IL107836A - Spiro piperidines and homologues, their preparation and pharmaceutical preparations containing them - Google Patents

Spiro piperidines and homologues, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL107836A
IL107836A IL107836A IL10783693A IL107836A IL 107836 A IL107836 A IL 107836A IL 107836 A IL107836 A IL 107836A IL 10783693 A IL10783693 A IL 10783693A IL 107836 A IL107836 A IL 107836A
Authority
IL
Israel
Prior art keywords
amino
indene
alkyl
oxopropyl
methyl
Prior art date
Application number
IL107836A
Other languages
English (en)
Hebrew (he)
Other versions
IL107836A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/146,848 external-priority patent/US5578593A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL107836A0 publication Critical patent/IL107836A0/xx
Publication of IL107836A publication Critical patent/IL107836A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06191Dipeptides containing heteroatoms different from O, S, or N
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Fodder In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Feed For Specific Animals (AREA)
IL107836A 1992-12-11 1993-12-02 Spiro piperidines and homologues, their preparation and pharmaceutical preparations containing them IL107836A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98932292A 1992-12-11 1992-12-11
US08/146,848 US5578593A (en) 1992-12-11 1993-11-03 Spiro piperidines and homologs promote release of growth hormone

Publications (2)

Publication Number Publication Date
IL107836A0 IL107836A0 (en) 1994-04-12
IL107836A true IL107836A (en) 1998-01-04

Family

ID=26844355

Family Applications (1)

Application Number Title Priority Date Filing Date
IL107836A IL107836A (en) 1992-12-11 1993-12-02 Spiro piperidines and homologues, their preparation and pharmaceutical preparations containing them

Country Status (14)

Country Link
EP (1) EP0662481B1 (de)
JP (1) JP2509147B2 (de)
CN (1) CN1040432C (de)
AT (1) ATE178070T1 (de)
AU (1) AU673017B2 (de)
CA (1) CA2110672A1 (de)
DE (1) DE69324148T2 (de)
DZ (1) DZ1735A1 (de)
ES (1) ES2129072T3 (de)
HR (1) HRP931484A2 (de)
IL (1) IL107836A (de)
MX (1) MX9307851A (de)
PH (1) PH31168A (de)
SI (1) SI9300647A (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
EP0900086A4 (de) * 1996-05-07 2000-01-12 Merck & Co Inc Verbesserung des schlafs mittels eines die sekretion von wachstumshormonen fördernden stoffes
WO1998016527A1 (en) * 1996-10-15 1998-04-23 Fujisawa Pharmaceutical Co., Ltd. Benzoxepine derivatives which promote release of growth hormone
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
US6828331B1 (en) 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
CO5160260A1 (es) * 1999-02-19 2002-05-30 Lilly Co Eli Secretagogos de la hormona del crecimiento derivados de imi- dazol 1,4- substituido
US7125840B2 (en) 2001-10-09 2006-10-24 Eli Lilly And Company Substituted dipeptides as growth hormone secretagogues
WO2003087069A2 (en) 2002-04-09 2003-10-23 Eli Lilly And Company Dipeptidic growth hormone secretagogues
DE10317878A1 (de) * 2003-04-17 2004-11-11 Consortium für elektrochemische Industrie GmbH Verfahren zur Herstellung von alpha-methylierten Cystein und Serin-Derivaten
US7547790B2 (en) * 2004-10-28 2009-06-16 Sankyo Company, Limited Optically active 4,4-di-substituted oxazolidine derivative and method for producing same
CN101081835B (zh) * 2006-05-30 2011-09-21 上海药明康德新药开发有限公司 一种螺[苯并环-3-酮-1-(4′-哌啶)]模板化合物的合成方法
WO2008088692A2 (en) * 2007-01-12 2008-07-24 Merck & Co., Inc. Spirochromanon derivatives
JP5585822B2 (ja) * 2010-05-11 2014-09-10 東レ・ファインケミカル株式会社 光学活性ニペコチン酸誘導体の製造方法
CA3209937A1 (en) * 2021-04-25 2022-11-03 Changchun Genescience Pharmaceutical Co., Ltd. Spiroindoline derivative, and preparation method and medical use thereof
WO2024083160A1 (zh) * 2022-10-21 2024-04-25 长春金赛药业有限责任公司 吲哚啉螺环类化合物的晶型、无定形物及二者的制备方法和应用
WO2024083164A1 (zh) * 2022-10-21 2024-04-25 长春金赛药业有限责任公司 吲哚啉螺环类化合物的溶剂化物及其晶型、制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8332704D0 (en) * 1983-12-07 1984-01-11 Pfizer Ltd Growth promotants for animals
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone

Also Published As

Publication number Publication date
CA2110672A1 (en) 1994-06-12
JPH0797367A (ja) 1995-04-11
EP0662481A1 (de) 1995-07-12
EP0662481B1 (de) 1999-03-24
CN1092767A (zh) 1994-09-28
AU5232193A (en) 1994-06-23
DZ1735A1 (fr) 2002-02-17
ATE178070T1 (de) 1999-04-15
HRP931484A2 (en) 1996-04-30
JP2509147B2 (ja) 1996-06-19
ES2129072T3 (es) 1999-06-01
SI9300647A (en) 1994-09-30
AU673017B2 (en) 1996-10-24
MX9307851A (es) 1994-06-30
DE69324148D1 (de) 1999-04-29
PH31168A (en) 1998-03-20
DE69324148T2 (de) 1999-10-28
IL107836A0 (en) 1994-04-12
CN1040432C (zh) 1998-10-28

Similar Documents

Publication Publication Date Title
US5578593A (en) Spiro piperidines and homologs promote release of growth hormone
EP0662481B1 (de) Spiropiperidine und ihre Homologen, die die Ausschüttung von Wachstumshormon stimulieren.
EP0615977B1 (de) Spiropiperidine and ihre Homologen, die die Ausschüttung von Wachstumshormonen stimulieren
EP0739204A4 (de) Piperidine, pyrrolidine und hexahydro-1h-azepine unterstützen die freisetzung des wachstumshormon
WO1995014666A1 (en) Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s)
WO1998010653A1 (en) Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
WO1997036873A1 (en) Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
US5965565A (en) Piperidines promote release of growth hormone
GB2298647A (en) Bridged piperidines promoting release of growth hormone
WO1997011697A1 (en) 3-spirolactam, 3-spiroamino, 3-spirolactone and 3-spirobenzopyran piperidines and pyrrolidines promote release of growth hormone
WO1998025897A1 (en) Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
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