DE69426836D1 - Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung - Google Patents

Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung

Info

Publication number
DE69426836D1
DE69426836D1 DE69426836T DE69426836T DE69426836D1 DE 69426836 D1 DE69426836 D1 DE 69426836D1 DE 69426836 T DE69426836 T DE 69426836T DE 69426836 T DE69426836 T DE 69426836T DE 69426836 D1 DE69426836 D1 DE 69426836D1
Authority
DE
Germany
Prior art keywords
group
optionally substituted
pct
amino
halogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69426836T
Other languages
English (en)
Inventor
Chan Son
Young Lee
Il Bae
Sik Han
Kwon Choi
Bok Chae
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Research Institute of Chemical Technology KRICT
Original Assignee
Korea Research Institute of Chemical Technology KRICT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR2019930028909U external-priority patent/KR950017498U/ko
Priority claimed from KR2019930028908U external-priority patent/KR0132614Y1/ko
Application filed by Korea Research Institute of Chemical Technology KRICT filed Critical Korea Research Institute of Chemical Technology KRICT
Application granted granted Critical
Publication of DE69426836D1 publication Critical patent/DE69426836D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69426836T 1993-12-21 1994-12-20 Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung Expired - Lifetime DE69426836D1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
KR2019930028909U KR950017498U (ko) 1993-12-21 1993-12-21 자동차의 스태빌라이저 장착구조
KR2019930028908U KR0132614Y1 (ko) 1993-12-21 1993-12-21 자동차의 좌석 틸트장치
KR19940010263 1994-05-11
KR19940010262 1994-05-11
KR19940010264 1994-05-11
KR1019940029388A KR0151811B1 (ko) 1993-12-21 1994-11-10 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법
PCT/KR1994/000178 WO1995018109A1 (en) 1993-12-21 1994-12-20 Novel antiviral 2,4-pyrimidinedione derivatives and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
DE69426836D1 true DE69426836D1 (de) 2001-04-12

Family

ID=27555064

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69426836T Expired - Lifetime DE69426836D1 (de) 1993-12-21 1994-12-20 Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung

Country Status (8)

Country Link
US (1) US5747500A (de)
EP (1) EP0736015B1 (de)
JP (1) JP2935573B2 (de)
KR (1) KR0151811B1 (de)
AT (1) ATE199549T1 (de)
AU (1) AU1250295A (de)
DE (1) DE69426836D1 (de)
WO (1) WO1995018109A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476855A (en) * 1993-11-02 1995-12-19 Mahmoud H. el Kouni Enzyme inhibitors, their synthesis and methods for use
CA2217026C (en) * 1996-02-22 2001-11-20 Samjin Pharmaceutical Co., Ltd. New antiviral substituted pyrimidinedione homocarbocyclic nucleoside derivatives and methods for the preparation thereof and compositions containing the same as active ingredients
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
EP0967208B1 (de) * 1998-06-26 2002-08-14 Crompton Vinyl Additives GmbH In 5-Stellung substituierte 6-Aminouracile als Stabilisatoren für halogen-haltige Polymere
IT1305313B1 (it) * 1998-07-17 2001-05-04 Colla Paolo 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.
KR100368891B1 (ko) * 1999-03-04 2003-01-24 한국화학연구원 신규한 항바이러스성 2,4-피리미딘디온 유도체
JP2002538144A (ja) * 1999-03-04 2002-11-12 コリア・リサーチ・インスティテュート・オブ・ケミカル・テクノロジー 抗ウイルス性２，４−ピリミジンジオン誘導体およびその製造方法
KR100311949B1 (ko) * 1999-03-10 2001-11-02 최승주 1-[(사이클로펜트-3-엔-1-일)메틸]-5-에틸-6-(3,5-다이메틸벤조일)-2,4-피리미딘다이온의제조방법
KR20000065885A (ko) * 1999-04-10 2000-11-15 최승주 항바이러스성 피리미딘다이온 유도체 및 그 제조방법
AU2002248910A1 (en) 2000-11-17 2002-05-27 Idenix (Cayman) Limited Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrmidines
KR20020074683A (ko) * 2001-03-21 2002-10-04 주식회사 엘지씨아이 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법
KR101257378B1 (ko) * 2006-04-19 2013-04-23 삼진제약주식회사 항바이러스성 피리미딘디온 유도체 및 이의 제조 방법
BRPI0813269A2 (pt) * 2007-06-29 2014-12-30 Korean Res Inst Of Chemical Technology Inibidores de hiv transcriptase reversa
US8354421B2 (en) * 2007-06-29 2013-01-15 Korea Research Insitute Of Chemical Technology HIV reverse transcriptase inhibitors
WO2009085797A1 (en) * 2007-12-21 2009-07-09 Gilead Sciences, Inc. Processes for preparing hiv reverse transcriptase inhibitors
CA2853024C (en) 2011-11-11 2017-08-22 Pfizer Inc. 2-thiopyrimidinones
PE20180503A1 (es) 2015-05-05 2018-03-09 Pfizer 2-tiopirimidinonas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4730001A (en) * 1986-01-22 1988-03-08 Southern Research Institute Carbocyclic analogues of amino and azido thymidines
HU205917B (en) * 1989-09-29 1992-07-28 Mitsubishi Chem Ind Process for producing 6-substituted pyrimidine derivatives and antiviral pharmaceutical compositions containing them as active components
DE69129998T2 (de) * 1990-02-15 1998-12-24 Takeda Chemical Industries Ltd Pyrimidindionderivate, deren Herstellung und Verwendung
EP0449726B1 (de) * 1990-03-29 1997-06-11 Mitsubishi Chemical Corporation Pyrimidin-Nukleosid-Derivate und antivirale Mittel, die diese Derivate als aktiven Bestandteil enthalten
USH1142H (en) * 1990-11-05 1993-02-02 Optically active cyclobutyl pyrimidine

Also Published As

Publication number Publication date
EP0736015B1 (de) 2001-03-07
EP0736015A1 (de) 1996-10-09
KR0151811B1 (ko) 1998-10-15
JPH09509405A (ja) 1997-09-22
ATE199549T1 (de) 2001-03-15
JP2935573B2 (ja) 1999-08-16
AU1250295A (en) 1995-07-17
WO1995018109A1 (en) 1995-07-06
US5747500A (en) 1998-05-05
KR950017971A (ko) 1995-07-22

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