DE69334187D1 - Stabil transfizierte Zelllinien welche Humane GABA-A Rezeptoren mit der Untereinheitskombination Alpha-2, Beta-3 und Gamma-2 exprimieren - Google Patents

Stabil transfizierte Zelllinien welche Humane GABA-A Rezeptoren mit der Untereinheitskombination Alpha-2, Beta-3 und Gamma-2 exprimieren

Info

Publication number
DE69334187D1
DE69334187D1 DE69334187T DE69334187T DE69334187D1 DE 69334187 D1 DE69334187 D1 DE 69334187D1 DE 69334187 T DE69334187 T DE 69334187T DE 69334187 T DE69334187 T DE 69334187T DE 69334187 D1 DE69334187 D1 DE 69334187D1
Authority
DE
Germany
Prior art keywords
sub
receptors
gamma
beta
cell lines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69334187T
Other languages
English (en)
Other versions
DE69334187T2 (de
Inventor
Karen L Hadingham
Paul J Whiting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929225776A external-priority patent/GB9225776D0/en
Priority claimed from GB939318528A external-priority patent/GB9318528D0/en
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Publication of DE69334187D1 publication Critical patent/DE69334187D1/de
Application granted granted Critical
Publication of DE69334187T2 publication Critical patent/DE69334187T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69334187T 1992-12-10 1993-12-07 Stabil transfizierte Zelllinien welche Humane GABA-A Rezeptoren mit der Untereinheitskombination Alpha-2, Beta-3 und Gamma-2 exprimieren Expired - Fee Related DE69334187T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929225776A GB9225776D0 (en) 1992-12-10 1992-12-10 Cell line
GB9225776 1992-12-10
GB939318528A GB9318528D0 (en) 1993-09-07 1993-09-07 Cell line
GB9318528 1993-09-07

Publications (2)

Publication Number Publication Date
DE69334187D1 true DE69334187D1 (de) 2008-01-03
DE69334187T2 DE69334187T2 (de) 2008-10-09

Family

ID=26302133

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69334187T Expired - Fee Related DE69334187T2 (de) 1992-12-10 1993-12-07 Stabil transfizierte Zelllinien welche Humane GABA-A Rezeptoren mit der Untereinheitskombination Alpha-2, Beta-3 und Gamma-2 exprimieren
DE69320985T Expired - Fee Related DE69320985T2 (de) 1992-12-10 1993-12-07 Stabil transfizierte zelllinien welche gaba-a rezeptoren exprimieren
DE69333923T Expired - Fee Related DE69333923T2 (de) 1992-12-10 1993-12-07 Stabil transfizierte Zelllinien welche Gaba-A- Rezeptoren mit der Untereinheitenzusammensetzung alpha-3, beta-3 und gamma-2 exprimieren

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69320985T Expired - Fee Related DE69320985T2 (de) 1992-12-10 1993-12-07 Stabil transfizierte zelllinien welche gaba-a rezeptoren exprimieren
DE69333923T Expired - Fee Related DE69333923T2 (de) 1992-12-10 1993-12-07 Stabil transfizierte Zelllinien welche Gaba-A- Rezeptoren mit der Untereinheitenzusammensetzung alpha-3, beta-3 und gamma-2 exprimieren

Country Status (9)

Country Link
US (1) US5652100A (de)
EP (3) EP0673419B1 (de)
JP (1) JP3464672B2 (de)
AT (2) ATE170921T1 (de)
AU (1) AU680852B2 (de)
DE (3) DE69334187T2 (de)
DK (1) DK0856581T3 (de)
ES (2) ES2296064T3 (de)
WO (1) WO1994013799A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9420010D0 (en) 1994-10-01 1994-11-16 Marck Sharp & Dohme Limited Nucleic acids
GB9503601D0 (en) * 1995-02-23 1995-04-12 Merck Sharp & Dohme Method of treatment and method of manufacture of medicament
WO1997017369A2 (en) * 1995-11-09 1997-05-15 Trustees Of Boston University Dna comprising a neuron-specific transcriptional promoter and its use in a gene therapy vector
JP3868502B2 (ja) * 1996-10-25 2007-01-17 ニューロサーチ・アクティーゼルスカブ 抗不安作用を有する化合物の同定方法
EP0948617A1 (de) * 1996-11-25 1999-10-13 Merck Sharp & Dohme Ltd. KLONIERTE cDNA-SEQUENZ EINER NEUEN GABA-REZEPTOR-UNTEREINHEIT UND STABIL KOTRANSFIZIERTE ZELLLINIEN
GB9708479D0 (en) 1997-04-25 1997-06-18 Merck Sharp & Dohme Nucleic acids
US7029870B1 (en) 1997-07-03 2006-04-18 Human Genome Sciences, Inc. Gabaa receptor epsilon subunits
GB9715164D0 (en) * 1997-07-19 1997-09-24 Medical Res Council Improvements in or relating to expression of nucleic acid sequences in cerebellar cells
US6762294B2 (en) 1999-02-19 2004-07-13 The United States Of America As Represented By The Department Of Health And Human Services Polynucleotides encoding polymorphic human GABAA receptor α-6 subunit
EP1153130B1 (de) * 1999-02-19 2005-11-23 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Polymorphismus im gen für die menschliche gaba a rezeptor alpha 6 untereinheit
WO2002029418A1 (en) * 2000-10-05 2002-04-11 Hanns Mohler Selective anxiolytic therapeutic agents
US7282344B2 (en) * 2001-06-06 2007-10-16 Neurosearch A/S Cation conducting GABAA receptors and their use
US20070112017A1 (en) * 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
EP3009513A1 (de) * 2008-02-01 2016-04-20 Chromocell Corporation Neuartige zelllinien und verfahren
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CN106854207B (zh) 2015-12-08 2019-10-29 上海赛默罗生物科技有限公司 呔嗪类衍生物、其制备方法、药物组合物和用途
CN110256440B (zh) 2018-03-12 2023-05-23 上海赛默罗生物科技有限公司 酞嗪异噁唑烷氧基衍生物、其制备方法、药物组合物和用途
CN112979655A (zh) 2019-12-16 2021-06-18 上海赛默罗生物科技有限公司 三唑并哒嗪类衍生物、其制备方法、药物组合物和用途
WO2023016521A1 (zh) 2021-08-12 2023-02-16 上海赛默罗生物科技有限公司 取代三唑类衍生物、其制备方法、药物组合物和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9112504D0 (en) * 1991-06-11 1991-07-31 Merck Sharp & Dohme Cell line
US5166066A (en) * 1991-07-11 1992-11-24 The Upjohn Company Transformed cells comprising GABAA receptors

Also Published As

Publication number Publication date
ES2296064T3 (es) 2008-04-16
EP0673419B1 (de) 1998-09-09
DE69320985D1 (de) 1998-10-15
AU5655494A (en) 1994-07-04
EP0856581B1 (de) 2005-11-30
WO1994013799A1 (en) 1994-06-23
DE69333923T2 (de) 2006-08-03
EP0856581A3 (de) 1999-11-24
DE69320985T2 (de) 1999-05-12
EP0856581A2 (de) 1998-08-05
DE69334187T2 (de) 2008-10-09
ATE170921T1 (de) 1998-09-15
JP3464672B2 (ja) 2003-11-10
AU680852B2 (en) 1997-08-14
EP1605046B1 (de) 2007-11-21
JPH08504330A (ja) 1996-05-14
ATE311449T1 (de) 2005-12-15
EP1605046A1 (de) 2005-12-14
DK0856581T3 (da) 2006-03-27
ES2251011T3 (es) 2006-04-16
EP0673419A1 (de) 1995-09-27
US5652100A (en) 1997-07-29
DE69333923D1 (de) 2006-01-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee