DE69208408D1 - Phenylthioharnstoffderivate und ihre pharmazeutische Verwendung - Google Patents

Phenylthioharnstoffderivate und ihre pharmazeutische Verwendung

Info

Publication number
DE69208408D1
DE69208408D1 DE69208408T DE69208408T DE69208408D1 DE 69208408 D1 DE69208408 D1 DE 69208408D1 DE 69208408 T DE69208408 T DE 69208408T DE 69208408 T DE69208408 T DE 69208408T DE 69208408 D1 DE69208408 D1 DE 69208408D1
Authority
DE
Germany
Prior art keywords
compounds
pharmaceutical use
subgroup
formula
concerns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69208408T
Other languages
English (en)
Other versions
DE69208408T2 (de
Inventor
Gary Mark Coppola
Robert Edson Ii Damon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Sandoz Patent GmbH
Original Assignee
Sandoz AG
Sandoz Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG, Sandoz Patent GmbH filed Critical Sandoz AG
Publication of DE69208408D1 publication Critical patent/DE69208408D1/de
Application granted granted Critical
Publication of DE69208408T2 publication Critical patent/DE69208408T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
DE69208408T 1991-07-01 1992-06-29 Phenylthioharnstoffderivate und ihre pharmazeutische Verwendung Expired - Fee Related DE69208408T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72400191A 1991-07-01 1991-07-01

Publications (2)

Publication Number Publication Date
DE69208408D1 true DE69208408D1 (de) 1996-03-28
DE69208408T2 DE69208408T2 (de) 1996-07-18

Family

ID=24908548

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69208408T Expired - Fee Related DE69208408T2 (de) 1991-07-01 1992-06-29 Phenylthioharnstoffderivate und ihre pharmazeutische Verwendung

Country Status (24)

Country Link
EP (1) EP0528146B1 (de)
JP (1) JPH05221959A (de)
KR (1) KR930002311A (de)
AT (1) ATE134364T1 (de)
AU (1) AU657141B2 (de)
CA (1) CA2072704A1 (de)
CZ (1) CZ204692A3 (de)
DE (1) DE69208408T2 (de)
DK (1) DK0528146T3 (de)
ES (1) ES2083625T3 (de)
FI (1) FI923033A (de)
GR (1) GR3019785T3 (de)
HK (1) HK73196A (de)
HU (1) HUT62558A (de)
IE (1) IE73488B1 (de)
IL (1) IL102355A0 (de)
MX (1) MX9203838A (de)
NO (1) NO922564L (de)
NZ (1) NZ243352A (de)
RO (1) RO111933B1 (de)
RU (1) RU2087467C1 (de)
SK (1) SK204692A3 (de)
TW (1) TW213448B (de)
ZA (1) ZA924823B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2271728A1 (en) * 1996-11-14 1998-05-22 American Home Products Corporation Substituted tetrahydro-1,3,5-triazin-2[1h]-thiones as anti-atherosclerotic agents
WO1998033775A1 (en) * 1997-02-03 1998-08-06 American Home Products Corporation 2-substituted-1-acyl-1,2-dihydroquinoline derivatives to increase hdl-cholesterol level
AU7498298A (en) * 1997-06-16 1999-01-04 American Home Products Corporation Elevation of hdl cholesterol by n-{2-{ (aminothioxomethyl)hydrazono} -2-arylethyl}amides
US6011053A (en) * 1997-08-01 2000-01-04 American Home Products Corporation Substituted indole-1-carbothioic acid amides as novel antiatherosclerotic agents
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
AU9211098A (en) * 1997-09-03 1999-03-22 American Home Products Corporation Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents
WO1999011618A1 (en) * 1997-09-03 1999-03-11 American Home Products Corporation Substituted indole-1-carbothioic acid amides as novel antiatherosclerotic agents
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
DE10017881A1 (de) * 2000-04-11 2001-10-25 Bayer Ag Wirkstoffkombinationen mit insektiziden und akariziden Eigenschaften
WO2003024441A1 (fr) 2001-09-14 2003-03-27 Shionogi & Co., Ltd. Nouvelle utilisation de composes tricycliques
US20030153596A1 (en) 2000-08-21 2003-08-14 Suh Young Ger Novel thiourea derivatives and the pharmaceutical compositions containing the same
WO2002016318A1 (en) 2000-08-21 2002-02-28 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
US6472430B2 (en) 2000-10-02 2002-10-29 Hassan M. Elokdah Amino thioxomethyl amino oxyacetic acid derivatives
US7429593B2 (en) 2001-09-14 2008-09-30 Shionogi & Co., Ltd. Utilities of amide compounds
US8124625B2 (en) 2001-09-14 2012-02-28 Shionogi & Co., Ltd. Method of enhancing the expression of apolipoprotein AI using olefin derivatives
ES2362770B1 (es) * 2009-12-24 2012-05-22 Universidad De Sevilla Uso de compuesto n-fenil-n'-(3-metil-2-butenil)tiourea para la elaboración de medicamentos destinados al tratamiento de la encefalopatía hepática.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950537A (en) * 1973-06-29 1976-04-13 Rohm And Haas Company Gastrointestinally active thioureas
IL67417A (en) * 1982-01-26 1989-10-31 American Cyanamid Co Antiatherosclerotic substituted ureas,process for their preparation and pharmaceutical compositions containing them
DE3861988D1 (en) * 1987-07-02 1991-04-18 Warner Lambert Co N-((2,6-disubstituierte)-phenyl)-harnstoff und -carbamat-inhibitoren der acyl-coenzym a:cholesterol-acyltransferase.
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
GB8908063D0 (en) * 1989-04-11 1989-05-24 Beecham Group Plc Novel compounds
JPH0395153A (ja) * 1989-06-15 1991-04-19 Mitsubishi Kasei Corp ジフェニル尿素誘導体

Also Published As

Publication number Publication date
HUT62558A (en) 1993-05-28
FI923033A (fi) 1993-01-02
TW213448B (de) 1993-09-21
RO111933B1 (ro) 1997-03-31
KR930002311A (ko) 1993-02-22
ES2083625T3 (es) 1996-04-16
IL102355A0 (en) 1993-01-14
RU2087467C1 (ru) 1997-08-20
ATE134364T1 (de) 1996-03-15
FI923033A0 (fi) 1992-06-30
AU657141B2 (en) 1995-03-02
DK0528146T3 (da) 1996-05-06
ZA924823B (en) 1993-12-29
AU1867792A (en) 1993-01-07
DE69208408T2 (de) 1996-07-18
CA2072704A1 (en) 1993-01-02
EP0528146B1 (de) 1996-02-21
NO922564D0 (no) 1992-06-29
HK73196A (en) 1996-05-03
MX9203838A (es) 1993-01-01
NZ243352A (en) 1995-02-24
IE73488B1 (en) 1997-06-04
JPH05221959A (ja) 1993-08-31
CZ204692A3 (en) 1993-01-13
GR3019785T3 (en) 1996-07-31
EP0528146A1 (de) 1993-02-24
NO922564L (no) 1993-01-04
HU9202047D0 (en) 1992-09-28
SK204692A3 (en) 1995-02-08
IE922132A1 (en) 1993-01-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee