DE69319914T2 - Vernetzte polymerische ammoniumsalze - Google Patents

Vernetzte polymerische ammoniumsalze

Info

Publication number
DE69319914T2
DE69319914T2 DE69319914T DE69319914T DE69319914T2 DE 69319914 T2 DE69319914 T2 DE 69319914T2 DE 69319914 T DE69319914 T DE 69319914T DE 69319914 T DE69319914 T DE 69319914T DE 69319914 T2 DE69319914 T2 DE 69319914T2
Authority
DE
Germany
Prior art keywords
pct
groups
atoms
ammonium
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69319914T
Other languages
English (en)
Other versions
DE69319914D1 (de
Inventor
Garret Figuly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of DE69319914D1 publication Critical patent/DE69319914D1/de
Application granted granted Critical
Publication of DE69319914T2 publication Critical patent/DE69319914T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • C08G73/0226—Quaternisation of polyalkylene(poly)amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyethers (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Steroid Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Silicon Polymers (AREA)
DE69319914T 1992-08-20 1993-08-18 Vernetzte polymerische ammoniumsalze Expired - Lifetime DE69319914T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93244992A 1992-08-20 1992-08-20
PCT/US1993/007647 WO1994004596A1 (en) 1992-08-20 1993-08-18 Crosslinked polymeric ammonium salts

Publications (2)

Publication Number Publication Date
DE69319914D1 DE69319914D1 (de) 1998-08-27
DE69319914T2 true DE69319914T2 (de) 1999-01-21

Family

ID=25462341

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69319914T Expired - Lifetime DE69319914T2 (de) 1992-08-20 1993-08-18 Vernetzte polymerische ammoniumsalze

Country Status (23)

Country Link
US (2) US5633344A (de)
EP (1) EP0656029B1 (de)
JP (1) JPH08500386A (de)
KR (1) KR950703016A (de)
CN (1) CN1088223A (de)
AT (1) ATE168707T1 (de)
AU (1) AU672824B2 (de)
CA (1) CA2142826A1 (de)
CZ (1) CZ43995A3 (de)
DE (1) DE69319914T2 (de)
DK (1) DK0656029T3 (de)
ES (1) ES2118254T3 (de)
FI (1) FI950704A0 (de)
GR (1) GR3027584T3 (de)
HU (1) HUT72658A (de)
IL (1) IL106733A (de)
MX (1) MX9305077A (de)
NZ (1) NZ255758A (de)
PL (1) PL307527A1 (de)
RU (1) RU95107405A (de)
SK (1) SK31395A3 (de)
WO (1) WO1994004596A1 (de)
ZA (1) ZA936127B (de)

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US5556619A (en) * 1992-08-20 1996-09-17 The Du Pont Merck Pharmaceutical Company Crosslinked polymeric ammonium salts
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5900475A (en) * 1994-06-10 1999-05-04 Geltex Pharmaceuticals, Inc. Hydrophobic sequestrant for cholesterol depletion
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5667775A (en) 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
ZA95390B (en) * 1994-01-18 1996-07-18 Du Pont Crosslinked polymeric ammonium salts
TW474813B (en) 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US5585115A (en) * 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
WO1996021454A1 (en) * 1995-01-12 1996-07-18 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
US6423754B1 (en) 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
US6083497A (en) * 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
US6294163B1 (en) * 1998-10-02 2001-09-25 Geltex Pharmaceuticals, Inc. Polymers containing guanidinium groups as bile acid sequestrants
US7166745B1 (en) 1998-11-12 2007-01-23 Invitrogen Corporation Transfection reagents
AU2374800A (en) * 1998-12-23 2000-07-31 Geltex Pharmaceuticals, Inc. Amine condensation polymer bile acid sequestrants
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US6649187B2 (en) 2001-02-16 2003-11-18 Bristol-Myers Squibb Pharma Company Use of polyalkylamine polymers in controlled release devices
US20030096414A1 (en) * 2001-03-27 2003-05-22 Invitrogen Corporation Culture medium for cell growth and transfection
EP1732973A1 (de) * 2004-02-23 2006-12-20 E.I.Du pont de nemours and company Aus biomasse gewonnene substanzen enthaltende vernetzte polymere
NO322564B1 (no) * 2004-03-22 2006-10-23 Ntnu Technology Transfer As Komposittmembran, fremgangsmate til fremstilling derav, samt anvendelse derav for separasjon av CO2 fra gassblandinger.
US7854924B2 (en) * 2004-03-30 2010-12-21 Relypsa, Inc. Methods and compositions for treatment of ion imbalances
KR101228233B1 (ko) 2004-03-30 2013-01-31 리립사, 인크. 이온 결합 중합체 및 이의 용도
US8282960B2 (en) * 2004-03-30 2012-10-09 Relypsa, Inc. Ion binding compositions
US8192758B2 (en) * 2004-03-30 2012-06-05 Relypsa, Inc. Ion binding compositions
US7556799B2 (en) * 2004-03-30 2009-07-07 Relypsa, Inc. Ion binding polymers and uses thereof
US7429394B2 (en) * 2004-03-30 2008-09-30 Relypsa, Inc. Ion binding compositions
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
CA2620406A1 (en) 2005-09-02 2007-03-08 Genzyme Corporation Method for removing phosphate and polymer used therefore
EP1924246B1 (de) 2005-09-15 2015-10-21 Genzyme Corporation Beutelformulierung für aminpolymere
AU2006294455B2 (en) * 2005-09-30 2013-06-20 Relypsa, Inc. Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
DE112006002618T5 (de) 2005-09-30 2008-08-28 Ilypsa Inc., Santa Clara Verfahren und Zusammensetzungen zum selektiven Entfernen von Kaliumionen aus dem Gastrointestinaltrakt eines Säugers
FI3431094T3 (fi) * 2008-08-22 2023-03-20 Vifor Int Ltd Silloitettuja kationinvaihtopolymeerejä, koostumuksia ja käyttö hyperkalemian hoidossa
WO2010022380A2 (en) 2008-08-22 2010-02-25 Relypsa, Inc. Linear polyol stabilized polyfluoroacrylate compositions
US20100104527A1 (en) * 2008-08-22 2010-04-29 Relypsa, Inc. Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties
AU2011220748B2 (en) * 2010-02-24 2015-11-05 Relypsa, Inc. Amine polymers for use as bile acid sequestrants
IN2014CN03841A (de) * 2011-11-25 2015-09-04 Basf Se
BR112015007749A2 (pt) 2012-10-08 2017-07-04 Relypsa Inc métodos para tratamento de hipertensão , de hipercaliemia , e de doença renal crônica.
CN103351444B (zh) * 2013-06-20 2015-04-15 山东诚创医药技术开发有限公司 包含n或氨基,铵或螺双环铵基团的交联聚合物凝胶的过滤洗涤方法
KR101631151B1 (ko) * 2014-05-22 2016-06-27 한국과학기술연구원 탄화수소계열 전해질 고분자 합성 방법 및 이에 사용되는 중합 용매
CN106572974B (zh) 2014-07-15 2021-04-23 生命技术公司 用于将分子有效递送到细胞的具有脂质聚集体的组合物和方法
MA41202A (fr) 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2
WO2016176270A1 (en) 2015-04-30 2016-11-03 The Chemours Company Tt, Llc Durable architectural coatings containing crosslinkable polymeric additives
CA3196156A1 (en) * 2020-09-21 2022-03-24 Stride Cross-linked polymeric ammonium salts and their use in absorbing organic contaminants
CN113583256B (zh) * 2021-07-05 2022-10-25 南京理工大学 一种阳离子水凝胶材料的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE467746A (de) * 1945-09-15
US3383281A (en) * 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
US3332841A (en) * 1961-10-04 1967-07-25 Lilly Co Eli Method of treating hyperacidity
US3803237A (en) * 1969-11-03 1974-04-09 Upjohn Co Reaction products of polyethylenepolyamines and chlorohydrins or epoxy containing compounds
US3692895A (en) * 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
US3980770A (en) * 1971-06-04 1976-09-14 Pharmacia Aktiebolag Polymerization products containing amino groups useful in serum cholesterol level control
US4205064A (en) * 1973-06-11 1980-05-27 Merck & Co., Inc. Bile acid sequestering composition containing poly[{alkyl-(3-ammoniopropyl)imino}-trimethylenedihalides]
US4027009A (en) * 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
US4147586A (en) * 1974-09-14 1979-04-03 Monsanto Company Cellulosic paper containing the reaction product of a dihaloalkane alkylene diamine adduct and epihalohydrin
US4071478A (en) * 1976-06-07 1978-01-31 Merck & Co., Inc. Controlled partially cross-linked 3,3-ionenes
JPS5566513A (en) * 1978-11-14 1980-05-20 Ono Pharmaceut Co Ltd Drug for arteriosclerosis comprising high polymer compound as active constituent
US4374244A (en) * 1979-04-13 1983-02-15 Kewanee Industries, Inc. Linear quaternary ammonium polymers
JPS5879022A (ja) * 1981-11-04 1983-05-12 Bitamin Kenkyusho:Kk 第四級窒素原子を含有する新規な金属架橋高分子化合物、その製法及び該高分子化合物を有効成分とする高脂血症治療剤
JPS60209523A (ja) * 1984-04-03 1985-10-22 Mitsubishi Petrochem Co Ltd コレステロ−ル低下剤
DE3609984A1 (de) * 1986-03-25 1987-10-01 Bayer Ag Verfahren zur behandlung von fasermaterialien
US5236701A (en) * 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
CA2042870C (en) * 1991-05-17 1996-11-26 Leon Edward St. Pierre Metal ion coordinated polyamine resins for the lowering of blood cholesterol

Also Published As

Publication number Publication date
ES2118254T3 (es) 1998-09-16
CN1088223A (zh) 1994-06-22
KR950703016A (ko) 1995-08-23
SK31395A3 (en) 1995-08-09
PL307527A1 (en) 1995-05-29
AU5010993A (en) 1994-03-15
AU672824B2 (en) 1996-10-17
US5633344A (en) 1997-05-27
ATE168707T1 (de) 1998-08-15
HUT72658A (en) 1996-05-28
EP0656029A1 (de) 1995-06-07
FI950704A (fi) 1995-02-16
GR3027584T3 (en) 1998-11-30
MX9305077A (es) 1994-06-30
CA2142826A1 (en) 1994-03-03
WO1994004596A1 (en) 1994-03-03
ZA936127B (en) 1995-02-20
DE69319914D1 (de) 1998-08-27
DK0656029T3 (da) 1999-02-15
RU95107405A (ru) 1997-02-10
CZ43995A3 (en) 1995-12-13
IL106733A0 (en) 1993-12-08
IL106733A (en) 1998-06-15
HU9500475D0 (en) 1995-04-28
FI950704A0 (fi) 1995-02-16
NZ255758A (en) 1997-10-24
US5667774A (en) 1997-09-16
EP0656029B1 (de) 1998-07-22
JPH08500386A (ja) 1996-01-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: MOSELPATENT TRIERPATENT, 54290 TRIER

8328 Change in the person/name/address of the agent

Representative=s name: PATENTANWAELTE SERWE & DR. WAGNER, 54290 TRIER