ATE147373T1 - Cycloalkylalkylamine als liganden für sigma- rezeptoren, verfahren und ihre herstellung und ihre anwendung in der therapie - Google Patents

Cycloalkylalkylamine als liganden für sigma- rezeptoren, verfahren und ihre herstellung und ihre anwendung in der therapie

Info

Publication number
ATE147373T1
ATE147373T1 AT93401959T AT93401959T ATE147373T1 AT E147373 T1 ATE147373 T1 AT E147373T1 AT 93401959 T AT93401959 T AT 93401959T AT 93401959 T AT93401959 T AT 93401959T AT E147373 T1 ATE147373 T1 AT E147373T1
Authority
AT
Austria
Prior art keywords
cycloalkylalkylamines
ligands
sigma receptors
therapy
production
Prior art date
Application number
AT93401959T
Other languages
English (en)
Inventor
Jean-Louis Junien
Alain Calvet
Henri Jacobelli
Francois Roman
Original Assignee
Jouveinal Inst Rech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jouveinal Inst Rech filed Critical Jouveinal Inst Rech
Application granted granted Critical
Publication of ATE147373T1 publication Critical patent/ATE147373T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/38Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C225/18Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings the carbon skeleton containing also rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32Oximes
    • C07C251/34Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/44Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/04Systems containing only non-condensed rings with a four-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Saccharide Compounds (AREA)
AT93401959T 1992-07-31 1993-07-28 Cycloalkylalkylamine als liganden für sigma- rezeptoren, verfahren und ihre herstellung und ihre anwendung in der therapie ATE147373T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR929209536A FR2694287B1 (fr) 1992-07-31 1992-07-31 Nouvelles cycloalkylalkylamines ligands aux récepteurs sigma, leur procédé de préparation et leur application en thérapeutique.

Publications (1)

Publication Number Publication Date
ATE147373T1 true ATE147373T1 (de) 1997-01-15

Family

ID=9432517

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93401959T ATE147373T1 (de) 1992-07-31 1993-07-28 Cycloalkylalkylamine als liganden für sigma- rezeptoren, verfahren und ihre herstellung und ihre anwendung in der therapie

Country Status (16)

Country Link
US (1) US5326784A (de)
EP (1) EP0581677B1 (de)
JP (1) JP3179942B2 (de)
KR (1) KR100314102B1 (de)
AT (1) ATE147373T1 (de)
AU (1) AU660829B2 (de)
CA (1) CA2101575C (de)
DE (1) DE69307210T2 (de)
ES (1) ES2099395T3 (de)
FI (1) FI112650B (de)
FR (1) FR2694287B1 (de)
MX (1) MX9304578A (de)
NO (1) NO179512C (de)
NZ (1) NZ248279A (de)
TW (1) TW230190B (de)
ZA (2) ZA935434B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504253A (en) * 1994-07-15 1996-04-02 Nps Pharmaceuticals, Inc. Amine preparation
US5648541A (en) * 1995-09-28 1997-07-15 Nps Pharmaceuticals, Inc. Chiral reductions of imines leading to the syntheses of optically active amines
FR2751645B1 (fr) * 1996-07-29 1998-12-24 Sanofi Sa Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales
JP2023541960A (ja) 2020-09-17 2023-10-04 メレティオス セラピューティクス ウイルス感染を治療するための化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0038388A1 (de) * 1980-04-17 1981-10-28 Exxon Research And Engineering Company Schaumverteilermundstück und Verfahren und Apparat zum Transport von Schichtprodukten, welche ein Mundstück verwendende Kunststoffschäume enthalten
JP2931986B2 (ja) * 1989-02-17 1999-08-09 武田薬品工業株式会社 アラルキルアミン誘導体
WO1991009594A1 (en) * 1989-12-28 1991-07-11 Virginia Commonwealth University Sigma receptor ligands and the use thereof

Also Published As

Publication number Publication date
FR2694287B1 (fr) 1994-09-16
NO932728D0 (no) 1993-07-29
JP3179942B2 (ja) 2001-06-25
FI933403A0 (fi) 1993-07-29
AU4427993A (en) 1994-02-03
KR940005550A (ko) 1994-03-21
CA2101575A1 (en) 1994-02-01
DE69307210T2 (de) 1997-05-15
FI112650B (fi) 2003-12-31
ZA935434B (en) 1994-02-22
MX9304578A (es) 1994-01-31
FR2694287A1 (fr) 1994-02-04
TW230190B (de) 1994-09-11
NO179512C (no) 1996-10-23
JPH06206851A (ja) 1994-07-26
NZ248279A (en) 1995-12-21
ZA935482B (en) 1994-02-28
NO179512B (no) 1996-07-15
AU660829B2 (en) 1995-07-06
KR100314102B1 (ko) 2002-08-28
EP0581677B1 (de) 1997-01-08
FI933403A (fi) 1994-02-01
EP0581677A1 (de) 1994-02-02
ES2099395T3 (es) 1997-05-16
US5326784A (en) 1994-07-05
CA2101575C (en) 2004-03-23
NO932728L (no) 1994-02-01
DE69307210D1 (de) 1997-02-20

Similar Documents

Publication Publication Date Title
KR900006318A (ko) 피페리디닐 벤즈이미다졸
BE1003230A3 (fr) Nouveaux derives du benzotriazole, leur preparation et leur utilisation comme absorbants u.v.
DE3481126D1 (de) Tricyclische ether, verfahren zu ihrer herstellung, ihre anwendung und sie enthaltende arzneimittel.
DE69405036D1 (de) Substituierte Phenoxy-isobuttersäuren und ihre Ester
ATE211386T1 (de) 7-(5-substituiertes zyklopentyl) und (5- substituiertes zyklopentyl) heptyl-alkohol, heptylamine und heptan-säure-amide und das verfahren zur senkung des augeninnendrucks bei säugetieren durch anwendung dieser neuen verbindungen
ATE147373T1 (de) Cycloalkylalkylamine als liganden für sigma- rezeptoren, verfahren und ihre herstellung und ihre anwendung in der therapie
ATE118523T1 (de) Flüssigkristall-racematmischung, flüssigkristallzusammensetzung und flüssigkristallelement, verfahren zur herstellung und verwendung.
ATE18549T1 (de) 1-carboxyalkanoylindolin-2-carbonsaeure-ester, verfahren zu ihrer herstellung, pharmazeutische praeparate enthaltend diese verbindungen, sowie ihre therapeutische verwendung.
EP0757988A4 (de) Imidazolderivat und ein verfahren zu seiner herstellung
ES2038710T3 (es) Un procedimiento de preparacion de un derivado de benzoxazina y su utilizacion.
FR2428040A1 (fr) Nouveaux derives de pyridylpiperazine, leurs procedes de preparation et leur application en therapeutique
ATE207460T1 (de) Benzocycloalken-verbindungen mit bindungsaffinität an den melatonin-rezeptor, ihre herstellung und verwendung
DE3688161D1 (de) Gegebenenfalls etherifizierte oder esterifizierte in stellung 2 substituierte 4-oh-chinolincarbonsaeurederivate, verfahren und zwischenprodukte zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
ATE190311T1 (de) Oxazolochinolinonderivate, ihre herstellung und ihre verwendung als arzneimittel
NZ332029A (en) Sulfonamide substituted chromans, process for their preparation, their use as a medicament and pharmaceutical preparations comprising them
FI894068A (fi) Sulfonamider med tetrazolylrest, foerfarande foer deras tillverkning och laekemedel.
DE59002723D1 (de) Neue leukotrien-b4-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE29496T1 (de) Tetrahydro-beta-carbolin-derivate und verfahren fuer ihre herstellung.
ATE195313T1 (de) 3-substituierte 1-arylindolverbindungen
PT75694A (de) Neue cis-bucyclo <3.3.0>octanderivate diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
DE59002088D1 (de) Neue leukotrien-b 4 -derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
IT1158695B (it) Analoghi prostaciclinici ad attivita' terapeutica e processo per la loro preparazione
YU47071B (sh) Spiro jedinjenje
JPS5742683A (en) Novel tricyclic cage amine compound

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee