DE69209113D1 - 4-Pyrimidinonderivate, ihre Herstellung und ihre Anwendung in der Therapie - Google Patents

4-Pyrimidinonderivate, ihre Herstellung und ihre Anwendung in der Therapie

Info

Publication number
DE69209113D1
DE69209113D1 DE69209113T DE69209113T DE69209113D1 DE 69209113 D1 DE69209113 D1 DE 69209113D1 DE 69209113 T DE69209113 T DE 69209113T DE 69209113 T DE69209113 T DE 69209113T DE 69209113 D1 DE69209113 D1 DE 69209113D1
Authority
DE
Germany
Prior art keywords
alkyl
optionally substituted
ring
branched
linear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69209113T
Other languages
English (en)
Other versions
DE69209113T2 (de
Inventor
Christian Hoornaert
Marc Daumas
Michel Aletru
Jean-Claude Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of DE69209113D1 publication Critical patent/DE69209113D1/de
Application granted granted Critical
Publication of DE69209113T2 publication Critical patent/DE69209113T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
DE69209113T 1991-02-20 1992-02-03 4-Pyrimidinonderivate, ihre Herstellung und ihre Anwendung in der Therapie Expired - Fee Related DE69209113T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9102032A FR2672892B1 (fr) 1991-02-20 1991-02-20 Derives de 4-pyrimidinones, leur preparation et leur application en therapeutique.

Publications (2)

Publication Number Publication Date
DE69209113D1 true DE69209113D1 (de) 1996-04-25
DE69209113T2 DE69209113T2 (de) 1996-10-31

Family

ID=9409925

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69209113T Expired - Fee Related DE69209113T2 (de) 1991-02-20 1992-02-03 4-Pyrimidinonderivate, ihre Herstellung und ihre Anwendung in der Therapie

Country Status (23)

Country Link
EP (1) EP0500409B1 (de)
JP (1) JP2529798B2 (de)
KR (1) KR920016434A (de)
CN (1) CN1034171C (de)
AT (1) ATE135695T1 (de)
AU (1) AU650319B2 (de)
CA (1) CA2061456A1 (de)
CS (1) CS49092A3 (de)
DE (1) DE69209113T2 (de)
DK (1) DK0500409T3 (de)
ES (1) ES2086090T3 (de)
FI (1) FI920720A (de)
FR (1) FR2672892B1 (de)
GR (1) GR3019404T3 (de)
HU (2) HUT60477A (de)
IE (1) IE76145B1 (de)
IL (1) IL101014A (de)
MX (1) MX9200690A (de)
NO (1) NO920648L (de)
NZ (1) NZ241659A (de)
PL (1) PL168617B1 (de)
RU (1) RU2073675C1 (de)
ZA (1) ZA921203B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
FR2700543B1 (fr) * 1993-01-15 1995-03-17 Synthelabo Sels de dérivés de 4-pyrimidinone, leur préparation et leur application en thérapeutique.
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
EP2998314B1 (de) 2007-06-04 2020-01-22 Bausch Health Ireland Limited Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
TW201444848A (zh) * 2009-01-30 2014-12-01 Takeda Pharmaceutical 稠環化合物及其用途
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
DK0479903T3 (da) * 1989-06-30 1996-03-18 Du Pont Substituerede imidazoler og deres anvendelse som angiotensin II hæmmere
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
EP0424317A3 (en) * 1989-10-19 1991-09-25 Ciba-Geigy Ag Pyrimidines
EP0435827A3 (en) * 1989-12-28 1991-11-13 Ciba-Geigy Ag Diaza compounds
CA2079344A1 (en) * 1990-03-30 1991-10-01 Eric E. Allen Substituted pyrimidines, pyrimidinones and pyridopyrimidines
IE912114A1 (en) * 1990-07-02 1992-01-15 Union Pharma Scient Appl Novel pyrimidine derivatives which are angiotensin ii¹receptor antagonists, their methods of preparation and¹pharmaceutical compositions in which they are present

Also Published As

Publication number Publication date
IE76145B1 (en) 1997-10-08
PL293531A1 (en) 1992-08-24
EP0500409B1 (de) 1996-03-20
ZA921203B (en) 1992-11-25
KR920016434A (ko) 1992-09-24
CN1064269A (zh) 1992-09-09
CA2061456A1 (en) 1992-08-21
GR3019404T3 (en) 1996-06-30
HU9200532D0 (en) 1992-05-28
DE69209113T2 (de) 1996-10-31
IE920525A1 (en) 1992-08-26
FI920720A0 (fi) 1992-02-19
FR2672892B1 (fr) 1994-01-14
PL168617B1 (pl) 1996-03-29
FI920720A (fi) 1992-08-21
NO920648D0 (no) 1992-02-19
FR2672892A1 (fr) 1992-08-21
RU2073675C1 (ru) 1997-02-20
AU650319B2 (en) 1994-06-16
EP0500409A1 (de) 1992-08-26
HUT60477A (en) 1992-09-28
CN1034171C (zh) 1997-03-05
IL101014A0 (en) 1992-11-15
HU211886A9 (en) 1995-12-28
DK0500409T3 (da) 1996-07-15
NO920648L (no) 1992-08-21
JPH04346980A (ja) 1992-12-02
JP2529798B2 (ja) 1996-09-04
MX9200690A (es) 1992-08-01
NZ241659A (en) 1993-03-26
ATE135695T1 (de) 1996-04-15
CS49092A3 (en) 1992-09-16
IL101014A (en) 1996-06-18
AU1105992A (en) 1992-08-27
ES2086090T3 (es) 1996-06-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee