DE69323060D1 - Optische Detektorvorrichtung für die chemische Analyse von kleinen fluiden Probenvolumina - Google Patents

Optische Detektorvorrichtung für die chemische Analyse von kleinen fluiden Probenvolumina

Info

Publication number
DE69323060D1
DE69323060D1 DE69323060T DE69323060T DE69323060D1 DE 69323060 D1 DE69323060 D1 DE 69323060D1 DE 69323060 T DE69323060 T DE 69323060T DE 69323060 T DE69323060 T DE 69323060T DE 69323060 D1 DE69323060 D1 DE 69323060D1
Authority
DE
Germany
Prior art keywords
fluid sample
optical detector
chemical analysis
detector device
sample volumes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69323060T
Other languages
English (en)
Other versions
DE69323060T2 (de
Inventor
Alfredo Emilio Dr Bruno
Beat Krattiger
Carlo S Dr Effenhauser
Francois Dr Maystre
Philippe Nussbaum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeptosens AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE69323060D1 publication Critical patent/DE69323060D1/de
Application granted granted Critical
Publication of DE69323060T2 publication Critical patent/DE69323060T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DE69323060T 1993-03-18 1993-03-18 Optische Detektorvorrichtung für die chemische Analyse von kleinen fluiden Probenvolumina Expired - Fee Related DE69323060T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93810196A EP0616211B1 (de) 1993-03-18 1993-03-18 Optische Detektorvorrichtung für die chemische Analyse von kleinen fluiden Probenvolumina

Publications (2)

Publication Number Publication Date
DE69323060D1 true DE69323060D1 (de) 1999-02-25
DE69323060T2 DE69323060T2 (de) 1999-06-10

Family

ID=8214934

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69323060T Expired - Fee Related DE69323060T2 (de) 1993-03-18 1993-03-18 Optische Detektorvorrichtung für die chemische Analyse von kleinen fluiden Probenvolumina

Country Status (4)

Country Link
US (1) US5636017A (de)
EP (1) EP0616211B1 (de)
JP (1) JPH06300690A (de)
DE (1) DE69323060T2 (de)

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EP1978351B1 (de) 1998-05-16 2011-11-30 Life Technologies Corporation Instrument zur Überwachung der Polymerase-Kettenreaktion von DNS
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
DE19824652A1 (de) * 1998-05-25 2000-01-20 Analyticon Ag Biotechnologie P Vorrichtung zur Detektion von flüssigchromatographisch getrennten Substanzen mittels UV- oder Fluoreszenzspektren
US6608671B2 (en) 1998-07-17 2003-08-19 Vertex Pharmaceuticals (San Diego) Llc Detector and screening device for ion channels
US6349160B2 (en) 1998-07-24 2002-02-19 Aurora Biosciences Corporation Detector and screening device for ion channels
DE19905983C2 (de) * 1999-02-12 2001-09-06 J & M Analytische Mess & Regeltechnik Gmbh Verfahren zum Herstellen eines Kapillarenhalters
US6378588B1 (en) * 1999-05-28 2002-04-30 The Standard Register Company Apparatus for in-line folding and affixing of tuck label
US6381025B1 (en) * 1999-08-19 2002-04-30 Texas Tech University Interferometric detection system and method
KR100360069B1 (ko) * 2000-05-29 2002-11-07 김성호 분석장치 및 생화학적 시료의 정량 방법
US6809828B2 (en) 2001-01-25 2004-10-26 Texas Tech University Universal detector for biological and chemical separations or assays using plastic microfluidic devices
DE10126282A1 (de) * 2001-02-01 2002-08-29 Hartmut Schlichting Gerät zur automatischen Gel-Elektrophorese, zum Blotten und zur Immundetektion
JP2004537053A (ja) 2001-07-25 2004-12-09 アプレラ コーポレイション 電気泳動検出システムにおける時間遅延積分
US7280207B2 (en) 2001-07-25 2007-10-09 Applera Corporation Time-delay integration in a flow cytometry system
US7265833B2 (en) 2001-07-25 2007-09-04 Applera Corporation Electrophoretic system with multi-notch filter and laser excitation source
US7250098B2 (en) * 2001-09-28 2007-07-31 Applera Corporation Multi-capillary array electrophoresis device
GB0219248D0 (en) * 2002-08-17 2002-09-25 Univ York OPtical assembly and method for detection of light transmission
US20040204866A1 (en) * 2003-04-09 2004-10-14 Allington Robert W. Method and apparatus to enhance the signal to noise ratio in chromatography
FR2878032B1 (fr) * 2004-11-18 2007-03-02 Horiba Abx Sa Sa Dispositif d'inspection d'un fluide par illumination uniforme au moyen d'un guide de lumiere conforme
WO2006081479A2 (en) * 2005-01-27 2006-08-03 Applera Corporation Sample preparation devices and methods
US9518955B2 (en) 2005-12-12 2016-12-13 Advanced Analytical Technologies, Inc. Capillary electrophoresis fluorescent detection system
US20070131870A1 (en) * 2005-12-12 2007-06-14 Combisep Multiplexed CE fluorescence system
WO2009039466A1 (en) 2007-09-20 2009-03-26 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
WO2011156713A1 (en) 2010-06-11 2011-12-15 Vanderbilt University Multiplexed interferometric detection system and method
GB201016270D0 (en) 2010-09-28 2010-11-10 Univ St Andrews Waveguide localised raman spectroscopy
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
US8901513B2 (en) 2011-03-08 2014-12-02 Horiba Instruments, Incorporated System and method for fluorescence and absorbance analysis
US9140666B2 (en) 2012-03-15 2015-09-22 Advanced Analytical Technologies, Inc. Capillary electrophoresis system
US11016057B2 (en) 2012-03-15 2021-05-25 Agilent Technologies, Inc. Pulse-field multiplex capillary electrophoresis system
US11340191B2 (en) 2012-03-15 2022-05-24 Agilent Technologies, Inc. UV-absorbance multichannel capillary electrophoresis system
KR101309129B1 (ko) * 2012-03-15 2013-09-16 주식회사 메카시스 소량 시료의 분석을 위한 시료 장착 장치와 이를 이용한 분석장치 및 분석방법
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
JP6196502B2 (ja) * 2013-08-30 2017-09-13 シスメックス株式会社 検体分析方法および検体分析装置
DE102014104268A1 (de) * 2014-03-26 2015-10-01 Anton Paar Gmbh Optisches Messsystem zum Messen von polarisationsoptischen Eigenschaften einer Probe
AU2015259004B2 (en) 2014-05-15 2018-11-08 Brigham Young University Low-power miniature LED-based UV absorption detector with low detection limits for capillary liquid chromatography
US10184892B2 (en) 2014-10-29 2019-01-22 Horiba Instruments Incorporated Determination of water treatment parameters based on absorbance and fluorescence
US9670072B2 (en) 2014-10-29 2017-06-06 Horiba Instruments Incorporated Determination of water treatment parameters based on absorbance and fluorescence
JP2018506715A (ja) 2015-01-23 2018-03-08 ヴァンダービルト ユニバーシティー 堅固なインターフェロメーター及びその使用方法
US10627396B2 (en) 2016-01-29 2020-04-21 Vanderbilt University Free-solution response function interferometry
US10901228B2 (en) * 2017-06-27 2021-01-26 The Boeing Company Cavity with curved beam replicator and method of determining a characteristic of a medium therein
EP3444603A3 (de) * 2017-08-15 2019-03-06 Advanced Analytical Technologies, Inc. Mehrkanalige kapillarelektrophoresesystem mit uv-absorption
US10843152B2 (en) 2017-08-29 2020-11-24 Delaware Capital Formation, Inc. Out-of-product detection using optical sensors
WO2019244358A1 (ja) * 2018-06-22 2019-12-26 株式会社日立ハイテクノロジーズ 電気泳動装置

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JPS55156840A (en) * 1979-05-25 1980-12-06 Olympus Optical Co Ltd Specimen detector
US4816123A (en) * 1986-04-16 1989-03-28 The Perkin-Elmer Corporation Method of fabricating capillary electrophoresis separation channels
US5199966A (en) * 1988-04-29 1993-04-06 At&T Bell Laboratories Optical coupler method
US5037199A (en) * 1989-02-22 1991-08-06 Linear Instruments Corporation Ball lens micro-cell
NL8902294A (nl) * 1989-09-14 1991-04-02 Philips Nv Werkwijze voor het vervaardigen van een uit optische vezels samengestelde vezelbundel.
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US5092973A (en) * 1990-01-26 1992-03-03 The Board Of Trustees Of The Leland Stanford Junior University Rectangular capillaries for capillary electrophoresis
JPH0663964B2 (ja) * 1990-09-05 1994-08-22 日本分光工業株式会社 微小流動セル
DE4139211C2 (de) * 1990-11-30 1994-03-24 Hitachi Ltd Elektrophoresegerät
US5324401A (en) * 1993-02-05 1994-06-28 Iowa State University Research Foundation, Inc. Multiplexed fluorescence detector system for capillary electrophoresis

Also Published As

Publication number Publication date
JPH06300690A (ja) 1994-10-28
DE69323060T2 (de) 1999-06-10
US5636017A (en) 1997-06-03
EP0616211B1 (de) 1999-01-13
EP0616211A1 (de) 1994-09-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ZEPTOSENS AG, WITTERSWIL, CH

8339 Ceased/non-payment of the annual fee