DE69427228T2 - Neue 1,3-benzodioxol und 1,2-dialkoxybenzol derivate als augendrucksenkende mittel - Google Patents

Neue 1,3-benzodioxol und 1,2-dialkoxybenzol derivate als augendrucksenkende mittel

Info

Publication number
DE69427228T2
DE69427228T2 DE69427228T DE69427228T DE69427228T2 DE 69427228 T2 DE69427228 T2 DE 69427228T2 DE 69427228 T DE69427228 T DE 69427228T DE 69427228 T DE69427228 T DE 69427228T DE 69427228 T2 DE69427228 T2 DE 69427228T2
Authority
DE
Germany
Prior art keywords
carbons
alkyl
phenyl
lower alkyl
eye
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69427228T
Other languages
English (en)
Other versions
DE69427228D1 (de
Inventor
Robert M Burk
David F Woodward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of DE69427228D1 publication Critical patent/DE69427228D1/de
Application granted granted Critical
Publication of DE69427228T2 publication Critical patent/DE69427228T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69427228T 1993-04-21 1994-04-18 Neue 1,3-benzodioxol und 1,2-dialkoxybenzol derivate als augendrucksenkende mittel Expired - Fee Related DE69427228T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/051,104 US5369127A (en) 1993-04-21 1993-04-21 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
PCT/US1994/004240 WO1994024121A1 (en) 1993-04-21 1994-04-18 Novel 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents

Publications (2)

Publication Number Publication Date
DE69427228D1 DE69427228D1 (de) 2001-06-21
DE69427228T2 true DE69427228T2 (de) 2001-08-30

Family

ID=21969369

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69427228T Expired - Fee Related DE69427228T2 (de) 1993-04-21 1994-04-18 Neue 1,3-benzodioxol und 1,2-dialkoxybenzol derivate als augendrucksenkende mittel

Country Status (10)

Country Link
US (6) US5369127A (de)
EP (1) EP0695300B1 (de)
JP (1) JP3989950B2 (de)
AT (1) ATE201205T1 (de)
AU (2) AU679749B2 (de)
CA (1) CA2160712C (de)
DE (1) DE69427228T2 (de)
ES (1) ES2156151T3 (de)
HU (1) HUT73416A (de)
WO (1) WO1994024121A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710288A (en) * 1993-04-21 1998-01-20 Allergan 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
US5369127A (en) * 1993-04-21 1994-11-29 Allergan, Inc. 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
US5633218A (en) * 1995-05-24 1997-05-27 E. I. Du Pont De Nemours And Company Herbicidal benzodioxoles and benzodioxanes
AU6053700A (en) * 1999-06-28 2001-01-31 Starpay.Com, Inc. Apparatus and method for performing secure network transactions
TWI225398B (en) 1999-07-14 2004-12-21 R Tech Ueno Ltd Composition for treatment of external secretion disorders
JP2003507468A (ja) 1999-08-23 2003-02-25 スミスクライン・ビーチャム・コーポレイション 脂肪酸シンターゼ阻害剤
AR029001A1 (es) * 1999-08-23 2003-06-04 Smithkline Beecham Corp Derivados de bencil-3,4-metilendioxicinamico y el uso de los mismos para la manufactura de un medicamento
ES2239621T3 (es) 1999-11-09 2005-10-01 Alcon Inc. Derivados bencenoides del acido 15-hidroxieicosatetraenoico y metodos para su uso en el tratamiento de trastornos del ojo seco.
AU2003297690A1 (en) * 2002-12-03 2004-06-23 Silver Eagle Outfitters Llc Personal hydration and cooling system
WO2006062839A1 (en) * 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
US20100147253A1 (en) * 2008-12-11 2010-06-17 International Engine Intellectual Property Company, Llc Oil Pan

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8203876A1 (es) * 1981-05-13 1982-04-01 Ferrer Int Procedimiento de obtencion de nuevos a-amino derivados ci- clicos del 1-(3',4'-metilendioxifenil)etanol
EP0292230B1 (de) * 1987-05-18 1992-01-22 Ajinomoto Co., Inc. Phenylessigsäurederivate und deren Verwendung zur Herstellung von Cephalosporin-Antibiotika
IT1230706B (it) * 1989-02-10 1991-10-29 Poli Ind Chimica Spa Derivati dell'acido 3 piroglutamoil tiazolidin 4 carbossilico e loro proprieta' farmacologiche.
US5066664A (en) * 1990-02-28 1991-11-19 Allergan, Inc. 2-(hydroxy-2-alkylphenylamino)-oxazolines and thiazolines as anti-glaucoma and vasoconstrictive agents
US5151440A (en) * 1990-02-28 1992-09-29 Allergan, Inc. Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenyl-amino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines
US5091528A (en) * 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
ATE136898T1 (de) * 1991-10-29 1996-05-15 Glaxo Wellcome Inc Wasserlösliche camptothecinderivate
US5530028A (en) * 1992-11-23 1996-06-25 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
WO1994002474A1 (en) * 1992-07-17 1994-02-03 Smithkline Beecham Corporation Endothelin receptor antagonists
US5369127A (en) * 1993-04-21 1994-11-29 Allergan, Inc. 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents

Also Published As

Publication number Publication date
WO1994024121A1 (en) 1994-10-27
EP0695300B1 (de) 2001-05-16
US5654329A (en) 1997-08-05
HUT73416A (en) 1996-07-29
JPH08509225A (ja) 1996-10-01
ATE201205T1 (de) 2001-06-15
CA2160712A1 (en) 1994-10-27
US5369127A (en) 1994-11-29
AU695059B2 (en) 1998-08-06
US5714621A (en) 1998-02-03
US5523296A (en) 1996-06-04
HU9502004D0 (en) 1995-09-28
US5814657A (en) 1998-09-29
AU6770094A (en) 1994-11-08
DE69427228D1 (de) 2001-06-21
EP0695300A1 (de) 1996-02-07
AU679749B2 (en) 1997-07-10
ES2156151T3 (es) 2001-06-16
US5874460A (en) 1999-02-23
AU1998697A (en) 1997-07-31
JP3989950B2 (ja) 2007-10-10
CA2160712C (en) 2005-12-27

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Legal Events

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8339 Ceased/non-payment of the annual fee