MX9307851A - Las espiropiperidinas y homologos promueven la liberacion de la hormona del crecimiento. - Google Patents

Las espiropiperidinas y homologos promueven la liberacion de la hormona del crecimiento.

Info

Publication number
MX9307851A
MX9307851A MX9307851A MX9307851A MX9307851A MX 9307851 A MX9307851 A MX 9307851A MX 9307851 A MX9307851 A MX 9307851A MX 9307851 A MX9307851 A MX 9307851A MX 9307851 A MX9307851 A MX 9307851A
Authority
MX
Mexico
Prior art keywords
growth hormone
promote
release
homologos
spiropiperidines
Prior art date
Application number
MX9307851A
Other languages
English (en)
Inventor
Ravi P Nargund
Arthur A Patchett
James R Tata
Meng-Hsin Chen
Lihu Yang
David B R Johnston
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/146,848 external-priority patent/US5578593A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX9307851A publication Critical patent/MX9307851A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Se describen ciertos compuestos nuevos que se identifican como espiropiperidinas y homólogos que promueven la liberación de la hormona del crecimiento en humanos y animales. Esta propiedad se puede utilizar para promover el crecimiento de animales de comida para rendir la producción más eficiente de productos de carne comestible, y en humanos, para tratar condiciones fisiológicas ó médicas caracterizadas por una deficiencia en la secreción de la hormona del crecimiento, tales como corta estatura en niños deficientes de hormona del crecimiento, y para tratar condiciones médicas que se mejoran mediante los efectos anabólicos de la hormona del crecimiento. También se describen las composiciones de liberación de la hormona del crecimiento que contienen estos compuestos espiro como el ingrediente activo en los mismos.
MX9307851A 1992-12-11 1993-12-10 Las espiropiperidinas y homologos promueven la liberacion de la hormona del crecimiento. MX9307851A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98932292A 1992-12-11 1992-12-11
US08/146,848 US5578593A (en) 1992-12-11 1993-11-03 Spiro piperidines and homologs promote release of growth hormone

Publications (1)

Publication Number Publication Date
MX9307851A true MX9307851A (es) 1994-06-30

Family

ID=26844355

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9307851A MX9307851A (es) 1992-12-11 1993-12-10 Las espiropiperidinas y homologos promueven la liberacion de la hormona del crecimiento.

Country Status (14)

Country Link
EP (1) EP0662481B1 (es)
JP (1) JP2509147B2 (es)
CN (1) CN1040432C (es)
AT (1) ATE178070T1 (es)
AU (1) AU673017B2 (es)
CA (1) CA2110672A1 (es)
DE (1) DE69324148T2 (es)
DZ (1) DZ1735A1 (es)
ES (1) ES2129072T3 (es)
HR (1) HRP931484A2 (es)
IL (1) IL107836A (es)
MX (1) MX9307851A (es)
PH (1) PH31168A (es)
SI (1) SI9300647A (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
TW432073B (en) * 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
EP0900086A4 (en) * 1996-05-07 2000-01-12 Merck & Co Inc IMPROVING THE SLEEP BY MEANS OF A SUBSTANCE PROMOTING THE SECRETION OF GROWTH HORMONES
WO1998016527A1 (en) * 1996-10-15 1998-04-23 Fujisawa Pharmaceutical Co., Ltd. Benzoxepine derivatives which promote release of growth hormone
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
CO5160260A1 (es) * 1999-02-19 2002-05-30 Lilly Co Eli Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido
US6828331B1 (en) 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
US7125840B2 (en) 2001-10-09 2006-10-24 Eli Lilly And Company Substituted dipeptides as growth hormone secretagogues
ES2271557T3 (es) 2002-04-09 2007-04-16 Eli Lilly And Company Secretagogos dipeptidicos de la hormona del crecimiento.
DE10317878A1 (de) * 2003-04-17 2004-11-11 Consortium für elektrochemische Industrie GmbH Verfahren zur Herstellung von alpha-methylierten Cystein und Serin-Derivaten
KR101285483B1 (ko) * 2004-10-28 2013-07-12 상꾜 가부시키가이샤 광학 활성 4,4-2치환 옥사졸리딘 유도체와 그 제조 방법
CN101081835B (zh) * 2006-05-30 2011-09-21 上海药明康德新药开发有限公司 一种螺[苯并环-3-酮-1-(4′-哌啶)]模板化合物的合成方法
JP5271917B2 (ja) * 2007-01-12 2013-08-21 メルク・シャープ・アンド・ドーム・コーポレーション スピロクロマノン誘導体
JP5585822B2 (ja) * 2010-05-11 2014-09-10 東レ・ファインケミカル株式会社 光学活性ニペコチン酸誘導体の製造方法
WO2022228318A1 (zh) * 2021-04-25 2022-11-03 长春金赛药业有限责任公司 含吲哚啉螺环类衍生物、其制备方法及其在医药上的应用
WO2024083164A1 (zh) * 2022-10-21 2024-04-25 长春金赛药业有限责任公司 吲哚啉螺环类化合物的溶剂化物及其晶型、制备方法和应用
WO2024083160A1 (zh) * 2022-10-21 2024-04-25 长春金赛药业有限责任公司 吲哚啉螺环类化合物的晶型、无定形物及二者的制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8332704D0 (en) * 1983-12-07 1984-01-11 Pfizer Ltd Growth promotants for animals
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone

Also Published As

Publication number Publication date
CN1092767A (zh) 1994-09-28
CN1040432C (zh) 1998-10-28
JPH0797367A (ja) 1995-04-11
DE69324148D1 (de) 1999-04-29
AU5232193A (en) 1994-06-23
ES2129072T3 (es) 1999-06-01
IL107836A0 (en) 1994-04-12
HRP931484A2 (en) 1996-04-30
PH31168A (en) 1998-03-20
CA2110672A1 (en) 1994-06-12
JP2509147B2 (ja) 1996-06-19
AU673017B2 (en) 1996-10-24
IL107836A (en) 1998-01-04
ATE178070T1 (de) 1999-04-15
EP0662481A1 (en) 1995-07-12
DE69324148T2 (de) 1999-10-28
SI9300647A (en) 1994-09-30
DZ1735A1 (fr) 2002-02-17
EP0662481B1 (en) 1999-03-24

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MY131439A (en) Spiro piperidines and homologs promote release of growth hormone
MX9307851A (es) Las espiropiperidinas y homologos promueven la liberacion de la hormona del crecimiento.
IL101206A0 (en) Benzo-fused lactams,their preparation and pharmaceutical compositions containing them
ZA88152B (en) Sustained release growth hormone compositions for parenteral administration and their use
ATE266658T1 (de) Amido-spiropiperidine promovieren die freisetzung von wachstumshormonen
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Legal Events

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FG Grant or registration
MM Annulment or lapse due to non-payment of fees