DE69433285D1 - Hepatitis-b-virusmutanten, und verbindungen und verfahren für ihre bestimmung - Google Patents

Hepatitis-b-virusmutanten, und verbindungen und verfahren für ihre bestimmung

Info

Publication number
DE69433285D1
DE69433285D1 DE69433285T DE69433285T DE69433285D1 DE 69433285 D1 DE69433285 D1 DE 69433285D1 DE 69433285 T DE69433285 T DE 69433285T DE 69433285 T DE69433285 T DE 69433285T DE 69433285 D1 DE69433285 D1 DE 69433285D1
Authority
DE
Germany
Prior art keywords
hepatitis
connections
determination
methods
virus mutants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69433285T
Other languages
English (en)
Other versions
DE69433285T2 (de
Inventor
William Carman
Richard H Decker
Lesley Wallace
Larry T Mimms
Larry R Solomon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Glasgow
Abbott Laboratories
Original Assignee
University of Glasgow
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Glasgow, Abbott Laboratories filed Critical University of Glasgow
Publication of DE69433285D1 publication Critical patent/DE69433285D1/de
Application granted granted Critical
Publication of DE69433285T2 publication Critical patent/DE69433285T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/82—Hepatitis associated antigens and antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69433285T 1993-05-07 1994-05-09 Hepatitis-b-virusmutanten, und verbindungen und verfahren für ihre bestimmung Expired - Lifetime DE69433285T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/059,031 US5595739A (en) 1993-05-07 1993-05-07 Hepatitis B virus mutants, reagents and methods for detection
US59031 1993-05-07
PCT/US1994/005090 WO1994026904A1 (en) 1993-05-07 1994-05-09 Hepatitis b virus mutants, reagents and methods for detection

Publications (2)

Publication Number Publication Date
DE69433285D1 true DE69433285D1 (de) 2003-12-04
DE69433285T2 DE69433285T2 (de) 2004-06-24

Family

ID=22020377

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69433285T Expired - Lifetime DE69433285T2 (de) 1993-05-07 1994-05-09 Hepatitis-b-virusmutanten, und verbindungen und verfahren für ihre bestimmung

Country Status (8)

Country Link
US (4) US5595739A (de)
EP (1) EP0745128B8 (de)
JP (1) JP3813168B2 (de)
AU (1) AU6908294A (de)
CA (1) CA2162132C (de)
DE (1) DE69433285T2 (de)
ES (1) ES2212796T3 (de)
WO (1) WO1994026904A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595739A (en) * 1993-05-07 1997-01-21 Abbott Laboratories Hepatitis B virus mutants, reagents and methods for detection
US7097839B1 (en) 1993-10-26 2006-08-29 Thomas Jefferson University ST receptor binding compounds and methods of using the same
US5879656A (en) * 1993-10-26 1999-03-09 Thomas Jefferson University Methods of treating metastatic colorectal cancer with ST receptor binding compounds
GB9401987D0 (en) * 1994-02-02 1994-03-30 Imperial College Modified nucleic acid
US5750341A (en) * 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
ZA973367B (en) 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
USRE40233E1 (en) 1996-11-08 2008-04-08 Melbourne Health Viral variants and methods for detecting same
AUPO351996A0 (en) * 1996-11-08 1996-12-05 Western Health Care Network Viral variants and methods for detecting same
EP0919568A1 (de) 1997-12-01 1999-06-02 Sorin Diagnostics S.r.l. Fluchtmutanten des Oberflächenantigens des Hepatitis B Virus
WO2000010991A1 (en) 1998-08-25 2000-03-02 Yale University Inhibition and treatment of hepatitis b virus and flavivirus by helioxanthin and its analogs
AUPP706098A0 (en) * 1998-11-11 1998-12-03 North Western Health Care Network Biological compositions, components thereof and uses therefor
NZ512504A (en) * 1998-12-31 2004-01-30 Aventis Pharma Sa Method for separating viral particles
AUPP967999A0 (en) 1999-04-09 1999-05-06 North Western Health Care Network Viral variants
US6670167B1 (en) 1999-11-01 2003-12-30 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof
KR100368756B1 (ko) * 2000-02-01 2003-01-24 주식회사 엘지생명과학 비형 간염 표면 항원에 대한 항체 진단 시약의 제조방법,이를 이용하여 수득되는 비형 간염 항원에 대한 항체 진단시약 및 비형 간염 바이러스 항체 진단 시약
EP1268854A4 (de) * 2000-03-27 2003-05-02 Univ Jefferson Markerdetektion mit hoher spezifität
SG90149A1 (en) * 2000-07-18 2002-07-23 Government Of The Republic Of Diagnostic assay
US6583279B1 (en) 2001-01-26 2003-06-24 Becton, Dickinson And Company Sequences and methods for detection of hepatitis B virus
US7202354B2 (en) 2001-03-30 2007-04-10 Abbott Laboratories Hepatitis B virus surface antigen mutant and methods of detection thereof
US7326536B2 (en) * 2001-05-03 2008-02-05 Eli Lilly And Company Agents for treatment of HCV and methods of use
ATE500808T1 (de) * 2001-05-11 2011-03-15 Wellstat Biologics Corp Onkolytische virustherapie
US7405039B2 (en) 2002-02-07 2008-07-29 Austin Health Viral variants with altered susceptibility to nucleoside analogs and uses thereof
TR200402517T1 (tr) 2002-03-29 2007-12-24 Innogenetics N.V. HBV ilaç direnci tespit metotları
EP2455390A1 (de) * 2002-04-12 2012-05-23 Melbourne Health Hepatitis-B-Virusvarianten mit reduzierter Suszeptibilität für Nukleosidanaloga und Verwendungen dafür
US20030219407A1 (en) 2002-05-15 2003-11-27 The Regents Of The University Of California RNA silencing in animals as an antiviral defense
EP1513958B1 (de) 2002-06-14 2011-08-10 Gen-Probe Incorporated Zusammensetzungen zum nachweis von hepatitis-b-virus
KR100632073B1 (ko) * 2002-06-28 2006-10-04 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 시스테인 잔기를 변형한 단백질로 이루어지는 중공 나노입자 및 이를 이용한 약제
PT1858915E (pt) 2005-03-15 2014-06-11 Justus Liebig Universität Giessen Variantes do vírus de hepatite b resistentes contra alguns análogos de nucleósido, mas sensíveis a outros, e suas utilizações
ES2494840T3 (es) 2005-03-15 2014-09-16 Fujirebio Europe N.V. Variantes víricas de la hepatitis B con susceptibilidad reducida a análogos de nucleósidos y usos de las mismas
AU2006230802A1 (en) * 2005-04-08 2006-10-12 Austin Health Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof
JP2008534020A (ja) 2005-04-08 2008-08-28 メルボルン ヘルス 抗ウイルス性のヌクレオシド剤に耐性を示すｂ型肝炎ウイルスのバリアントおよびその応用法
US8138318B2 (en) 2007-09-13 2012-03-20 Abbott Laboratories Hepatitis B pre-S2 nucleic acid
US20100136520A1 (en) 2007-09-13 2010-06-03 Abbott Laboratories Detecting hepatitis b virus
US20090098531A1 (en) * 2007-09-13 2009-04-16 Abbott Laboratories Detecting hepatitis b virus
US8741595B2 (en) * 2008-12-31 2014-06-03 3M Innovative Properties Company Coliform detection process and kit for use therein
CN117843811A (zh) 2019-09-30 2024-04-09 吉利德科学公司 Hbv疫苗和治疗hbv的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2597606B1 (fr) * 1986-04-16 1989-10-06 Pasteur Institut Nouveau reactif pour la detection d'hepatites virales non a non b et procede de diagnostic de telles hepatites par voie immunoenzymatique
US5565354A (en) * 1986-09-05 1996-10-15 Sandoz Ltd. Production of human monoclonal antibodies specific for hepatitis B surface antigen
GB9007024D0 (en) * 1990-03-29 1990-05-30 Imperial College Novel vaccine
IT1241154B (it) * 1990-05-18 1993-12-29 Slavo Metodo e composizione reagente per la determinazione dell'alanina amminotrasferasi e dell'antigene hbsag in uno stesso campione biologico
CA2067003A1 (en) * 1991-04-29 1992-10-30 Peter J. Kniskern Hbsag escape mutant vaccine
US5595739A (en) * 1993-05-07 1997-01-21 Abbott Laboratories Hepatitis B virus mutants, reagents and methods for detection
GB9401987D0 (en) * 1994-02-02 1994-03-30 Imperial College Modified nucleic acid

Also Published As

Publication number Publication date
ES2212796T3 (es) 2004-08-01
JP3813168B2 (ja) 2006-08-23
EP0745128B1 (de) 2003-10-29
US5591440A (en) 1997-01-07
EP0745128A4 (de) 2000-01-12
US5593825A (en) 1997-01-14
AU6908294A (en) 1994-12-12
CA2162132A1 (en) 1994-11-24
EP0745128A1 (de) 1996-12-04
JPH08510129A (ja) 1996-10-29
WO1994026904A1 (en) 1994-11-24
CA2162132C (en) 2001-12-11
US5595739A (en) 1997-01-21
DE69433285T2 (de) 2004-06-24
EP0745128B8 (de) 2004-07-14
US5925512A (en) 1999-07-20

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