CA2151236A1 - Stably transfected cell lines expressing gaba-a receptors - Google Patents

Stably transfected cell lines expressing gaba-a receptors

Info

Publication number
CA2151236A1
CA2151236A1 CA002151236A CA2151236A CA2151236A1 CA 2151236 A1 CA2151236 A1 CA 2151236A1 CA 002151236 A CA002151236 A CA 002151236A CA 2151236 A CA2151236 A CA 2151236A CA 2151236 A1 CA2151236 A1 CA 2151236A1
Authority
CA
Canada
Prior art keywords
gamma
beta
alpha
receptors
cell lines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002151236A
Other languages
French (fr)
Other versions
CA2151236C (en
Inventor
Karen Hadingham
Paul J. Whiting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929225776A external-priority patent/GB9225776D0/en
Priority claimed from GB939318528A external-priority patent/GB9318528D0/en
Application filed by Individual filed Critical Individual
Priority claimed from PCT/GB1993/002506 external-priority patent/WO1994013799A1/en
Publication of CA2151236A1 publication Critical patent/CA2151236A1/en
Application granted granted Critical
Publication of CA2151236C publication Critical patent/CA2151236C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to a stably co-transfected eukaryotic cell line capable of expressing a human GABA A receptor, which receptor comprises the .alpha.1.beta.3.gamma.2, .alpha.2.beta.3.gamma.2, .alpha.5.beta.3.gamma.2, .alpha.1.beta.1.gamma.2, .alpha.1.beta.2.gamma.2, .alpha.3.beta.3.gamma.2 or .alpha.6.beta.3.gamma.2 subunit combination; to membrane preparations derived from cultures thereof; and to the use of the cell line in designing and developing GABA A receptor subtype-selective medicaments.
CA002151236A 1992-12-10 1993-12-07 Stably transfected cell lines expressing gaba-a receptors Expired - Fee Related CA2151236C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9225776.5 1992-12-10
GB929225776A GB9225776D0 (en) 1992-12-10 1992-12-10 Cell line
GB939318528A GB9318528D0 (en) 1993-09-07 1993-09-07 Cell line
GB9318528.8 1993-09-07
PCT/GB1993/002506 WO1994013799A1 (en) 1992-12-10 1993-12-07 Stably transfected cell lines expressing gaba-a receptors

Publications (2)

Publication Number Publication Date
CA2151236A1 true CA2151236A1 (en) 1994-06-23
CA2151236C CA2151236C (en) 2007-07-24

Family

ID=38325168

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002151236A Expired - Fee Related CA2151236C (en) 1992-12-10 1993-12-07 Stably transfected cell lines expressing gaba-a receptors

Country Status (1)

Country Link
CA (1) CA2151236C (en)

Also Published As

Publication number Publication date
CA2151236C (en) 2007-07-24

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed