NO920648L - 4-pyrimidonderivater, deres fremstilling og anvendelse - Google Patents

4-pyrimidonderivater, deres fremstilling og anvendelse

Info

Publication number
NO920648L
NO920648L NO92920648A NO920648A NO920648L NO 920648 L NO920648 L NO 920648L NO 92920648 A NO92920648 A NO 92920648A NO 920648 A NO920648 A NO 920648A NO 920648 L NO920648 L NO 920648L
Authority
NO
Norway
Prior art keywords
alkyl
optionally substituted
ring
branched
linear
Prior art date
Application number
NO92920648A
Other languages
English (en)
Other versions
NO920648D0 (no
Inventor
Christian Hoornaert
Marc Daumas
Michel Aletru
Jean-Claude Muller
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of NO920648D0 publication Critical patent/NO920648D0/no
Publication of NO920648L publication Critical patent/NO920648L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Pyrimidinonforbindelser i sine tre tautomere former som svarer til de generelle formler (I), (I1) og (II") (I) (r) R! = rettkjedet eller forgrenet (C1_7)alkyl, rettkjedet eller forgrenet (C3_g) alkenyl eller syklo(C3_7> alkyl (Ci-$) alkyl, R2 = H, rettkjedet eller forgrenet (C1_7)alkyl, syklo(C3_7)- alkyl(C1_3) alkyl, aryl (Cl_-2t alkyl som eventuelt er kjernesubstituert, aryloksy (C!_3) alkyl som eventuelt er aryltio(Ci_3) alkyl som eventuelt er arylsulf onyl (C!_3) alkyl eventuelt heteroaryl (Ci.3) alkyl som eventuelt er kjernesubstituert, kjernesubstituert, kjernesubstituert, kjernesubstituert , R3 = C02H, lH-tetrazol-5-yl, NHCORn, NHS02Ri;l, CONHS02Rn eller CONHOR12, hvori RU = CH3, CF3 eller fenyl som eventuelt er substituert, Ri2 = H, CH3 eller fenyl som eventuelt er substituert, såvel som deres farmasøytisk tålbare organiske eller uorganiske salter. Forbindelsene er nye og har terapeutisk anvendelse, fremstilling er beskrevet.
NO92920648A 1991-02-20 1992-02-19 4-pyrimidonderivater, deres fremstilling og anvendelse NO920648L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9102032A FR2672892B1 (fr) 1991-02-20 1991-02-20 Derives de 4-pyrimidinones, leur preparation et leur application en therapeutique.

Publications (2)

Publication Number Publication Date
NO920648D0 NO920648D0 (no) 1992-02-19
NO920648L true NO920648L (no) 1992-08-21

Family

ID=9409925

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92920648A NO920648L (no) 1991-02-20 1992-02-19 4-pyrimidonderivater, deres fremstilling og anvendelse

Country Status (23)

Country Link
EP (1) EP0500409B1 (no)
JP (1) JP2529798B2 (no)
KR (1) KR920016434A (no)
CN (1) CN1034171C (no)
AT (1) ATE135695T1 (no)
AU (1) AU650319B2 (no)
CA (1) CA2061456A1 (no)
CS (1) CS49092A3 (no)
DE (1) DE69209113T2 (no)
DK (1) DK0500409T3 (no)
ES (1) ES2086090T3 (no)
FI (1) FI920720A (no)
FR (1) FR2672892B1 (no)
GR (1) GR3019404T3 (no)
HU (2) HUT60477A (no)
IE (1) IE76145B1 (no)
IL (1) IL101014A (no)
MX (1) MX9200690A (no)
NO (1) NO920648L (no)
NZ (1) NZ241659A (no)
PL (1) PL168617B1 (no)
RU (1) RU2073675C1 (no)
ZA (1) ZA921203B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
FR2700543B1 (fr) * 1993-01-15 1995-03-17 Synthelabo Sels de dérivés de 4-pyrimidinone, leur préparation et leur application en thérapeutique.
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US8592431B2 (en) * 2009-01-30 2013-11-26 Takeda Pharmaceutical Company Limited Fused ring compound and use thereof
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
DE69025473T2 (de) * 1989-06-30 1996-10-17 Du Pont Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin ii
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
EP0424317A3 (en) * 1989-10-19 1991-09-25 Ciba-Geigy Ag Pyrimidines
EP0435827A3 (en) * 1989-12-28 1991-11-13 Ciba-Geigy Ag Diaza compounds
EP0522038A4 (en) * 1990-03-30 1993-05-26 Merck & Co. Inc. Substituted pyrimidines, pyrimidinones and pyridopyrimidines
IE912114A1 (en) * 1990-07-02 1992-01-15 Union Pharma Scient Appl Novel pyrimidine derivatives which are angiotensin ii¹receptor antagonists, their methods of preparation and¹pharmaceutical compositions in which they are present

Also Published As

Publication number Publication date
PL168617B1 (pl) 1996-03-29
ES2086090T3 (es) 1996-06-16
JPH04346980A (ja) 1992-12-02
CN1064269A (zh) 1992-09-09
IE920525A1 (en) 1992-08-26
DK0500409T3 (da) 1996-07-15
FR2672892A1 (fr) 1992-08-21
HU211886A9 (en) 1995-12-28
IE76145B1 (en) 1997-10-08
PL293531A1 (en) 1992-08-24
CA2061456A1 (en) 1992-08-21
CS49092A3 (en) 1992-09-16
EP0500409A1 (fr) 1992-08-26
KR920016434A (ko) 1992-09-24
RU2073675C1 (ru) 1997-02-20
FR2672892B1 (fr) 1994-01-14
HU9200532D0 (en) 1992-05-28
ATE135695T1 (de) 1996-04-15
MX9200690A (es) 1992-08-01
FI920720A (fi) 1992-08-21
JP2529798B2 (ja) 1996-09-04
EP0500409B1 (fr) 1996-03-20
DE69209113T2 (de) 1996-10-31
HUT60477A (en) 1992-09-28
NZ241659A (en) 1993-03-26
DE69209113D1 (de) 1996-04-25
AU650319B2 (en) 1994-06-16
FI920720A0 (fi) 1992-02-19
IL101014A (en) 1996-06-18
CN1034171C (zh) 1997-03-05
ZA921203B (en) 1992-11-25
AU1105992A (en) 1992-08-27
GR3019404T3 (en) 1996-06-30
NO920648D0 (no) 1992-02-19
IL101014A0 (en) 1992-11-15

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