KR890700030A - 인플루엔자균(Haemophilus influenzae)의 백신 및 진단방법 - Google Patents
인플루엔자균(Haemophilus influenzae)의 백신 및 진단방법Info
- Publication number
- KR890700030A KR890700030A KR1019880701053A KR880701053A KR890700030A KR 890700030 A KR890700030 A KR 890700030A KR 1019880701053 A KR1019880701053 A KR 1019880701053A KR 880701053 A KR880701053 A KR 880701053A KR 890700030 A KR890700030 A KR 890700030A
- Authority
- KR
- South Korea
- Prior art keywords
- proteins
- peptides
- viruses
- pbomp
- influenzae
- Prior art date
Links
- 241000606768 Haemophilus influenzae Species 0.000 title abstract 4
- 229940047650 haemophilus influenzae Drugs 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 238000002405 diagnostic procedure Methods 0.000 title 1
- 206010022000 influenza Diseases 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 108090000623 proteins and genes Proteins 0.000 abstract 7
- 102000004169 proteins and genes Human genes 0.000 abstract 7
- 241000700605 Viruses Species 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 241000238631 Hexapoda Species 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 101710116435 Outer membrane protein Proteins 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 108020005202 Viral DNA Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 241001515965 unidentified phage Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94836486A | 1986-12-31 | 1986-12-31 | |
US948,364 | 1986-12-31 | ||
US2084987A | 1987-03-02 | 1987-03-02 | |
US020,849 | 1987-03-02 | ||
US13207387A | 1987-12-11 | 1987-12-11 | |
US132,073 | 1987-12-11 | ||
PCT/US1987/003423 WO1988004932A1 (en) | 1986-12-31 | 1987-12-23 | Vaccines and diagnostic assays for haemophilus influenzae |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890700030A true KR890700030A (ko) | 1989-03-02 |
KR960016208B1 KR960016208B1 (ko) | 1996-12-06 |
Family
ID=27361526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880701053A KR960016208B1 (ko) | 1986-12-31 | 1987-12-23 | 인플루엔자균(Haemophilus influenzae)의 백신 및 진단방법. |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP0786472A1 (ko) |
JP (5) | JP2534529B2 (ko) |
KR (1) | KR960016208B1 (ko) |
AT (1) | ATE159170T1 (ko) |
AU (1) | AU615429B2 (ko) |
CA (1) | CA1335655C (ko) |
DE (1) | DE3752131T2 (ko) |
DK (1) | DK482788A (ko) |
WO (1) | WO1988004932A1 (ko) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5300632A (en) * | 1986-11-18 | 1994-04-05 | Research Foundation Of State University Of New York | Method for purifying an outer membrane protein of Haemophilus influenzae |
NZ219515A (en) * | 1987-02-10 | 1989-09-27 | Wellcome Found | Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope |
AU623353B2 (en) * | 1987-12-10 | 1992-05-14 | Board Of Regents, The University Of Texas System | Methods and compositions for the production of haemophilus influenzae type b major outer membrane protein antigens |
CA1340888C (en) * | 1988-09-01 | 2000-02-01 | Algis Anilionis | Vaccines and diagnostic assays for haemophilus influenzae |
EP0606921B1 (en) * | 1989-03-09 | 2000-08-02 | American Cyanamid Company | Method of isolating haemophilus influenzae protein E |
ATE132160T1 (de) * | 1989-03-29 | 1996-01-15 | Univ New York State Res Found | Verfahren zur reinigung von aussenmembran-protein von haemophilus influenza |
FI903414A (fi) * | 1990-07-06 | 1992-01-07 | Kansanterveyslaitos | Produktion av proteiner i grampositiva bakterier. |
DE69127628T2 (de) * | 1991-10-01 | 1998-01-22 | Biostar Inc | Hochempfindlicher optischer Immunoassay durch Gebrauch von Enzymmarkierten Reagenz |
GB9202219D0 (en) * | 1992-02-03 | 1992-03-18 | Connaught Lab | A synthetic heamophilus influenzae conjugate vaccine |
DE4232073C2 (de) * | 1992-09-25 | 2001-09-20 | Chiron Behring Gmbh & Co | Verfahren zur immunchemischen Quantifizierung von inaktivierten, immunreaktiven Antigenen |
JPH07245887A (ja) * | 1994-03-08 | 1995-09-19 | Rhythm Watch Co Ltd | バックアップバッテリー回路 |
KR20040090987A (ko) * | 2002-01-25 | 2004-10-27 | 에리코 인터내셔날 코포레이션 | 용접 장치 및 용접 방법 |
AU2004215133B2 (en) | 2003-02-27 | 2010-10-14 | Yeda Research And Development Co. Ltd. | Nucleic acid molecules, polypeptides, antibodies and compositions containing same useful for treating and detecting influenza virus infection |
US20130156803A1 (en) | 2011-06-04 | 2013-06-20 | Rochester General Hospital Research Institute | Compositions and methods related to p6 |
JP5396498B2 (ja) | 2012-03-02 | 2014-01-22 | 株式会社エス・ケー・ジー | 発光装置 |
CN105242040B (zh) * | 2014-08-18 | 2017-01-18 | 董俊 | 人流感嗜血杆菌量子点免疫层析检测卡及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US304863A (en) | 1884-09-09 | Railway car | ||
US4237224A (en) | 1974-11-04 | 1980-12-02 | Board Of Trustees Of The Leland Stanford Jr. University | Process for producing biologically functional molecular chimeras |
US4261968A (en) * | 1979-05-10 | 1981-04-14 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4358535A (en) * | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
FI63596C (fi) * | 1981-10-16 | 1983-07-11 | Orion Yhtymae Oy | Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser |
US4455296A (en) * | 1982-02-02 | 1984-06-19 | Board Of Regents, The University Of Texas System | Hybrid cell lines producing monoclonal antibodies directed against Haemophilus influenzae |
GB8426469D0 (en) * | 1984-10-19 | 1984-11-28 | Technology Licence Co Ltd | Monoclonal antibodies |
US5173294A (en) * | 1986-11-18 | 1992-12-22 | Research Foundation Of State University Of New York | Dna probe for the identification of haemophilus influenzae |
-
1987
- 1987-02-02 JP JP62501089A patent/JP2534529B2/ja not_active Expired - Lifetime
- 1987-12-23 AT AT88900927T patent/ATE159170T1/de not_active IP Right Cessation
- 1987-12-23 AU AU11541/88A patent/AU615429B2/en not_active Expired
- 1987-12-23 EP EP96119698A patent/EP0786472A1/en not_active Withdrawn
- 1987-12-23 EP EP88900927A patent/EP0294469B1/en not_active Expired - Lifetime
- 1987-12-23 DE DE3752131T patent/DE3752131T2/de not_active Expired - Lifetime
- 1987-12-23 WO PCT/US1987/003423 patent/WO1988004932A1/en active IP Right Grant
- 1987-12-23 KR KR1019880701053A patent/KR960016208B1/ko not_active IP Right Cessation
- 1987-12-23 JP JP63501089A patent/JP2872254B2/ja not_active Expired - Lifetime
- 1987-12-24 CA CA000555440A patent/CA1335655C/en not_active Expired - Lifetime
-
1988
- 1988-08-30 DK DK482788A patent/DK482788A/da not_active Application Discontinuation
-
1997
- 1997-04-18 JP JP9101865A patent/JP3066339B2/ja not_active Expired - Lifetime
-
1998
- 1998-09-01 JP JP10247197A patent/JP3023089B2/ja not_active Expired - Lifetime
- 1998-11-30 JP JP10340385A patent/JP3124753B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH11146797A (ja) | 1999-06-02 |
EP0294469A4 (en) | 1990-02-05 |
DE3752131D1 (de) | 1997-11-20 |
AU615429B2 (en) | 1991-10-03 |
JP3124753B2 (ja) | 2001-01-15 |
AU1154188A (en) | 1988-07-27 |
JP2872254B2 (ja) | 1999-03-17 |
JPH1057059A (ja) | 1998-03-03 |
DK482788A (da) | 1988-10-31 |
JP3023089B2 (ja) | 2000-03-21 |
DK482788D0 (da) | 1988-08-30 |
KR960016208B1 (ko) | 1996-12-06 |
JPH11253160A (ja) | 1999-09-21 |
EP0294469B1 (en) | 1997-10-15 |
JPH01502190A (ja) | 1989-08-03 |
DE3752131T2 (de) | 1998-02-26 |
EP0294469A1 (en) | 1988-12-14 |
JPS63502314A (ja) | 1988-09-01 |
JP2534529B2 (ja) | 1996-09-18 |
ATE159170T1 (de) | 1997-11-15 |
JP3066339B2 (ja) | 2000-07-17 |
WO1988004932A1 (en) | 1988-07-14 |
CA1335655C (en) | 1995-05-23 |
EP0786472A1 (en) | 1997-07-30 |
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Legal Events
Date | Code | Title | Description |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20101129 Year of fee payment: 15 |
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EXPY | Expiration of term |