DE69314613D1 - Neues chelatisierungsmittel, komplexverbindungen, die aus diesem mittel und metallatomen aufgebaut sind, und diagnostische mittel, die diese verbindungen enthalten - Google Patents

Neues chelatisierungsmittel, komplexverbindungen, die aus diesem mittel und metallatomen aufgebaut sind, und diagnostische mittel, die diese verbindungen enthalten

Info

Publication number
DE69314613D1
DE69314613D1 DE69314613T DE69314613T DE69314613D1 DE 69314613 D1 DE69314613 D1 DE 69314613D1 DE 69314613 T DE69314613 T DE 69314613T DE 69314613 T DE69314613 T DE 69314613T DE 69314613 D1 DE69314613 D1 DE 69314613D1
Authority
DE
Germany
Prior art keywords
agent
compounds
metal atoms
diagnostic agents
agents containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69314613T
Other languages
English (en)
Other versions
DE69314613T2 (de
DE69314613T3 (de
Inventor
Fumio Mori
Tadashi Okano
Kazuki Murakami
Masakazu Shintome
Hiromichi Mukai
Ikuko Miyagi
Takashi Imagawa
Shogen Kindaichi
Taro Marukawa
Takahiro Kozuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16423568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69314613(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP4200392A external-priority patent/JP2807852B2/ja
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Publication of DE69314613D1 publication Critical patent/DE69314613D1/de
Publication of DE69314613T2 publication Critical patent/DE69314613T2/de
Application granted granted Critical
Publication of DE69314613T3 publication Critical patent/DE69314613T3/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69314613T 1992-07-03 1993-03-22 Neues chelatisierungsmittel, komplexverbindungen, die aus diesem mittel und metallatomen aufgebaut sind, und diagnostische mittel, die diese verbindungen enthalten Expired - Fee Related DE69314613T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4200392A JP2807852B2 (ja) 1991-07-18 1992-07-03 新規キレート化剤、該キレート化剤と金属原子との錯化合物及びそれを含む診断剤
PCT/JP1993/000331 WO1994001393A1 (en) 1992-07-03 1993-03-22 Novel chelating agent, complex compound composed of said agent and metallic atom, and diagnostic agent containing said compound

Publications (3)

Publication Number Publication Date
DE69314613D1 true DE69314613D1 (de) 1997-11-20
DE69314613T2 DE69314613T2 (de) 1998-05-14
DE69314613T3 DE69314613T3 (de) 2002-07-04

Family

ID=16423568

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69314613T Expired - Fee Related DE69314613T3 (de) 1992-07-03 1993-03-22 Neues chelatisierungsmittel, komplexverbindungen, die aus diesem mittel und metallatomen aufgebaut sind, und diagnostische mittel, die diese verbindungen enthalten

Country Status (7)

Country Link
US (2) US5453264A (de)
EP (1) EP0603403B2 (de)
CA (1) CA2116867C (de)
DE (1) DE69314613T3 (de)
DK (1) DK0603403T4 (de)
ES (1) ES2108269T5 (de)
WO (1) WO1994001393A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US5843399A (en) * 1990-04-06 1998-12-01 Schering Aktiengesellschaft DTPA monoamides for MRI
US5807535A (en) * 1992-07-31 1998-09-15 Australian Nuclear Science & Technology Organisation Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents
ES2140469T3 (es) * 1992-10-14 2000-03-01 Nycomed Imaging As Composiciones y metodos terapeuticos y de diagnostico por obtencion de imagenes.
DE19507820A1 (de) * 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
US5660815A (en) * 1995-04-28 1997-08-26 Molecular Biosystems, Inc. Water soluble fluorinated fatty acid sulfonate derivatives useful as magnetic resonance imaging agents
JP2759627B2 (ja) * 1995-07-21 1998-05-28 東北大学長 非エステル結合性ｄｔｐａ誘導体およびその製造方法
IT1290417B1 (it) * 1996-08-02 1998-12-03 Bracco Spa Composti chelanti derivati di acidi poliamminopolicarbossilici, loro chelati con ioni metallici paramagnetici, loro preparazione ed
US6403055B1 (en) 1996-08-02 2002-06-11 Dibra S.P.A. Diagnostic imaging contrast agent with improved in serum relaxivity
US6458337B1 (en) 1996-08-02 2002-10-01 Dibra S.P.A Diagnostic imaging contrast agent with improved in serum relaxivity
US5888476A (en) * 1996-11-13 1999-03-30 Mallinckrodt Medical, Inc. Magnetic resonance blood pool agents
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6495118B1 (en) 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
US6462034B1 (en) 1998-04-03 2002-10-08 Theravance, Inc. Local anesthetic compounds and uses
AR014809A1 (es) 1998-04-03 2001-03-28 Advanced Medicine Inc Compuestos multiligazon, composicion farmaceutica, metodo para prepara dichos compuestos y uso de dichos compuestos para preparar medicamentos
US6677483B2 (en) * 2001-01-26 2004-01-13 Schering Ag Process for the production of monoamides of DTPA
DE10105014C2 (de) * 2001-01-26 2003-03-27 Schering Ag Neues Verfahren zur Herstellung von Monoamiden der DTPA
CN101010107A (zh) * 2004-08-26 2007-08-01 马林克罗特公司 监测肾功能的发光金属络合物
CN100439468C (zh) * 2005-12-16 2008-12-03 湖州星星研磨有限公司 一种抛磨块

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH569405A5 (en) † 1972-07-11 1975-11-28 Ciba Geigy Ag Combatting metal deficiency in biological systems - with metal chelates of ethylene diamine tetraacetic acid diamide derivs
DE2511891A1 (de) † 1975-03-19 1976-10-07 Gruenenthal Chemie Neue derivate des 2,6-dioxopiperazins, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel sowie verfahren zu deren herstellung
DE3927444A1 (de) * 1989-08-16 1991-02-28 Schering Ag Verwendung von amid-komplexverbindungen
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
JP2776953B2 (ja) * 1990-04-10 1998-07-16 日本メジフィジックス株式会社 多官能性金属キレート化合物とその用途
GB9027922D0 (en) * 1990-12-21 1991-02-13 Nycomed As Compounds
JP2807852B2 (ja) * 1991-07-18 1998-10-08 株式会社ミドリ十字 新規キレート化剤、該キレート化剤と金属原子との錯化合物及びそれを含む診断剤
JPH05186372A (ja) * 1991-07-18 1993-07-27 Green Cross Corp:The 脂肪乳剤及びｍｒｉ診断用造影剤
WO1993003351A1 (en) * 1991-08-09 1993-02-18 The Regents Of The University Of California Amino acid, ester and/or catechol contrast agents for mri
JPH09211232A (ja) * 1996-02-06 1997-08-15 Fine Rubber Kenkyusho:Kk 導光板および照明装置
JPH09303351A (ja) * 1996-05-13 1997-11-25 Toa Corp 機器取付装置

Also Published As

Publication number Publication date
EP0603403B1 (de) 1997-10-15
EP0603403B2 (de) 2001-06-27
US5453264A (en) 1995-09-26
EP0603403A1 (de) 1994-06-29
ES2108269T5 (es) 2001-09-01
EP0603403A4 (en) 1994-08-24
CA2116867A1 (en) 1994-01-20
US5575986A (en) 1996-11-19
DK0603403T4 (da) 2002-12-16
ES2108269T3 (es) 1997-12-16
DE69314613T2 (de) 1998-05-14
DK0603403T3 (da) 1998-03-16
DE69314613T3 (de) 2002-07-04
CA2116867C (en) 2004-04-27
WO1994001393A1 (en) 1994-01-20

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD., OSAKA,

8327 Change in the person/name/address of the patent owner

Owner name: WELFIDE CORP., OSAKA, JP

8366 Restricted maintained after opposition proceedings
8332 No legal effect for de
8327 Change in the person/name/address of the patent owner

Owner name: MITSUBISHI PHARMA CORP., OSAKA, JP

8339 Ceased/non-payment of the annual fee