DE69426725T2 - Peptide, die neutralisierende antikörper gegen genetisch divergierende hiv-1 stämme, induzieren - Google Patents

Peptide, die neutralisierende antikörper gegen genetisch divergierende hiv-1 stämme, induzieren

Info

Publication number
DE69426725T2
DE69426725T2 DE69426725T DE69426725T DE69426725T2 DE 69426725 T2 DE69426725 T2 DE 69426725T2 DE 69426725 T DE69426725 T DE 69426725T DE 69426725 T DE69426725 T DE 69426725T DE 69426725 T2 DE69426725 T2 DE 69426725T2
Authority
DE
Germany
Prior art keywords
hiv
peptides
nucleotide sequences
sequences
fusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69426725T
Other languages
English (en)
Other versions
DE69426725D1 (de
Inventor
Hermann Katinger
Thomas Muster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
POLIMUN SCIENT IMMUNBIOLOGISCH
Original Assignee
POLIMUN SCIENT IMMUNBIOLOGISCH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by POLIMUN SCIENT IMMUNBIOLOGISCH filed Critical POLIMUN SCIENT IMMUNBIOLOGISCH
Publication of DE69426725D1 publication Critical patent/DE69426725D1/de
Application granted granted Critical
Publication of DE69426725T2 publication Critical patent/DE69426725T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
DE69426725T 1993-09-11 1994-09-12 Peptide, die neutralisierende antikörper gegen genetisch divergierende hiv-1 stämme, induzieren Expired - Fee Related DE69426725T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93114631 1993-09-11
PCT/EP1994/003039 WO1995007354A1 (en) 1993-09-11 1994-09-12 Peptides that elicit neutralizing antibodies against genetically divergent hiv-1 strains

Publications (2)

Publication Number Publication Date
DE69426725D1 DE69426725D1 (de) 2001-03-29
DE69426725T2 true DE69426725T2 (de) 2001-09-06

Family

ID=8213253

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69426725T Expired - Fee Related DE69426725T2 (de) 1993-09-11 1994-09-12 Peptide, die neutralisierende antikörper gegen genetisch divergierende hiv-1 stämme, induzieren

Country Status (15)

Country Link
EP (1) EP0725825B1 (de)
JP (1) JPH09502348A (de)
CN (1) CN1135237A (de)
AT (1) ATE199260T1 (de)
AU (1) AU682893B2 (de)
BR (1) BR9407531A (de)
CA (1) CA2171544C (de)
CZ (1) CZ287808B6 (de)
DE (1) DE69426725T2 (de)
ES (1) ES2156902T3 (de)
HU (1) HU219507B (de)
PT (1) PT725825E (de)
RU (1) RU2181379C2 (de)
UA (1) UA43350C2 (de)
WO (1) WO1995007354A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1754715A1 (de) 2005-08-19 2007-02-21 Bundesrepublik Deutschland vertreten durch das Bundesminsterium für Gesundheit, dieses vertr. durch das Robert-Koch-Institut Impfstoff auf Basis virusneutralisierender Antikörper

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9708008A (es) * 1995-04-19 1998-03-31 Polymun Scient Immunbio Forsch Anticuerpos monoclonales contra vih-1 y vacunas hechas de los mismos.
US6319890B1 (en) 1996-12-30 2001-11-20 Manfred P. Dierich Inhibition of binding of complement Factor H
CN100383158C (zh) * 1998-03-23 2008-04-23 特莱默里斯公司 关于肽合成的方法以及组合物
US6482928B1 (en) 1999-04-13 2002-11-19 Aventis Pasteur Limited And University Of Toronto Fab′-epitope complex from HIV-1 cross-neutralizing monoclonal antibody 2F5
CN1172717C (zh) * 2000-08-18 2004-10-27 清华大学 一种治疗艾滋病的药物及其制备方法
FR2851165A1 (fr) * 2003-02-19 2004-08-20 Aventis Pasteur Antigene derivant de l'helice c de la proteine gp41
EP1868651A4 (de) 2005-04-12 2010-10-06 Univ Duke Verfahren zur induktion von neutralisierenden antikörpern gegen das hiv-virus
CA2683752A1 (en) 2007-04-13 2008-10-23 Duke University Method of inducing neutralizing antibodies to human immunodeficiency virus
CN102365095B (zh) * 2009-02-06 2015-11-25 麦米提斯公司 分裂gp41
US10076567B2 (en) 2013-09-27 2018-09-18 Duke University MPER-liposome conjugates and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2053413T3 (es) * 1992-05-14 1997-11-16 Polymun Scient Immunbio Forsch Peptidos que inducen anticuerpos que neutralizan aislados de vih-1 geneticamente divergentes.
US5817767A (en) * 1993-02-24 1998-10-06 Progenics Pharmaceuticals, Inc. Synergistic composition of CD4-based protein and anti-HIV-1 antibody, and methods of using same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1754715A1 (de) 2005-08-19 2007-02-21 Bundesrepublik Deutschland vertreten durch das Bundesminsterium für Gesundheit, dieses vertr. durch das Robert-Koch-Institut Impfstoff auf Basis virusneutralisierender Antikörper

Also Published As

Publication number Publication date
ATE199260T1 (de) 2001-03-15
CA2171544C (en) 2003-06-24
WO1995007354A1 (en) 1995-03-16
EP0725825B1 (de) 2001-02-21
CZ287808B6 (en) 2001-02-14
EP0725825A1 (de) 1996-08-14
DE69426725D1 (de) 2001-03-29
RU2181379C2 (ru) 2002-04-20
CZ74196A3 (en) 1996-07-17
AU7696594A (en) 1995-03-27
CA2171544A1 (en) 1995-03-16
BR9407531A (pt) 1997-08-26
UA43350C2 (uk) 2001-12-17
JPH09502348A (ja) 1997-03-11
AU682893B2 (en) 1997-10-23
ES2156902T3 (es) 2001-08-01
PT725825E (pt) 2001-08-30
CN1135237A (zh) 1996-11-06
HU9600587D0 (en) 1996-05-28
HUT76102A (en) 1997-06-30
HU219507B (hu) 2001-04-28

Similar Documents

Publication Publication Date Title
DE3588251T2 (de) DNS-Fragmente des GAG-Gens von LAV
Kleny et al. Improved antigenicity of the HIV env protein by cleavage site removal
EP0339504A3 (de) Menschliches immunoinsuffizientes Virus (HIV) env-codiertes Peptid, welches im Stande ist, die HIV hemmenden Antikörper bei Säugetieren hervorzurufen
CA2164818A1 (en) Tandem synthetic hiv-1 peptides
CA2392877A1 (en) Improvements in or relating to immune responses to hiv
DE69426725D1 (de) Peptide, die neutralisierende antikörper gegen genetisch divergierende hiv-1 stämme, induzieren
CA2107732A1 (en) Retrovirus from the hiv group and its use
ATE328589T1 (de) Präparate zur verabreichung von genetischem material
CA2143163A1 (en) Peptides derived from a retrovirus of the hiv group, and their use
BRAND et al. Comparative analysis of humoral immune responses to HIV type 1 envelope glycoproteins in mice immunized with a DNA vaccine, recombinant Semliki Forest virus RNA, or recombinant Semliki Forest virus particles
FR2700169B1 (fr) Nouveaux variants trans-dominants TAT du virus de l'immunodéficience humaine.
JP2004509601A5 (de)
JPH07110877B2 (ja) Ｈｉｖ逆転写酵素に対する細胞毒性ｔ細胞免疫を刺激するペプチド
Le Blanc et al. HTLV-1 structural proteins
CA2169603A1 (en) Retrovirus from the hiv group and its use
WO1993018055B1 (en) Peptides stimulating cytotoxic lymphocytes respone to hiv-1 gp160
RU96108781A (ru) Пептиды, создающие нейтрализующие антитела к генетически дифергентным штаммам вич-1
CA2084386A1 (en) Hiv antigen
Lockey et al. Multi-envelope HIV vaccine safety and immunogenicity in small animals and chimpanzees
Girard et al. Progress in the development of HIV vaccines
FR2600079B1 (fr) Vecteur viral et adn recombinant codant pour la proteine f du virus agent causal du s.i.d.a., culture cellulaire infectee par ce vecteur, procede de preparation de la proteine, proteine obtenue, vaccin et anticorps obtenus
Wang et al. DNA inoculation induces cross clade anti-HIV-1 responses
EP0950063B1 (de) Vielfältig verzweigte peptidkonstruktionen
EP0469089A1 (de) Erzeugung von hybrid-genen und proteinen durch rekombination mittels viren
WO1998037089A8 (en) Matrix derived anti-hiv peptides and transdominant proteins

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee