A1 (en) 2023-01-05 2024-07-11 Basf Se Use of foldases to improve heterologous expression of secreted molecules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711843A (en) * 1980-12-31 1987-12-08 Cetus Corporation Method and vector organism for controlled accumulation of cloned heterologous gene products in Bacillus subtilis
US4952508A (en) * 1980-03-10 1990-08-28 Cetus Corporation Method and vector organism for controlled accumulation of cloned heterologous gene products in Bacillus subtilis
US4994379A (en) * 1983-03-09 1991-02-19 Cetus Corporation Modified signal peptides
US5017477A (en) * 1985-10-25 1991-05-21 Biotechnica International, Inc. Enhancing DNA sequencies derived from the sacQ gene
US4879213A (en) * 1986-12-05 1989-11-07 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
US4965197A (en) * 1987-06-12 1990-10-23 Massachusetts Institute Of Technology Coryneform expression and secretion system

Also Published As

Publication number Publication date
WO1994019471A1 (en) 1994-09-01
CN1120853A (zh) 1996-04-17
EP0686195A1 (de) 1995-12-13
JP4202985B2 (ja) 2008-12-24
AU6142694A (en) 1994-09-14
DK0686195T3 (da) 2006-11-27
JPH08507207A (ja) 1996-08-06
DE69434807T2 (de) 2007-03-29
ATE335083T1 (de) 2006-08-15
US5780261A (en) 1998-07-14
EP0686195B1 (de) 2006-08-02
JP2004350691A (ja) 2004-12-16
CN1080307C (zh) 2002-03-06

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