ATE178070T1 - Spiropiperidine und ihre homologen, die die ausschüttung von wachstumshormon stimulieren. - Google Patents
Spiropiperidine und ihre homologen, die die ausschüttung von wachstumshormon stimulieren.Info
- Publication number
- ATE178070T1 ATE178070T1 AT93309868T AT93309868T ATE178070T1 AT E178070 T1 ATE178070 T1 AT E178070T1 AT 93309868 T AT93309868 T AT 93309868T AT 93309868 T AT93309868 T AT 93309868T AT E178070 T1 ATE178070 T1 AT E178070T1
- Authority
- AT
- Austria
- Prior art keywords
- growth hormone
- release
- humans
- promote
- spiropiperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Fodder In General (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Feed For Specific Animals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98932292A | 1992-12-11 | 1992-12-11 | |
US08/146,848 US5578593A (en) | 1992-12-11 | 1993-11-03 | Spiro piperidines and homologs promote release of growth hormone |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE178070T1 true ATE178070T1 (de) | 1999-04-15 |
Family
ID=26844355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93309868T ATE178070T1 (de) | 1992-12-11 | 1993-12-08 | Spiropiperidine und ihre homologen, die die ausschüttung von wachstumshormon stimulieren. |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0662481B1 (de) |
JP (1) | JP2509147B2 (de) |
CN (1) | CN1040432C (de) |
AT (1) | ATE178070T1 (de) |
AU (1) | AU673017B2 (de) |
CA (1) | CA2110672A1 (de) |
DE (1) | DE69324148T2 (de) |
DZ (1) | DZ1735A1 (de) |
ES (1) | ES2129072T3 (de) |
HR (1) | HRP931484A2 (de) |
IL (1) | IL107836A (de) |
MX (1) | MX9307851A (de) |
PH (1) | PH31168A (de) |
SI (1) | SI9300647A (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK78692D0 (da) * | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
TW432073B (en) * | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
CA2253390A1 (en) * | 1996-05-07 | 1997-11-13 | Merck & Co., Inc. | Enhancement of sleep with a growth hormone secretagogue |
WO1998016527A1 (en) * | 1996-10-15 | 1998-04-23 | Fujisawa Pharmaceutical Co., Ltd. | Benzoxepine derivatives which promote release of growth hormone |
US6639076B1 (en) | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
CO5160260A1 (es) * | 1999-02-19 | 2002-05-30 | Lilly Co Eli | Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido |
US6828331B1 (en) | 1999-02-19 | 2004-12-07 | Eli Lilly And Company | Growth hormone secretagogues |
US7125840B2 (en) | 2001-10-09 | 2006-10-24 | Eli Lilly And Company | Substituted dipeptides as growth hormone secretagogues |
WO2003087069A2 (en) | 2002-04-09 | 2003-10-23 | Eli Lilly And Company | Dipeptidic growth hormone secretagogues |
DE10317878A1 (de) * | 2003-04-17 | 2004-11-11 | Consortium für elektrochemische Industrie GmbH | Verfahren zur Herstellung von alpha-methylierten Cystein und Serin-Derivaten |
US7547790B2 (en) * | 2004-10-28 | 2009-06-16 | Sankyo Company, Limited | Optically active 4,4-di-substituted oxazolidine derivative and method for producing same |
CN101081835B (zh) * | 2006-05-30 | 2011-09-21 | 上海药明康德新药开发有限公司 | 一种螺[苯并环-3-酮-1-(4′-哌啶)]模板化合物的合成方法 |
JP5271917B2 (ja) * | 2007-01-12 | 2013-08-21 | メルク・シャープ・アンド・ドーム・コーポレーション | スピロクロマノン誘導体 |
JP5585822B2 (ja) * | 2010-05-11 | 2014-09-10 | 東レ・ファインケミカル株式会社 | 光学活性ニペコチン酸誘導体の製造方法 |
KR20230145454A (ko) * | 2021-04-25 | 2023-10-17 | 장춘 진사이언스 파마슈티컬 씨오., 엘티디. | 인돌린 함유 스피로 고리 유도체, 그 제조 방법 및 의약에서의 응용 |
WO2024083160A1 (zh) * | 2022-10-21 | 2024-04-25 | 长春金赛药业有限责任公司 | 吲哚啉螺环类化合物的晶型、无定形物及二者的制备方法和应用 |
WO2024083164A1 (zh) * | 2022-10-21 | 2024-04-25 | 长春金赛药业有限责任公司 | 吲哚啉螺环类化合物的溶剂化物及其晶型、制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8332704D0 (en) * | 1983-12-07 | 1984-01-11 | Pfizer Ltd | Growth promotants for animals |
US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
-
1993
- 1993-12-02 IL IL107836A patent/IL107836A/en active IP Right Grant
- 1993-12-03 CA CA002110672A patent/CA2110672A1/en not_active Abandoned
- 1993-12-08 AT AT93309868T patent/ATE178070T1/de not_active IP Right Cessation
- 1993-12-08 EP EP93309868A patent/EP0662481B1/de not_active Expired - Lifetime
- 1993-12-08 DE DE69324148T patent/DE69324148T2/de not_active Expired - Fee Related
- 1993-12-08 ES ES93309868T patent/ES2129072T3/es not_active Expired - Lifetime
- 1993-12-08 DZ DZ930130A patent/DZ1735A1/fr active
- 1993-12-10 SI SI9300647A patent/SI9300647A/sl unknown
- 1993-12-10 JP JP5341449A patent/JP2509147B2/ja not_active Expired - Lifetime
- 1993-12-10 MX MX9307851A patent/MX9307851A/es not_active IP Right Cessation
- 1993-12-10 AU AU52321/93A patent/AU673017B2/en not_active Ceased
- 1993-12-10 HR HR931484A patent/HRP931484A2/hr not_active Application Discontinuation
- 1993-12-10 PH PH47421A patent/PH31168A/en unknown
- 1993-12-11 CN CN93112857A patent/CN1040432C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
MX9307851A (es) | 1994-06-30 |
JP2509147B2 (ja) | 1996-06-19 |
EP0662481A1 (de) | 1995-07-12 |
JPH0797367A (ja) | 1995-04-11 |
CN1040432C (zh) | 1998-10-28 |
IL107836A0 (en) | 1994-04-12 |
ES2129072T3 (es) | 1999-06-01 |
AU5232193A (en) | 1994-06-23 |
EP0662481B1 (de) | 1999-03-24 |
IL107836A (en) | 1998-01-04 |
CA2110672A1 (en) | 1994-06-12 |
CN1092767A (zh) | 1994-09-28 |
DE69324148D1 (de) | 1999-04-29 |
DE69324148T2 (de) | 1999-10-28 |
HRP931484A2 (en) | 1996-04-30 |
PH31168A (en) | 1998-03-20 |
DZ1735A1 (fr) | 2002-02-17 |
AU673017B2 (en) | 1996-10-24 |
SI9300647A (en) | 1994-09-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE220071T1 (de) | Spiropiperidine and ihre homologen, die die ausschüttung von wachstumshormonen stimulieren | |
MY131439A (en) | Spiro piperidines and homologs promote release of growth hormone | |
ATE178070T1 (de) | Spiropiperidine und ihre homologen, die die ausschüttung von wachstumshormon stimulieren. | |
IL101206A0 (en) | Benzo-fused lactams,their preparation and pharmaceutical compositions containing them | |
DE69331197T2 (de) | Die freisetzung von wachstumshormon stimulierende benzoverknüpfte lactame | |
DK1179984T3 (da) | Metode til fremstilling af en sammensætning til forbedring af immunforsvaret hos kæledyr under anvendelse af en kombination af antioxidanter | |
ATE266658T1 (de) | Amido-spiropiperidine promovieren die freisetzung von wachstumshormonen | |
ITMI910705U1 (it) | Manufatti per l'alimentazione stimolatori dell'assunzione del cibo |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |