DK0572478T3 - HBGAD- og HIGAD-polypeptider og nukleinsyre og anvendelse heraf til diagnostik og behandling af GAD-autoantigen-associerede sygdomme - Google Patents
HBGAD- og HIGAD-polypeptider og nukleinsyre og anvendelse heraf til diagnostik og behandling af GAD-autoantigen-associerede sygdommeInfo
- Publication number
- DK0572478T3 DK0572478T3 DK92905170T DK92905170T DK0572478T3 DK 0572478 T3 DK0572478 T3 DK 0572478T3 DK 92905170 T DK92905170 T DK 92905170T DK 92905170 T DK92905170 T DK 92905170T DK 0572478 T3 DK0572478 T3 DK 0572478T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- nucleic acid
- polypeptides
- hbgad
- higad
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 208000011688 Generalised anxiety disease Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 208000029364 generalized anxiety disease Diseases 0.000 title 1
- 102000008214 Glutamate decarboxylase Human genes 0.000 abstract 2
- 108091022930 Glutamate decarboxylase Proteins 0.000 abstract 2
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Transplantation (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPK477391 | 1991-02-22 | ||
| AUPK862091 | 1991-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0572478T3 true DK0572478T3 (da) | 2006-01-16 |
Family
ID=25644008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92905170T DK0572478T3 (da) | 1991-02-22 | 1992-02-21 | HBGAD- og HIGAD-polypeptider og nukleinsyre og anvendelse heraf til diagnostik og behandling af GAD-autoantigen-associerede sygdomme |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5837812A (de) |
| EP (1) | EP0572478B1 (de) |
| JP (1) | JP3027190B2 (de) |
| AT (1) | ATE304050T1 (de) |
| AU (1) | AU659133B2 (de) |
| CA (1) | CA2104225C (de) |
| DE (1) | DE69233507T2 (de) |
| DK (1) | DK0572478T3 (de) |
| WO (1) | WO1992014485A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998366A (en) * | 1990-09-21 | 1999-12-07 | The Regents Of The University Of California | Method for ameliorating glutamic acid decarboxylase associated autoimmune disorders |
| US5674978A (en) | 1990-09-21 | 1997-10-07 | The Regents Of The University Of California | Peptides derived from glutamic acid decarboxylase |
| US6682906B1 (en) * | 1990-09-21 | 2004-01-27 | The Regents Of The University Of California | Cloned glutamic acid decarboxylase |
| CA2103159A1 (en) * | 1991-05-15 | 1992-11-16 | Ake Lernmark | Cloning and expression of human islet glutamic acid decarboxylase autoantigen |
| AU661684B2 (en) * | 1991-06-18 | 1995-08-03 | Regents Of The University Of California, The | Cloned glutamic acid decarboxylase |
| DE4237244A1 (de) * | 1992-11-04 | 1994-05-05 | Elias Entwicklungslabor Fuer I | Verfahren zur Herstellung hochreiner humaner GAD-1- und GAD-2- Proteine |
| AU688304B2 (en) * | 1993-02-09 | 1998-03-12 | Monash University | Methods for the diagnosis of diabetes and prediabetic conditions |
| IL108587A (en) * | 1993-02-09 | 1998-01-04 | Univ Monash | Methods and kit for diagnosing diabetes and pre-diabetic conditions |
| CA2213301C (en) | 1995-02-20 | 2010-01-26 | Amrad Operations Pty. Ltd. | Immunoreactive and immunotherapeutic molecules which interact in subjects with insulin-dependent diabetes mellitus (iddm) |
| CA2232834A1 (en) * | 1995-09-21 | 1997-03-27 | University Of Utah | Targeting of conjugates of poly(ethylene glycol) and antibodies against glutamic acid decarboxylase to islet cells |
| AU2044197A (en) * | 1996-04-01 | 1997-10-22 | Chugai Seiyaku Kabushiki Kaisha | Diagnostic composition for diseases accompanied by autoimmune reactions caused by 65k-glutamic acid decarboxylase |
| US7361331B2 (en) | 1996-10-18 | 2008-04-22 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Plant bioreactors |
| WO2001074845A2 (en) * | 2000-03-31 | 2001-10-11 | Aventis Pasteur Limited | Immunogenic peptides derived from prostate-specific membrane antigen (psma) and uses thereof |
| AU2002314887A1 (en) * | 2001-06-05 | 2002-12-16 | Exelixis, Inc. | Gads as modifiers of the p53 pathway and methods of use |
| WO2003016575A1 (en) * | 2001-08-17 | 2003-02-27 | Luminex Corporation | Method for characterizing autoimmune disorders |
| US20050191309A1 (en) * | 2002-05-06 | 2005-09-01 | Kakkis Emil D. | Induction of antigen specific immunologic tolerance |
| US7485314B2 (en) * | 2002-05-06 | 2009-02-03 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Induction of antigen specific immunologic tolerance |
| EP1893754A4 (de) * | 2005-05-31 | 2009-01-21 | Neurologix Inc | Neue glutaminsäure-decarboxylase (gad)-chimäre und verwendungsverfahren |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0543945B1 (de) * | 1990-08-17 | 1996-10-16 | The University Of Florida | Verfahren und komposition zum frühnachweiss und behandlung insulinabhängiger diabetes |
| DE69133393T2 (de) * | 1990-09-07 | 2005-06-16 | The Regents Of The University Of California, Oakland | Verfahren zur diagnose und behandlung von diabetes |
| US6682906B1 (en) * | 1990-09-21 | 2004-01-27 | The Regents Of The University Of California | Cloned glutamic acid decarboxylase |
| US5475086A (en) * | 1990-09-21 | 1995-12-12 | The Regents Of The University Of California | Cloned glutamic acid decarboxylase peptides |
-
1992
- 1992-02-21 AT AT92905170T patent/ATE304050T1/de not_active IP Right Cessation
- 1992-02-21 AU AU12748/92A patent/AU659133B2/en not_active Ceased
- 1992-02-21 DK DK92905170T patent/DK0572478T3/da active
- 1992-02-21 CA CA002104225A patent/CA2104225C/en not_active Expired - Fee Related
- 1992-02-21 JP JP4504792A patent/JP3027190B2/ja not_active Expired - Fee Related
- 1992-02-21 DE DE69233507T patent/DE69233507T2/de not_active Expired - Fee Related
- 1992-02-21 WO PCT/AU1992/000063 patent/WO1992014485A1/en active IP Right Grant
- 1992-02-21 EP EP92905170A patent/EP0572478B1/de not_active Expired - Lifetime
-
1994
- 1994-09-20 US US08/308,952 patent/US5837812A/en not_active Expired - Fee Related
-
1998
- 1998-07-29 US US09/124,141 patent/US6211352B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0572478B1 (de) | 2005-09-07 |
| US6211352B1 (en) | 2001-04-03 |
| EP0572478A1 (de) | 1993-12-08 |
| JP3027190B2 (ja) | 2000-03-27 |
| EP0572478A4 (en) | 1994-05-18 |
| US5837812A (en) | 1998-11-17 |
| AU1274892A (en) | 1992-09-15 |
| WO1992014485A1 (en) | 1992-09-03 |
| ATE304050T1 (de) | 2005-09-15 |
| JPH06505385A (ja) | 1994-06-23 |
| DE69233507T2 (de) | 2009-09-10 |
| AU659133B2 (en) | 1995-05-11 |
| CA2104225A1 (en) | 1992-08-23 |
| DE69233507D1 (de) | 2005-06-16 |
| CA2104225C (en) | 2001-07-17 |
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