DE69231664D1 - Zyklische dna sequenzierung - Google Patents

Zyklische dna sequenzierung

Info

Publication number
DE69231664D1
DE69231664D1 DE69231664T DE69231664T DE69231664D1 DE 69231664 D1 DE69231664 D1 DE 69231664D1 DE 69231664 T DE69231664 T DE 69231664T DE 69231664 T DE69231664 T DE 69231664T DE 69231664 D1 DE69231664 D1 DE 69231664D1
Authority
DE
Germany
Prior art keywords
dna sequencing
cyclic dna
dna
preparing
cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69231664T
Other languages
English (en)
Other versions
DE69231664T2 (de
Inventor
W Fuller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Global Life Sciences Solutions USA LLC
Original Assignee
Amersham Pharmacia Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Pharmacia Biotech Inc filed Critical Amersham Pharmacia Biotech Inc
Application granted granted Critical
Publication of DE69231664D1 publication Critical patent/DE69231664D1/de
Publication of DE69231664T2 publication Critical patent/DE69231664T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69231664T 1991-09-27 1992-08-28 Zyklische dna sequenzierung Expired - Lifetime DE69231664T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/767,137 US5674679A (en) 1991-09-27 1991-09-27 DNA cycle sequencing
PCT/US1992/007303 WO1993006243A1 (en) 1991-09-27 1992-08-28 Dna cycle sequencing

Publications (2)

Publication Number Publication Date
DE69231664D1 true DE69231664D1 (de) 2001-03-01
DE69231664T2 DE69231664T2 (de) 2001-05-03

Family

ID=25078586

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69233041T Expired - Lifetime DE69233041T2 (de) 1991-09-27 1992-08-28 Behandlung von amplifizierter DNS mit alkalischer Phosphatase
DE69231664T Expired - Lifetime DE69231664T2 (de) 1991-09-27 1992-08-28 Zyklische dna sequenzierung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69233041T Expired - Lifetime DE69233041T2 (de) 1991-09-27 1992-08-28 Behandlung von amplifizierter DNS mit alkalischer Phosphatase

Country Status (9)

Country Link
US (3) US5674679A (de)
EP (2) EP0654091B1 (de)
JP (1) JP2695045B2 (de)
AT (2) ATE198913T1 (de)
AU (1) AU2573992A (de)
CA (1) CA2119140A1 (de)
DE (2) DE69233041T2 (de)
ES (1) ES2156861T3 (de)
WO (1) WO1993006243A1 (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4214112A1 (de) * 1991-08-02 1993-02-04 Europ Lab Molekularbiolog Neues verfahren zur sequenzierung von nukleinsaeuren
AU1854895A (en) * 1994-03-08 1995-09-25 Amersham International Plc Modifying nucleotide analogues
DE19515552A1 (de) * 1995-04-27 1996-10-31 Europ Lab Molekularbiolog Simultane Sequenzierung von Nukleinsäuren
US5928906A (en) * 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
IL119342A0 (en) * 1996-10-02 1997-01-10 Yeda Research And Development C Methods for priming and DNA sequencing
US6291164B1 (en) 1996-11-22 2001-09-18 Invitrogen Corporation Methods for preventing inhibition of nucleic acid synthesis by pyrophosphate
US6235471B1 (en) * 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6197510B1 (en) 1998-10-01 2001-03-06 Bio-Id Diagnostic Inc. Multi-loci genomic analysis
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US20080199935A1 (en) * 1999-10-29 2008-08-21 Stratagene California Compositions and methods utilizing DNA polymerases
US20030228616A1 (en) * 1999-10-29 2003-12-11 Stratagene DNA polymerase mutants with reverse transcriptase activity
US8268605B2 (en) * 1999-10-29 2012-09-18 Agilent Technologies, Inc. Compositions and methods utilizing DNA polymerases
US20040009486A1 (en) * 1999-10-29 2004-01-15 Sorge Joseph A. Compositions and methods utilizing DNA polymerases
JP4949585B2 (ja) 1999-10-29 2012-06-13 アジレント・テクノロジーズ・インク Ｄｎａポリメラーゼを使用した組成物および方法
US20050123940A1 (en) * 1999-10-29 2005-06-09 Stratagene California Compositions and methods for synthesizing cDNA
US6762018B1 (en) * 1999-12-23 2004-07-13 Tetragen Sa Analysis of nucleotide polymorphisms at a site
US6379940B2 (en) 2000-03-21 2002-04-30 Usb Corporation Stable composition comprising a nuclease and a phosphatase
CA2403438C (en) * 2000-03-21 2008-10-21 Usb Corporation Stable composition comprising a nuclease and a phosphatase
US6994963B1 (en) * 2000-07-10 2006-02-07 Ambion, Inc. Methods for recombinatorial nucleic acid synthesis
US6379932B1 (en) * 2000-07-17 2002-04-30 Incyte Genomics, Inc. Single primer PCR amplification of RNA
GB0024827D0 (en) * 2000-10-10 2000-11-22 Norwegian Inst Of Fisheries & Product
WO2002072892A1 (en) * 2001-03-12 2002-09-19 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
EP1463825B1 (de) 2001-10-15 2017-12-06 BioArray Solutions Ltd. Gemultiplexte analyse polymorphischer stellen durch gleichzeitige abfrage und enzymvermittelte detektion
EP1474532A4 (de) * 2002-02-12 2005-05-04 Applera Corp Polymerasezusammensetzungen
US20040241723A1 (en) * 2002-03-18 2004-12-02 Marquess Foley Leigh Shaw Systems and methods for improving protein and milk production of dairy herds
WO2004083443A1 (en) 2002-12-20 2004-09-30 Caliper Life Sciences, Inc. Single molecule amplification and detection of dna
US20060147935A1 (en) * 2003-02-12 2006-07-06 Sten Linnarsson Methods and means for nucleic acid sequencing
GB2398383B (en) * 2003-02-12 2005-03-09 Global Genomics Ab Method and means for nucleic acid sequencing
EP2390352A1 (de) 2003-03-18 2011-11-30 Quantum Genetics Ireland Limited Systeme und Methoden zur Erhöhung der Milchproduktion bei Tieren
WO2005047543A2 (en) * 2003-06-10 2005-05-26 Applera Corporation Ligation assay
EP1704246A4 (de) * 2003-09-30 2007-11-28 Perkinelmer Las Inc Zusammensetzungen und verfahren zur genotypisierung von einzelnukleotidpolymorphismen
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
JP2007525217A (ja) 2004-02-19 2007-09-06 ザ ガバナーズ オブ ザ ユニバーシティー オブ アルバータ レプチンプロモーター多型及びその使用
US7981604B2 (en) 2004-02-19 2011-07-19 California Institute Of Technology Methods and kits for analyzing polynucleotide sequences
US20060046258A1 (en) * 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
US20050260609A1 (en) * 2004-05-24 2005-11-24 Lapidus Stanley N Methods and devices for sequencing nucleic acids
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US7635562B2 (en) * 2004-05-25 2009-12-22 Helicos Biosciences Corporation Methods and devices for nucleic acid sequence determination
FI20040723A0 (fi) * 2004-05-26 2004-05-26 Orpana Aarne Menetelmä mRNA:n ilmentymistasojen kvantitatiiviseksi ja/tai suhteelliseksi mittaamiseksi pienissä biologisissa näytteissä
US7264934B2 (en) * 2004-06-10 2007-09-04 Ge Healthcare Bio-Sciences Corp. Rapid parallel nucleic acid analysis
US20060292584A1 (en) * 2004-08-24 2006-12-28 New England Biolabs, Inc. Compositions and methods for accomplishing nucleotide depletion
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US7604940B1 (en) * 2005-03-16 2009-10-20 Applied Biosystems, Llc Compositions and methods for analyzing isolated polynucleotides
US8785130B2 (en) 2005-07-07 2014-07-22 Bio-Id Diagnostic Inc. Use of markers including nucleotide sequence based codes to monitor methods of detection and identification of genetic material
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US20090305248A1 (en) * 2005-12-15 2009-12-10 Lander Eric G Methods for increasing accuracy of nucleic acid sequencing
US20080309926A1 (en) * 2006-03-08 2008-12-18 Aaron Weber Systems and methods for reducing detected intensity non uniformity in a laser beam
US7397546B2 (en) * 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
US9150906B2 (en) 2006-06-28 2015-10-06 Bio-Id Diagnostic Inc. Determination of variants produced upon replication or transcription of nucleic acid sequences
US7501254B2 (en) * 2006-07-20 2009-03-10 Ghc Technologies, Inc. Methods and compositions for amplification and capture of nucleic acid sequences
US20090137405A1 (en) * 2007-11-16 2009-05-28 Christopher Bowman Detection of nucleic acid biomarkers using polymerization-based amplification
EP2489744B1 (de) 2008-02-04 2014-09-03 Life Technologies Corporation Zusammensetzung und Verfahren zum Sequenzieren von Nukleinsäure
EP2364368B1 (de) 2008-11-07 2014-01-15 Sequenta, Inc. Verfahren zur überwachung von krankheitszuständen mittels sequenzanalyse
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8129168B2 (en) * 2009-01-14 2012-03-06 Affymetrix, Inc. Recombinant colwellia psychrerythraea alkaline phosphatase and uses thereof
DK2387627T3 (en) 2009-01-15 2016-07-04 Adaptive Biotechnologies Corp Adaptive immunity profiling and methods for producing monoclonal antibodies
EP2446052B1 (de) 2009-06-25 2018-08-08 Fred Hutchinson Cancer Research Center Verfahren zur messung der adaptiven immunität
WO2012058647A1 (en) 2010-10-28 2012-05-03 Life Technologies Corporation Chemically-enhanced primer compositions, methods and kits
CA2858070C (en) 2011-12-09 2018-07-10 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
DK2823060T3 (en) 2012-03-05 2018-05-28 Adaptive Biotechnologies Corp Determination of associated immune receptor chains from frequency-matched subunits
ES2582554T3 (es) 2012-05-08 2016-09-13 Adaptive Biotechnologies Corporation Composiciones y método para medir y calibrar el sesgo de la amplificación en reacciones de PCR multiplexadas
DK2904111T3 (en) 2012-10-01 2018-03-12 Adaptive Biotechnologies Corp Immune competence evaluation of adaptive immune receptor diversity and clonality characterization
WO2014145706A2 (en) 2013-03-15 2014-09-18 Life Technologies Corporation A recombinant fusion protein possessing nuclease and phosphatase activity
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
AU2015227054A1 (en) 2014-03-05 2016-09-22 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
EP3132059B1 (de) 2014-04-17 2020-01-08 Adaptive Biotechnologies Corporation Quantifizierung von adaptiven immunzellgenomen in einer komplexen mischung von zellen
GB201414745D0 (en) 2014-08-19 2014-10-01 Articzymes As Exonucleases
WO2016053883A1 (en) 2014-10-03 2016-04-07 Life Technologies Corporation Detection, identification, validation and enrichment of target nucleic acids
ES2784343T3 (es) 2014-10-29 2020-09-24 Adaptive Biotechnologies Corp Detección simultánea altamente multiplexada de ácidos nucleicos que codifican heterodímeros de receptores inmunes adaptativos emparejados de muchas muestras
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
AU2015353581A1 (en) 2014-11-25 2017-06-15 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
US10302494B2 (en) 2014-12-18 2019-05-28 Palo Alto Research Center Incorporated Obtaining spectral information from a moving object
US10048192B2 (en) * 2014-12-18 2018-08-14 Palo Alto Research Center Incorporated Obtaining spectral information from moving objects
EP3262196B1 (de) 2015-02-24 2020-12-09 Adaptive Biotechnologies Corp. Verfahren zur bestimmung des hla-status mittels immunrepertoiresequenzierung
EP3277294B1 (de) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Verfahren zur identifizierung von menschlichen kompatiblen t-zell-rezeptoren spezifisch für ein antigen-ziel
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
US4795699A (en) * 1987-01-14 1989-01-03 President And Fellows Of Harvard College T7 DNA polymerase
US5075216A (en) * 1988-09-23 1991-12-24 Cetus Corporation Methods for dna sequencing with thermus aquaticus dna polymerase
DE3923895A1 (de) * 1989-07-19 1991-01-24 Basf Ag Verfahren zur sequenzierung von desoxyribonukleinsaeuren
DE69131891T2 (de) * 1990-02-16 2000-06-15 Hoffmann La Roche Verbesserungen in der spezifität und zweckmässigkeit der polymerase-kettenreaktion

Also Published As

Publication number Publication date
EP1038973A1 (de) 2000-09-27
EP1038973B1 (de) 2003-05-02
US5674679A (en) 1997-10-07
JPH06510433A (ja) 1994-11-24
EP0654091A4 (de) 1997-11-12
DE69233041D1 (de) 2003-06-05
EP0654091A1 (de) 1995-05-24
CA2119140A1 (en) 1993-04-01
WO1993006243A1 (en) 1993-04-01
AU2573992A (en) 1993-04-27
US5741676A (en) 1998-04-21
ATE239094T1 (de) 2003-05-15
DE69231664T2 (de) 2001-05-03
ES2156861T3 (es) 2001-08-01
ATE198913T1 (de) 2001-02-15
US5741640A (en) 1998-04-21
DE69233041T2 (de) 2004-03-11
JP2695045B2 (ja) 1997-12-24
EP0654091B1 (de) 2001-01-24

Similar Documents

Publication Publication Date Title
ATE198913T1 (de) Zyklische dna sequenzierung
DE59007374D1 (de) Optisch gegengekoppelter Verstärker.
DE3854533T2 (de) Plattenförmiger Kohlendioxid-Laser.
DE3876037T2 (de) Kohlendioxidsensor.
NO950381D0 (no) Nukleinsyresekvens amplifikasjon
DE69213112D1 (de) Verbesserte Methoden zur Nukleinsäure-Amplifizierung
DE3680997D1 (de) Einrichtung zur als sprache empfundenen rueckkopplung.
DE3873842D1 (de) Verfahren zur gen-amplifikation.
DE3853136T2 (de) Operationsverstärker mit stabilem Arbeitspunkt.
DE69022108T2 (de) Verstärkeranordnung.
DE3860103D1 (de) Antriebseinrichtung fuer eine luftleitvorrichtung.
FI883160A0 (fi) Vakuumfoerpackning, isynnerhet foer (malet) rostat kaffe.
DE3879600D1 (de) Operationsverstaerker.
FI893249A0 (fi) Azacykliska foereningar, deras framstaellning och anvaendning.
FI880454A0 (fi) Laosanordning, saerskilt foer en lucka till en dammsugare.
ES525050A0 (es) Un dispositivo aireador, destinado particularmente a cultivo.
DE69011919T2 (de) Ausgangsstufe für einen Operationsverstärker.
DE59009044D1 (de) Transportluftregelung.
DE3851080T2 (de) Elektronenemittierende Vorrichtung.
NO165451C (no) Skjoeteanordning, spesielt for betongdeler.
DE3768847D1 (de) Offset-korrigierter verstaerker.
DE69018326T2 (de) Hybridverstärker.
DE3850923D1 (de) Operationsverstärkerstufen.
DE3882942D1 (de) Abfuehlverstaerker.
PT85546A (en) Protein protease inhibitors from straptomyces

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE BIO-SCIENCES CORP. (N.D.GES.D.STAATE

R071 Expiry of right

Ref document number: 654091

Country of ref document: EP