DE69233507D1 - Hbgad und higad polypeptide und nukleinsäuren und deren verwendung zur diagnose und behandlung von gad autoantigen assoziierten krankheiten - Google Patents
Hbgad und higad polypeptide und nukleinsäuren und deren verwendung zur diagnose und behandlung von gad autoantigen assoziierten krankheitenInfo
- Publication number
- DE69233507D1 DE69233507D1 DE69233507T DE69233507T DE69233507D1 DE 69233507 D1 DE69233507 D1 DE 69233507D1 DE 69233507 T DE69233507 T DE 69233507T DE 69233507 T DE69233507 T DE 69233507T DE 69233507 D1 DE69233507 D1 DE 69233507D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- polypeptides
- hbgad
- higad
- diagnosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 title 1
- 102000008214 Glutamate decarboxylase Human genes 0.000 abstract 2
- 108091022930 Glutamate decarboxylase Proteins 0.000 abstract 2
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Transplantation (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPK477391 | 1991-02-22 | ||
AU477391 | 1991-02-22 | ||
AU862091 | 1991-09-27 | ||
AUPK862091 | 1991-09-27 | ||
PCT/AU1992/000063 WO1992014485A1 (en) | 1991-02-22 | 1992-02-21 | A method for the diagnosis and treatment of glutamic acid decarboxylase autoantigen associated diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69233507D1 true DE69233507D1 (de) | 2005-06-16 |
DE69233507T2 DE69233507T2 (de) | 2009-09-10 |
Family
ID=25644008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233507T Expired - Fee Related DE69233507T2 (de) | 1991-02-22 | 1992-02-21 | Hbgad und higad polypeptide und nukleinsäuren und deren verwendung zur diagnose und behandlung von gad autoantigen assoziierten krankheiten |
Country Status (9)
Country | Link |
---|---|
US (2) | US5837812A (de) |
EP (1) | EP0572478B1 (de) |
JP (1) | JP3027190B2 (de) |
AT (1) | ATE304050T1 (de) |
AU (1) | AU659133B2 (de) |
CA (1) | CA2104225C (de) |
DE (1) | DE69233507T2 (de) |
DK (1) | DK0572478T3 (de) |
WO (1) | WO1992014485A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5998366A (en) * | 1990-09-21 | 1999-12-07 | The Regents Of The University Of California | Method for ameliorating glutamic acid decarboxylase associated autoimmune disorders |
US6682906B1 (en) * | 1990-09-21 | 2004-01-27 | The Regents Of The University Of California | Cloned glutamic acid decarboxylase |
US5674978A (en) * | 1990-09-21 | 1997-10-07 | The Regents Of The University Of California | Peptides derived from glutamic acid decarboxylase |
JPH06508030A (ja) * | 1991-05-15 | 1994-09-14 | ザイモジェネティクス,インコーポレイティド | ヒトすい島グルタミン酸デカルボキシラーゼ自己抗原のクローニング及び発現 |
AU661684B2 (en) * | 1991-06-18 | 1995-08-03 | Regents Of The University Of California, The | Cloned glutamic acid decarboxylase |
DE4237244A1 (de) * | 1992-11-04 | 1994-05-05 | Elias Entwicklungslabor Fuer I | Verfahren zur Herstellung hochreiner humaner GAD-1- und GAD-2- Proteine |
IL108587A (en) * | 1993-02-09 | 1998-01-04 | Univ Monash | Methods and kit for diagnosing diabetes and pre-diabetic conditions |
AU688304B2 (en) * | 1993-02-09 | 1998-03-12 | Monash University | Methods for the diagnosis of diabetes and prediabetic conditions |
EP0815136B1 (de) | 1995-02-20 | 2007-06-13 | The Walter And Eliza Hall Institute Of Medical Research | Immunoreaktive und immunotherapeutische moleküle welche in individuen mit insulin-abhängiger diabetes mellitus interagieren |
WO1997010847A1 (en) * | 1995-09-21 | 1997-03-27 | University Of Utah Research Foundation | Targeting of conjugates of poly(ethylene glycol) and antibodies against glutamic acid decarboxylase to islet cells |
WO1997036618A1 (fr) * | 1996-04-01 | 1997-10-09 | Chugai Seiyaku Kabushiki Kaisha | Composition diagnostique pour maladies s'accompagnant de reactions auto-immunes declenchees par la decarboxylase d'acide 65k-glutamique |
US7361331B2 (en) | 1996-10-18 | 2008-04-22 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Plant bioreactors |
AU2001242190A1 (en) * | 2000-03-31 | 2001-10-15 | Aventis Pasteur Limited | Immunogenic peptides derived from prostate-specific membrane antigen (psma) and uses thereof |
CA2448112A1 (en) * | 2001-06-05 | 2002-12-12 | Exelixis Inc. | Lces as modifiers of the p53 pathway and methods of use |
WO2003016575A1 (en) * | 2001-08-17 | 2003-02-27 | Luminex Corporation | Method for characterizing autoimmune disorders |
US7485314B2 (en) * | 2002-05-06 | 2009-02-03 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Induction of antigen specific immunologic tolerance |
US20050191309A1 (en) * | 2002-05-06 | 2005-09-01 | Kakkis Emil D. | Induction of antigen specific immunologic tolerance |
EP1893754A4 (de) * | 2005-05-31 | 2009-01-21 | Neurologix Inc | Neue glutaminsäure-decarboxylase (gad)-chimäre und verwendungsverfahren |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE144326T1 (de) * | 1990-08-17 | 1996-11-15 | Univ Florida | Verfahren und komposition zum frühnachweiss und behandlung insulinabhängiger diabetes |
AU8721991A (en) * | 1990-09-07 | 1992-03-30 | Regents Of The University Of California, The | Methods for the diagnosis and treatment of diabetes |
US5475086A (en) * | 1990-09-21 | 1995-12-12 | The Regents Of The University Of California | Cloned glutamic acid decarboxylase peptides |
US6682906B1 (en) * | 1990-09-21 | 2004-01-27 | The Regents Of The University Of California | Cloned glutamic acid decarboxylase |
-
1992
- 1992-02-21 WO PCT/AU1992/000063 patent/WO1992014485A1/en active IP Right Grant
- 1992-02-21 DE DE69233507T patent/DE69233507T2/de not_active Expired - Fee Related
- 1992-02-21 CA CA002104225A patent/CA2104225C/en not_active Expired - Fee Related
- 1992-02-21 EP EP92905170A patent/EP0572478B1/de not_active Expired - Lifetime
- 1992-02-21 AU AU12748/92A patent/AU659133B2/en not_active Ceased
- 1992-02-21 AT AT92905170T patent/ATE304050T1/de not_active IP Right Cessation
- 1992-02-21 DK DK92905170T patent/DK0572478T3/da active
- 1992-02-21 JP JP4504792A patent/JP3027190B2/ja not_active Expired - Fee Related
-
1994
- 1994-09-20 US US08/308,952 patent/US5837812A/en not_active Expired - Fee Related
-
1998
- 1998-07-29 US US09/124,141 patent/US6211352B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH06505385A (ja) | 1994-06-23 |
EP0572478B1 (de) | 2005-09-07 |
CA2104225A1 (en) | 1992-08-23 |
DK0572478T3 (da) | 2006-01-16 |
JP3027190B2 (ja) | 2000-03-27 |
AU659133B2 (en) | 1995-05-11 |
US6211352B1 (en) | 2001-04-03 |
DE69233507T2 (de) | 2009-09-10 |
US5837812A (en) | 1998-11-17 |
CA2104225C (en) | 2001-07-17 |
ATE304050T1 (de) | 2005-09-15 |
AU1274892A (en) | 1992-09-15 |
EP0572478A4 (en) | 1994-05-18 |
WO1992014485A1 (en) | 1992-09-03 |
EP0572478A1 (de) | 1993-12-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8372 | Publication of ep patent withdrawn | ||
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: ADVOTEC. PATENT- UND RECHTSANWAELTE, 57234 WILNSDO |
|
8339 | Ceased/non-payment of the annual fee |