DE69330745T2 - Chemerische immunogene - Google Patents
Chemerische immunogeneInfo
- Publication number
- DE69330745T2 DE69330745T2 DE69330745T DE69330745T DE69330745T2 DE 69330745 T2 DE69330745 T2 DE 69330745T2 DE 69330745 T DE69330745 T DE 69330745T DE 69330745 T DE69330745 T DE 69330745T DE 69330745 T2 DE69330745 T2 DE 69330745T2
- Authority
- DE
- Germany
- Prior art keywords
- protein
- piv
- rsv
- gene sequence
- pathogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 3
- 244000052769 pathogen Species 0.000 abstract 3
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 230000001717 pathogenic effect Effects 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 208000002606 Paramyxoviridae Infections Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18611—Respirovirus, e.g. Bovine, human parainfluenza 1,3
- C12N2760/18622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/115—Paramyxoviridae, e.g. parainfluenza virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/115—Paramyxoviridae, e.g. parainfluenza virus
- G01N2333/135—Respiratory syncytial virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929200117A GB9200117D0 (en) | 1992-01-06 | 1992-01-06 | Production of recombinant chimeric proteins for vaccine use |
PCT/CA1993/000001 WO1993014207A1 (en) | 1992-01-06 | 1993-01-05 | Chimeric immunogens |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69330745D1 DE69330745D1 (de) | 2001-10-18 |
DE69330745T2 true DE69330745T2 (de) | 2002-05-29 |
Family
ID=10708117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69330745T Expired - Lifetime DE69330745T2 (de) | 1992-01-06 | 1993-01-05 | Chemerische immunogene |
Country Status (16)
Country | Link |
---|---|
US (13) | US6225091B1 (de) |
EP (1) | EP0621898B1 (de) |
JP (1) | JP3290662B2 (de) |
KR (1) | KR100208310B1 (de) |
AT (1) | ATE205535T1 (de) |
AU (1) | AU667502B2 (de) |
CA (1) | CA2126863C (de) |
DE (1) | DE69330745T2 (de) |
DK (1) | DK0621898T3 (de) |
ES (1) | ES2164070T3 (de) |
FI (1) | FI117514B (de) |
GB (1) | GB9200117D0 (de) |
NO (1) | NO316622B1 (de) |
PT (1) | PT621898E (de) |
RU (1) | RU2123047C1 (de) |
WO (1) | WO1993014207A1 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9200117D0 (en) * | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
US6479055B1 (en) | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
FR2718452B1 (fr) | 1994-04-06 | 1996-06-28 | Pf Medicament | Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation. |
US6300090B1 (en) | 1994-07-29 | 2001-10-09 | The Rockefeller University | Methods of use of viral vectors to deliver antigen to dendritic cells |
US20030054505A1 (en) * | 1997-09-26 | 2003-03-20 | Hong Jin | Recombinant rsv expression systems and vaccines |
FR2726472B1 (fr) * | 1994-11-07 | 1997-01-31 | Pf Medicament | Proteine porteuse a effet adjuvant, complexe immunogene la contenant, leur procede de preparation, sequence nucleotidique et vaccin |
US7485440B2 (en) | 1995-09-27 | 2009-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
US6699476B1 (en) | 1996-07-15 | 2004-03-02 | Peter L. Collins | Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules |
WO1998002530A1 (en) | 1996-07-15 | 1998-01-22 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences |
FR2751229B1 (fr) | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique notamment contre la pathologie respiratoire des bovins |
US7250171B1 (en) | 1997-05-23 | 2007-07-31 | United States Of America As Represented By The Dept. Of Health & Human Services | Construction and use of recombinant parainfluenza viruses expressing a chimeric glycoprotein |
US7314631B1 (en) | 1997-05-23 | 2008-01-01 | The United States Of America As Represented By The Department Of Health And Human Services | Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV) |
US20030082209A1 (en) | 2000-07-05 | 2003-05-01 | Skiadopoulos Mario H. | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
US7632508B2 (en) | 1997-05-23 | 2009-12-15 | The United States Of America | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
US6410023B1 (en) | 1997-05-23 | 2002-06-25 | United States Of America | Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene |
US7192593B2 (en) * | 1997-05-23 | 2007-03-20 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens |
US7951383B2 (en) | 1997-05-23 | 2011-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated parainfluenza virus (PIV) vaccines |
US7201907B1 (en) | 1997-05-23 | 2007-04-10 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines |
US6258782B1 (en) | 1998-05-20 | 2001-07-10 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
US6656906B1 (en) | 1998-05-20 | 2003-12-02 | Trimeris, Inc. | Hybrid polypeptides with enhanced pharmacokinetic properties |
AU5980899A (en) * | 1998-09-25 | 2000-04-17 | Smithkline Beecham Biologicals (Sa) | Novel compounds |
CN100354425C (zh) | 1999-07-09 | 2007-12-12 | 美国政府健康及人类服务部 | 减毒的人-牛嵌合呼吸道合胞病毒疫苗的生产 |
KR100940776B1 (ko) * | 1999-07-09 | 2010-02-11 | 더 가버먼트 오브 더 유나이티드 스테이츠 오브 어메리카 애즈 리프리젠티드 바이 더 디파트먼트 오브 헬스 앤 휴먼 서비씨즈 | 약독화된 사람-소 키메라 파라인플루엔자바이러스(piv) 백신 |
US6764685B1 (en) | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
US20030232055A1 (en) * | 2000-07-31 | 2003-12-18 | Ruslan Medzhitov | Innate immune system-directed vaccines |
US20030175287A1 (en) * | 2001-01-03 | 2003-09-18 | Yale University | Innate immune system-directed vaccines |
CN101921732A (zh) | 2001-01-19 | 2010-12-22 | 维洛诺瓦蒂夫公司 | 在易感哺乳动物中引起呼吸道疾病的病毒 |
US8715922B2 (en) | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
IL163646A0 (en) | 2002-02-21 | 2005-12-18 | Vironovative Bv | Recombinant parainfluenza virus expression systemsand vaccines comprising heterologous antigens derived from metapneumovirus |
US7402427B2 (en) * | 2002-04-30 | 2008-07-22 | Dnavec Research Inc. | Vectors with modified protease-dependent tropism |
JP2005533861A (ja) * | 2002-07-25 | 2005-11-10 | メデュームン,インコーポレーテッド | 抗RSV、抗hMPV、および抗PIV抗体を使用するRSV、hMPV、およびPIVの治療法と予防法 |
WO2004066961A2 (en) * | 2003-01-20 | 2004-08-12 | St. Jude Children's Research Hospital | Use of sendai virus as a human parainfluenza vaccine |
CA2520671C (en) * | 2003-03-28 | 2014-03-18 | Medimmune Vaccines, Inc. | Compositions and methods involving respiratory syncytial virus subgroup b strain 9320 |
US7704720B2 (en) | 2003-04-25 | 2010-04-27 | Medimmune, Llc | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus |
CA2594612A1 (en) | 2005-01-19 | 2006-07-27 | Vaxinnate Corporation | Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response |
CA2638760A1 (en) | 2006-03-07 | 2007-09-13 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
DE102006060799A1 (de) | 2006-12-21 | 2008-06-26 | RUHR-UNIVERSITäT BOCHUM | RSV F-Protein und seine Verwendung |
EP2391383B1 (de) | 2009-02-02 | 2015-12-23 | ChronTech Pharma AB | Codon-optimiertes hepatitis b virus core antigen (hbcag) |
EA201270062A1 (ru) * | 2009-06-24 | 2013-02-28 | АйДи БАЙОМЕДИКАЛ КОРПОРЕЙШН ОФ КВЕБЕК | Вакцина |
WO2012103496A2 (en) * | 2011-01-28 | 2012-08-02 | Medimmune, Llc | Expression of soluble viral fusion glycoproteins in mammalian cells |
US9463236B2 (en) | 2011-08-29 | 2016-10-11 | Tokushima University | RSV mucosal vaccine |
US9662379B2 (en) | 2011-12-02 | 2017-05-30 | Rhode Island Hospital | Vaccine for falciparum malaria |
KR102435054B1 (ko) | 2012-08-01 | 2022-08-22 | 버베리안 노딕 에이/에스 | 재조합 변형된 백시니아 바이러스 앙카라(ankara) (mva) 호흡기 신시티알 바이러스(rsv) 백신 |
US20160324954A1 (en) | 2013-05-15 | 2016-11-10 | Chrontech Pharma Ab | Immunogenic compositions for inhibiting hepatitis d virus |
MD3718565T2 (ro) | 2015-10-22 | 2022-09-30 | Modernatx Inc | Vaccinuri împotriva virusului respirator |
MA50335A (fr) | 2016-12-08 | 2020-08-19 | Modernatx Inc | Vaccins à acide nucléique contre des virus respiratoires |
US20200030432A1 (en) | 2017-03-17 | 2020-01-30 | Modernatx, Inc. | Zoonotic disease rna vaccines |
US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5110587A (en) * | 1981-12-24 | 1992-05-05 | Health Research, Incorporated | Immunogenic composition comprising synthetically modified vaccinia virus |
US4722848A (en) * | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
US4866034A (en) * | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
SE8205892D0 (sv) * | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
DE3584866D1 (de) * | 1984-09-12 | 1992-01-23 | Chiron Corp | Hybridpartikel-immunogene. |
US4722898A (en) * | 1985-04-29 | 1988-02-02 | Minnesota Mining And Manufacturing Company | Immobilization of biological cells in polytetrafluoroethylene matrix |
GB8610983D0 (en) * | 1986-05-06 | 1986-06-11 | Connaught Lab | Enhancement of antigen immunogenicity |
US4879213A (en) * | 1986-12-05 | 1989-11-07 | Scripps Clinic And Research Foundation | Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse |
US5098998A (en) * | 1987-04-29 | 1992-03-24 | President And Fellows Of Harvard College | Cholera vaccines and peptides |
EP0316695B1 (de) * | 1987-11-16 | 1993-03-31 | F. Hoffmann-La Roche Ag | Rekombinante HIV-2 Polypeptide |
AU617739B2 (en) * | 1987-12-23 | 1991-12-05 | Pharmacia & Upjohn Company | Chimeric glycoproteins containing immunogenic segments of the glycoproteins of human respiratory syncytial virus |
ATE105334T1 (de) * | 1988-04-22 | 1994-05-15 | Upjohn Co | Schimaerische glykoproteine enthaltende immunogenische abschnitte von menschlichem parainfluenzavirus typ 3. |
FR2636842B1 (fr) | 1988-09-27 | 1994-06-10 | Liege Universite Etat | Proteine de fusion d'une sequence derivee de la sous-unite b de la toxine cholerique et d'un antigene heterologue doue de proprietes immunogenes, compositions de vaccins les contenant et acides nucleiques recombinants contenant une sequence de nucleotides codant pour ladite proteine de fusion |
EP0421626A1 (de) | 1989-09-19 | 1991-04-10 | Merck & Co. Inc. | Vakzin gegen AIDS und Hepatitis B |
GB9200117D0 (en) * | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
IL105456A (en) | 1992-04-21 | 1996-12-05 | American Home Prod | Vaccines of attenuated respiratory syncytial virus |
-
1992
- 1992-01-06 GB GB929200117A patent/GB9200117D0/en active Pending
-
1993
- 1993-01-05 DK DK93901988T patent/DK0621898T3/da active
- 1993-01-05 ES ES93901988T patent/ES2164070T3/es not_active Expired - Lifetime
- 1993-01-05 AT AT93901988T patent/ATE205535T1/de active
- 1993-01-05 RU RU94042722A patent/RU2123047C1/ru active
- 1993-01-05 PT PT93901988T patent/PT621898E/pt unknown
- 1993-01-05 EP EP93901988A patent/EP0621898B1/de not_active Expired - Lifetime
- 1993-01-05 WO PCT/CA1993/000001 patent/WO1993014207A1/en active IP Right Grant
- 1993-01-05 CA CA002126863A patent/CA2126863C/en not_active Expired - Lifetime
- 1993-01-05 AU AU33402/93A patent/AU667502B2/en not_active Expired
- 1993-01-05 DE DE69330745T patent/DE69330745T2/de not_active Expired - Lifetime
- 1993-01-05 JP JP51203593A patent/JP3290662B2/ja not_active Expired - Lifetime
- 1993-01-05 KR KR1019940702329A patent/KR100208310B1/ko not_active IP Right Cessation
- 1993-01-06 US US08/001,554 patent/US6225091B1/en not_active Expired - Lifetime
-
1994
- 1994-07-05 NO NO19942530A patent/NO316622B1/no not_active IP Right Cessation
- 1994-07-05 FI FI943211A patent/FI117514B/fi not_active IP Right Cessation
- 1994-11-14 US US08/344,639 patent/US6033668A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/467,961 patent/US6171783B1/en not_active Expired - Lifetime
- 1995-06-06 US US08/467,963 patent/US5968776A/en not_active Expired - Lifetime
- 1995-06-06 US US08/467,969 patent/US6168786B1/en not_active Expired - Lifetime
-
1997
- 1997-04-16 US US08/838,189 patent/US5998169A/en not_active Expired - Lifetime
- 1997-05-07 US US08/852,344 patent/US6017539A/en not_active Expired - Lifetime
-
2004
- 2004-05-10 US US10/842,032 patent/US7244589B2/en not_active Expired - Fee Related
-
2007
- 2007-06-13 US US11/808,802 patent/US7498153B2/en not_active Expired - Fee Related
- 2007-06-13 US US11/808,800 patent/US7405273B2/en not_active Expired - Fee Related
- 2007-06-13 US US11/808,807 patent/US7514535B2/en not_active Expired - Fee Related
- 2007-06-13 US US11/808,789 patent/US7619063B2/en not_active Expired - Fee Related
- 2007-06-13 US US11/808,794 patent/US7671186B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69330745T2 (de) | Chemerische immunogene | |
Weck et al. | Antiviral activities of hybrids of two major human leukocyte interferons | |
KR900700508A (ko) | 인간의 호흡기 합포체성 바이러스에 대한 당단백질 면역 단편을 함유하는 키메라(chimeric) 당단백질 | |
BR9608615A (pt) | Vacinas de vírus sincicial respiratório de ácido nucléico | |
DK0770679T3 (da) | HCV-specifikke peptider, præparater indeholdende dem og anvendelse deraf | |
WO1992017493A3 (en) | Peptides and mixtures thereof for detecting antibodies to hepatitis c virus (hcv) | |
DK251890A (da) | Polypeptid og dets anvendelse samt ekspressionssystem til dets eksprimering | |
ATE263243T1 (de) | Schützende antikörper induzierende antigene aus plasmodium falciparum | |
DE69515613D1 (de) | Immunogenes Hybridprotein OprF-Oprl erhältlich aus Membranproteinen von Pseudomonas aeruginosa | |
BR9202024A (pt) | Virus de apivox recombinante,cultura de celulas eucariotica infectadas por um virus de avipox,vacina,sequencia de transferencia e plasmideo | |
ATE355375T1 (de) | Bakterioferritin aus helicobacter pylori | |
KR890700030A (ko) | 인플루엔자균(Haemophilus influenzae)의 백신 및 진단방법 | |
Dietzschold et al. | Serological characterization of the three major proteins of vesicular stomatitis virus | |
EP0652287A3 (de) | Poxvirusvektoren und deren Anwendung als Impstoff gegen Katzenansteckende Peritonitis-Viruskrankheit. | |
ATE342920T1 (de) | Methylierte smd homologe peptide, die mit antikörpern aus sera von lebewesen mit systemischer lupus erythematodes reagieren | |
LU et al. | Preparation and development of equine hyperimmune globulin F (ab′) 2 against severe acute respiratory syndrome coronavirus 1 | |
EP0432220A4 (en) | Vaccines and diagnostic assays for haemophilus influenzae | |
EP1572721A4 (de) | Prävention und behandlung von hcv-infektionen unter anwendung von gegen konformationelle und lineare epitope gerichteten antikörpern | |
ATE201693T1 (de) | Hämoregulierende peptide | |
ATE133708T1 (de) | Immunogenisches peptid von echinococcus granulosis, dafür kodierende dns sowie diagnostische und therapeutische verwendungen | |
MY101874A (en) | Vaccine | |
WO1995005460A3 (en) | Feline immunodeficiency virus isolate ncsu 1 | |
DE69334276D1 (de) | Immunreaktive peptide des epstein-barrvirus | |
HU9201590D0 (en) | Recombinant vaccine against marek's illness | |
DK708488D0 (da) | Faktor i praeparat |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
R071 | Expiry of right |
Ref document number: 621898 Country of ref document: EP |