DE69324148D1 - Spiropiperidine und ihre Homologen, die die Ausschüttung von Wachstumshormon stimulieren. - Google Patents

Spiropiperidine und ihre Homologen, die die Ausschüttung von Wachstumshormon stimulieren.

Info

Publication number
DE69324148D1
DE69324148D1 DE69324148T DE69324148T DE69324148D1 DE 69324148 D1 DE69324148 D1 DE 69324148D1 DE 69324148 T DE69324148 T DE 69324148T DE 69324148 T DE69324148 T DE 69324148T DE 69324148 D1 DE69324148 D1 DE 69324148D1
Authority
DE
Germany
Prior art keywords
growth hormone
release
humans
promote
spiropiperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69324148T
Other languages
English (en)
Other versions
DE69324148T2 (de
Inventor
Meng-Hsin Chen
Arthur A Patchett
David B R Johnston
James R Tata
Ravi P Nargund
Lihu Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/146,848 external-priority patent/US5578593A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69324148D1 publication Critical patent/DE69324148D1/de
Application granted granted Critical
Publication of DE69324148T2 publication Critical patent/DE69324148T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Fodder In General (AREA)
  • Steroid Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Feed For Specific Animals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69324148T 1992-12-11 1993-12-08 Spiropiperidine und ihre Homologen, die die Ausschüttung von Wachstumshormon stimulieren. Expired - Fee Related DE69324148T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98932292A 1992-12-11 1992-12-11
US08/146,848 US5578593A (en) 1992-12-11 1993-11-03 Spiro piperidines and homologs promote release of growth hormone

Publications (2)

Publication Number Publication Date
DE69324148D1 true DE69324148D1 (de) 1999-04-29
DE69324148T2 DE69324148T2 (de) 1999-10-28

Family

ID=26844355

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69324148T Expired - Fee Related DE69324148T2 (de) 1992-12-11 1993-12-08 Spiropiperidine und ihre Homologen, die die Ausschüttung von Wachstumshormon stimulieren.

Country Status (14)

Country Link
EP (1) EP0662481B1 (de)
JP (1) JP2509147B2 (de)
CN (1) CN1040432C (de)
AT (1) ATE178070T1 (de)
AU (1) AU673017B2 (de)
CA (1) CA2110672A1 (de)
DE (1) DE69324148T2 (de)
DZ (1) DZ1735A1 (de)
ES (1) ES2129072T3 (de)
HR (1) HRP931484A2 (de)
IL (1) IL107836A (de)
MX (1) MX9307851A (de)
PH (1) PH31168A (de)
SI (1) SI9300647A (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
TW432073B (en) * 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
EP0900086A4 (de) * 1996-05-07 2000-01-12 Merck & Co Inc Verbesserung des schlafs mittels eines die sekretion von wachstumshormonen fördernden stoffes
WO1998016527A1 (en) * 1996-10-15 1998-04-23 Fujisawa Pharmaceutical Co., Ltd. Benzoxepine derivatives which promote release of growth hormone
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
CO5160260A1 (es) * 1999-02-19 2002-05-30 Lilly Co Eli Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido
US6828331B1 (en) 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
US7125840B2 (en) 2001-10-09 2006-10-24 Eli Lilly And Company Substituted dipeptides as growth hormone secretagogues
ES2271557T3 (es) 2002-04-09 2007-04-16 Eli Lilly And Company Secretagogos dipeptidicos de la hormona del crecimiento.
DE10317878A1 (de) * 2003-04-17 2004-11-11 Consortium für elektrochemische Industrie GmbH Verfahren zur Herstellung von alpha-methylierten Cystein und Serin-Derivaten
KR101285483B1 (ko) * 2004-10-28 2013-07-12 상꾜 가부시키가이샤 광학 활성 4,4-2치환 옥사졸리딘 유도체와 그 제조 방법
CN101081835B (zh) * 2006-05-30 2011-09-21 上海药明康德新药开发有限公司 一种螺[苯并环-3-酮-1-(4′-哌啶)]模板化合物的合成方法
JP5271917B2 (ja) * 2007-01-12 2013-08-21 メルク・シャープ・アンド・ドーム・コーポレーション スピロクロマノン誘導体
JP5585822B2 (ja) * 2010-05-11 2014-09-10 東レ・ファインケミカル株式会社 光学活性ニペコチン酸誘導体の製造方法
WO2022228318A1 (zh) * 2021-04-25 2022-11-03 长春金赛药业有限责任公司 含吲哚啉螺环类衍生物、其制备方法及其在医药上的应用
WO2024083164A1 (zh) * 2022-10-21 2024-04-25 长春金赛药业有限责任公司 吲哚啉螺环类化合物的溶剂化物及其晶型、制备方法和应用
WO2024083160A1 (zh) * 2022-10-21 2024-04-25 长春金赛药业有限责任公司 吲哚啉螺环类化合物的晶型、无定形物及二者的制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8332704D0 (en) * 1983-12-07 1984-01-11 Pfizer Ltd Growth promotants for animals
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone

Also Published As

Publication number Publication date
CN1092767A (zh) 1994-09-28
CN1040432C (zh) 1998-10-28
JPH0797367A (ja) 1995-04-11
AU5232193A (en) 1994-06-23
MX9307851A (es) 1994-06-30
ES2129072T3 (es) 1999-06-01
IL107836A0 (en) 1994-04-12
HRP931484A2 (en) 1996-04-30
PH31168A (en) 1998-03-20
CA2110672A1 (en) 1994-06-12
JP2509147B2 (ja) 1996-06-19
AU673017B2 (en) 1996-10-24
IL107836A (en) 1998-01-04
ATE178070T1 (de) 1999-04-15
EP0662481A1 (de) 1995-07-12
DE69324148T2 (de) 1999-10-28
SI9300647A (en) 1994-09-30
DZ1735A1 (fr) 2002-02-17
EP0662481B1 (de) 1999-03-24

Similar Documents

Publication Publication Date Title
ATE220071T1 (de) Spiropiperidine and ihre homologen, die die ausschüttung von wachstumshormonen stimulieren
MY131439A (en) Spiro piperidines and homologs promote release of growth hormone
DE69324148D1 (de) Spiropiperidine und ihre Homologen, die die Ausschüttung von Wachstumshormon stimulieren.
IL101206A0 (en) Benzo-fused lactams,their preparation and pharmaceutical compositions containing them
DK1179984T3 (da) Metode til fremstilling af en sammensætning til forbedring af immunforsvaret hos kæledyr under anvendelse af en kombination af antioxidanter
ZA88152B (en) Sustained release growth hormone compositions for parenteral administration and their use
DE60010711D1 (de) Amido-spiropiperidine promovieren die freisetzung von wachstumshormonen
ITMI910705U1 (it) Manufatti per l'alimentazione stimolatori dell'assunzione del cibo

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee