DE69316751D1 - Azlaktonfunktionen aufweisende substrate, hornhautprothesen und ihre verwendung - Google Patents

Azlaktonfunktionen aufweisende substrate, hornhautprothesen und ihre verwendung

Info

Publication number
DE69316751D1
DE69316751D1 DE69316751T DE69316751T DE69316751D1 DE 69316751 D1 DE69316751 D1 DE 69316751D1 DE 69316751 T DE69316751 T DE 69316751T DE 69316751 T DE69316751 T DE 69316751T DE 69316751 D1 DE69316751 D1 DE 69316751D1
Authority
DE
Germany
Prior art keywords
azlakton
functional substrates
corneal prostheses
prostheses
corneal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69316751T
Other languages
English (en)
Other versions
DE69316751T2 (de
Inventor
John Capecchi
Steven Heilmann
Larry Krepski
Oh-Seung Kwon
David Olson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Co
Original Assignee
Minnesota Mining and Manufacturing Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minnesota Mining and Manufacturing Co filed Critical Minnesota Mining and Manufacturing Co
Publication of DE69316751D1 publication Critical patent/DE69316751D1/de
Application granted granted Critical
Publication of DE69316751T2 publication Critical patent/DE69316751T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/15—Implant having one or more holes, e.g. for nutrient transport, for facilitating handling

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE69316751T 1992-06-24 1993-05-13 Azlaktonfunktionen aufweisende substrate, hornhautprothesen und ihre verwendung Expired - Fee Related DE69316751T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/903,367 US5292514A (en) 1992-06-24 1992-06-24 Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof
PCT/US1993/004554 WO1994000165A2 (en) 1992-06-24 1993-05-13 Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof

Publications (2)

Publication Number Publication Date
DE69316751D1 true DE69316751D1 (de) 1998-03-05
DE69316751T2 DE69316751T2 (de) 1998-09-10

Family

ID=25417387

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69316751T Expired - Fee Related DE69316751T2 (de) 1992-06-24 1993-05-13 Azlaktonfunktionen aufweisende substrate, hornhautprothesen und ihre verwendung

Country Status (6)

Country Link
US (1) US5292514A (de)
EP (1) EP0647143B1 (de)
JP (1) JPH07508196A (de)
CA (1) CA2136728A1 (de)
DE (1) DE69316751T2 (de)
WO (1) WO1994000165A2 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5344701A (en) * 1992-06-09 1994-09-06 Minnesota Mining And Manufacturing Company Porous supports having azlactone-functional surfaces
US6197056B1 (en) * 1992-07-15 2001-03-06 Ras Holding Corp. Segmented scleral band for treatment of presbyopia and other eye disorders
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
GB9310241D0 (en) * 1993-05-18 1993-06-30 Unilever Plc Cosmetic treatment of substrates
US5408002A (en) * 1993-09-09 1995-04-18 Minnesota Mining And Manufacturing Company Azlactone-functional polymer blends, articles produced therefrom and methods for preparing both
US5420197A (en) * 1994-01-13 1995-05-30 Hydromer, Inc. Gels formed by the interaction of polyvinylpyrrolidone with chitosan derivatives
US5476665A (en) * 1994-04-13 1995-12-19 Minnesota Mining And Manufacturing Company Azlactone functional particles incorporated in a membrane formed by solvent phase inversion
US5561097A (en) * 1994-04-28 1996-10-01 Minnesota Mining And Manufacturing Company Method of controlling density of ligand coupled onto supports and products produced therefrom
US5510421A (en) * 1994-05-26 1996-04-23 Minnesota Mining And Manufacturing Company Azlactone-functional membranes and methods of preparing and using same
US5714632A (en) * 1995-11-13 1998-02-03 Minnesota Mining And Manufacturing Company Azlactone-based surfactants
US5840106A (en) * 1995-11-13 1998-11-24 Minnesota Mining And Manufacturing Company Water-based pigmented inks
AR009439A1 (es) 1996-12-23 2000-04-12 Novartis Ag Un articulo que comprende un sustrato con un recubrimiento polimerico primario que porta grupos reactivos predominantemente en su superficie, unmetodo para preparar dicho articulo, un articulo que posee un recubrimiento de tipo hibrido y una lente de contacto
WO1999011692A1 (en) * 1997-09-03 1999-03-11 The Regents Of The University Of California Novel biomimetic hydrogel materials
JP4111546B2 (ja) * 1997-12-15 2008-07-02 ウルトラデント プロダクツ インコーポレイテッド 重合可能な隔離バリア、およびかかるバリアを形成しかつ使用する方法
US6958212B1 (en) * 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US6379952B1 (en) 1999-02-01 2002-04-30 3M Innovative Properties Company Method for cell selection utilizing azlactone-functional supports
EP1181323B1 (de) * 1999-02-01 2011-06-29 Eidgenössische Technische Hochschule Zürich Biomaterialien die durch nukleophile reaktion auf konjugierten ungesättigten gruppen addiert sind
EP1173790A2 (de) * 1999-03-01 2002-01-23 Boston Innovative Optics, Inc. Vorrichtung und verfahren zur erhöhung der tiefenschärfe des menschlichen auges
US6440571B1 (en) * 1999-05-20 2002-08-27 Bausch & Lomb Incorporated Surface treatment of silicone medical devices with reactive hydrophilic polymers
US6630243B2 (en) * 1999-05-20 2003-10-07 Bausch & Lomb Incorporated Surface treatment of silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating
AUPQ197799A0 (en) * 1999-08-02 1999-08-26 Commonwealth Scientific And Industrial Research Organisation Hydrophilic biomedical compositions
GB0002626D0 (en) 2000-02-05 2000-03-29 Eastman Kodak Co Nonionic oligomeric surfactants and their use as dispersants and stabilisers
US7291673B2 (en) * 2000-06-02 2007-11-06 Eidgenossiche Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US6787635B2 (en) * 2001-04-05 2004-09-07 3M Innovative Properties Company Solid phase synthesis supports and methods
US7147661B2 (en) * 2001-12-20 2006-12-12 Boston Scientific Santa Rosa Corp. Radially expandable stent
US8282912B2 (en) * 2002-03-22 2012-10-09 Kuros Biosurgery, AG Compositions for tissue augmentation
EP1549255A4 (de) * 2002-09-13 2007-12-19 Coopervision Inc Vorrichtungen und verfahren zur verbesserung der sehstärke
US7628810B2 (en) * 2003-05-28 2009-12-08 Acufocus, Inc. Mask configured to maintain nutrient transport without producing visible diffraction patterns
US20050046794A1 (en) * 2003-06-17 2005-03-03 Silvestrini Thomas A. Method and apparatus for aligning a mask with the visual axis of an eye
CN1318463C (zh) * 2003-09-24 2007-05-30 天津工业大学 一种环境响应型共聚水凝胶及其制备方法
US20050228484A1 (en) * 2004-03-11 2005-10-13 Trivascular, Inc. Modular endovascular graft
JP2007537829A (ja) 2004-05-20 2007-12-27 クーパーヴィジョン インコーポレイテッド 視力強化のための角膜アンレー及び波面収差修正
JP5255274B2 (ja) * 2004-07-06 2013-08-07 スリーディー マトリックス， インコーポレイテッド 精製両親媒性ペプチド組成物およびその使用
US20080269119A1 (en) * 2004-08-13 2008-10-30 May Griffith Ophthalmic Device and Related Methods and Compositions
US7556858B2 (en) * 2004-09-30 2009-07-07 3M Innovative Properties Company Substrate with attached dendrimers
US9999497B2 (en) * 2005-01-31 2018-06-19 Yichieh Shiuey Corneal implants and methods and systems for placement
US7976577B2 (en) 2005-04-14 2011-07-12 Acufocus, Inc. Corneal optic formed of degradation resistant polymer
US20070182920A1 (en) * 2006-02-08 2007-08-09 Coopervision, Inc. Corneal Onlays and Related Methods
US7883520B2 (en) * 2006-04-10 2011-02-08 Forsight Labs, Llc Corneal epithelial pocket formation systems, components and methods
US8911496B2 (en) 2006-07-11 2014-12-16 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
MX367099B (es) 2006-07-11 2019-08-05 Refocus Group Inc Protesis escleral para tratar presbiopia y otros transtornos del ojo y dispositivos y metodos relacionados.
CN100512889C (zh) * 2006-12-08 2009-07-15 华南理工大学 结构仿生的角膜组织工程支架的制备方法
DK2136850T3 (da) * 2007-04-13 2012-04-10 Kuros Biosurgery Ag Polymervævforsegling
US20080255663A1 (en) * 2007-04-13 2008-10-16 Akpek Esen K Artificial Cornea and Method of Making Same
WO2009018440A1 (en) * 2007-08-02 2009-02-05 Refocus Group, Inc. Scleral prosthesis having crossbars for treating presbyopia and other eye disorders
US8480638B2 (en) * 2007-10-04 2013-07-09 Aciont, Inc. Intraocular iontophoretic device and associated methods
EP2276420B1 (de) 2008-04-04 2021-10-06 Journey1, Inc. Vorrichtung zur behandlung eines auges mit einem epithel mit einem defekt
BRPI0914610B1 (pt) 2008-06-26 2018-03-06 3M Innovative Properties Company Suporte sólido com uma cadeia enxertada
CN105435211A (zh) 2008-10-06 2016-03-30 三维肽胶株式会社 组织闭塞剂
US20100087920A1 (en) * 2008-10-07 2010-04-08 Forsight Labs, Llc Corneal Onlay Lenses and Related Methods for Improving Vision of Presbyopic Patients
MX2011005311A (es) * 2008-11-19 2011-07-29 Refocus Group Inc Lente intraocular artificial, lente cristalino natural alterado, o capsula de lente cristalino natural relleno con una o mas protesis esclerales para funcionamiento mejorado.
US20100198348A1 (en) * 2009-01-30 2010-08-05 Hiles Michael C Biomaterials with modified optical character and methods for preparing and using same
EP3290003B1 (de) 2009-08-13 2023-12-13 AcuFocus, Inc. Verfahren zur herstellung von maskierten intraokularen implantaten und linsen
CA2770732C (en) 2009-08-13 2017-04-25 Acufocus, Inc. Corneal inlay with nutrient transport structures
US10004593B2 (en) 2009-08-13 2018-06-26 Acufocus, Inc. Intraocular lens with elastic mask
WO2011050365A1 (en) 2009-10-23 2011-04-28 Forsight Labs, Llc Conformable therapeutic shield for vision and pain
EP2490635B1 (de) 2009-10-23 2017-09-06 Nexisvision, Inc. Hornhaut-denervation zur behandlung von augenschmerzen
EP2496987B1 (de) * 2009-11-04 2020-04-29 Alcon Inc. Siliciumhydrogellinse mit gepfropfter hydrophiler beschichtung
US8795727B2 (en) 2009-11-09 2014-08-05 Spotlight Technology Partners Llc Fragmented hydrogels
EP2498763A4 (de) 2009-11-09 2015-10-07 Spotlight Technology Partners Llc Hydrogele auf polysaccharidbasis
USD656526S1 (en) 2009-11-10 2012-03-27 Acufocus, Inc. Ocular mask
EP2506803A1 (de) * 2009-12-04 2012-10-10 AcuFocus, Inc. Hornhautimplantat zur brechungskorrektur
TWI483996B (zh) * 2009-12-08 2015-05-11 Novartis Ag 具有共價貼合塗層之聚矽氧水凝膠鏡片
PL2461767T3 (pl) 2010-07-30 2013-09-30 Novartis Ag Soczewki silikonowo-hydrożelowe z powierzchniami bogatymi w wodę
EP2621405B8 (de) 2010-09-30 2019-01-09 KeraMed, Inc. Reversibel verformbare künstliche hornhaut
US12044905B2 (en) 2011-04-28 2024-07-23 Journey1 Inc Contact lenses for refractive correction
WO2014210186A2 (en) 2013-06-26 2014-12-31 Nexisvision, Inc. Contact lenses for refractive correction
EP2766750B1 (de) 2011-10-12 2016-02-03 Novartis AG Verfahren zur herstellung uv-licht-absorbierender brillengläser mit einer beschichtung
US9545303B2 (en) 2011-12-02 2017-01-17 Acufocus, Inc. Ocular mask having selective spectral transmission
AU2013286676B2 (en) 2012-07-06 2016-12-15 3-D Matrix, Ltd. Fill-finish process for peptide solutions
WO2014039495A1 (en) 2012-09-05 2014-03-13 University Of Miami Novel keratoprosthesis, and system and method of corneal repair using same
WO2014095690A1 (en) 2012-12-17 2014-06-26 Novartis Ag Method for making improved uv-absorbing ophthalmic lenses
US9204962B2 (en) 2013-03-13 2015-12-08 Acufocus, Inc. In situ adjustable optical mask
US9427922B2 (en) 2013-03-14 2016-08-30 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask
CN105829081B (zh) 2013-12-17 2017-12-19 诺华股份有限公司 具有交联的亲水性涂层的硅水凝胶镜片
BR112016020584A2 (pt) 2014-03-10 2017-10-03 3 D Matrix Ltd Composições de peptídeo auto-organizável
WO2015136370A2 (en) 2014-03-10 2015-09-17 3-D Matrix, Ltd. Sterilization and filtration of peptide compositions
ES2712608T3 (es) 2014-03-10 2019-05-14 3 D Matrix Ltd Péptidos autoensamblantes para el tratamiento de las bullas pulmonares
US11002884B2 (en) 2014-08-26 2021-05-11 Alcon Inc. Method for applying stable coating on silicone hydrogel contact lenses
EP3220859B8 (de) 2014-11-19 2020-06-10 AcuFocus, Inc. Brechbare maske zur behandlung von presbyopie
USD844145S1 (en) * 2014-12-22 2019-03-26 Henry Ford Health System Vision assessment chart
CN104830135B (zh) * 2015-05-04 2017-07-25 中国科学院长春应用化学研究所 一种抗菌涂层
WO2017062316A1 (en) 2015-10-05 2017-04-13 Acufocus, Inc. Methods of molding intraocular lenses
CA3005891C (en) 2015-11-24 2023-12-12 Acufocus, Inc. Toric small aperture intraocular lens with extended depth of focus
CN108369291B (zh) 2015-12-15 2021-07-20 爱尔康公司 用于将稳定的涂层施加在硅酮水凝胶接触镜片上的方法
WO2017120092A1 (en) 2016-01-06 2017-07-13 3-D Matrix, Ltd. Combination compositions
US20170342211A1 (en) 2016-05-31 2017-11-30 Robert Bosch Gmbh Azlactone functionalized substrates for conjugation of biomolecules
KR20200098540A (ko) 2017-12-13 2020-08-20 알콘 인코포레이티드 한 주 및 한 달 착용용 워터 그래디언트 콘택트 렌즈
CN111712230B (zh) 2017-12-15 2024-04-26 立美基股份有限公司 表面活性剂肽纳米结构及在药物递送中的用途
WO2019217471A1 (en) 2018-05-09 2019-11-14 Acufocus, Inc. Intraocular implant with removable optic
USD948724S1 (en) 2019-04-16 2022-04-12 Henry Ford Health System Vision assessment chart
US11950997B2 (en) * 2019-05-20 2024-04-09 The Trustees Of The Stevens Institute Of Technology Artificial cornea with double-side microtextured pHEMA hydrogel
JP7472470B2 (ja) * 2019-11-11 2024-04-23 ａｒｔｉｅｎｃｅ株式会社 紫外線吸収性単量体、紫外線吸収性ポリマー、成形用樹脂組成物、および成形体

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2714721A (en) * 1953-01-23 1955-08-09 Jr William Stone Artificial corneal implants
CA1073648A (en) * 1976-08-02 1980-03-18 Edward R. Hauser Web of blended microfibers and crimped bulking fibers
US4304705A (en) * 1980-01-02 1981-12-08 Minnesota Mining And Manufacturing Company Radiation-curable polymers containing pendant unsaturated peptide groups derived from azlactone polymers
US4914223A (en) * 1981-10-29 1990-04-03 Minnesota Mining And Manufacturing Company Acrylamidoacylated oligomers
SE8200751L (sv) * 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
US4612012A (en) * 1982-07-28 1986-09-16 White Thomas C Corneal implant
US4485236A (en) * 1982-09-27 1984-11-27 Minnesota Mining And Manufacturing Company Azlactone-functional compounds
US4451619A (en) * 1982-09-30 1984-05-29 Minnesota Mining And Manufacturing Company Method of hydrophilizing or hydrophobizing polymers
US5059654A (en) * 1983-02-14 1991-10-22 Cuno Inc. Affinity matrices of modified polysaccharide supports
US4528325A (en) * 1983-06-03 1985-07-09 Minnesota Mining And Manufacturing Co. Copolymers of poly(vinyl trifluoroacetate) or poly(vinyl alcohol)
US4618649A (en) * 1983-06-03 1986-10-21 Minnesota Mining And Manufacturing Company Copolymers of poly(vinyl trifluoroacetate) or poly(vinyl alcohol)
US4673539A (en) * 1983-06-03 1987-06-16 Minnesota Mining And Manufacturing Company Process for thermoformed articles
IE56908B1 (en) * 1983-09-08 1992-01-29 Minnesota Mining & Mfg Polymer blends with high water absorption
US4655770A (en) * 1985-06-06 1987-04-07 Ioptex, Inc. Surface passivated intraocular lens
DE3521684A1 (de) * 1985-06-18 1986-12-18 Dr. Müller-Lierheim KG, Biologische Laboratorien, 8033 Planegg Verfahren zur beschichtung von polymeren
EP0238508B1 (de) * 1985-08-23 1991-05-22 Washington Research Foundation Innenaugenlinse mit verbesserter oberfläche
JPS6283885A (ja) * 1985-10-08 1987-04-17 Nitto Electric Ind Co Ltd 酵素固定膜及びその製造方法
US4757014A (en) * 1985-11-08 1988-07-12 Minnesota Mining And Manufacturing Company Immobilization of biologically active protein on a polymeric fibrous support
US4772283A (en) * 1986-05-16 1988-09-20 White Thomas C Corneal implant
US4715858A (en) * 1986-07-25 1987-12-29 Lindstrom Richard L Epicorneal lens
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
US5292840A (en) * 1987-03-13 1994-03-08 Minnesota Mining And Manufacturing Company Polymeric supports
US4865601A (en) * 1987-07-07 1989-09-12 Caldwell Delmar R Intraocular prostheses
US4910277A (en) * 1988-02-09 1990-03-20 Bambury Ronald E Hydrophilic oxygen permeable polymers
FR2627078B1 (fr) * 1988-02-16 1994-03-18 Allergan Inc Dispositif oculaire
US5108428A (en) * 1988-03-02 1992-04-28 Minnesota Mining And Manufacturing Company Corneal implants and manufacture and use thereof
US5032131A (en) * 1988-03-02 1991-07-16 Minnesota Mining And Manufacturing Company Prosthesis holding device
US4852969A (en) * 1988-03-17 1989-08-01 Minnesota Mining And Manufacturing Company Silyl 2-amidoacetate and silyl 3-amidopropionate compositions and optical fiber made therefrom
JP2561309B2 (ja) * 1988-03-28 1996-12-04 テルモ株式会社 医療用材料およびその製造方法
ATE196728T1 (de) * 1988-07-22 2000-10-15 Surmodics Inc Herstellung von polymeren oberflächen
CA2001720C (en) * 1988-10-31 2001-10-02 Randal A. Goffe Membrane affinity apparatus and purification methods related thereto
US5013795A (en) * 1989-04-10 1991-05-07 Minnesota Mining And Manufacturing Company Azlactone graft copolymers
US5064578A (en) * 1989-04-21 1991-11-12 Minnesota Mining And Manufacturing Company Method for making a high wet-strength polyolefin blown microfiber web
US5149806A (en) * 1990-03-28 1992-09-22 Minnesota Mining And Manufacturing Company Azlactone michael adducts
US5081197A (en) * 1990-10-23 1992-01-14 Minnesota Mining And Manufacturing Company Oligo(2-alkenyl azlactones)
KR100216669B1 (ko) * 1990-10-30 1999-09-01 스프레이그 로버트 월터 친수성 중합체 외장을 가진 제품 및 이것의 제조 방법
US5200471A (en) * 1990-11-05 1993-04-06 Minnesota Mining And Manufacturing Company Biomolecules covalently immobilized with a high bound specific biological activity and method of preparing same

Also Published As

Publication number Publication date
DE69316751T2 (de) 1998-09-10
WO1994000165A2 (en) 1994-01-06
WO1994000165A3 (en) 1994-02-17
JPH07508196A (ja) 1995-09-14
EP0647143B1 (de) 1998-01-28
CA2136728A1 (en) 1994-01-06
US5292514A (en) 1994-03-08
EP0647143A1 (de) 1995-04-12

Similar Documents

Publication Publication Date Title
DE69316751D1 (de) Azlaktonfunktionen aufweisende substrate, hornhautprothesen und ihre verwendung
DE69638056D1 (de) Azeotropähnliche zusammensetzungen und ihre verwendung
DE69009822D1 (de) Zusammensetzung und ihre Verwendung.
ATA188592A (de) Alkyl-bisacylphosphinoxide, diese enthaltende zusammensetzungen und ihre verwendung
DE68916512D1 (de) Zusammensetzung zur Verminderung von postoperativen Adhäsionen und ihre Verwendung.
DE69324987D1 (de) Lösungsmittelfreie Organosiloxanzusammensetzung und ihre Verwendung
DE69814431D1 (de) 3,3-diarylpropylamine , ihre verwendung und herstellung
DE69620270D1 (de) Backfett und dessen Verwendung
DE69625857D1 (de) Siliconderivate, ihre Herstellung und Verwendung
DE69106689D1 (de) Umkehrlackierungsverfahrenzusammensetzungen und ihre Verwendung.
DE69109852D1 (de) Ausrichtungskontrollvorrichtung und ihre verwendung.
DE68903665D1 (de) Balg-pipette und ihre verwendung.
DE69623844D1 (de) Beschichtungszusammensetzung und dessen Verwendung
DE69418203D1 (de) Zementiermittel und ihre verwendung
ATE202782T1 (de) Optisch-aktives benzothiepin-derivate, ihre herstellung und verwendung
DE69027170D1 (de) Uracilderivate, ihre Herstellung und ihre Verwendung
DE68906462D1 (de) Praeparat aus reiskleie und dessen verwendung.
DE69123162D1 (de) Ascorbatoxidase und ihre Verwendung
ATE227278T1 (de) Substituierte benzylamine-derivate und ihre verwendung zur behandlung von depression
DE69633503D1 (de) 1,2,4- triazolo (4,3-b) pyridazinderivate und ihre verwendung
DE69527037D1 (de) Zusammensetzungen auf der basis von biologisch aktiven silizium und ihre verwendung
DE69618264D1 (de) Verbesserungen bei der Herstellung von Kristallsubstraten
DE69114342D1 (de) Fluorhaltige Diaminobenzolderivate und ihre Verwendung.
DE69630391D1 (de) Prolylendopeptidase-inhibitoren, ihre herstellung und ihre pharmazeutische verwendung
DE69832407D1 (de) Chipträgerelement und dessen verwendung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee