DE69224983T2 - Anti-wachstumsfaktor antikörper in der behandlung von gefässstenose - Google Patents
Anti-wachstumsfaktor antikörper in der behandlung von gefässstenoseInfo
- Publication number
- DE69224983T2 DE69224983T2 DE69224983T DE69224983T DE69224983T2 DE 69224983 T2 DE69224983 T2 DE 69224983T2 DE 69224983 T DE69224983 T DE 69224983T DE 69224983 T DE69224983 T DE 69224983T DE 69224983 T2 DE69224983 T2 DE 69224983T2
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- antibodies
- pdgf
- antibody
- bfgf
- igg
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- VCMGMSHEPQENPE-UHFFFAOYSA-N ketamine hydrochloride Chemical compound [Cl-].C=1C=CC=C(Cl)C=1C1([NH2+]C)CCCCC1=O VCMGMSHEPQENPE-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000008747 mitogenic response Effects 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000009696 proliferative response Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 108700038606 rat Smooth muscle Proteins 0.000 description 1
- 238000001525 receptor binding assay Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000002966 stenotic effect Effects 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
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- 231100000216 vascular lesion Toxicity 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64175891A | 1991-01-17 | 1991-01-17 | |
| PCT/US1992/000438 WO1992012734A1 (fr) | 1991-01-17 | 1992-01-17 | Anticorps contre les facteurs de croissance dans le traitement de la stenose vasculaire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69224983D1 DE69224983D1 (de) | 1998-05-07 |
| DE69224983T2 true DE69224983T2 (de) | 1998-07-30 |
Family
ID=24573729
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69224983T Expired - Fee Related DE69224983T2 (de) | 1991-01-17 | 1992-01-17 | Anti-wachstumsfaktor antikörper in der behandlung von gefässstenose |
| DE69232579T Expired - Fee Related DE69232579T2 (de) | 1991-01-17 | 1992-01-17 | Anti-Plättchen-Wachstumsfaktor-Antikörper in der Behandlung von Restenose |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69232579T Expired - Fee Related DE69232579T2 (de) | 1991-01-17 | 1992-01-17 | Anti-Plättchen-Wachstumsfaktor-Antikörper in der Behandlung von Restenose |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5648076A (fr) |
| EP (2) | EP0798002B1 (fr) |
| JP (2) | JP3667752B2 (fr) |
| AT (2) | ATE164521T1 (fr) |
| AU (1) | AU665529B2 (fr) |
| CA (1) | CA2100876A1 (fr) |
| DE (2) | DE69224983T2 (fr) |
| DK (2) | DK0573510T3 (fr) |
| ES (2) | ES2174144T3 (fr) |
| WO (1) | WO1992012734A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770198A (en) * | 1988-05-18 | 1998-06-23 | The Research Foundation Of The State Of New York | Platelet-specific chimeric 7E3 immunoglobulin |
| EP0835135A2 (fr) * | 1995-06-07 | 1998-04-15 | Centocor, Inc. | Immunoglobuline chimerique specifique des plaquettes et procedes d'utilisation |
| US7241568B2 (en) | 1996-04-03 | 2007-07-10 | Kyowa Hakko Kogyo Co., Ltd. | Anti-fibroblast growth factor-8 monoclonal antibody |
| AU6497198A (en) * | 1997-02-14 | 1998-09-08 | Boehringer Mannheim Gmbh | Improved method for the reduction of neointima formation after angioplasty |
| AU2002346127B2 (en) * | 2001-06-28 | 2008-05-29 | Kyowa Hakko Kirin Co., Ltd. | Humanized antibody against fibroblast growth factor-8 and fragment of the antibody |
| WO2005037235A2 (fr) * | 2003-10-16 | 2005-04-28 | Imclone Systems Incorporated | Inhibiteurs du recepteur 1 du facteur de croissance du fibroblaste et methodes therapeutiques associees |
| US9339593B2 (en) * | 2007-01-11 | 2016-05-17 | Robert L. Bjork, JR. | Drug-eluting coronary artery stent coated with anti-platelet-derived growth factor antibodies overlaying extracellular matrix proteins with an outer coating of anti-inflammatory (calcineurin inhibitor) and/or anti-proliferatives |
| EP2101683A4 (fr) * | 2007-01-11 | 2014-12-03 | Robert Lamar Bjork Jr | Endoprothèse coronaire à élution de médicaments multiples pour intervention coronarienne percutanée |
| WO2016149103A1 (fr) * | 2015-03-13 | 2016-09-22 | The Regents Of The University Of California | Anticorps monoclonal pour la prévention et/ou le traitement d'une maladie à astrovirus |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3852561T2 (de) * | 1987-03-03 | 1995-07-13 | Takeda Chemical Industries, Ltd., Osaka | Monoklonaler Antikörper, Hybridomen, ihre Herstellung und ihre Verwendung. |
| CA1339356C (fr) * | 1988-02-02 | 1997-08-26 | Lewis T. Williams | Recepteur de facteur de croissance derive de plaquettes humaines |
| US5268358A (en) * | 1988-12-08 | 1993-12-07 | Cor Therapeutics, Inc. | PDGF receptor blocking peptides |
| WO1991006668A1 (fr) * | 1989-10-27 | 1991-05-16 | The Du Pont Merck Pharmaceutical Company | Anticorps monoclonaux luttant contre le facteur de croissance du fibroblaste basique qui inhibe son activite biologique |
| JP4350370B2 (ja) * | 2002-12-27 | 2009-10-21 | 株式会社半導体エネルギー研究所 | 電子回路及び電子機器 |
-
1992
- 1992-01-17 DE DE69224983T patent/DE69224983T2/de not_active Expired - Fee Related
- 1992-01-17 DK DK92905617.4T patent/DK0573510T3/da active
- 1992-01-17 WO PCT/US1992/000438 patent/WO1992012734A1/fr active IP Right Grant
- 1992-01-17 DE DE69232579T patent/DE69232579T2/de not_active Expired - Fee Related
- 1992-01-17 CA CA002100876A patent/CA2100876A1/fr not_active Abandoned
- 1992-01-17 EP EP97106298A patent/EP0798002B1/fr not_active Expired - Lifetime
- 1992-01-17 AT AT92905617T patent/ATE164521T1/de not_active IP Right Cessation
- 1992-01-17 DK DK97106298T patent/DK0798002T3/da active
- 1992-01-17 AU AU13274/92A patent/AU665529B2/en not_active Ceased
- 1992-01-17 JP JP50537192A patent/JP3667752B2/ja not_active Expired - Fee Related
- 1992-01-17 ES ES97106298T patent/ES2174144T3/es not_active Expired - Lifetime
- 1992-01-17 AT AT97106298T patent/ATE216592T1/de not_active IP Right Cessation
- 1992-01-17 EP EP92905617A patent/EP0573510B1/fr not_active Expired - Lifetime
- 1992-01-17 ES ES92905617T patent/ES2117046T3/es not_active Expired - Lifetime
-
1994
- 1994-07-26 US US08/281,132 patent/US5648076A/en not_active Expired - Fee Related
-
2002
- 2002-03-04 JP JP2002057904A patent/JP2002316945A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP3667752B2 (ja) | 2005-07-06 |
| AU665529B2 (en) | 1996-01-11 |
| EP0798002B1 (fr) | 2002-04-24 |
| US5648076A (en) | 1997-07-15 |
| EP0573510B1 (fr) | 1998-04-01 |
| ATE216592T1 (de) | 2002-05-15 |
| DE69232579D1 (de) | 2002-05-29 |
| WO1992012734A1 (fr) | 1992-08-06 |
| EP0573510A1 (fr) | 1993-12-15 |
| CA2100876A1 (fr) | 1992-07-18 |
| ES2117046T3 (es) | 1998-08-01 |
| JPH06504551A (ja) | 1994-05-26 |
| DK0573510T3 (da) | 1998-04-27 |
| AU1327492A (en) | 1992-08-27 |
| EP0798002A1 (fr) | 1997-10-01 |
| DK0798002T3 (da) | 2002-08-19 |
| ES2174144T3 (es) | 2002-11-01 |
| JP2002316945A (ja) | 2002-10-31 |
| DE69232579T2 (de) | 2002-08-22 |
| DE69224983D1 (de) | 1998-05-07 |
| ATE164521T1 (de) | 1998-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |