DE69432787D1 - Klonierung von Enterokinase und Verfahren zu deren Verwendung - Google Patents
Klonierung von Enterokinase und Verfahren zu deren VerwendungInfo
- Publication number
- DE69432787D1 DE69432787D1 DE69432787T DE69432787T DE69432787D1 DE 69432787 D1 DE69432787 D1 DE 69432787D1 DE 69432787 T DE69432787 T DE 69432787T DE 69432787 T DE69432787 T DE 69432787T DE 69432787 D1 DE69432787 D1 DE 69432787D1
- Authority
- DE
- Germany
- Prior art keywords
- enterokinase
- cloning
- methods
- nucleic acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102100029727 Enteropeptidase Human genes 0.000 title abstract 2
- 108010013369 Enteropeptidase Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000010367 cloning Methods 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US594493A | 1993-01-15 | 1993-01-15 | |
PCT/US1994/000616 WO1994016083A1 (en) | 1993-01-15 | 1994-01-13 | Cloning of enterokinase and method of use |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69432787D1 true DE69432787D1 (de) | 2003-07-10 |
Family
ID=21718492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69432787T Expired - Lifetime DE69432787D1 (de) | 1993-01-15 | 1994-01-13 | Klonierung von Enterokinase und Verfahren zu deren Verwendung |
Country Status (8)
Country | Link |
---|---|
US (1) | US5665566A (de) |
EP (1) | EP0679189B1 (de) |
JP (1) | JP3149185B2 (de) |
AT (1) | ATE242330T1 (de) |
AU (1) | AU675506B2 (de) |
CA (1) | CA2153254C (de) |
DE (1) | DE69432787D1 (de) |
WO (1) | WO1994016083A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998024886A1 (en) * | 1996-12-04 | 1998-06-11 | Brigham And Women's Hospital, Inc. | Mast cell protease that cleaves fibrinogen |
WO1998033812A1 (en) * | 1997-02-05 | 1998-08-06 | Brigham And Women's Hospital, Inc. | Mast cell protease peptide inhibitors |
DK0977873T3 (da) * | 1997-04-25 | 2007-02-05 | Sembiosys Genetics Inc | Fremgangsmåde til spaltning af fusionsproteiner |
PT1082341E (pt) * | 1998-06-01 | 2011-02-15 | Agensys Inc | Antigénio de tumor útil em diagnóstico e terapêutica de cancro da próstata e do cólon |
US7037667B1 (en) | 1998-06-01 | 2006-05-02 | Agensys, Inc. | Tumor antigen useful in diagnosis and therapy of prostate and colon cancer |
US6461812B2 (en) | 1998-09-09 | 2002-10-08 | Agilent Technologies, Inc. | Method and multiple reservoir apparatus for fabrication of biomolecular arrays |
US6420157B1 (en) * | 1999-04-30 | 2002-07-16 | Ortho-Mcneil Pharmaceutical, Inc. | Zymogen activation system |
US6485957B1 (en) | 1999-04-30 | 2002-11-26 | Ortho-Mcneil Pharmaceutical, Inc. | DNA encoding the human serine protease EOS |
JP2003531567A (ja) * | 1999-04-30 | 2003-10-28 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | チモーゲン活性化系 |
US6426199B1 (en) | 1999-08-31 | 2002-07-30 | Ortho-Mcneil Pharmaceutical, Inc. | Dna |
US6458564B1 (en) * | 1999-08-31 | 2002-10-01 | Ortho-Mcneil Pharmaceutical, Inc. | DNA encoding the human serine protease T |
WO2001098366A2 (en) | 2000-06-19 | 2001-12-27 | Dyax Corp. | Enterokinase cleavage sequences and their use |
US20050158838A1 (en) * | 2000-06-19 | 2005-07-21 | Dyax Corp., A Delaware Corporation | Novel enterokinase cleavage sequences |
US6750034B1 (en) | 2000-06-30 | 2004-06-15 | Ortho-Mcneil Pharmaceutical, Inc. | DNA encoding human serine protease D-G |
JPWO2003033695A1 (ja) * | 2001-10-11 | 2005-02-03 | 片倉工業株式会社 | 組換え融合タンパク質の精製方法およびこれを利用するタンパク質の製造方法 |
KR100507980B1 (ko) * | 2002-06-18 | 2005-08-17 | 프로테온 주식회사 | 엔테로키나제 경사슬의 아미노말단 또는 카르복실말단이 변형된 재조합 엔테로키나제 |
PL213309B1 (pl) | 2006-02-09 | 2013-02-28 | Polska Akademia Nauk Inst Biochemii I Biofizyki | Sposób hydrolizy wiazania peptydowego |
WO2008136014A1 (en) * | 2007-05-07 | 2008-11-13 | Usv Limited | Cloning and expression of enterokinase and its process for production |
WO2010077806A1 (en) | 2008-12-15 | 2010-07-08 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways |
NZ601472A (en) | 2010-01-25 | 2013-08-30 | Allergan Inc | Methods of intracellular conversion of single-chain proteins into their di-chain form |
WO2011140516A2 (en) | 2010-05-07 | 2011-11-10 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through enzyme relocation |
CA2809284C (en) * | 2010-08-31 | 2021-02-23 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through protease manipulation |
RU2495934C2 (ru) * | 2011-05-30 | 2013-10-20 | Общество с ограниченной ответственностью "Лаборатория медицинской биотехнологии" (ООО "ЛМБТ") | ПЛАЗМИДА ДЛЯ ЭКСПРЕССИИ В КЛЕТКАХ БАКТЕРИИ РОДА Escherichia НЕАКТИВНОГО ПРЕДШЕСТВЕННИКА МУТЕИНА [C112S] ЛЕГКОЙ ЦЕПИ ЭНТЕРОКИНАЗЫ ЧЕЛОВЕКА, БАКТЕРИЯ, ПРИНАДЛЕЖАЩАЯ К РОДУ Escherichia, - ПРОДУЦЕНТ ПРЕДШЕСТВЕННИКА РЕКОМБИНАНТНОГО МУТЕИНА [C112S] ЛЕГКОЙ ЦЕПИ ЭНТЕРОКИНАЗЫ ЧЕЛОВЕКА, ПРЕДШЕСТВЕННИК РЕКОМБИНАНТНОГО МУТЕИНА [C112S] ЛЕГКОЙ ЦЕПИ ЭНТЕРОКИНАЗЫ ЧЕЛОВЕКА, СПОСОБ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО МУТЕИНА [C112S] ЛЕГКОЙ ЦЕПИ ЭНТЕРОКИНАЗЫ ЧЕЛОВЕКА, РЕКОМБИНАНТНЫЙ МУТЕИН [C112S] ЛЕГКОЙ ЦЕПИ ЭНТЕРОКИНАЗЫ ЧЕЛОВЕКА |
SG2014014377A (en) | 2011-09-09 | 2014-05-29 | Greenlight Biosciences Inc | Cell-free preparation of carbapenems |
ES2819288T3 (es) | 2011-12-23 | 2021-04-15 | Novo Nordisk As | Cadena ligera de enteroquinasa modificada |
AU2013364025A1 (en) | 2012-12-21 | 2015-07-23 | Greenlight Biosciences, Inc. | Cell-free system for converting methane into fuel, pyruvate or isobutanol |
JP6483687B2 (ja) | 2013-08-05 | 2019-03-13 | グリーンライト バイオサイエンシーズ インコーポレーテッドGreenlight Biosciences,Inc. | プロテアーゼ切断部位を有する操作されたタンパク質 |
KR20180002636A (ko) | 2015-03-30 | 2018-01-08 | 그린라이트 바이오사이언시스, 아이엔씨. | 리보핵산의 무세포 생산 |
RU2018138975A (ru) | 2016-04-06 | 2020-05-12 | Гринлайт Байосайенсис, Инк. | Бесклеточная продукция рибонуклеиновой кислоты |
KR102571743B1 (ko) | 2017-10-11 | 2023-08-29 | 그린라이트 바이오사이언시스, 아이엔씨. | 뉴클레오시드 트리포스페이트 및 리보핵산 생산을 위한 방법 및 조성물 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA769697A (en) * | 1967-10-17 | Ercoli Nicholas | Anti inflammation therapeutic composition | |
US4769326A (en) * | 1980-02-29 | 1988-09-06 | The Regents Of The University Of California | Expression linkers |
US4745069A (en) * | 1982-05-25 | 1988-05-17 | Eli Lilly And Company | Cloning vectors for expression of exogenous protein |
GB8312339D0 (en) * | 1983-05-05 | 1983-06-08 | Austen B M | Peptides |
US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
DK122687A (da) * | 1986-03-14 | 1987-09-15 | Takeda Chemical Industries Ltd | Polypeptid, dna og anvendelse deraf |
US4828988A (en) * | 1986-05-15 | 1989-05-09 | Smith Kline - Rit | Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine |
NZ220917A (en) * | 1986-07-11 | 1991-05-28 | Merck & Co Inc | Human and bovine acidic fibroblast growth factor vectors, hosts and compositions |
GR871029B (en) * | 1986-07-14 | 1987-11-02 | Genetics Inst | Novel osteoinductive factors |
US5270181A (en) * | 1991-02-06 | 1993-12-14 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin and thioredoxin-like molecules |
US5292646A (en) * | 1991-02-06 | 1994-03-08 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin and thioredoxin-like molecules |
-
1994
- 1994-01-13 EP EP94907240A patent/EP0679189B1/de not_active Expired - Lifetime
- 1994-01-13 AT AT94907240T patent/ATE242330T1/de not_active IP Right Cessation
- 1994-01-13 JP JP51351894A patent/JP3149185B2/ja not_active Expired - Lifetime
- 1994-01-13 DE DE69432787T patent/DE69432787D1/de not_active Expired - Lifetime
- 1994-01-13 AU AU60898/94A patent/AU675506B2/en not_active Expired
- 1994-01-13 CA CA002153254A patent/CA2153254C/en not_active Expired - Lifetime
- 1994-01-13 WO PCT/US1994/000616 patent/WO1994016083A1/en active IP Right Grant
- 1994-02-23 US US08/200,900 patent/US5665566A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0679189B1 (de) | 2003-06-04 |
EP0679189A1 (de) | 1995-11-02 |
AU675506B2 (en) | 1997-02-06 |
JP3149185B2 (ja) | 2001-03-26 |
JPH08502176A (ja) | 1996-03-12 |
ATE242330T1 (de) | 2003-06-15 |
CA2153254A1 (en) | 1994-07-21 |
CA2153254C (en) | 2002-05-21 |
WO1994016083A1 (en) | 1994-07-21 |
AU6089894A (en) | 1994-08-15 |
US5665566A (en) | 1997-09-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |