DE69133214D1 - Medikamente zur topischen anwendung von sexualhormonen zur behandlung des trockenen auges, und verfahren zu ihrer herstellung und anwendung - Google Patents
Medikamente zur topischen anwendung von sexualhormonen zur behandlung des trockenen auges, und verfahren zu ihrer herstellung und anwendungInfo
- Publication number
- DE69133214D1 DE69133214D1 DE69133214T DE69133214T DE69133214D1 DE 69133214 D1 DE69133214 D1 DE 69133214D1 DE 69133214 T DE69133214 T DE 69133214T DE 69133214 T DE69133214 T DE 69133214T DE 69133214 D1 DE69133214 D1 DE 69133214D1
- Authority
- DE
- Germany
- Prior art keywords
- dry eye
- medicines
- treating
- production
- vehicle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1991/005863 WO1993003731A1 (en) | 1991-08-17 | 1991-08-17 | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69133214D1 true DE69133214D1 (de) | 2003-04-17 |
DE69133214T2 DE69133214T2 (de) | 2003-12-18 |
Family
ID=22225745
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69133214T Expired - Fee Related DE69133214T2 (de) | 1991-08-17 | 1991-08-17 | Medikamente zur topischen anwendung von sexualhormonen zur behandlung des trockenen auges, und verfahren zu ihrer herstellung und anwendung |
DE0652754T Pending DE652754T1 (de) | 1991-08-17 | 1991-08-17 | Medikamente zur topischen anwendung von sexualhormonen zur behandlung des trockenen auges, und verfahren zu ihrer herstellung und anwendung. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0652754T Pending DE652754T1 (de) | 1991-08-17 | 1991-08-17 | Medikamente zur topischen anwendung von sexualhormonen zur behandlung des trockenen auges, und verfahren zu ihrer herstellung und anwendung. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5041434A (de) |
EP (1) | EP0652754B1 (de) |
AT (1) | ATE234100T1 (de) |
DE (2) | DE69133214T2 (de) |
DK (1) | DK0652754T3 (de) |
ES (1) | ES2086268T3 (de) |
GR (1) | GR960300027T1 (de) |
WO (1) | WO1993003731A1 (de) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5041434A (en) * | 1991-08-17 | 1991-08-20 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
DE4038128A1 (de) * | 1990-11-27 | 1992-06-04 | Schering Ag | 8-en-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate |
US5958912A (en) * | 1992-04-21 | 1999-09-28 | The Schepens Eye Research Institute, Inc. | Ocular therapy in keratoconjunctivitis sicca using topically applied androgens of TGF-β |
US5352445A (en) * | 1992-05-07 | 1994-10-04 | Lavaux Joseph E | Lavaux tear test lacrimal equilibration time (LET) |
US5827245A (en) * | 1992-07-16 | 1998-10-27 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Transdermal therapeutic system comprising the active subtance 17-β-Estradiol (Anhydrous) |
US5830508A (en) * | 1992-08-06 | 1998-11-03 | Deo Corporation | Composition for treating dry eye |
US5290572A (en) * | 1992-08-06 | 1994-03-01 | Deo Corporation | Opthalmic composition for treating dry eye |
WO1994004155A1 (en) * | 1992-08-19 | 1994-03-03 | Health Resource Institute, Ltd. | Dehydroepiandrosterone therapy for the treatment of eye disorders |
US5639743A (en) * | 1992-11-13 | 1997-06-17 | University Of Georgia Research Foundation | Compositions and methods for treating exocrine gland atrophy |
US5696166A (en) * | 1995-10-31 | 1997-12-09 | Yanni; John M. | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders |
WO1997020578A1 (en) * | 1995-12-04 | 1997-06-12 | University Of Miami | Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance |
AUPO427196A0 (en) * | 1996-12-19 | 1997-01-23 | University Of Sydney, The | A method for preventing or controlling cataract |
ZA989513B (en) | 1997-10-21 | 1999-04-21 | Alcon Lab Inc | Compositions containing histamine H2 agonists and methods of use in treating dry eye |
US6096733A (en) * | 1998-12-10 | 2000-08-01 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
WO2000038663A2 (en) | 1998-12-24 | 2000-07-06 | Alcon Laboratories, Inc. | Ep4 receptor agonists for treatment of dry eye |
AU775189B2 (en) | 1999-11-09 | 2004-07-22 | Alcon Inc. | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders |
WO2001034550A2 (en) | 1999-11-09 | 2001-05-17 | Alcon Universal Ltd. | 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders |
AU1101301A (en) | 1999-11-09 | 2001-06-06 | Alcon Universal Limited | 2,2-difluoro 15-hydroxyeicosatetraenoic acid analogs and methods of use |
CA2386636A1 (en) | 1999-11-09 | 2001-05-17 | Alcon, Inc. | 15-hydroxyeicosatetraenoic acid-related compounds and methods of use |
ATE265996T1 (de) | 1999-11-09 | 2004-05-15 | Alcon Inc | Tri-heteroatom-substituierte und zwei kohlenstoff homologe von 15-hete und verfahren zur verwendung |
US6803385B2 (en) | 1999-11-09 | 2004-10-12 | Alcon, Inc. | Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders |
US6458854B2 (en) | 1999-11-09 | 2002-10-01 | Alcon Universal Ltd. | Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use |
JP2003514782A (ja) | 1999-11-09 | 2003-04-22 | アルコン,インコーポレイテッド | ドライアイの処置のためのリポキシンa4およびそのアナログ |
PL356092A1 (en) | 1999-11-09 | 2004-06-14 | Alcon Inc. | Heteroatom-interrupted analogs of 15-hydroxyeicosatetraenoic acid and methods of use |
US6552084B2 (en) | 1999-11-09 | 2003-04-22 | Alcon Universal Ltd. | Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders |
WO2001034549A1 (en) | 1999-11-09 | 2001-05-17 | Alcon Universal Ltd. | Hydroxyeicosatetraenoate salts, compositions and methods of use in treating dry eye disorders |
DE60007548T2 (de) | 1999-11-09 | 2004-06-17 | Alcon, Inc. | Omega kettenmodifizierte hydroxyeicosatetraensäure derivate verwendbar in der behandlung der "trockenes auge" krankheit |
AU1226001A (en) | 1999-11-09 | 2001-06-06 | Alcon Universal Limited | Phospholipids of hydroxyeicosatetraenoic acid-like derivatives |
PT1228030E (pt) | 1999-11-09 | 2005-08-31 | Alcon Inc | Derivados benzenoidicos do acido 15-hidroxieicosatetraenoico e metodos para a sua utilizacao no tratamento das perturbacoes do olho seco |
WO2001046134A1 (en) | 1999-12-22 | 2001-06-28 | Alcon Universal Ltd. | 6-KETO PROSTAGLANDIN F1α AND ANALOGS FOR TREATING DRY EYE |
AUPR549901A0 (en) | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
CA2426885C (en) * | 2000-11-14 | 2010-06-29 | Vital Health Sciences Pty Ltd | Complexes of phosphate derivatives |
MXPA03010634A (es) | 2001-05-21 | 2004-03-09 | Alcon Inc | Uso de inhibidores de proteasoma para tratar trastornos del ojo seco. |
CA2447883A1 (en) | 2001-05-21 | 2002-11-28 | Alcon, Inc. | Use of nf-kappa-b inhibitors to treat dry eye disorders |
EP1392322A1 (de) * | 2001-05-21 | 2004-03-03 | Alcon, Inc. | Methode zur behandlung des trockenen auges |
US6872382B1 (en) | 2001-05-21 | 2005-03-29 | Alcon, Inc. | Use of selective PDE IV inhibitors to treat dry eye disorders |
US7112588B2 (en) * | 2001-05-21 | 2006-09-26 | Alcon, Inc. | Use of proteasome inhibitors to treat dry eye disorders |
US6645994B1 (en) | 2001-06-01 | 2003-11-11 | Alcon, Inc. | Method of treating dry eye disorders |
US6750250B1 (en) | 2001-07-12 | 2004-06-15 | Alcon, Inc. | 11,12-oxidoarachidonic acid derivatives and methods of their use in treating dry eye disorders |
CN1547475B (zh) * | 2001-07-27 | 2010-12-15 | 生命健康科学有限公司 | 含电子转移试剂的磷酸酯衍生物的皮肤制剂 |
WO2003028667A2 (en) * | 2001-10-04 | 2003-04-10 | Cellegy Pharmaceuticals, Inc. | Semisolid topical hormonal compositions and methods for treatment |
WO2003030892A1 (en) * | 2001-10-11 | 2003-04-17 | Alcon, Inc. | Methods for treating dry eye |
WO2003030894A1 (en) * | 2001-10-11 | 2003-04-17 | Alcon, Inc. | Methods for treating dry eye |
US20030109509A1 (en) * | 2001-10-11 | 2003-06-12 | Alcon, Inc. | Methods for treating dry eye |
EP1460995B1 (de) * | 2001-12-13 | 2010-11-10 | Vital Health Sciences Pty Ltd. | Transdermaler transport von verbindungen |
US6659985B2 (en) | 2002-01-30 | 2003-12-09 | Southern College Of Optometry | Method to use transdermal administration of androgens to the adnexa of the eye |
US20070213310A1 (en) * | 2002-04-01 | 2007-09-13 | Laszlo Prokai | Prodrugs for Use as Ophthalmic Agents |
US7186707B2 (en) * | 2002-04-01 | 2007-03-06 | University Of Florida | Prodrugs for use as ophthalmic agents |
AU2002950713A0 (en) * | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
MXPA05003063A (es) * | 2002-09-20 | 2005-05-27 | Alcon Inc | Uso de inhibidores de la sintesis de citosina para el tratamiento de trastornos de ojos secos. |
AU2003290776A1 (en) * | 2002-11-15 | 2004-06-15 | Panaseca, Inc. | Methods and compositions for alleviating dry eyes |
WO2004069248A1 (en) * | 2002-12-09 | 2004-08-19 | University Of Florida | Prodrugs for use a ophthalmic agents |
US20040248794A1 (en) * | 2002-12-20 | 2004-12-09 | Yanni John M. | Treatment of dry eye by restoring 15-lipoxygenase activity to ocular surface cells |
ATE534384T1 (de) * | 2003-01-17 | 2011-12-15 | Vital Health Sciences Pty Ltd | Verbindungen mit proliferationshemmenden eigenschaften |
AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
US7235556B2 (en) * | 2003-04-16 | 2007-06-26 | Alcon, Inc. | Methods of treating dry eye disorders |
US20060281716A1 (en) | 2004-03-03 | 2006-12-14 | West Simon M | Alkaloid formulations |
CA2562356A1 (en) | 2004-04-08 | 2005-10-27 | Retmed Pty Ltd | Treatment of ophthalmic conditions with mineralcorticoids |
PL1744736T3 (pl) * | 2004-05-14 | 2010-03-31 | Alcon Inc | Sposób leczenia zespołu suchego oka i zapalenia błony naczyniowej oka |
US7923471B2 (en) * | 2004-05-14 | 2011-04-12 | Alcon, Inc. | Method of treating dry eye disorders and uveitis |
US7223737B1 (en) | 2004-08-13 | 2007-05-29 | Alcon, Inc. | Method of treating dry eye disorders using glycosides |
US20060128803A1 (en) * | 2004-12-14 | 2006-06-15 | Alcon, Inc. | Method of treating dry eye disorders using 13(S)-HODE and its analogs |
US9161905B2 (en) * | 2005-01-12 | 2015-10-20 | Ocular Research Of Boston, Inc. | Dry eye treatment |
EP1858523A1 (de) * | 2005-03-02 | 2007-11-28 | Nascent Pharmaceutical, Inc. | Kombinationstherapie zur topischen applikation bei der behandlung von trockenen augen |
JP2008531602A (ja) * | 2005-03-03 | 2008-08-14 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | 抗癌特性を有する化合物 |
WO2006132033A1 (ja) | 2005-06-10 | 2006-12-14 | Pola Chemical Industries Inc. | 新規トリテルペン酸誘導体及びそれを含有してなる皮膚外用剤 |
NZ565049A (en) * | 2005-06-17 | 2012-02-24 | Vital Health Sciences Pty Ltd | A carrier comprising one or more DI and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
CA2631653A1 (en) * | 2005-12-23 | 2007-06-28 | Vital Health Sciences Pty Ltd. | Compounds having cytokine modulating properties |
US7745461B1 (en) | 2006-02-27 | 2010-06-29 | Alcon Research, Ltd. | Method of treating dry eye disorders |
PL2374472T3 (pl) | 2006-03-16 | 2018-11-30 | Dyax Corp. | Kompozycje i sposoby leczenia zaburzeń okulistycznych |
US20080132475A1 (en) * | 2006-12-05 | 2008-06-05 | Charles Gerald Connor | Treatment for dry eye |
US20080221070A1 (en) * | 2007-03-06 | 2008-09-11 | Pierce William M | Methods and compounds for the targeted delivery of agents to bone for interaction therewith |
EP2129373B1 (de) * | 2007-04-02 | 2013-05-22 | DSM IP Assets B.V. | Verwendung von Genistein zur Behandlung von trockenem Auge |
NZ582188A (en) * | 2007-07-11 | 2012-03-30 | Pfizer | Pharmaceutical compositions and methods of treating dry eye disorders |
US20090098136A1 (en) * | 2007-10-15 | 2009-04-16 | Alcon Research, Ltd. | Use of tnf receptor antagonists for treating dry eye |
TW200927192A (en) * | 2007-11-19 | 2009-07-01 | Alcon Res Ltd | Use of TRPV1 receptor antagonists for treating dry eye and ocular pain |
US20100016264A1 (en) * | 2007-12-05 | 2010-01-21 | Connor Charles G | Treatment for dry eye using testosterone and progestagen |
US8207226B1 (en) | 2008-06-03 | 2012-06-26 | Alcon Research, Ltd. | Use of FAAH antagonists for treating dry eye and ocular pain |
CN102317288A (zh) | 2009-02-13 | 2012-01-11 | 佛维雅制药公司 | 作为激酶抑制剂的[1,2,4]三唑并[1,5-a]吡啶 |
EP2496233A1 (de) * | 2009-11-06 | 2012-09-12 | Alcon Research, Ltd. | Nahrungsergänzungen zur linderung von trockenem auge |
US10071030B2 (en) | 2010-02-05 | 2018-09-11 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
CA2794734C (en) | 2010-03-30 | 2017-12-12 | Phosphagenics Limited | Transdermal delivery patch |
AR081960A1 (es) | 2010-06-22 | 2012-10-31 | Fovea Pharmaceuticals Sa | Compuestos heterociclicos, su preparacion y su aplicacion terapeutica |
US20120079612A1 (en) * | 2010-09-24 | 2012-03-29 | West Virginia University | Dry eye animal model |
EP2685992A4 (de) | 2011-03-15 | 2014-09-10 | Phosphagenics Ltd | Aminochinoline als kinasehemmer |
CN110812486A (zh) * | 2012-07-09 | 2020-02-21 | 华柏恩视觉研究中心 | 用于预防和/或治疗干眼症的组合物、方法和/或装置 |
US10507245B2 (en) * | 2012-07-19 | 2019-12-17 | Luis Felipe Vejarano Restrepo | Ophthalmic formulation and method for ameliorating presbyopia |
EP3021857B1 (de) * | 2013-07-19 | 2018-03-21 | The Johns Hopkins University | Biomaterialien mit hyaluronsäurebindenden peptiden und extrazellulären matrixbindenden peptiden für hyaluronsäureretention und gewebezüchtungsanwendungen |
CN114712308A (zh) | 2015-12-09 | 2022-07-08 | 磷肌酸有限公司 | 药物制剂 |
CA3032790A1 (en) | 2016-06-20 | 2017-12-28 | Novartis Ag | Methods of treating dry eye disease using tnf.alpha. antagonists |
AU2017381395A1 (en) | 2016-12-21 | 2019-06-20 | Phosphagenics Limited | Process |
US10843325B2 (en) | 2017-03-08 | 2020-11-24 | DePuy Synthes Products, Inc. | Quick coupling apparatus on instrument handle |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2861920A (en) * | 1954-05-04 | 1958-11-25 | Upjohn Co | Therapeutic suspensions of steroids containing pvp and/or pva |
US3299104A (en) * | 1963-04-09 | 1967-01-17 | Leo Ab | Certain steroid nu-bis-(haloethyl)-carbamates |
US3962430A (en) * | 1974-08-07 | 1976-06-08 | Merck & Co., Inc. | Sterilization of solid non-electrolyte medicinal agents employing sodium chloride |
US4154820A (en) * | 1976-02-23 | 1979-05-15 | Akzona Incorporated | Compositions containing alkali metal sulfate salts of conjugated estrogens and antioxidants as stabilizers |
US4082881A (en) * | 1976-12-23 | 1978-04-04 | E. R. Squibb & Sons, Inc. | Topical and other type pharmaceutical formulations containing isosorbide carrier |
HU181703B (en) * | 1980-05-09 | 1983-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing aqueus solutuins of water insoluble or hardly soluble vitamines, steroides, localanesthetics, prostanoides and non-steroid and antiphlogistic agents |
JPS58126810A (ja) * | 1981-12-24 | 1983-07-28 | Kaken Pharmaceut Co Ltd | 抗炎症眼科用液剤およびその製法 |
US4478818A (en) * | 1982-12-27 | 1984-10-23 | Alza Corporation | Ocular preparation housing steroid in two different therapeutic forms |
US4581226A (en) * | 1983-04-07 | 1986-04-08 | Dillon Richard S | Method of treating sensitive animal tissue with a specially processed seawater solution |
US4474751A (en) * | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Ophthalmic drug delivery system utilizing thermosetting gels |
SE8305864D0 (sv) * | 1983-10-25 | 1983-10-25 | L E Medical | Ogondroppar |
US4617299A (en) * | 1983-12-19 | 1986-10-14 | Knepper Paul A | Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension |
US4812448A (en) * | 1984-10-22 | 1989-03-14 | Knepper Paul A | Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension |
US4863912A (en) * | 1986-05-19 | 1989-09-05 | New York Medical College | Use of tetrahydrocortisol in glaucoma therapy |
US4774236A (en) * | 1986-09-17 | 1988-09-27 | Research Triangle Institute | 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them |
US4861763A (en) * | 1986-09-17 | 1989-08-29 | Research Triangle Institute | 17 α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and their progestational use |
US4866049A (en) * | 1987-08-10 | 1989-09-12 | Spectra Pharmaceutical Services, Inc. | Ophthalmic compositionn and method of using same |
US4954490A (en) * | 1988-06-23 | 1990-09-04 | Research Triangle Institute | 11 β-substituted progesterone analogs |
US4951683A (en) * | 1989-01-19 | 1990-08-28 | Davis Jeffrey P | Device for detecting keratoconjunctivitis sicca |
US5041434A (en) * | 1991-08-17 | 1991-08-20 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
-
1990
- 1990-05-07 US US07/520,077 patent/US5041434A/en not_active Ceased
-
1991
- 1991-08-17 AT AT91917537T patent/ATE234100T1/de not_active IP Right Cessation
- 1991-08-17 DE DE69133214T patent/DE69133214T2/de not_active Expired - Fee Related
- 1991-08-17 ES ES91917537T patent/ES2086268T3/es not_active Expired - Lifetime
- 1991-08-17 EP EP91917537A patent/EP0652754B1/de not_active Expired - Lifetime
- 1991-08-17 DK DK91917537T patent/DK0652754T3/da active
- 1991-08-17 WO PCT/US1991/005863 patent/WO1993003731A1/en active IP Right Grant
- 1991-08-17 DE DE0652754T patent/DE652754T1/de active Pending
-
1996
- 1996-05-31 GR GR960300027T patent/GR960300027T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE234100T1 (de) | 2003-03-15 |
GR960300027T1 (en) | 1996-05-31 |
EP0652754A4 (de) | 1994-11-09 |
EP0652754B1 (de) | 2003-03-12 |
EP0652754A1 (de) | 1995-05-17 |
DK0652754T3 (da) | 2003-06-10 |
ES2086268T1 (es) | 1996-07-01 |
DE69133214T2 (de) | 2003-12-18 |
ES2086268T3 (es) | 2003-11-16 |
WO1993003731A1 (en) | 1993-03-04 |
US5041434A (en) | 1991-08-20 |
DE652754T1 (de) | 1996-09-12 |
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