DE69132348T2 - Verbindungen vom chinolizinon-typ - Google Patents

Verbindungen vom chinolizinon-typ

Info

Publication number
DE69132348T2
DE69132348T2 DE69132348T DE69132348T DE69132348T2 DE 69132348 T2 DE69132348 T2 DE 69132348T2 DE 69132348 T DE69132348 T DE 69132348T DE 69132348 T DE69132348 T DE 69132348T DE 69132348 T2 DE69132348 T2 DE 69132348T2
Authority
DE
Germany
Prior art keywords
loweralkyl
group
loweralkoxy
amino
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69132348T
Other languages
English (en)
Other versions
DE69132348D1 (de
Inventor
T Chu
M Lee
Qun Li
S Cooper
J Plattner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of DE69132348D1 publication Critical patent/DE69132348D1/de
Publication of DE69132348T2 publication Critical patent/DE69132348T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69132348T 1990-05-02 1991-05-01 Verbindungen vom chinolizinon-typ Expired - Fee Related DE69132348T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51778090A 1990-05-02 1990-05-02
PCT/US1991/002998 WO1991016894A1 (en) 1990-05-02 1991-05-01 Quinolizinone type compounds

Publications (2)

Publication Number Publication Date
DE69132348D1 DE69132348D1 (de) 2000-09-07
DE69132348T2 true DE69132348T2 (de) 2001-03-15

Family

ID=24061202

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69132348T Expired - Fee Related DE69132348T2 (de) 1990-05-02 1991-05-01 Verbindungen vom chinolizinon-typ

Country Status (10)

Country Link
EP (1) EP0527889B1 (de)
JP (1) JP2514136B2 (de)
AT (1) ATE195122T1 (de)
CA (1) CA2081891C (de)
DE (1) DE69132348T2 (de)
DK (1) DK0527889T3 (de)
ES (1) ES2150904T3 (de)
GR (1) GR3034694T3 (de)
IE (1) IE911472A1 (de)
WO (1) WO1991016894A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599816A (en) * 1990-05-02 1997-02-04 Abbott Laboratories Quinolizinone type compounds
US5252747A (en) * 1992-09-11 1993-10-12 Abbott Laboratories Chiral quinolone intermediates
CN1053188C (zh) * 1993-10-14 2000-06-07 艾博特公司 喹嗪酮类化合物
CZ12097A3 (en) * 1994-07-18 1997-09-17 Ube Industries Trifluoromethylquinolinecarboxylic acid derivatives and pharmaceutical composition containing thereof
US5618813A (en) * 1995-05-26 1997-04-08 Abbott Laboratories Benzo[5.6]pyrano[2.3.4-ij]quinolizine and benzo[5.6]thiopyrano[2.3.4-ij]quinolizine derivatives as antibacterial and antineoplastic agents
IL122296A0 (en) * 1995-06-06 1998-04-05 Abbott Lab Quinolizinone type compounds
US5703244A (en) * 1996-11-21 1997-12-30 Abbott Laboratories Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds
US5693813A (en) * 1997-02-26 1997-12-02 Abbott Laboratories Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid
PL339408A1 (en) 1997-09-15 2000-12-18 Procter & Gamble Antimicrobial quinolones, agents containing them and their applications
US6630488B1 (en) 1998-09-21 2003-10-07 Biochem Pharma, Inc. Quinolizinones as integrin inhibitors
US6197974B1 (en) 1998-10-26 2001-03-06 Abbott Laboratories Enantioselective synthesis of 3-aminopyrrolidines
AU2001286191A1 (en) * 2000-09-12 2002-03-26 Sankyo Company, Limited Quinolizine derivatives
AU3089102A (en) 2000-12-14 2002-06-24 Procter & Gamble Antimicrobial quinolones
NZ525570A (en) 2000-12-14 2005-04-29 Procter & Gamble Antimicrobial 2-pyridones, their compositions and uses
US7745459B2 (en) 2004-09-21 2010-06-29 Japan Tobacco Inc. Quinolizinone compound and use thereof as HIV integrase inhibitor
WO2006033422A1 (ja) * 2004-09-21 2006-03-30 Japan Tobacco Inc. キノリジノン化合物、およびそのｈｉｖインテグラーゼ阻害剤としての利用
MX2008012328A (es) 2006-03-28 2008-10-09 Procter & Gamble Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil- piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinc arboxilico.
JP2009531418A (ja) 2006-03-28 2009-09-03 ザ プロクター アンド ギャンブル カンパニー キノロン中間体調製のためのカップリング方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1067079A (en) * 1976-07-22 1979-11-27 Yamanouchi Pharmaceutical Co. Nitrogen-containing heterobicyclic compounds
HU178910B (en) * 1977-08-19 1982-07-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 2,3-disubstituted-4-oxo-4h-pyrido/1,2-a/-pyrimidines
JPS57203085A (en) * 1981-06-09 1982-12-13 Dai Ichi Seiyaku Co Ltd 1,8-cyclic substituted quinoline derivative
US4650804A (en) * 1984-03-30 1987-03-17 Fujisawa Pharmaceutical Co., Ltd. Quinolizinone compounds and pharmaceutical composition comprising the same, useful as anti-ulcerative and anti-allergic agents
GB8408292D0 (en) * 1984-03-30 1984-05-10 Fujisawa Pharmaceutical Co Quinolizinone compound
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
DE3517535A1 (de) * 1985-05-15 1986-11-20 Bayer Ag, 5090 Leverkusen 1-aryl-4-chinolon-3-carbonsaeuren
JPS6277385A (ja) * 1985-08-30 1987-04-09 Fujisawa Pharmaceut Co Ltd キノリジノン化合物、その製造法およびそれを含有する医薬組成物
EP0224121A3 (de) * 1985-11-19 1987-11-11 ROTTAPHARM S.p.A. 7-[4-Aminopiperazinyl]- oder 7-[4-Chlorpiperazinyl]chinolinonderivate,Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4877795A (en) * 1987-01-30 1989-10-31 Kissei Pharmaceutical Co., Ltd. 4H-quinolizin-4-one compounds useful for the treatment of allergic bronchial asthma, allergic rhinitis atropic dermatitis and the like
US4921857A (en) * 1987-09-18 1990-05-01 Merck & Co., Inc. 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof
NZ232091A (en) * 1989-01-16 1990-12-21 Bellon Labor Sa Roger 7-fluoro-8-(piperazin-1-yl)-4-oxo-1,4-dihydro-benzo(b)(1,8)naphthyridine-3-carboxylic acid derivatives, preparation and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
EP0527889A4 (en) 1994-08-10
CA2081891A1 (en) 1991-11-03
IE911472A1 (en) 1991-11-06
GR3034694T3 (en) 2001-01-31
EP0527889A1 (de) 1993-02-24
JP2514136B2 (ja) 1996-07-10
ES2150904T3 (es) 2000-12-16
CA2081891C (en) 1999-03-16
JPH05503709A (ja) 1993-06-17
DK0527889T3 (da) 2000-12-18
EP0527889B1 (de) 2000-08-02
ATE195122T1 (de) 2000-08-15
WO1991016894A1 (en) 1991-11-14
DE69132348D1 (de) 2000-09-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee